Abstract:
PURPOSE OF REVIEW:To discuss the most recent literature regarding the long-term use (≥52 weeks of follow-up) of antivascular endothelial growth factor (VEGF) therapy for neovascular age-related macular degeneration (NVAMD). RECENT FINDINGS:Intravitreal ranibizumab has been demonstrated to provide outstanding vision outcomes relative to the standard therapy in patients with NVAMD. The VEGF Trap-Eye: Investigation of Efficacy and Safety in Wet AMD studies showed that patients managed with intravitreal aflibercept achieved visual acuity and anatomic improvements similar to individuals managed with monthly ranibizumab while receiving an average of five fewer injections during the first 12 months of treatment. In the Comparison of AMD Treatment Trials, intravitreal bevacizumab dosed monthly met noninferiority to ranibizumab monthly, as well as noninferiority to ranibizumab dosed as-needed with respect to change in visual acuity 1 year after the treatment initiation. Furthermore, patients switched to as-needed regimens in their second year of follow-up from monthly dosing during the first year demonstrated an incremental loss of visual acuity during the second year of follow-up irrespective of the drug used. To date, trials evaluating anti-VEGF therapy for NVAMD demonstrate a low incidence of serious ocular or systemic adverse events. However, the potential for deleterious effects of long-term (beyond 2 years) pan-VEGF blockade remains unknown. SUMMARY:Patients with NVAMD enjoy heretofore unprecedented vision gains when managed with anti-VEGF therapy, and the limited body of evidence to date regarding long-term anti-VEGF treatment shows these vision gains can be maintained through 2 years. Further investigation is needed to explore the effects of long-term anti-VEGF therapy beyond 2 years.
journal_name
Curr Opin Ophthalmoljournal_title
Current opinion in ophthalmologyauthors
Scott AW,Bressler SBdoi
10.1097/ICU.0b013e32835fefeesubject
Has Abstractpub_date
2013-05-01 00:00:00pages
190-6issue
3eissn
1040-8738issn
1531-7021journal_volume
24pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:To review new developments in the medical and surgical treatment options for benign essential blepharospasm (BEB). RECENT FINDINGS:Botulinum toxin injections remain the mainstay treatment for BEB with several formulations currently commercially available. Reports in the medical literature support pho...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000500
更新日期:2018-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Cataract surgery in India has seen exponential growth in the past decade. This leap was possible due to cost-effective cataract surgery with intraocular lenses. The purpose of this review is to update the reader regarding the Indian scenario of cataract surgery and intraocular lens manufacturing. REC...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3282f2aaed
更新日期:2008-01-01 00:00:00
abstract::Diabetes and thyroid-related eye disease cause significant morbidity. Although these are endocrine disorders, they cause different ocular manifestations. Previously unexamined epidemiologic factors offer new insight to diabetic eye disease. The association of hyperglycemia, systemic medical therapy, and visual loss is...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199412000-00011
更新日期:1994-12-01 00:00:00
abstract:PURPOSE OF REVIEW:This review summarizes the recent literature of the impact of cataract surgery from the patient's perspective, with a focus on second-generation patient reported outcome (PRO) measures that used Rasch analysis to explore their data. RECENT FINDINGS:Irrespective of the instrument utilized, the overrid...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3283414284
更新日期:2011-01-01 00:00:00
abstract:PURPOSE OF REVIEW:This article presents, summarizes, and interprets the most recent advances in the study and understanding of the lamina cribrosa in glaucoma, in the context of previous work. RECENT FINDINGS:The lamina is an active living structure that responds to strain by changing morphology at the micro-scale and...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000354
更新日期:2017-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to review the retinal complications that may occur after laser-assisted in situ keratomileusis (LASIK). RECENT FINDINGS:One study investigated the incidence, characteristics, and surgical management of rhegmatogenous retinal detachment after LASIK surgery in myopia. The inc...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3282fb7c15
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The evolution of laser technology has left today's refractive surgeon with a choice between multiple laser platforms. The purpose of this review is to compare currently available femtosecond and excimer laser platforms, providing a summary of current evidence. RECENT FINDINGS:Femtosecond lasers creat...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000268
更新日期:2016-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Scleral rigid gas-permeable lenses play an important and underappreciated role in the treatment of corneal disease. This review provides an update on scleral rigid gas-permeable lenses for the visual rehabilitation of ectasia and irregular astigmatism, and an update on scleral rigid gas-permeable lens...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e328302cc4f
更新日期:2008-07-01 00:00:00
abstract::The optic nerve head and the retinal nerve fiber layer (RNFL) are the sites of clinically detectable glaucomatous tissue damage. Photographic techniques are used to document the optic disk and the RNFL to monitor patients with suspected primary open-angle glaucoma or to follow-up patients already suffering from this d...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199604000-00017
更新日期:1996-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To perform a literature review of articles published between 2016 and 2017 to assess recent advances in intraocular lens (IOL) selection. RECENT FINDINGS:A literature review revealed five areas of recent study including advances in biometric technology, formula selection for challenging eyes, accurat...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000493
更新日期:2018-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The Charles Bonnet syndrome is a disorder of visual hallucinations typically occurring in older persons with vision impairment or deafferentation of the visual cortex. This review cites recent studies on Charles Bonnet syndrome and discusses treatment options. The numbers of affected persons will incr...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000193100.13551.ac
更新日期:2006-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an update on clinical and experimental literature for ocular surface effects of glaucoma therapy and to provide practical guidelines for ophthalmologists treating glaucoma patients with ocular surface disease (OSD). RECENT FINDINGS:Preservatives, notably benzalkonium chloride (BAK), contin...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32835c8aba
更新日期:2013-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Many causes of toxic optic neuropathy have been described to date and novel causes of toxicity are continuously being added to the current literature. The pathophysiological basis for the toxicity or a direct causal relationship is yet to be determined for many of these agents. This review highlights ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000001
更新日期:2013-11-01 00:00:00
abstract::This article reviews some of the advances that have taken place in the surgical techniques for difficult cataracts such as rock-hard, white, and posterior polar cataracts. Fashioning a central space, modified chopping maneuvers, and creation of multiple small fragments have enabled the surgeon to consistently achieve ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199902000-00009
更新日期:1999-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent developments in the diagnosis and management of sickle cell ocular manifestations are reviewed to enable the clinician to better manage the ophthalmic care of these patients. RECENT FINDINGS:Research over the past year has focused upon systemic and ocular clues to the presence of sickle cell r...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e328358b921
更新日期:2012-11-01 00:00:00
abstract::Modern molecular genetics has had a profound effect on our understanding of corneal dystrophies. Mutations in the BIGH3 gene are responsible for four autosomal dominant corneal dystrophies. The mutation spectrum reveals the phenotypically diverse possibilities stemming from mutations of a single gene. Dystrophies have...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200208000-00002
更新日期:2002-08-01 00:00:00
abstract::Recent advances in the field of infectious conjunctivitis and keratitis include new diagnostic methods, the identification of new pathogens, and novel therapeutic agents. Tandem confocal microscopy has been used to diagnose Acanthamoeba keratitis, and polymerase chain reaction has proven to be a rapid and sensitive te...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199708000-00002
更新日期:1997-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To review recent studies on potential neurodevelopmental impacts on the pediatric population through general anesthesia events or intravitreal anti-vascular endothelial growth factor (VEGF) injection. RECENT FINDINGS:Studies on this topic have been extensive with varied reported neurodevelopmental ou...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000598
更新日期:2019-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Although researchers continue to investigate the multifarious etiologic, anatomical, physiological, and pathological factors of dry eye, successful treatment remains a challenge. RECENT FINDINGS:Dry eye prevalence is substantial across populations and the term 'dry eye' is used to describe numerous c...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32832b7578
更新日期:2009-07-01 00:00:00
abstract::Glaucoma is a progressive optic neuropathy that has a multi-factorial etiology. The most important risk factor is certainly an increased intraocular pressure. However, clinical observations have indicated that factors other than increased intraocular pressure also damage the neural tissue in glaucomatous optic neuropa...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199804000-00016
更新日期:1998-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the ocular findings of patients with West Nile Virus. RECENT FINDINGS:Ocular findings have included multifocal choroiditis, vitritis, intraretinal hemorrhages, iritis, keratic precipitates, optic neuritis, branch retinal artery occlusions, and chorioretinal scarring in a case of intrauterin...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000143687.45232.f1
更新日期:2004-12-01 00:00:00
abstract::Patients with Alzheimer's disease may present to the ophthalmologist with visual symptoms that precede or overshadow the features of dementia. This visual variant of Alzheimer's disease has been recognized only recently and typically appears in late middle age as progressive visuospatial and reading dysfunction, with ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:
更新日期:1994-12-01 00:00:00
abstract::The detection of true visual field deterioration in glaucoma is of fundamental importance but is limited by inherent variability of the measurements. New techniques have been developed that use powerful statistical regression analysis methods to objectively quantify progression of visual field defects. These have be...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章
doi:10.1097/00055735-199404000-00016
更新日期:1994-04-01 00:00:00
abstract:PURPOSE OF REVIEW:There have been many reports in recent literature concerning the use of scanning laser polarimetry, Heidelberg retinal tomography and optical coherence topography in assessing the optic nerve and peripapillary nerve fibre layer. It is important to assess the validity of new equipment and see whether t...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3283112bc8
更新日期:2008-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The history, pharmacology, indications, complications, and success rates of botulinum administration are discussed in this review as they relate to strabismus and associated conditions. RECENT FINDINGS:Botulinum has been used to treat strabismus and a variety of other ocular conditions for over three...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000243018.97627.4c
更新日期:2006-10-01 00:00:00
abstract::The reasons for having combined glaucoma and corneal transplant surgery are myriad. Patients with corneal transplants have a high frequency of developing secondary glaucoma. Patients with preexisting glaucoma have even higher risk for developing glaucoma refractory to medical management after penetrating keratoplasty....
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200304000-00008
更新日期:2003-04-01 00:00:00
abstract::Using a liberal definition of corneal irregularity, modern videokeratoscopy may define approximately 40% of normal corneas with a toric refractive error as possessing primary irregular astigmatism. The causes of secondary forms of irregular astigmatism include corneal surgery, trauma, dystrophies, and infections. Inte...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200008000-00007
更新日期:2000-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this study is to discuss current controversies surrounding the proposed treatments for traumatic optic neuropathy (TON) and review recent evidence from the literature relating to these therapeutic options. RECENT FINDINGS:No recent randomized controlled trials investigating surgical or...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000198
更新日期:2015-11-01 00:00:00
abstract::Porous high-density polyethylene implants have become well accepted for the repair of orbital wall fractures, delayed orbital reconstruction, orbital rim and malar bony onlay augmentation, and volume replacement as orbital spherical implants for the treatment of anophthalmos. Medpor (Porex Surgical, Inc. College Park,...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199710000-00012
更新日期:1997-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Corneal transplantation is the most commonly performed solid organ transplantation in the world. Despite a glorious history of more than a 100 years, the success of conventional corneal transplantation surgery is marred by problems like graft rejection,graft infection and associated glaucoma due to lo...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:
更新日期:2010-07-01 00:00:00