Abstract:
:Twelve substrains of inbred senescence-accelerated mice (SAM) have been developed, among which the SAMP8 and SAMP10 strains show a significant age-related deterioration in learning and memory for passive and active avoidance tasks. These strains have, respectively, a low and high incidence of systemic senile amyloidosis. Although we found no amyloid deposits in their brain parenchyma, a variety of age-related alterations were identified, involving neurons, glia, and vessels in the brain tissues. Here we review the degenerative changes in aged SAMP8 and SAMP10 brains. These changes are generally similar to the pathology of aging human brain and may be characterized by their association with some specific glial reactions.
journal_name
Microsc Res Techjournal_title
Microscopy research and techniqueauthors
Kawamata T,Akiguchi I,Maeda K,Tanaka C,Higuchi K,Hosokawa M,Takeda Tdoi
10.1002/(SICI)1097-0029(19981001)43:1<59::AID-JEMTsubject
Has Abstractpub_date
1998-10-01 00:00:00pages
59-67issue
1eissn
1059-910Xissn
1097-0029pii
10.1002/(SICI)1097-0029(19981001)43:1<59::AID-JEMTjournal_volume
43pub_type
杂志文章,评审abstract::The mammary adenocarcinoma cell line MTLn3 is chemotactic towards epidermal growth factor (EGF), and this induced motility is thought to promote breast cancer invasion and metastasis. Stimulation of MTLn3 cells with EGF results in the extension of a flat, thin structure filled with filamentous actin and termed a lamel...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0029(19981201)43:5<433::AID-JEM
更新日期:1998-12-01 00:00:00
abstract::The morphology and ultrastructure of the rectum in Poecilimon cervus Karabağ, 1950 (Orthoptera, Tettigoniidae) were analyzed by light microscope, scanning (SEM) and transmission electron microscopes (TEM). The rectum is the final part of the digestive tract that plays an important role in water reabsorption in insects...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.22787
更新日期:2017-02-01 00:00:00
abstract::Correlative microscopy has become increasingly important for the analysis of the structure, function, and dynamics of cells. This is largely due to the result of recent advances in light-, probe-, laser- and various electron microscopy techniques that facilitate three-dimensional studies. Furthermore, the improved und...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/jemt.20408
更新日期:2007-03-01 00:00:00
abstract::Immunohistochemistry as well as immunohistofluorescence were used to investigate the distribution of the neurotrophin-3 (NT3) in the adult rat cochlear nucleus. We found a widespread distribution of NT3 immunolabeled neurons throughout the three divisions of this nucleus. NT3-like immunoreactivity was clearly populati...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0029(19980501)41:3<224::AID-JEM
更新日期:1998-05-01 00:00:00
abstract::The aim was to assess the effects of 1% peracetic acid (PAA) as a single endodontic irrigant on microhardness, roughness, and erosion of root canal dentin, compared with 2.5% sodium hypochlorite (NaOCl) and with 2.5% NaOCl combined with 17% EDTA. Forty human, single-rooted tooth hemisections were submitted to Knoop mi...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23424
更新日期:2020-04-01 00:00:00
abstract::Fluorescence correlation spectroscopy (FCS) has become an increasingly important measurement tool for biological and biomedical investigations, with the capability to assay molecular dynamics and interactions both in vitro and within living cells. Information recovery in FCS requires an accurate characterization and c...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20454
更新日期:2007-08-01 00:00:00
abstract::In present study, multiple microscope techniques were used for the systematics identification of the species Asplenium dalhousiae. The plant was collected from different phytogeographical and its natural habitat of Pakistan, where it shows higher diversity. Morphology, foliar epidermal anatomy, and spore morphological...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23189
更新日期:2019-04-01 00:00:00
abstract::This review examines the morphology of the adrenal gland with particular reference to the adrenal vasculature. It examines the possibility that variability in adrenal gland responsiveness may be attributable to neural or hormonal modulation of adrenal blood flow. Changes in the rate of blood flow through the adrenal c...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0029(19970315)36:6<546::AID-JEM
更新日期:1997-03-15 00:00:00
abstract:OBJECTIVES:This study investigated the effects of sliding on the ultrastructure of three representative esthetic superelastic 0.014 inch nickel-titanium (NiTi) archwires. METHODS:Atomic force microscopy, scanning electron microscopy, and light microscopy were used to estimate the surface roughness of archwires and bra...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.22557
更新日期:2015-10-01 00:00:00
abstract::Low voltage electron microscopes working in transmission mode, like LVEM5 (Delong Instruments, Czech Republic) working at accelerating voltage 5 kV or scanning electron microscope working in transmission mode with accelerating voltage below 1 kV, require ultrathin sections with the thickness below 20 nm. Decreasing of...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.22659
更新日期:2016-06-01 00:00:00
abstract::The photoreceptor population in Xenopus consists of a green-sensitive rod (lambda(max) = 523 nm), a blue-sensitive rod (lambda(max) = 445 nm) and three classes of cone. The largest cone is red-sensitive (lambda(max) = 611 nm). The intermediate cone is presumed to be blue-sensitive based on physiological criteria, wher...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/1097-0029(20000901)50:5<338::AID-JEMT3>3.0
更新日期:2000-09-01 00:00:00
abstract::We report on a novel laser source, emitting high energy (20 nanoJoule) femtosecond pulses, in a broad spectrum (250 nm). This source is easily tuned from 950 to 1200 nm, without any laser adjustment, and delivers sub-300 femtosecond pulses with a 10-nm spectral width. ...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.10419
更新日期:2004-01-01 00:00:00
abstract::We present a semiautomated software solution to the problem of extending the lateral field of view of a classical microscope. The initial requirements are a set of overlapping images, along with their user-provided coarse mosaic. Our solution then refines this initial mosaic in a fully automatic fashion. We rely on a ...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20393
更新日期:2007-02-01 00:00:00
abstract::The mint beetle or green mint beetle, Chrysolina herbacea, is one of the most important insect pests of mint herb. These insects are associated with plants belonging to the Lamiaceae family, in particular the Mentha genus. They cause serious damages to plants by consuming their leaves. For this reason, it is an import...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23671
更新日期:2020-12-11 00:00:00
abstract::The aim of this report was to investigate the ultrastructure and three-dimensional organization of the pleural lymphatic stomata in the adult rabbit costal pleura by electron microscopy. A computer image processing system attached to the scanning electron microscopy was used to get statistical evaluation of the dimens...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.10388
更新日期:2003-10-15 00:00:00
abstract::The effects of crystal and beam tilt on high-resolution transmission electron microscope (HRTEM) images of planar coherent interfaces were investigated by multislice image simulations. It was found that a beam tilt of 0.5 Bragg angle (theta B) was sufficient to introduce detrimental artifacts into most images of inter...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.1070230306
更新日期:1992-11-01 00:00:00
abstract::Studies in insect gustation have a long history in general physiology, particularly with work on fly labellar and tarsal sensilla and in the general field of insect-plant interactions, where work on immature Lepidoptera and chrysomelid beetles has been prominent. Much more emphasis has been placed on the physiological...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0029(19991215)47:6<401::AID-JEM
更新日期:1999-12-15 00:00:00
abstract::We discuss the use of fluorescence correlation spectroscopy for the measurement of relatively slow rotations of large macromolecules in solution or attached to other macromolecular structures. We present simulations and experimental results to illustrate the range of rotational correlation times and diffusion times th...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20121
更新日期:2004-11-01 00:00:00
abstract::Basement membranes (BMs) were first described in the mid-19th century, but they were not isolated and prepared for compositional studies until nearly 100 years later. Early methods of isolation were carried out on renal glomeruli, which were first sub-fractionated from kidney tissues by sieving. BMs were then isolated...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/jemt.1070280302
更新日期:1994-06-15 00:00:00
abstract::Laser scanning confocal microscopy (LSCM) and atomic force microscopy (AFM) were used to characterize changes in nanoscale structure that occur when ultrathin polyelectrolyte multilayers (PEMs) are incubated in aqueous media. The PEMs investigated here were fabricated by the deposition of alternating layers of plasmid...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20830
更新日期:2010-09-01 00:00:00
abstract::Atomic force microscopy has been used to study self-assembled structures of two alpha-hemolysin mutants. For a mutant (alphaHL-H5) that was locked into the prepore state on fluid phase egg-PC membranes, we visualized, for the first time, heptameric prepores and showed that the 7-fold axis in the prepore lies perpendic...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0029(19990301)44:5<353::AID-JEM
更新日期:1999-03-01 00:00:00
abstract::Adrenomedullin (AM) is a novel neuropeptide with special significance in the mammalian hypothalamo-hypophysial axis. By using an antiserum specific for human AM, we have studied the localization of AM-like immunoreactive (AMi) cell bodies and fibers in the hypothalamus and hypophysis of the amphibians Rana perezi (anu...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.1131
更新日期:2001-08-01 00:00:00
abstract::This in vitro study aimed to investigate the tubular penetration depth of four different sealers used with two different obturation methods in the apical, middle, and coronal root canal dentin. Eighty-four single-rooted teeth were instrumented until the F4 ProTaper universal rotary file and filled with AH26, AH Plus (...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23548
更新日期:2020-12-01 00:00:00
abstract::Voltage-gated sodium channels are largely localized to the nodes of Ranvier in myelinated axons, providing the physiological basis for saltatory conduction. Studies using antisodium channel antibodies have shown that along demyelinated axons sodium channels form new distributions. The nature of this changed distributi...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0029(19960801)34:5<445::AID-JEM
更新日期:1996-08-01 00:00:00
abstract::Central to the control of vascular resistance in the systemic and pulmonary circulation and at the solid organ level is the function of the endothelial-derived vasomediators, endothelin-1 (ET-1) and nitric oxide. Regulation of steady-state levels of ET-1 and endothelial nitric oxide synthase (eNOS) mRNAs represents an...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/jemt.10242
更新日期:2003-01-01 00:00:00
abstract::Scanning electron microscope (SEM) investigations on the holdfast elements, proboscis hooks, and trunk spines of Dentitruncus truttae (Acanthocephala, Palaeacanthocephala), an endoparasite of Salmo trutta (brown trout), provide more data about the surface of these taxonomic relevant structures. In both acanthocephalan...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20543
更新日期:2008-03-01 00:00:00
abstract::Isoform diversity in striated muscle is largely controlled at the level of transcription. In this review we will concentrate on studies concerning transcriptional regulation of the alkali myosin light chain 1F/3F gene. Uncoupled activity of the MLC1F and 3F promoters, together with complex patterns of transcription in...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/1097-0029(20000915)50:6<510::AID-JEMT8>3.0
更新日期:2000-09-15 00:00:00
abstract::The effect of nerve growth factor (NGF) on ontogenesis of frog mast cells was investigated in vivo by histochemical, morphometric, and ultrastructural analysis. Three groups of tadpoles at various stages of development were used. In the first group, the larvae received i.p. injections of 1 ng NGF/g; the second group r...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.10391
更新日期:2003-12-01 00:00:00
abstract::Virus particles and viral inclusions were detected by transmission electron microscopy examination of sections of the seminal vesicles and mucus gland of asymptomatic young drones from colonies of Apis mellifera lightly infested by Varroa mite. In the mucus gland the infection was found in the muscular sheath and epit...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.22024
更新日期:2012-07-01 00:00:00
abstract::Because of the morphological and macroscopic similarity, many species of Erigeron and Aster (Asteraceae) are confusable and usually used under the same name "Meiduoluomi" in traditional Tibetan medicine (TTM). To find an easy, quick, and reliable method to authenticate and distinguish the eight main medicinal plants o...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20725
更新日期:2009-10-01 00:00:00