Abstract:
:Hereditary Persistence of Fetal Hemoglobin (HPFH) is a benign clinical condition characterized by the synthesis of HbF and which continues without hematological alterations during adult life. Since the function of HPFH in many hemoglobinopathies is that of a severity modulator, it is important to learn its frequency. To obtain this information, a study was conducted on 1,846 blood donors from Bragança Paulista, São Paulo State. Hemoglobin was qualitatively analyzed by hemolytic electrophoresis on agarose gel. Qualitative analysis of gammaG and gammaA chains was performed by electrophoresis in polyacrylamide-triton-urea. Two individuals were found to have a high fetal index (0.1%). The percentage of FHb in one individual was 17% and in the other 18%. The gamma G chain was missing in both electrophoretic chains. Cases screened according to laboratory characteristics were of the pancellular hereditary persistence type due to mutation. The frequency in this sample was thus 1/1,000 individuals.
journal_name
Cad Saude Publicajournal_title
Cadernos de saude publicaauthors
Costa VA,Acedo MJ,Polimeno NC,Bertuzzo CSdoi
10.1590/s0102-311x2002000500040keywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
1469-71issue
5eissn
0102-311Xissn
1678-4464pii
S0102-311X2002000500040journal_volume
18pub_type
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