Age-related macular degeneration therapy: a review.

Abstract:

PURPOSE OF REVIEW:The purpose of this review is to describe the current clinical landscape of potential future therapies for both nonexudative (dry) and exudative (wet) age-related macular degeneration (AMD). We highlight some of the more promising treatments that are furthest along in development. RECENT FINDINGS:Patients with dry AMD have long been hoping for a highly efficacious treatment that may slow disease progression or even help regain vision. Patients with wet AMD have many effective treatment options but still there are those who have suboptimal responses or are burdened by the high frequency of treatment. We detail exciting new concepts and targets for novel medications. Specifically, for dry AMD we discuss research looking at complement inhibition, neuroprotection, visual cycle modulators, cell-based therapies, and anti-inflammatory agents. For wet AMD we summarize new, potentially more durable anti-vascular endothelial growth factor agents, extended release options, and gene therapy. SUMMARY:There are promising new strategies for AMD. Many of the potential new treatments are in or have recently completed phase 2 or phase 3 clinical trials with promising results thus far, including some that have received US Food and Drug Administration approval. Additional therapeutic breakthroughs will likely continue to occur thanks to the number of clinical trials that are nearing the finish line.

journal_name

Curr Opin Ophthalmol

authors

Ammar MJ,Hsu J,Chiang A,Ho AC,Regillo CD

doi

10.1097/ICU.0000000000000657

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

215-221

issue

3

eissn

1040-8738

issn

1531-7021

journal_volume

31

pub_type

杂志文章,评审
  • Amniotic membrane surgery.

    abstract::Human amniotic membrane (AM) is composed of three layers: a single epithelial layer, a thick basement membrane, and an avascular stroma. Amniotic membrane has anti-adhesive properties and is felt to promote epithelialization and decrease inflammation, neovascularization, and fibrosis. Amniotic membrane transplantation...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-200108000-00006

    authors: Sippel KC,Ma JJ,Foster CS

    更新日期:2001-08-01 00:00:00

  • Neuroadaptation of presbyopia-correcting intraocular lenses.

    abstract:PURPOSE OF REVIEW:Advances in the design of intraocular lenses give options to patients for some return to the optical accommodation needed to focus on objects at different distances. Technology is only improving these options for presbyopic-correcting intraocular lenses. Surgeons must consider the possible neuroadapta...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e3282f31758

    authors: Pepin SM

    更新日期:2008-01-01 00:00:00

  • Cataract surgical techniques.

    abstract::Cataract surgery continues to evolve as modifications in techniques are introduced. Extracapsular surgery, whether by phacoemulsification or planned extracapsular cataract extraction, is a very safe and effective technique. Maintaining versatility in operative techniques, depending on the clinical situation, is a di...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199302000-00008

    authors: Agapitos PJ

    更新日期:1993-02-01 00:00:00

  • Extracellular matrix and growth factors in corneal wound healing.

    abstract::Healing of corneal wounds is a complex process involving epithelial, keratocyte, and endothelial interactions that are affected by their associations with wound bed matrix and by cytokine availability and activation. The spectrum of possible cellular-matrix-growth factor interactions is indeed great and growing. Sever...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199508000-00002

    authors: Gipson IK,Inatomi T

    更新日期:1995-08-01 00:00:00

  • Mechanical methods in refractive corneal surgery.

    abstract::Keratorefractive surgery has developed rapidly over the past decade. For patients with aphakia, however, posterior chamber lenses are safer and more predictable than refractive corneal surgery; myopia is the greatest challenge to this type of surgery. No technique as yet has an accuracy that is adequate for the gener...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199308000-00013

    authors: Hoffmann F,Kruse H,Schüler A

    更新日期:1993-08-01 00:00:00

  • Molecularly targeted agents in oculoplastic surgery.

    abstract:PURPOSE OF REVIEW:Significant advances have been made in oncology and rheumatology with the introduction of molecularly targeted agents (MTAs). MTAs consist of monoclonal antibodies and small molecule inhibitors. The purpose of this manuscript is to review the recent applications of MTAs to orbital, lacrimal, and eyeli...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000403

    authors: Allen RC

    更新日期:2017-09-01 00:00:00

  • Continuation of anticoagulant and antiplatelet therapy during phacoemulsification cataract surgery.

    abstract:PURPOSE OF REVIEW:The objective of this review is to evaluate the result of cataract surgery in patients continuing antiplatelet and/or anticoagulant treatment. RECENT FINDINGS:The number of elderly patients using anticoagulant and antiplatelet treatment in prevention of venous thromboembolism has significantly increa...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000117

    authors: Grzybowski A,Ascaso FJ,Kupidura-Majewski K,Packer M

    更新日期:2015-01-01 00:00:00

  • Management of canalicular obstructions.

    abstract:PURPOSE OF REVIEW:The successful treatment of canalicular obstructions continues to represent a therapeutic challenge. Conjuctivodacryocystorhinostomy with a Lester Jones bypass tube is the standard treatment in these situations. Although a high rate of anatomic success can be achieved with this procedure, a relatively...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e32832ec3e0

    authors: Liarakos VS,Boboridis KG,Mavrikakis E,Mavrikakis I

    更新日期:2009-09-01 00:00:00

  • Optic nerve disorders.

    abstract::This review highlights recent advances related to diagnosis, clinical course, and management of nonglaucomatous optic neuropathies. Optic nerve disorders of particular interest and importance are emphasized, including ischemic optic neuropathy, optic neuritis, HIV-related infection, neoplastic disease, and pseudotumor...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199712000-00002

    authors: Balcer LJ

    更新日期:1997-12-01 00:00:00

  • Idiopathic orbital inflammation: a new dimension with the discovery of immunoglobulin G4-related disease.

    abstract:PURPOSE OF REVIEW:To review idiopathic orbital inflammation, with particular reference to the evolving entity of ocular adnexal immunoglobulin G4 (IgG4) disease. RECENT FINDINGS:Emerging evidence suggests that sclerosing idiopathic orbital inflammation can be an IgG4-related disease and discovery of this link has furt...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e32835563ec

    authors: Berry-Brincat A,Rose GE

    更新日期:2012-09-01 00:00:00

  • Surgical excision of subfoveal choroidal neovascular membranes.

    abstract::The possibility for visual improvement after the treatment of subfoveal choroidal neovascular membranes with laser photocoagulation is poor. The surgical excision of these membranes in age-related macular degeneration, the presumed ocular histoplasmosis syndrome, idiopathic neovascularization, and myopia is the focus ...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199306000-00004

    authors: Lambert HM,Lopez PF

    更新日期:1993-06-01 00:00:00

  • Vascular risk factors in glaucoma.

    abstract::The role of the villain in high-pressure glaucoma is played by ocular hypertension. Alterations of lamina cribosa, other mechanical alterations, and a possible loss of optic nerve head capillaries are all accountable, and from a therapeutic standpoint most clinicians readily perceive that lowering ocular pressure is t...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:

    authors: Béchetoille A

    更新日期:1996-04-01 00:00:00

  • Resident laser refractive surgery training.

    abstract:PURPOSE OF REVIEW:The Residency Review Committee Ophthalmology of the Accreditation Council for Graduate Medical Education has recently established guidelines pertaining to the minimum operative requirements for training ophthalmology residents in refractive surgery. Despite being one of the most frequently performed o...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e32833a8967

    authors: Madu AA,Ali T

    更新日期:2010-07-01 00:00:00

  • New treatments for serpiginous choroiditis.

    abstract::Serpiginous choroiditis is a bilateral, inflammatory condition of the inner choroid and overlying retinal pigment epithelium with a distinctive retinal distribution. Although rare, serpiginous choroiditis deserves attention because it can lead to permanent loss of vision due to foveal involvement by inflammation or ch...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-200306000-00003

    authors: Akpek EK,Ilhan-Sarac O

    更新日期:2003-06-01 00:00:00

  • Chemodenervation for facial dystonias and wrinkles.

    abstract:PURPOSE OF REVIEW:Chemodenervation has evolved greatly over the past 30 years since botulinum toxin was first introduced as a therapeutic injection for managing strabismus. RECENT FINDINGS:Botulinum toxins are now accepted as a first-line treatment for patients suffering from spasms secondary to facial dystonias. Thes...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-200310000-00003

    authors: Harrison AR

    更新日期:2003-10-01 00:00:00

  • Should patients with ocular genetic disorders have genetic testing?

    abstract:PURPOSE OF REVIEW:To discuss the risks, benefits and value of genetic testing for ocular genetic disease. RECENT FINDINGS:Testing for ocular genetics diseases is becoming more available and successful gene therapy is being reported. Clinicians must prepare for this trend by considering diagnostic genetic testing for t...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000083

    authors: Zanolli MT,Khetan V,Dotan G,Pizzi L,Levin AV

    更新日期:2014-09-01 00:00:00

  • Advances in cataract surgery: preserving the corneal endothelium.

    abstract:PURPOSE OF REVIEW:Cataract surgery is known to lead to some degree of corneal endothelial cell loss (ECL). The purpose of this review is to describe how recent technological advancements such as femtosecond laser-assisted cataract surgery (FLACS) affect corneal endothelium during cataract surgery. RECENT FINDINGS:It h...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000121

    authors: Ho JW,Afshari NA

    更新日期:2015-01-01 00:00:00

  • Anterior segment uses of bevacizumab.

    abstract:PURPOSE OF REVIEW:A significant recent advancement in the treatment of neovascularization of the anterior segment of the eye is the development of antivascular endothelial growth factor (anti-VEGF) therapeutic agents.We present a review of the current knowledge on anti-VEGF therapy with bevacizumab for anterior segment...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e3283548459

    authors: Bahar I,Yeung SN,Sella R,Slomovic A

    更新日期:2012-07-01 00:00:00

  • Pituitary apoplexy: evaluation, management, and prognosis.

    abstract:PURPOSE OF REVIEW:To review the current standard of care in the diagnosis and treatment of pituitary apoplexy and to determine any updated clinical management strategies. RECENT FINDINGS:Pituitary apoplexy is a rare but life-threatening medical emergency. Presenting signs and symptoms often include severe headache, vi...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e3283319061

    authors: Murad-Kejbou S,Eggenberger E

    更新日期:2009-11-01 00:00:00

  • Cross-linking for microbial keratitis.

    abstract:PURPOSE OF REVIEW:Microbial keratitis is one of the leading causes of ocular morbidity. The standard treatment consists of antibiotics, which is intensive and is fraught with risks of antibiotic resistance. Corneal collagen cross-linking (CXL) has recently been advocated as an adjunctive therapy for management of micro...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000271

    authors: Chan TC,Agarwal T,Vajpayee RB,Jhanji V

    更新日期:2016-07-01 00:00:00

  • Current concepts in lacrimal drainage surgery.

    abstract::Dacryocystorhinostomy remains the mainstay of treatment of acquired primary and secondary obstructions of the lacrimal drainage system. The advent of the endoscope has prompted renewed interest in the intranasal or endonasal approach to fistulae formation. As results of the intranasal approach are reported, they are c...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199610000-00010

    authors: Yeatts RP

    更新日期:1996-10-01 00:00:00

  • Ocular manifestations of immunological and rheumatological inflammatory disorders.

    abstract::Our understanding of ocular manifestations in immunological and rheumatological inflammatory disorders has continued to expand over the past year. A report on the characteristics of ocular disease in children with Behçet's disease is presented. Two reports of Vogt-Koyanagi-Harada syndrome in 4-year-old children are di...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199612000-00015

    authors: Bredvik BK,Trocme SD

    更新日期:1996-12-01 00:00:00

  • Comparison of femtosecond and excimer laser platforms available for corneal refractive surgery.

    abstract:PURPOSE OF REVIEW:The evolution of laser technology has left today's refractive surgeon with a choice between multiple laser platforms. The purpose of this review is to compare currently available femtosecond and excimer laser platforms, providing a summary of current evidence. RECENT FINDINGS:Femtosecond lasers creat...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000268

    authors: Chen LY,Manche EE

    更新日期:2016-07-01 00:00:00

  • Acute demyelinating optic neuritis.

    abstract::Acute demyelinating optic neuritis associated with multiple sclerosis (MS) is the most common cause of inflammation of the optic nerve. The Optic Neuritis Treatment Trial (ONTT) has provided important clinical data on the use of corticosteroids, and demonstrated that patients with characteristic inflammatory lesions w...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-200212000-00006

    authors: Foroozan R,Buono LM,Savino PJ,Sergott RC

    更新日期:2002-12-01 00:00:00

  • Instrument-based pediatric vision screening.

    abstract:PURPOSE OF REVIEW:The purpose is to review currently available instruments for vision screening in young children. RECENT FINDINGS:Instrumentation continues to evolve. Although the current generation of photoscreeners and autorefractors strive to identify amblyopia risk factors, newer technology aims to directly ident...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000289

    authors: O'Hara MA

    更新日期:2016-09-01 00:00:00

  • Corneal collagen cross-linking: ectasia and beyond.

    abstract:PURPOSE OF REVIEW:Corneal collagen cross-linking has recently emerged as a novel approach for management of ectasia. This article reviews the literature published in the past 3 years about the expanding spectrum of cross-linking as a therapeutic modality and its complications. RECENT FINDINGS:Recent studies have confi...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e328354865e

    authors: Suri K,Hammersmith KM,Nagra PK

    更新日期:2012-07-01 00:00:00

  • Impact of intravitreal pharmacotherapies including antivascular endothelial growth factor and corticosteroid agents on diabetic retinopathy.

    abstract:PURPOSE OF REVIEW:Diabetic retinopathy is common and increasing in prevalence. Pharmacologic management of diabetic macular edema (DME) has improved tremendously over the last decade with the use of two families of intravitreally administered medications: antivascular endothelial growth factor-specific agents and corti...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000364

    authors: Wykoff CC

    更新日期:2017-05-01 00:00:00

  • Factors for progression and glaucoma treatment: the Early Manifest Glaucoma Trial.

    abstract:PURPOSE OF REVIEW:This review summarizes factors for progression in the Early Manifest Glaucoma Trial (EMGT), including the effect of treatment. EMGT randomized patients with early glaucoma either to argon laser trabeculoplasty plus betaxolol (n = 129) or to no immediate treatment (n = 126) and followed them every 3 mo...

    journal_title:Current opinion in ophthalmology

    pub_type: 临床试验,杂志文章,随机对照试验,评审

    doi:10.1097/00055735-200404000-00008

    authors: Leske MC,Heijl A,Hyman L,Bengtsson B,Komaroff E

    更新日期:2004-04-01 00:00:00

  • Assessing abnormal head posture: a new paradigm.

    abstract:PURPOSE OF REVIEW:We aim to give a systematic approach on how to assess the cause of a patient's abnormal head posture (AHP). RECENT FINDINGS:Over the decades, many important clinical observers and teachers have described diagnostic techniques for patients with AHP. Recently, Wong has added a new set of office-based d...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e3283644f17

    authors: Halachmi-Eyal O,Kowal L

    更新日期:2013-09-01 00:00:00

  • Lasers in cataract surgery.

    abstract::Several laser technologies including 1053-nm picosecond, excimer, erbium:yttrium-aluminum-garnet, and neodymium:yttrium-aluminum-garnet (Nd:YAG) have been studied for use in the removal of cataractous lens tissue. Nd:YAG laser phacolysis involves laser pulses striking a titanium target that are incorporated into an i...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199302000-00017

    authors: Dodick JM,Lally JM,Sperber LT

    更新日期:1993-02-01 00:00:00