Ticlopidine-induced aplastic anemia: two new case reports, review, and meta-analysis of 55 additional cases.

abstract：:In this study we investigated the possible role of neutrophil (PMN) elastase and its natural inhibitor, alpha1-proteinase inhibitor (alpha1-PI) in the pathogenesis of the pseudoxanthoma elasticum (PXE)-like syndrome which is found in patients with homozygous beta-thalassemia. We studied 30 beta-thalassemia homozygotes...

journal_title：American journal of hematology

authors： Samarkos M,Aessopos A,Fragodimitri C,Karagiorga M,Kalotychou V,Voskaridou E,Kavouklis E,Loukopoulos D

更新日期：2000-02-01 00:00:00

abstract：:Matching for HLA-A, -B, -C, and -DRB1 loci (8/8 match) is currently the gold standard for unrelated donor hematopoietic cell transplantation (HCT). In Europe, patients are also matched at the HLA-DQB1 loci (10/10 match). However, there is increasing evidence that matching at HLA-DRB3/4/5 loci may help to lower transpl...

journal_title：American journal of hematology

authors： Ducreux S,Dubois V,Amokrane K,Yakoub-Agha I,Labalette M,Michallet M,Rubio MT,Kennel A,Forcade E,Lafarge X,Bulabois CE,Masson D,Daguindau E,Devys A,Moalic V,Quelvennec E,Boudifa A,Picard C,Van Endert P,de Matteis M,

更新日期：2018-05-04 00:00:00

abstract：:Hemophagocytic syndrome (HPS) is an unusual acute syndrome presenting with fever, hepatosplenomegaly, and cytopenias. The hallmark of HPS is the accumulation of activated macrophages that engulf hematopoietic cells in the reticuloendothelial system. Most cases of HPS in adults are secondary to infection or malignancy,...

journal_title：American journal of hematology

authors： Goldschmidt N,Gural A,Kornberg A,Spectre G,Shopen A,Paltiel O

更新日期：2004-08-01 00:00:00

abstract：:Since platelets express both platelet-specific and class I HLA antigens, serum antiplatelet reactivity assessed by most platelet antibody techniques could be due to antibodies with either or both specificities. Flow cytometric analysis of sera for detection of antiplatelet antibody commonly employs a purified platelet...

journal_title：American journal of hematology

authors： Freedman J,Hornstein A

更新日期：1991-12-01 00:00:00

abstract：:Familial and metachronous aggregations of malignant lymphoma are well-documented, but the molecular basis of a predisposition for development of lymphoma is as yet unclear. Malignant lymphomas have been described as part of the spectrum of neoplasias in Li-Fraumeni syndrome (LFS), which is associated with constitution...

journal_title：American journal of hematology

authors： Pötzsch C,Schaefer HE,Lübbert M

更新日期：1999-11-01 00:00:00

abstract：DISEASE OVERVIEW:Cutaneous T-cell lymphomas are a heterogenous group of T-cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS). DIAGNOSIS:The diagnosis of MF or SS requires the integration of clinical and histopathologic data. ...

journal_title：American journal of hematology

authors： Wilcox RA

更新日期：2014-08-01 00:00:00

abstract：:The erythrocytes of 90 pregnant women were evaluated for the presence of in vivo or in vitro oxidant damage. The reduced glutathione (P less than 0.005) and the membrane reduced sulfhydryl (P less than 0.001) concentrations were decreased in fresh erythrocytes. Following incubation with acetylphenylhydrazine, Heinz bo...

journal_title：American journal of hematology

authors： Lachant NA,Gottlieb AJ,DiFino SM,Landaw SA,Tanaka KR

更新日期：1985-02-01 00:00:00

abstract：:The trial CICL670AUS04 was a single-arm, open-label study of the cardiac efficacy of 18 months of deferasirox monotherapy [1]. Cardiac response in this study was related to the degree of liver siderosis. Patients with mild to moderate liver siderosis improved their cardiac T2* while more severely siderotic patients di...

journal_title：American journal of hematology

authors： Wood JC,Glynos T,Thompson A,Giardina P,Harmatz P,Kang BP,Paley C,Coates TD

更新日期：2010-10-01 00:00:00

abstract：:Immune dysregulation and altered T-cell hemostasis play important roles in the pathogenesis of myelodysplastic syndromes (MDS). Recent studies suggest an increased risk of MDS among patients with autoimmune diseases. Here, we investigated the prevalence of autoimmune diseases among MDS patients, comparing characterist...

journal_title：American journal of hematology

authors： Komrokji RS,Kulasekararaj A,Al Ali NH,Kordasti S,Bart-Smith E,Craig BM,Padron E,Zhang L,Lancet JE,Pinilla-Ibarz J,List AF,Mufti GJ,Epling-Burnette PK

更新日期：2016-05-01 00:00:00

abstract：:Autoimmune hemolytic anemia (AIHA) associated with giant cell hepatitis (GCH) is a rare disorder in infants. AIHA usually precedes the development of liver disease by months to years. Early recognition of the disease and prompt institution of immunosuppressive therapy results in clinical remission and prevents liver d...

journal_title：American journal of hematology

authors： Kashyap R,Sarangi JN,Choudhry VP

更新日期：2006-03-01 00:00:00

abstract：:We report a case of a 61-year-old man with head and neck cancer who presented with pancytopenia two months after the completion of his chemotherapy and was diagnosed with myelodysplasia on the basis of two bone marrow examinations, before the correct diagnosis of visceral leishmaniasis was established with splenectomy...

journal_title：American journal of hematology

authors： Kopterides P,Halikias S,Tsavaris N

更新日期：2003-11-01 00:00:00

abstract：:Cytotoxic agents like Hydroxyurea, Busulfan and Interferon-alpha are to date the most commonly used therapeutic approaches in Essential Thrombocythemia (ET). However, few data on the efficacy and safety of these agents in the long-term are currently available. We report a retrospective analysis of the long-term outcom...

journal_title：American journal of hematology

authors： Palandri F,Catani L,Testoni N,Ottaviani E,Polverelli N,Fiacchini M,De Vivo A,Salmi F,Lucchesi A,Baccarani M,Vianelli N

更新日期：2009-04-01 00:00:00

abstract：:Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. CAR T cells are then expanded for clinical use and infused back into the patie...

journal_title：American journal of hematology

authors： Feins S,Kong W,Williams EF,Milone MC,Fraietta JA

更新日期：2019-05-01 00:00:00

abstract：:A 37-year-old untransfused, non-drinking man with Hemoglobin H-CS disease presented with insulin-dependent diabetes mellitus, markedly elevated serum ferritin level, and marked iron deposition in hepatocytes. He did not carry either of the two common mutations of the HLA-H gene for hereditary hemochromatosis, namely, ...

journal_title：American journal of hematology

authors： Chim CS,Chan V,Todd D

更新日期：1998-02-01 00:00:00

abstract：:We present a case of chronic tonsillitis in a patient with chronic lymphocytic leukemia. Despite empiric radiation and antibiotic therapy, the patient's sore throat and tonsillar enlargement persisted. Excisional biopsy of the involved tonsil revealed the presence of Cryptococcus neoformans. Blood cultures also yielde...

journal_title：American journal of hematology

authors： Korvick J,Yu VL

更新日期：1987-08-01 00:00:00

abstract：:Thirty-seven patients with chronic phase chronic myeloid leukaemia and fourteen healthy controls have been evaluated for lineage differentiation with immunological markers on purified bone marrow CD34 positive cells by multiparameter flow cytometry. The myeloid-associated antigen CD33 and the stem cell factor receptor...

journal_title：American journal of hematology

authors： Martín-Henao GA,Quiroga R,Sureda A,García J

更新日期：1999-07-01 00:00:00

abstract：:To better assess the efficacy and safety of rituximab in adults' warm antibody autoimmune hemolytic anemia (wAIHA), we conducted a retrospective study including 27 adults (mean age 49.7 +/- 21 years) with either primary (n = 17) or secondary (n = 10) wAIHA. On average, the patients received 2.1 +/- 1.4 treatment lines...

journal_title：American journal of hematology

authors： Bussone G,Ribeiro E,Dechartres A,Viallard JF,Bonnotte B,Fain O,Godeau B,Michel M

更新日期：2009-03-01 00:00:00

abstract：:We have previously shown that humic acid (well-water humic acid, HA, and synthetic humic acid, SHA) enhances cell surface expression of tissue factor (TF). Here we report that incubation of human umbilical vein endothelial cells (HUVEC) for 2 hr with HA or SHA cause a rapid rise in TF mRNA levels, as shown by Northern...

journal_title：American journal of hematology

authors： Yang HL,Chiu HC,Lu FJ

更新日期：1996-03-01 00:00:00

abstract：:In light of the relationship between immune system dysregulation and multiple myeloma (MM) risk, we investigated whether genetic variation in 92 immune function genes among 77 gene regions are associated with MM susceptibility in a population-based case-control study (108 cases and 482 controls) conducted among Caucas...

journal_title：American journal of hematology

authors： Lee KM,Baris D,Zhang Y,Hosgood HD 3rd,Menashe I,Yeager M,Zahm SH,Wang SS,Purdue MP,Chanock S,Zheng T,Rothman N,Lan Q

更新日期：2010-08-01 00:00:00

abstract：:Transformation to secondary myelofibrosis (MF) occurs as part of the natural history of polycythemia vera (PPV-MF) and essential thrombocythemia (PET-MF). Although primary (PMF) and secondary MF are considered similar diseases and managed similarly, there are few studies specifically focused on the latter. The aim of ...

journal_title：American journal of hematology

authors： Rotunno G,Pacilli A,Artusi V,Rumi E,Maffioli M,Delaini F,Brogi G,Fanelli T,Pancrazzi A,Pietra D,Bernardis I,Belotti C,Pieri L,Sant'Antonio E,Salmoiraghi S,Cilloni D,Rambaldi A,Passamonti F,Barbui T,Manfredini R,Ca

更新日期：2016-07-01 00:00:00

abstract：:Since trisomy 12 is the most common chromosome abnormality found in CLL and MDM2 has been mapped to this chromosome, we examined the possible association of MDM2 in the pathogenesis of CLL. A rearrangement of the MDM2 gene was observed in 4 of 11 peripheral blood mononuclear cells (PBMC) from patients with CLL by Sout...

journal_title：American journal of hematology

authors： Huang YQ,Raphael B,Buchbinder A,Li JJ,Zhang WG,Friedman-Kien AE

更新日期：1994-10-01 00:00:00

abstract：:The standard dose of clofarabine is 52 mg/m2 for pediatrics and 40 mg/m2 in adults. Clofarabine dosed at 52 mg/m2 was used in adult patients with refractory ALL to maximize response before allo-HSCT. All patients had a significant response to therapy. Published pharmacokinetic analysis revealed no difference in peak p...

journal_title：American journal of hematology

authors： McGregor BA,Brown AW,Osswald MB,Savona MR

更新日期：2009-04-01 00:00:00

abstract：:Pentosan polysulfate is a low-molecular-weight sulfated polysaccharide used as an antithrombotic drug. We present two patients who developed thrombocytopenia and venous thrombosis during treatment with pentosan polysulfate. The relationship between pentosan polysulfate and thrombocytopenia is supported by platelet agg...

journal_title：American journal of hematology

authors： Tardy-Poncet B,Tardy B,Grelac F,Reynaud J,Mismetti P,Bertrand JC,Guyotat D

更新日期：1994-03-01 00:00:00

abstract：:A single-strand conformation polymorphism (SSCP) analysis of polymerase chain reaction (PCR)-amplified products of immunoglobulin (Ig) heavy chain rearrangements can be used to analyze B cell clonalities and clonal identities of B cells from different samples. However, the usefulness of the PCR-SSCP analysis is not fu...

journal_title：American journal of hematology

authors： Shiokawa S,Nishimura J,Uike N,Saburi Y,Suehiro T,Yamamoto K

更新日期：1999-10-01 00:00:00

abstract：:This analysis, using data from the bortezomib-melphalan-prednisone (VMP) arm of the Phase III VISTA study, investigated whether increased cumulative bortezomib dose could improve overall survival (OS) in transplant-ineligible patients with previously untreated multiple myeloma. Median cumulative bortezomib dose receiv...

journal_title：American journal of hematology

authors： Mateos MV,Richardson PG,Dimopoulos MA,Palumbo A,Anderson KC,Shi H,Elliott J,Dow E,van de Velde H,Niculescu L,San Miguel JF

更新日期：2015-04-01 00:00:00

abstract：:The aim of this study was to investigate whether genetic polymorphisms in cytochrome P450s (CYPs), glutathione S-transferases (GSTs), and N-acetyltransferases (NATs) genes modify the relationship between alcohol consumption and risk of non-Hodgkin's lymphoma (NHL) in a population-based, case-control study including 1,...

journal_title：American journal of hematology

authors： Li Y,Zheng T,Kilfoy BA,Lan Q,Holford T,Han X,Zhao P,Dai M,Leaderer B,Rothman N,Zhang Y

更新日期：2010-03-01 00:00:00

abstract：:Neonatal alloimmune thrombocytopenia is an uncommon but important cause of thrombocytopenia in infants. Because of the severity of the thrombocytopenia, some of these infants will have intracranial hemorrhage with resultant long-term disability. Obstetricians and neonatologists have recommended delivery by caesarean s...

journal_title：American journal of hematology

authors： Burrows RF,Caco CC,Kelton JG

更新日期：1988-06-01 00:00:00

abstract：:FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia (F/P+ MN-eo) is a rare disease: robust epidemiological data are lacking and reported issues are scarce, of low sample-size and limited follow-up. Imatinib mesylate (IM) is highly efficient but no predictive factor of relapse after discontinuation has yet been i...

journal_title：American journal of hematology

authors： Rohmer J,Couteau-Chardon A,Trichereau J,Panel K,Gesquiere C,Ben Abdelali R,Bidet A,Bladé JS,Cayuela JM,Cony-Makhoul P,Cottin V,Delabesse E,Ebbo M,Fain O,Flandrin P,Galicier L,Godon C,Grardel N,Guffroy A,Hamidou M,

更新日期：2020-11-01 00:00:00

abstract：:Clopidogrel is a widely used antiplatelet agent that irreversibly inhibits platelet P2Y12 ADP receptors after conversion to an active metabolite. There are a number of laboratory tests capable of detecting clopidogrel-induced platelet inhibition and published literature correlates suboptimal clopidogrel response to ad...

journal_title：American journal of hematology

authors： Smock KJ,Saunders PJ,Rodgers GM,Johari V

更新日期：2011-12-01 00:00:00

abstract：:To clarify the idea that an alteration of the transferrin receptor (TF-R) gene, localized to 3q26, may be of pathogenetic significance in hematological disorders with 3q anomaly, we studied the TF-R systems of erythroblasts from both functional and genetic aspects. The patient described here had refractory anemia with...

journal_title：American journal of hematology

authors： Abe Y,Muta K,Yufu Y,Takahira H,Nishimura J,Nawata H

更新日期：1990-03-01 00:00:00