Abstract:
PURPOSE OF REVIEW:Tubulointerstitial nephritis and uveitis syndrome (TINU) is a specific form of intraocular inflammation (uveitis) combined with kidney disease that was first described in two patients by Dobrin et al. in 1975. Since then, approximately 200 more cases have been published. The cause of the disease is still unknown. A hypersensitivity reaction is suspected, especially an infection or very rarely a medication reaction is thought to trigger the disease. It is considered to be a rare disease and thus unfortunately is still unfamiliar to most ophthalmologists. Therefore, it is frequently overlooked in the differential diagnosis. In this review we want to show advances in diagnostics and treatment as well as progress in deciphering the pathogenesis. RECENT FINDINGS:Beta-2 microglobulin (Ub2MG) analysis in urine and human leukocyte antigen (HLA) typing is helpful to diagnose TINU cases. A high association of HLA-DRB1*01 has been shown with TINU. A first single case report suggests a common antibody production against ocular and renal proteins. SUMMARY:TINU is a common cause of uveitis among patients who present with bilateral, anterior uveitis of sudden onset. It is more frequent in children and apparently in boys. Although the activity of the eye disease can persist for many months, it is usually controlled with little treatment and the outcome is very good.
journal_name
Curr Opin Ophthalmoljournal_title
Current opinion in ophthalmologyauthors
Mackensen F,Billing Hdoi
10.1097/ICU.0b013e3283318f9asubject
Has Abstractpub_date
2009-11-01 00:00:00pages
525-31issue
6eissn
1040-8738issn
1531-7021journal_volume
20pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:The phaco machine is frequently overlooked as the crucial surgical instrument it is. Understanding how to set parameters is initiated by understanding fundamental concepts of machine function. RECENT FINDINGS:This study analyses the critical concepts of partial occlusion phaco, occlusion phaco and pu...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32835b0770
更新日期:2013-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Corneal collagen cross-linking has recently emerged as a novel approach for management of ectasia. This article reviews the literature published in the past 3 years about the expanding spectrum of cross-linking as a therapeutic modality and its complications. RECENT FINDINGS:Recent studies have confi...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e328354865e
更新日期:2012-07-01 00:00:00
abstract::The current literature and meeting abstracts regarding combined cataract and glaucoma surgery are reviewed. Potential acuity measurements are compared. Intraoperative manipulation of the pupil, wound size, antimetabolites, and types of filtration surgery are also discussed. Postoperative intraocular pressure rise, f...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:
更新日期:1993-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To review current practices for trachoma treatment with a focus on recent studies, particularly those discussing trachoma trichiasis surgery. RECENT FINDINGS:Azithromycin eye drops twice daily for 3 days may be as efficient as oral azithromycin in treating active trachoma. Facial cleanliness and envi...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000504
更新日期:2018-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe recent advances in the understanding of the pathogenesis of the most common malignant lymphomas that occur as primary and secondary tumors in ocular tissues. RECENT FINDINGS:Advances have been made in the understanding of the genetic alterations in mucosa-associated lymphoid tissue lympho...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e328010948d
更新日期:2006-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The successful treatment of canalicular obstructions continues to represent a therapeutic challenge. Conjuctivodacryocystorhinostomy with a Lester Jones bypass tube is the standard treatment in these situations. Although a high rate of anatomic success can be achieved with this procedure, a relatively...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32832ec3e0
更新日期:2009-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Eye pain is one of the most common presenting symptoms in ophthalmology. It can range from bothersome to debilitating for patients, and it can be vexing for clinicians, especially in the white and quiet eye. The purpose of this review is to provide updates of recent literature regarding eye pain and t...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000702
更新日期:2020-11-01 00:00:00
abstract::Strabismus surgery may restore limited binocular function and improve cosmesis in patients with paralytic strabismus. Evaluation of the amount of residual function of the affected extraocular muscles is essential to determine which surgical procedure will yield the best results. Standard muscle resection techniques ar...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200112000-00005
更新日期:2001-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Intraocular lens (IOL) calculations in patients with keratoconus and other keratoectatic disorders continues to be a challenge for today's cataract surgeon. In this article, we review data published over the past 18 months (June 2018 to January 2020). RECENT FINDINGS:Cataract surgery in keratoconus p...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000671
更新日期:2020-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Cataracts are a significant cause of blindness and visual impairment worldwide. The present article reviews the literature and describes the current extent of cataracts globally, barriers to treatment, and recommendations for improving the treatment of cataracts. RECENT FINDINGS:Prevalence and absolu...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000340
更新日期:2017-01-01 00:00:00
abstract::Patients with Alzheimer's disease may present to the ophthalmologist with visual symptoms that precede or overshadow the features of dementia. This visual variant of Alzheimer's disease has been recognized only recently and typically appears in late middle age as progressive visuospatial and reading dysfunction, with ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:
更新日期:1994-12-01 00:00:00
abstract::Healing of corneal wounds is a complex process involving epithelial, keratocyte, and endothelial interactions that are affected by their associations with wound bed matrix and by cytokine availability and activation. The spectrum of possible cellular-matrix-growth factor interactions is indeed great and growing. Sever...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199508000-00002
更新日期:1995-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Although researchers continue to investigate the multifarious etiologic, anatomical, physiological, and pathological factors of dry eye, successful treatment remains a challenge. RECENT FINDINGS:Dry eye prevalence is substantial across populations and the term 'dry eye' is used to describe numerous c...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32832b7578
更新日期:2009-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Glaucoma has a disproportionate prevalence among specific ethnic groups. Therefore, the issue of 'race' and glaucoma has been the focus of much discussion. The purpose of this article is to provide a review of the literature regarding the prevalence, management, and outcome of glaucoma among different...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000156137.28193.48
更新日期:2005-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the current standard of care in the diagnosis and treatment of pituitary apoplexy and to determine any updated clinical management strategies. RECENT FINDINGS:Pituitary apoplexy is a rare but life-threatening medical emergency. Presenting signs and symptoms often include severe headache, vi...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3283319061
更新日期:2009-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe recent evidence regarding methods of evaluation of retinal structure and function prior to cataract surgery. RECENT FINDINGS:Studies in patients with cataract but no clinically detectable retinal disease have shown that routine use of optical coherence tomography (OCT) prior to cataract s...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000432
更新日期:2018-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Significant advances have been made in oncology and rheumatology with the introduction of molecularly targeted agents (MTAs). MTAs consist of monoclonal antibodies and small molecule inhibitors. The purpose of this manuscript is to review the recent applications of MTAs to orbital, lacrimal, and eyeli...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000403
更新日期:2017-09-01 00:00:00
abstract::Clonidine hydrochloride, apraclonidine hydrochloride, and brimonidine tartrate constitute the three topical alpha agonists that are used in the treatment of elevated intraocular pressure. All the alpha agonists have prejunctional (alpha 2) as well as postjunctional (alpha 1) effects. Within the past year, questions ha...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199804000-00006
更新日期:1998-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent advances in experimental studies of optic nerve regeneration to better understand the pathophysiology of axon regrowth and provide insights into the future treatment of numerous optic neuropathies. RECENT FINDINGS:The optic nerve is part of the central nervous system and cannot regenerate if i...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000417
更新日期:2017-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Chemodenervation has evolved greatly over the past 30 years since botulinum toxin was first introduced as a therapeutic injection for managing strabismus. RECENT FINDINGS:Botulinum toxins are now accepted as a first-line treatment for patients suffering from spasms secondary to facial dystonias. Thes...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200310000-00003
更新日期:2003-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Advances in the design of intraocular lenses give options to patients for some return to the optical accommodation needed to focus on objects at different distances. Technology is only improving these options for presbyopic-correcting intraocular lenses. Surgeons must consider the possible neuroadapta...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3282f31758
更新日期:2008-01-01 00:00:00
abstract::Recent advances in cataract surgery have reduced the incidence of corneal complications. Review of the current literature reveals a trend toward early visual rehabilitation and minimization of postoperative astigmatism by careful selection of incision type and location for small-incision cataract surgery. Since the in...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199608000-00010
更新日期:1996-08-01 00:00:00
abstract::Angiogenesis is a fundamental component of normal development and pathologic processes within the eye. Complications due to abnormal ocular neovascularization remain the leading cause of visual loss throughout the world today. Neovascularization and the associated increase in vascular permeability are the underlying t...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199706000-00005
更新日期:1997-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe the emerging applications of deep learning in ophthalmology. RECENT FINDINGS:Recent studies have shown that various deep learning models are capable of detecting and diagnosing various diseases afflicting the posterior segment of the eye with high accuracy. Most of the initial studies hav...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000470
更新日期:2018-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Methods of flap creation have changed over the years from the evolution of the mechanical microkeratome to the introduction of the IntraLase femtosecond laser keratome, both of which have different mechanisms of action to create corneal resections. Previous studies report the advantages and disadvanta...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000233957.88509.2d
更新日期:2006-08-01 00:00:00
abstract:PURPOSE OF REVIEW:A variety of options exist for perioperative, intraoperative, and postoperative medications in cataract surgery. This article reviews some of the more timely literature on "controversial" subjects in this area. RECENT FINDINGS:Recent literature may support the rationale for intracameral vancomycin at...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200402000-00010
更新日期:2004-02-01 00:00:00
abstract::The reasons for having combined glaucoma and corneal transplant surgery are myriad. Patients with corneal transplants have a high frequency of developing secondary glaucoma. Patients with preexisting glaucoma have even higher risk for developing glaucoma refractory to medical management after penetrating keratoplasty....
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200304000-00008
更新日期:2003-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The phakomatoses are a group of inherited disorders with variable clinical manifestations that are characterized by brain, cutaneous, ocular and other distinct lesions in multiple organs. Correctly recognizing the neuro-ophthalmic signs and symptoms can lead to early diagnosis and treatment. The group...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000609
更新日期:2019-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss the risks, benefits and value of genetic testing for ocular genetic disease. RECENT FINDINGS:Testing for ocular genetics diseases is becoming more available and successful gene therapy is being reported. Clinicians must prepare for this trend by considering diagnostic genetic testing for t...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000083
更新日期:2014-09-01 00:00:00
abstract::Modern molecular genetics has had a profound effect on our understanding of corneal dystrophies. Mutations in the BIGH3 gene are responsible for four autosomal dominant corneal dystrophies. The mutation spectrum reveals the phenotypically diverse possibilities stemming from mutations of a single gene. Dystrophies have...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200208000-00002
更新日期:2002-08-01 00:00:00