Age-related changes in the brains of senescence-accelerated mice (SAM): association with glial and endothelial reactions.

Abstract:

:Twelve substrains of inbred senescence-accelerated mice (SAM) have been developed, among which the SAMP8 and SAMP10 strains show a significant age-related deterioration in learning and memory for passive and active avoidance tasks. These strains have, respectively, a low and high incidence of systemic senile amyloidosis. Although we found no amyloid deposits in their brain parenchyma, a variety of age-related alterations were identified, involving neurons, glia, and vessels in the brain tissues. Here we review the degenerative changes in aged SAMP8 and SAMP10 brains. These changes are generally similar to the pathology of aging human brain and may be characterized by their association with some specific glial reactions.

journal_name

Microsc Res Tech

authors

Kawamata T,Akiguchi I,Maeda K,Tanaka C,Higuchi K,Hosokawa M,Takeda T

doi

10.1002/(SICI)1097-0029(19981001)43:1<59::AID-JEMT

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

59-67

issue

1

eissn

1059-910X

issn

1097-0029

pii

10.1002/(SICI)1097-0029(19981001)43:1<59::AID-JEMT

journal_volume

43

pub_type

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