Abstract:
:The availability of a draft human genome sequence and ability to monitor the transcription of thousands of genes with DNA microarrays has necessitated the need for new computational tools that can analyze cis-regulatory elements controlling genes that display similar expression patterns. We have developed a tool designated EZ-Retrieve that can: (i) retrieve any particular region of human genome sequence from the NCBI database and (ii) analyze retrieved sequences for putative transcription factor-binding sites (TFBSs) as they appear on the TRANSFAC database. The tool is web-based, user-friendly and offers both batch sequence retrieval and batch TFBS prediction. A major application of EZ-Retrieve is the analysis of co-expressed genes that are highlighted as expression clusters in DNA microarray experiments.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Zhang H,Ramanathan Y,Soteropoulos P,Recce ML,Tolias PPdoi
10.1093/nar/gnf120keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
e121issue
21eissn
0305-1048issn
1362-4962journal_volume
30pub_type
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