A new member of the plasma protease inhibitor gene family.

Abstract:

:A 2.1-kb cDNA clone representing a new member of the protease inhibitor family was isolated from a human liver cDNA library. The inhibitor, named human Leuserpin 2 (hLS2), comprises 480 amino acids and contains a leucine residue at its putative reactive center. HLS2 is about 25-28% homologous to three human members of the plasma protease inhibitor family: antithrombin III, alpha 1-antitrypsin and alpha 1-antichymotrypsin. A comparison with published partial amino acid sequences shows that hLS2 is closely related to the thrombin inhibitor heparin cofactor II.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Ragg H

doi

10.1093/nar/14.2.1073

subject

Has Abstract

pub_date

1986-01-24 00:00:00

pages

1073-88

issue

2

eissn

0305-1048

issn

1362-4962

journal_volume

14

pub_type

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