Etiopathogenesis and clinical presentation of carotid body tumors.

Abstract:

:The carotid body (CB) is a highly specialized small organ located at the bifurcation of the common carotid artery in the neck and plays an important role in acute adaptation to hypoxia. The most common diseased state of the carotid body is its enlargement (i.e., the CB paraganglioma), which can be caused by a genetic predisposition (hereditary paraganglioma, PGL) and by chronic hypoxic stimulation. The CB is the most common tumor site in head and neck paragangliomas. Currently, inactivating germline mutations in the mitochondrial complex II subunits SDHB, SDHC, and SDHD have been identified as genetic risk factors for CB tumors (CBTs). Another locus at chromosome 11q13, identified by linkage analysis in a single family, may harbor a fourth susceptibility gene. Although CBTs are mostly slow-growing and benign, they can cause significant morbidity because of their proximity to major arteries and nerves in the head and neck. Here, we review the etiological factors implicated in the development of CBTs and provide information pertaining to their clinical presentation. Although CBTs are rare, they have the potential to provide unique insights for tumorigenesis and oxygen sensing and signaling mechanisms.

journal_name

Microsc Res Tech

authors

Baysal BE,Myers EN

doi

10.1002/jemt.10200

keywords:

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

256-61

issue

3

eissn

1059-910X

issn

1097-0029

journal_volume

59

pub_type

杂志文章,评审
  • Presence and distribution of FMRFamide-like immunoreactivity in the cyprid of the barnacle Balanus amphitrite (Cirripedia, Crustacea).

    abstract::The presence and distribution of FMRFamide-like peptides (FLPs) in the cyprid larvae of the barnacle Balanus amphitrite were investigated using immunohistochemical methods. Barnacles are considered to be one of the most important constituents of animal fouling communities, and the cyprid stage is specialized for settl...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20649

    authors: Gallus L,Ferrando S,Bottaro M,Diaspro A,Girosi L,Faimali M,Ramoino P,Tagliafierro G

    更新日期:2009-02-01 00:00:00

  • Evaluating the lucrative role of probiotics in the aquaculture using microscopic and biochemical techniques.

    abstract::The present study focused to elucidate the promising role of probiotics in the fish culture, by employing microscopic and biochemical parameters to rationalize the possible outcomes. After preliminary feeding trial histopathological analysis revealed clear and visible changes in the intestinal and liver cells of CTRL ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.23416

    authors: Noor Z,Noor M,Khan I,Khan SA

    更新日期:2020-03-01 00:00:00

  • A descriptive study to provide evidence of the teratogenic and cellular effects of sibutramine and ephedrine on cardiac- and liver-tissue of chick embryos.

    abstract::Exposure to drugs during pregnancy is a major concern, as some teratogenic compounds can influence normal foetal development. Although the use of drugs during pregnancy should generally be avoided, exposure of the developing foetus to teratogens may occur unknowingly since these compounds may be hidden in products tha...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.22539

    authors: Oberholzer HM,Van Der Schoor C,Taute H,Bester MJ

    更新日期:2015-08-01 00:00:00

  • Facilitating the pickup of individual DNA molecules by AFM nanomanipulation with tips mechanically worn on bare mica.

    abstract::The tip is one of the critical factors to improve the efficiency in picking up individual DNA molecules from solid substrates based on atomic force microscope (AFM) nanomanipulation. We found that wearing AFM tips on certain solid substrates in advance to nanomanipulation operation would largely improve the pickup eff...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.21104

    authors: Duan N,Long F,Wang X,Li B,Hu J,Zhang Y

    更新日期:2012-05-01 00:00:00

  • Age-related changes in the brains of senescence-accelerated mice (SAM): association with glial and endothelial reactions.

    abstract::Twelve substrains of inbred senescence-accelerated mice (SAM) have been developed, among which the SAMP8 and SAMP10 strains show a significant age-related deterioration in learning and memory for passive and active avoidance tasks. These strains have, respectively, a low and high incidence of systemic senile amyloidos...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章,评审

    doi:10.1002/(SICI)1097-0029(19981001)43:1<59::AID-JEMT

    authors: Kawamata T,Akiguchi I,Maeda K,Tanaka C,Higuchi K,Hosokawa M,Takeda T

    更新日期:1998-10-01 00:00:00

  • Osteoclastic bone resorption around intraosseous screws in rat and pig mandibles.

    abstract::This report describes osteoclastic bone resorption around intraosseous fixation screws in rat and pig mandibles. These screws supported distraction devices and provided for neutral fixation following the distraction period. Progressive clinical instability of bicortical screws and radiographic and histologic evidence ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.10376

    authors: Schulten AJ,Zimmermann CE,Glowacki J

    更新日期:2003-08-15 00:00:00

  • Organ culture of the bovine subcommissural organ: evidence for synthesis and release of the secretory material.

    abstract::The subcommissural organ (SCO) is a brain circumventricular organ formed by ependymal and hypendymal secretory cells. It secretes glycoproteins into the cerebrospinal fluid of the third ventricle where they condense into a thread-like structure known as Reissner's fiber (RF). The present study was designed to investig...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/1097-0029(20010301)52:5<496::AID-JEMT1035>

    authors: Schöbitz K,Gonzalez C,Peruzzo B,Yulis CR,Rodríguez EM

    更新日期:2001-03-01 00:00:00

  • Microvasculature of the bovine claw demonstrated by improved micro-corrosion-casting technique.

    abstract::A new and improved technique for microvascular corrosion casting was developed and verified by examination of corrosion casts of 90 bovine limbs. The described technique renders a complete filling of the vasculature of the claw even in regions that hitherto proved to be difficult regarding completeness of filling such...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0029(19990501)45:3<184::AID-JEM

    authors: Hirschberg RM,Mülling CK,Bragulla H

    更新日期:1999-05-01 00:00:00

  • Structure, assembly, and dynamics of actin filaments in situ and in vitro.

    abstract::Actin, though highly conserved, exhibits a myriad of diverse functions, most of which ultimately depend on its intrinsic ability to rapidly assemble and disassemble filamentous structures. Many organisms synthesize multiple actin isoforms even within the same cell. Tissue-specific expression patterns and tight develop...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章,评审

    doi:10.1002/(SICI)1097-0029(19991001)47:1<38::AID-JEMT

    authors: Schoenenberger CA,Steinmetz MO,Stoffler D,Mandinova A,Aebi U

    更新日期:1999-10-01 00:00:00

  • High resolution and image processing of otoconia matrix.

    abstract::This study was designed to investigate patterns of fibrils organization in histochemically stained otoconia. Transmission electron microscope and video imaging were used. These data indicate that otoconia of the chick (Gallus domesticus) inner ear may have central cores in vivo. The data also show that the ultrastruct...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.1070250406

    authors: Fermin CD

    更新日期:1993-07-01 00:00:00

  • Years-identification mathematical model of Paeonia lactiflora Pall. based on the allometric-scaling.

    abstract::The fixed number years-identification of Chinese material medicinal was a difficulty in the process of the traditional Chinese pharmacology, the phenomenon was found in our study of telomerase that the speed of the vascular cambium outside expanding growth fluctuated in a definite value. Based on it, we put forward a ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.22154

    authors: Cheng C,Peng D,Huang L,Ma X

    更新日期:2013-02-01 00:00:00

  • Antennal sensilla of the pine weevil Pissodes nitidus Roel. (Coleoptera: Curculionidae).

    abstract::The antennal sensilla of the pine weevil (Pissodes nitidus Roel.) were observed with scanning electron microscopy and transmission electron microscopy (TEM). The weevil antenna consists of a long scape, a pedicel, and a flagellum with 10 segments; the last four flagellum segments are fused, forming the antennal club, ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20920

    authors: Yan SC,Meng ZJ,Peng L,Liu D

    更新日期:2011-05-01 00:00:00

  • The nasal cavity of the sheep and its olfactory sensory epithelium.

    abstract::Macro and microdissection methods, conventional histology and immunohistochemical procedures were used to investigate the nasal cavity and turbinate complex in fetal and adult sheep, with special attention to the ethmoturbinates, the vestibular mucosa, and the septal mucosa posterior to the vomeronasal organ. The ecto...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.22436

    authors: Barrios AW,Sanchez Quinteiro P,Salazar I

    更新日期:2014-12-01 00:00:00

  • Ultrastructural study on the body surface of the acanthocephalan parasite Dentitruncus truttae in brown trout.

    abstract::Scanning electron microscope (SEM) investigations on the holdfast elements, proboscis hooks, and trunk spines of Dentitruncus truttae (Acanthocephala, Palaeacanthocephala), an endoparasite of Salmo trutta (brown trout), provide more data about the surface of these taxonomic relevant structures. In both acanthocephalan...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20543

    authors: Dezfuli BS,Lui A,Giari L,Boldrini P,Giovinazzo G

    更新日期:2008-03-01 00:00:00

  • Formation and microscopic investigation of iron oxide aligned nanowires into polymeric nanocomposite films.

    abstract::We present a microscopic investigation of nanocomposite films of iron oxide (γ-Fe(2)O(3)) magnetic nanowires (NWs) aligned into polymers, formed upon evaporation of solutions of acrylate polymer/magnetic nanoparticles under magnetic field (MF). The field causes the assembly of the γ-Fe(2)O(3) nanoparticles along the d...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20848

    authors: Fragouli D,Torre B,Bertoni G,Buonsanti R,Cingolani R,Athanassiou A

    更新日期:2010-10-01 00:00:00

  • Neuropeptides in the crayfish stomatogastric nervous system.

    abstract::Neuropeptides are peptides with profound effects on the nervous system. The function of neuropeptides can be studied in detail in the stomatogastric nervous system (STNS). Neuropeptides are ubiquitously distributed in the STNS and it contains well-studied neural circuits that are strongly modulated by neuropeptides. T...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章,评审

    doi:10.1002/jemt.10269

    authors: Skiebe P

    更新日期:2003-02-15 00:00:00

  • Node distribution and packing density in the rat CNS-PNS transitional zone.

    abstract::The density of nodes of Ranvier was examined at CNS, PNS, and transitional zone (TZ) levels of rat lumbar ventral motoneurone fibres. It was found to be significantly greater in the TZ than at the other levels: The difference was sevenfold for the ventral root and at least fourfold for central fibre levels. Node distr...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0029(19960815)34:6<507::AID-JEM

    authors: Fraher J

    更新日期:1996-08-15 00:00:00

  • Characterization of elemental distribution across human dentin-enamel junction by scanning electron microscopy with energy-dispersive X-ray spectroscopy.

    abstract::The human dentin-enamel junction (DEJ) is a natural junction that unites two dissimilar mineralized tissues in the human tooth: enamel and dentin. DEJ plays a critical role in maintaining structural and functional integrity of the tooth. However, its structure, chemical composition and function remain unclear and cont...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.23648

    authors: Wang R,Zhao D,Wang Y

    更新日期:2020-11-19 00:00:00

  • Asymmetrical distribution of antennal sensilla in the female Anastatus japonicus Ashmead (Hymenoptera: Eupelmidae).

    abstract::Anastatus japonicus Ashmead (Hymenoptera: Eupelmidae) is an important egg parasitoid of several major insect pests. To better understand its host finding mechanisms, the antennal sensilla of female wasp were investigated by scanning electron microscopy. Sensilla chaetica were found mainly on radicle and pedicel segmen...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.22032

    authors: Meng ZJ,Yan SC,Yang CP,Ruan CC

    更新日期:2012-08-01 00:00:00

  • Visualizing subsurface defects in graphite by acoustic atomic force microscopy.

    abstract::We describe a versatile platform, which combines atomic force acoustic microscopy, ultrasonic atomic force microscopy and heterodyne force microscopy. The AFM system can enable in-situ switching among these operation modes flexibly and thus benefit the discrimination of differences in mechanical properties and buried ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.22668

    authors: Wang T,Ma C,Hu W,Chen Y,Chu J

    更新日期:2017-01-01 00:00:00

  • Assessing the multiscale architecture of muscular tissue with Q-space magnetic resonance imaging: Review.

    abstract::Contraction of muscular tissue requires the synchronized shortening of myofibers arrayed in complex geometrical patterns. Imaging such myofiber patterns with diffusion-weighted MRI reveals architectural ensembles that underlie force generation at the organ scale. Restricted proton diffusion is a stochastic process res...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章,评审

    doi:10.1002/jemt.22777

    authors: Hoffman MP,Taylor EN,Aninwene GE 2nd,Sadayappan S,Gilbert RJ

    更新日期:2018-02-01 00:00:00

  • A negative contrast stain for ultra-thin frozen sections.

    abstract::Ultra-thin frozen sections are ideal substrates for immunolabelling in high resolution electron microscopy. However, visualization of subcellular structures is inferior to that obtained with corresponding plastic sections. Although negative staining is generally effective and even superior to positive staining, the ac...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.1070290104

    authors: Himmelhoch S

    更新日期:1994-09-01 00:00:00

  • Comparative analysis of adrenomedullin-like immunoreactivity in the hypothalamus of amphibians.

    abstract::Adrenomedullin (AM) is a novel neuropeptide with special significance in the mammalian hypothalamo-hypophysial axis. By using an antiserum specific for human AM, we have studied the localization of AM-like immunoreactive (AMi) cell bodies and fibers in the hypothalamus and hypophysis of the amphibians Rana perezi (anu...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.1131

    authors: Muñoz M,López JM,Sánchez-Camacho C,Moreno N,Crespo M,González A

    更新日期:2001-08-01 00:00:00

  • A thermoregulatory center in hornets: IR photography.

    abstract::In the Oriental hornet Vespa orientalis (Hymenoptera, Vespinae), there is on the dorsal side of the thorax, beneath the mesoscutum plate of the prothorax and around the median notal suture, a lump that, in the course of hornet activity, is warmer by 9 degrees C from the surrounding milieu and by up to 6 degrees C from...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20257

    authors: Plotkin M,Ermakov NY,Volynchik S,Barkay Z,Bergman DJ,Ishay JS

    更新日期:2005-12-15 00:00:00

  • Induced maturation of frog mast cells by nerve growth factor during ontogenesis.

    abstract::The effect of nerve growth factor (NGF) on ontogenesis of frog mast cells was investigated in vivo by histochemical, morphometric, and ultrastructural analysis. Three groups of tadpoles at various stages of development were used. In the first group, the larvae received i.p. injections of 1 ng NGF/g; the second group r...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.10391

    authors: Baccari GC,Raucci F,Di Fiore MM,Monteforte R

    更新日期:2003-12-01 00:00:00

  • HVEM ultrastructural analysis of mouse fungiform taste buds, cell types, and associated synapses.

    abstract::We have used high voltage electron microscopy and computer-generated three-dimensional reconstructions from serial sections to elucidate the structure of taste bud cells and their associated synapses in fungiform taste buds of the mouse. Five fungiform taste buds (two of which were serially sectioned) were examined wi...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.1070260207

    authors: Kinnamon JC,Henzler DM,Royer SM

    更新日期:1993-10-01 00:00:00

  • Effect of age on the structure of Meissner corpuscles in murine digital pads.

    abstract::A light and electron microscopic study was performed to determine age changes in Meissner corpuscles. In forepaw digital pads of mice aged to their maximum life expectancy, corpuscles were found to increase in size and complexity until middle age, and then to become smaller, disorganized and lobulated with more advanc...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0029(19960701)34:4<376::AID-JEM

    authors: Nava PB,Mathewson RC

    更新日期:1996-07-01 00:00:00

  • Ionic composition of rat airway surface liquid determined by X-ray microanalysis.

    abstract::The thin layer of liquid that lines the conducting airway epithelium, the airway surface liquid (ASL), is important for mucociliary clearance. Altered ionic composition and/ or volume of the ASL play a major role in the pathology of airway diseases such as cystic fibrosis. Since the ASL is a thin layer, it has been di...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20217

    authors: Vanthanouvong V,Kozlova I,Roomans GM

    更新日期:2005-09-01 00:00:00

  • Embedding of large specimens in glycol methacrylate: prerequisites for multi-signal detection and high-resolution imaging.

    abstract::Acrylic resin mixtures are commonly used to study microscopic sections of biological specimens, giving the advantage of good morphological preservation. Existing embedding protocols, however, are suitable for tissue blocks, not exceeding 1 mm in thickness. We have developed a protocol to embed larger specimens (up to ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20139

    authors: De Jonge HW,De Bakker MA,Verbeek FJ,Weijs WA

    更新日期:2005-01-01 00:00:00

  • A microscopical study of wound repair in the human placenta.

    abstract::In order to fulfill its many functions as the selective interface between maternal and fetal circulations it is imperative that the human placenta remains intact and in good operational order. That damage of some sort occurs during its short but extremely active life seems inevitable given the dynamic environment in w...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0029(19980901)42:5<351::AID-JEM

    authors: Watson AL,Burton GJ

    更新日期:1998-09-01 00:00:00