Abstract:
:Glaucoma is a progressive optic neuropathy that has a multi-factorial etiology. The most important risk factor is certainly an increased intraocular pressure. However, clinical observations have indicated that factors other than increased intraocular pressure also damage the neural tissue in glaucomatous optic neuropathy. The most prominent of these to be vascular dysregulation. Vascular tone is permanently regulated by a number of regulatory systems and factors, and the endothelial cell layer acts as an important mediator for the response to these factors. According to recent evidence, glaucomatous optic neuropathy may be associated with changes in endothelium-dependent vascular regulation. Consequently, therapeutic approaches based on vasodilator drugs acting via endothelium-derived substances are being developed. Although promising preliminary studies have been performed, the clinical relevance of such treatment remains to be clarified.
journal_name
Curr Opin Ophthalmoljournal_title
Current opinion in ophthalmologyauthors
Orgül S,Prünte C,Flammer Jdoi
10.1097/00055735-199804000-00016keywords:
subject
Has Abstractpub_date
1998-04-01 00:00:00pages
88-94issue
2eissn
1040-8738issn
1531-7021journal_volume
9pub_type
杂志文章,评审abstract::A wealth of antiallergic drugs is available for ocular allergy, and many new drugs will soon be approved. Pharmaceutical companies frequently seek approval of anti-inflammatory drugs for allergic indications, because it is relatively easy to perform clinical trials for ocular allergy. Extremely safe drugs for mild to ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199808000-00010
更新日期:1998-08-01 00:00:00
abstract::New knowledge of the pathophysiology of amblyopia has evolved through animal research over the past 30 years. We now know that development and treatment of amblyopia have a critical and sensitive period. After more than a millennium, patching of the dominant eye remains the cornerstone of amblyopia treatment, and comp...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199610000-00003
更新日期:1996-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The diagnosis and successful treatment of visually significant refractive errors in children are a subject of continued study and debate. RECENT FINDINGS:Treatment of significant refractive errors is widely accepted to reduce lifelong vision loss from amblyopia. Children aged 3-5 years may be screene...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e328244dfed
更新日期:2007-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Many causes of toxic optic neuropathy have been described to date and novel causes of toxicity are continuously being added to the current literature. The pathophysiological basis for the toxicity or a direct causal relationship is yet to be determined for many of these agents. This review highlights ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000001
更新日期:2013-11-01 00:00:00
abstract::Certain paraneoplastic disorders associated with degeneration of the retina, optic nerve, brainstem, and cerebellum may cause visual loss, impairment of ocular motility, or nystagmus and other saccadic intrusions and oscillations. Most of these remote effects of cancer are probably autoimmune conditions. Many affected...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199612000-00005
更新日期:1996-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Although lens surgery for high myopia has a long History, it has been extremely controversial. Colin's study of 1999 indicated a much higher than expected rate of retinal detachment. The purpose of this review is to reassess the place of refractive lens exchange in high myopia in the light of more rec...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200502000-00009
更新日期:2005-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The phaco machine is frequently overlooked as the crucial surgical instrument it is. Understanding how to set parameters is initiated by understanding fundamental concepts of machine function. RECENT FINDINGS:This study analyses the critical concepts of partial occlusion phaco, occlusion phaco and pu...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32835b0770
更新日期:2013-01-01 00:00:00
abstract:PURPOSE OF REVIEW:There is a suggestion of increased risk or progression of age-related macular degeneration after cataract surgery, which is related to the increased exposure of the retina to short-wavelength light. RECENT FINDINGS:Cell culture and animal work has described retinal and retinal pigment epithelium phot...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3280112a0f
更新日期:2007-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Molecular genetics is revolutionizing the diagnosis and treatment of inherited eye diseases. The National Eye Institute of the National Institutes of Health (NIH), in an effort to facilitate future basic and clinical research in inherited eye disease, created The National Ophthalmic Disease Genotyping...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32835715c9
更新日期:2012-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Corneal measurement uses Placido-disc topographers and tomographers, creating three-dimensional corneal models from cross-sectional images. Technology includes slit scanning, Scheimpflug imaging, very high frequency ultrasound, and high-speed anterior segment optical coherence tomography. RECENT FIND...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3281ca7121
更新日期:2007-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Although researchers continue to investigate the multifarious etiologic, anatomical, physiological, and pathological factors of dry eye, successful treatment remains a challenge. RECENT FINDINGS:Dry eye prevalence is substantial across populations and the term 'dry eye' is used to describe numerous c...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32832b7578
更新日期:2009-07-01 00:00:00
abstract::Our understanding of ocular manifestations in immunological and rheumatological inflammatory disorders has continued to expand over the past year. A report on the characteristics of ocular disease in children with Behçet's disease is presented. Two reports of Vogt-Koyanagi-Harada syndrome in 4-year-old children are di...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199612000-00015
更新日期:1996-12-01 00:00:00
abstract::A comprehensive review of the ophthalmic literature on cataracts during the past year is presented. Topics covered include new epidemiologic associations, diabetic cataracts, and syndromes involving cataracts. Data from the Beaver Dam Eye Study suggest the presence of a recessive gene for nuclear sclerosis. Estrogen e...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:
更新日期:1995-02-01 00:00:00
abstract::Exfoliation syndrome is the most common identifiable cause leading to chronic open-angle glaucoma. It affects the treatment of glaucoma in various ways. The prognosis of capsular glaucoma (exfoliative glaucoma) is worse than that of open-angle glaucoma. Medical therapy and the long-term effect of laser treatment seem ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199504000-00003
更新日期:1995-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to collate evidence and make recommendations regarding the use of multifocal intraocular lenses in patients with glaucoma. RECENT FINDINGS:Multifocal intraocular implants have been in use since the 1980s. Several studies have been done comparing their advantages and disa...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e328011d108
更新日期:2007-02-01 00:00:00
abstract:PURPOSE OF REVIEW:As Reese first described the vitreomacular traction (VMT) syndrome in 1970, the knowledge base about the disease has been changing over time due to the advent of the high-definition optical coherence tomography (HD-OCT). The aim of this article was to present the current information on the pathophysio...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e328352404c
更新日期:2012-05-01 00:00:00
abstract:PURPOSE OF REVIEW:A significant recent advancement in the treatment of neovascularization of the anterior segment of the eye is the development of antivascular endothelial growth factor (anti-VEGF) therapeutic agents.We present a review of the current knowledge on anti-VEGF therapy with bevacizumab for anterior segment...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3283548459
更新日期:2012-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to describe the current clinical landscape of potential future therapies for both nonexudative (dry) and exudative (wet) age-related macular degeneration (AMD). We highlight some of the more promising treatments that are furthest along in development. RECENT FINDINGS:Pat...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000657
更新日期:2020-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To highlight recent advances in basic research, diagnostic as well as therapeutic advances in ocular parasitosis and to evaluate their application in medical practice. RECENT FINDINGS:Knowledge relating to immunoreactivity in ocular parasitology has grown impressively in past few years. The outcome o...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32833ef67e
更新日期:2010-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe recent advances in clinical features, diagnostic tools, and treatment modalities for lymphoproliferative diseases affecting the ocular adnexa. RECENT FINDINGS:A close relationship of non-Hodgkin lymphoma with long-term use of aspirin and nonaspirin nonsteroidal antiinflammatory drugs has ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000139302.16648.80
更新日期:2004-10-01 00:00:00
abstract:PURPOSE OF REVIEW:A process is ongoing to produce a definition of glaucomatous optic neuropathy (GON) using quantitative, objective data from structural and functional tests. At present, a common practice is to define GON by subjective features said to be 'characteristic' as judged by those experienced in glaucoma care...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000644
更新日期:2020-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The Charles Bonnet syndrome is a disorder of visual hallucinations typically occurring in older persons with vision impairment or deafferentation of the visual cortex. This review cites recent studies on Charles Bonnet syndrome and discusses treatment options. The numbers of affected persons will incr...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000193100.13551.ac
更新日期:2006-06-01 00:00:00
abstract::Healing of corneal wounds is a complex process involving epithelial, keratocyte, and endothelial interactions that are affected by their associations with wound bed matrix and by cytokine availability and activation. The spectrum of possible cellular-matrix-growth factor interactions is indeed great and growing. Sever...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199508000-00002
更新日期:1995-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Diabetic retinopathy and diabetic macular edema (DME) are common eye diseases leading to vision loss. The Diabetic Retinopathy Clinical Research Network (DRCRnet), a collaboration of private and academic practices supported by the National Eye Institute and the National Institute of Diabetes, Digestiv...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000262
更新日期:2016-05-01 00:00:00
abstract::An improvement in our understanding of the pathogenesis and natural history of idiopathic macular holes over the last 10 years has led to a more optimistic and interventionist approach to the surgical management of this vitreoretinal disorder. This article reviews the theories postulated for the pathogenesis of this c...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199706000-00015
更新日期:1997-06-01 00:00:00
abstract:PURPOSE OF REVIEW:A variety of options exist for perioperative, intraoperative, and postoperative medications in cataract surgery. This article reviews some of the more timely literature on "controversial" subjects in this area. RECENT FINDINGS:Recent literature may support the rationale for intracameral vancomycin at...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200402000-00010
更新日期:2004-02-01 00:00:00
abstract::The development of ocular imaging devices has progressed rapidly during the past 10 years. Ultrasound biomicroscopy has revolutionized the evaluation of the anterior segment of the eye. The qualitative information gathered using this technology has contributed to our understanding of the pathophysiology of angle-closu...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200004000-00012
更新日期:2000-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The recent literature was reviewed to analyze the developments in the diagnosis, pathogenesis, and immunology of this group of paraneoplastic syndromes. Clinical features and pathologic findings are summarized. RECENT FINDINGS:The mechanism of cell death in cancer-associated retinopathy appears to oc...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200312000-00017
更新日期:2003-12-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an update on current management of retinoblastoma RECENT FINDINGS:The current major treatment strategies for retinoblastoma involve enucleation, intravenous chemoreduction, and intra-arterial chemotherapy. Enucleation is reserved for eyes with extensive retinoblastoma, in which there is no...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e328338676a
更新日期:2010-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To present an overview on the clinical manifestations and an update on the current management of neuromyelitis optica (NMO). RECENT FINDINGS:NMO is associated with a significant risk of neurological, ocular and systemic morbidity. Many cases of NMO assume a relapsing course, which can lead clinicians...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3283313d1d
更新日期:2009-11-01 00:00:00