Elliptic Yang-Mills equation.

abstract：:The multifunctional Creb-binding protein (CBP) protein plays a pivotal role in many critical cellular processes. Here we demonstrate that the bromodomain of CBP binds to histone H3 acetylated on lysine 56 (K56Ac) with higher affinity than to its other monoacetylated binding partners. We show that autoacetylation of CB...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Das C,Roy S,Namjoshi S,Malarkey CS,Jones DN,Kutateladze TG,Churchill ME,Tyler JK

更新日期：2014-03-25 00:00:00

abstract：:In multicellular organisms, the higher order organization of chromatin during interphase and the reassembly of the nuclear envelope during mitosis are thought to involve an interaction between the nuclear lamina and chromatin. The nuclear distribution of lamins and of peripheral chromatin is highly correlated in vivo,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldberg M,Harel A,Brandeis M,Rechsteiner T,Richmond TJ,Weiss AM,Gruenbaum Y

更新日期：1999-03-16 00:00:00

abstract：:Rap phosphatases are a recently discovered family of protein aspartate phosphatases that dephosphorylate the Spo0F--P intermediate of the phosphorelay, thus preventing sporulation of Bacillus subtilis. They are regulators induced by physiological processes that are antithetical to sporulation. The RapA phosphatase is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perego M,Hoch JA

更新日期：1996-02-20 00:00:00

abstract：:Certain cheU mutants of Salmonella show inverted chemotactic behavior, being repelled by attractants and attracted by repellents. Such a dramatic change in behavioral pattern would seem at first glance to require drastic and complex alterations in the sensory processing system. In fact, the behavior can be explained b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khan S,Macnab RM,DeFranco AL,Koshland DE Jr

更新日期：1978-09-01 00:00:00

abstract：:Inflammation plays an important role in pathological angiogenesis. Receptor-interacting protein 1 (RIP1) is highly expressed in inflammatory cells and is known to play an important role in the regulation of apoptosis, necroptosis, and inflammation; however, a comprehensive description of its role in angiogenesis remai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueta T,Ishihara K,Notomi S,Lee JJ,Maidana DE,Efstathiou NE,Murakami Y,Hasegawa E,Azuma K,Toyono T,Paschalis EI,Aihara M,Miller JW,Vavvas DG

更新日期：2019-11-19 00:00:00

abstract：:CHD7 encodes an ATP-dependent chromatin remodeling factor. Mutation of this gene causes multiple developmental disorders, including CHARGE (Coloboma of the eye, Heart defects, Atresia of the choanae, Retardation of growth/development, Genital abnormalities, and Ear anomalies) syndrome, in which conotruncal anomalies a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan S,Thienthanasit R,Chen D,Engelen E,Brühl J,Crossman DK,Kesterson R,Wang Q,Bouazoune K,Jiao K

更新日期：2020-11-17 00:00:00

abstract：:Priming of cytotoxic T lymphocytes (CTLs) by dendritic cells (DCs) is crucial for elimination of pathogens and malignant cells. To activate CTLs, DCs present antigenic peptide-complexed MHC class I molecules (MHC-I) that will be recognized by the CTLs with T cell receptors and CD8 molecules. Here we show that paired I...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Endo S,Sakamoto Y,Kobayashi E,Nakamura A,Takai T

更新日期：2008-09-23 00:00:00

abstract：:Patchy particles with shape complementarity can serve as building blocks for assembling colloidal superstructures. Alternatively, encoding information on patches using DNA can direct assembly into a variety of crystalline or other preprogrammed structures. Here, we present a tool where DNA is used both to engineer sha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diaz A JA,Oh JS,Yi GR,Pine DJ

更新日期：2020-05-19 00:00:00

abstract：:B-lymphocyte-specific class switch recombination is known to occur between pairs of 2- to 10-kb switch regions located immediately upstream of the immunoglobulin constant heavy-chain genes. Others have shown that the recombination is temporally correlated with the induction of transcription at the targeted switch regi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daniels GA,Lieber MR

更新日期：1995-06-06 00:00:00

abstract：:Myosins play countless critical roles in the cell, each requiring it to be activated at a specific location and time. To control myosin VI with this specificity, we created an optogenetic tool for activating myosin VI by fusing the light-sensitive Avena sativa phototropin1 LOV2 domain to a peptide from Dab2 (LOVDab), ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： French AR,Sosnick TR,Rock RS

更新日期：2017-02-28 00:00:00

abstract：:Global demand for agricultural products such as food, feed, and fuel is now a major driver of cropland and pasture expansion across much of the developing world. Whether these new agricultural lands replace forests, degraded forests, or grasslands greatly influences the environmental consequences of expansion. Althoug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gibbs HK,Ruesch AS,Achard F,Clayton MK,Holmgren P,Ramankutty N,Foley JA

更新日期：2010-09-21 00:00:00

abstract：:The cellular basis of the magnetic sense remains an unsolved scientific mystery. One theory that aims to explain how animals detect the magnetic field is the magnetite hypothesis. It argues that intracellular crystals of the iron oxide magnetite (Fe3O4) are coupled to mechanosensitive channels that elicit neuronal act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edelman NB,Fritz T,Nimpf S,Pichler P,Lauwers M,Hickman RW,Papadaki-Anastasopoulou A,Ushakova L,Heuser T,Resch GP,Saunders M,Shaw JA,Keays DA

更新日期：2015-01-06 00:00:00

abstract：:Many cell surface receptors are multimeric proteins, composed of several structural domains, some involved in ligand recognition, whereas others are responsible for signal transduction. In most cases, the mechanism of how ligand interaction in the extracellular domains leads to the activation of effector domains remai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang S,Cao J,Jiang M,Labesse G,Liu J,Pin JP,Rondard P

更新日期：2011-09-13 00:00:00

abstract：:Vasopressin's action in renal cells to regulate water transport depends on protein phosphorylation. Here we used mass spectrometry-based quantitative phosphoproteomics to identify signaling pathways involved in the short-term V2-receptor-mediated response in cultured collecting duct cells (mpkCCD) from mouse. Using St...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rinschen MM,Yu MJ,Wang G,Boja ES,Hoffert JD,Pisitkun T,Knepper MA

更新日期：2010-02-23 00:00:00

abstract：:A plasmid that consists of an 812-base-pair segment containing the replication origin of plasmid ColE1 and of a 1240-base-pair segment containing a beta-lactamase gene has been constructed. The plasmid DNA has three principal sites where transcription is initiated in vitro. One is located in the ColE1 segment 555 nucl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Itoh T,Tomizawa J

更新日期：1980-05-01 00:00:00

abstract：:The HIV type 1 (HIV-1) virion infectivity factor (Vif) protein blocks the action of the host defense factor APOBEC3G in human cells, thereby allowing release of infectious virions, but fails to inhibit similar APOBEC3G proteins present in some simian cells. Conversely, the Vif protein encoded by the African green monk...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bogerd HP,Doehle BP,Wiegand HL,Cullen BR

更新日期：2004-03-16 00:00:00

abstract：:In yeasts and mammals, PEX10 encodes an integral membrane protein with a C3HC4 RING finger motif in its C-terminal domain and is required for peroxisome biogenesis and matrix protein import. In humans, its dysfunction in peroxisome biogenesis leads to severe Zellweger Syndrome and infantile Refsum disease. Here we sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schumann U,Wanner G,Veenhuis M,Schmid M,Gietl C

更新日期：2003-08-05 00:00:00

abstract：:Fungi must recognize plant-specific signals to initiate subsequent morphogenetic events such as filamentation that lead to infection. Here we show that the plant hormone indoleacetic acid (IAA) induces adhesion and filamentation of Saccharomyces cerevisiae. Genome expression profiling of cells treated with IAA identif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prusty R,Grisafi P,Fink GR

更新日期：2004-03-23 00:00:00

abstract：:Transcription, splicing, and translation are potentially coordinately regulatable in a temporospatial-dependent manner, although supporting experimental evidence for this notion is scarce. Yeast two-hybrid screening of a mammary gland cDNA library with human p21-activated kinase 1 (Pak1) as bait identified polyC-RNA-b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meng Q,Rayala SK,Gururaj AE,Talukder AH,O'Malley BW,Kumar R

更新日期：2007-04-03 00:00:00

abstract：:Comparison of about 50 pairs of homologous nucleotide sequences for different genes revealed that the substitutions between synonymous codons occurred at much higher rates than did amino acid substitutions. Furthermore, five pairs of mRNA sequences for different genes were compared in species that had diverged at the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyata T,Yasunaga T,Nishida T

更新日期：1980-12-01 00:00:00

abstract：:In all organisms, mild heat pretreatments induce tolerance to high temperatures. In the yeast Saccharomyces cerevisiae, such pretreatments strongly induce heat-shock protein (Hsp) 104, and hsp104 mutations greatly reduce high-temperature survival, indicating Hsp1O4 plays a critical role in induced thermotolerance. Sur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lindquist S,Kim G

更新日期：1996-05-28 00:00:00

abstract：:This work describes the rational design, synthesis, and study of a ligand that selectively complexes CUG repeats in RNA (and CTG repeats in DNA) with high nanomolar affinity. This sequence is considered a causative agent of myotonic dystrophy type 1 (DM1) because of its ability to sequester muscleblind-like (MBNL) pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arambula JF,Ramisetty SR,Baranger AM,Zimmerman SC

更新日期：2009-09-22 00:00:00

abstract：:The tumor suppressor protein p53 plays a crucial role in coordinating cellular processes, such as cell cycle arrest, apoptosis, and senescence. The nerve injury-induced protein 1 (Ninjurin1, Ninj1) is a homophilic adhesion molecule and involved in nerve regeneration. Interestingly, Ninj1 is found to be overexpressed i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho SJ,Rossi A,Jung YS,Yan W,Liu G,Zhang J,Zhang M,Chen X

更新日期：2013-06-04 00:00:00

abstract：:The cycles of carbon and oxygen at the Earth surface are intimately linked, where the burial of organic carbon into sediments represents a source of oxygen to the surface environment. This coupling is typically quantified through the isotope records of organic and inorganic carbon. Yet, the late Neoproterozoic Eon, th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bjerrum CJ,Canfield DE

更新日期：2011-04-05 00:00:00

abstract：:Targeted gene disruption in the murine TOP3beta gene-encoding DNA topoisomerase IIIbeta was carried out. In contrast to the embryonic lethality of mutant mice lacking DNA topoisomerase IIIalpha, top3beta(-/-) nulls are viable and grow to maturity with no apparent defects. Mice lacking DNA topoisomerase IIIbeta have a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwan KY,Wang JC

更新日期：2001-05-08 00:00:00

abstract：:Assembly of light-harvesting complexes requires synchronization of chlorophyll (Chl) biosynthesis with biogenesis of light-harvesting Chl a/b-binding proteins (LHCPs). The chloroplast signal recognition particle (cpSRP) pathway is responsible for transport of nucleus-encoded LHCPs in the stroma of the plastid and thei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang P,Liang FC,Wittmann D,Siegel A,Shan SO,Grimm B

更新日期：2018-04-10 00:00:00

abstract：:Two brefeldin A (BFA)-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors, 200-kDa BIG1 and 190-kDa BIG2, were copurified from bovine brain cytosol associated with >670-kDa macromolecular complexes. When observed by immunofluorescence in HeLa S3 and HepG2 cells, endogenous BIG1 and coexpressed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaji R,Adamik R,Takeda K,Togawa A,Pacheco-Rodriguez G,Ferrans VJ,Moss J,Vaughan M

更新日期：2000-03-14 00:00:00

abstract：:To identify genetic factors that interact with social environments to impact human health, we used a bioinformatic strategy that couples expression array-based detection of environmentally responsive transcription factors with in silico discovery of regulatory polymorphisms to predict genetic loci that modulate transc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cole SW,Arevalo JM,Takahashi R,Sloan EK,Lutgendorf SK,Sood AK,Sheridan JF,Seeman TE

更新日期：2010-03-23 00:00:00

abstract：:Natural environments can present diverse challenges, but some genotypes remain fit across many environments. Such "generalists" can be hard to evolve, outcompeted by specialists fitter in any particular environment. Here, inspired by the search for broadly neutralizing antibodies during B cell affinity maturation, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sachdeva V,Husain K,Sheng J,Wang S,Murugan A

更新日期：2020-06-09 00:00:00

abstract：:Activation of the androgen receptor (AR) may play a role in androgen-independent progression of prostate cancer. Multiple mechanisms of AR activation, including stimulation by tyrosine kinases, have been postulated. We and others have recently shown involvement of activated Cdc42-associated tyrosine kinase Ack1 in adv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mahajan NP,Liu Y,Majumder S,Warren MR,Parker CE,Mohler JL,Earp HS,Whang YE

更新日期：2007-05-15 00:00:00