[Interleukin 10 and tumor necrosis factor alpha gene expression in respiratory and peripheral muscles. Relation to sarcolemmal damage].


BACKGROUND:Tumor necrosis factor alpha (TNF-alpha) has been implicated in loss of muscle mass in chronic obstructive pulmonary disease and other consumptive processes. TNF-alpha production would be related to inflammation arising from pulmonary disease itself or, alternatively, from smoking, and would be carried to the muscle through the blood stream. However, it has also been suggested that TNF-alpha may be expressed directly in muscle tissue. Regardless the site of production of TNF-alpha, its relation to subsequent muscle damage is unclear. OBJECTIVE:We studied the expression of TNF-alpha and an interleukin inhibitor of its production (IL-10) in the main respiratory muscles and a peripheral muscle in the dog. METHOD:Nine young, male Beagle dogs were included. From all animals we obtained a biopsy of the diaphragm (Dph) and external intercostal (ExtI) muscles and a leg muscle (internal vastus of the quadriceps, IntV). TNF-alpha and IL-10 gene expressions were measured through the analysis of messenger RNA levels, using reverse transcription and polymerase chain reaction. We also assessed sarcolemmal damage using intracellular fibronectin detection (immunohistochemistry). RESULTS:The expression of both cytokines showed wide interindividual variability. On the one hand, TNF-alpha (was very low in Dph and ExtI (0.02 0.03 and 0.05 0.06 a.u., respectively), but relatively high in the IntV (0.14 0.08 a.u.). IL-10 expression, on the other hand was low in the Dph (0.06 0.05 a.u.) and slightly higher in the ExtI (2.7 1.9 a.u., p < 0.01) and IntV (1.6 1.7 a.u.). Sarcolemmal damage was minimal in all three muscles and was related to TNF-alpha expression in the peripheral muscle (r = 0.682, p < 0.05). CONCLUSIONS:1) TNF-alpha and IL-10 appear to be constitutively expressed within the skeletal muscle in dogs. 2) Basal TNF-alpha expression is lower in respiratory muscles than in peripheral muscles. 3) The expression in the latter is related to membrane damage.


Arch Bronconeumol


Palacio J,Gáldiz JB,Bech JJ,Mariñán M,Casadevall C,Martínez P,Gea J





Has Abstract


2002-07-01 00:00:00














  • [COPD: what is there beyond BODE index?].

    abstract::Chronic obstructive pulmonary disease (COPD) is a multidimensional disease with wide phenotypic heterogeneity that is not adequately reflected by forced expiratory volume in 1 second (FEV(1)). Assessment of patients with COPD requires analysis of multiple variables that encompass respiratory and extrapulmonary involve...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Casanova Macario C,de Torres Tajes JP,Lanus EC

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  • Activating and resistance mutations of the epidermal growth factor receptor (EGFR) gene and non-small cell lung cancer: a clinical reality.

    abstract::In non-small cell lung cancer, the EGFR gene mutations identify a patient sub-population with different clinical characteristics and treatment responses to those that do not have these mutations. There are mutations that derive in increased sensitive to EGFR targeted therapy, as well as mutations that result in resist...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Taus A,Vollmer I,Arriola E

    更新日期:2011-02-01 00:00:00

  • [Stage IB non-small cell lung cancer: impact of the number of lymph nodes examined on survival].

    abstract:INTRODUCTION AND OBJECTIVES:To determine the causes of death in patients operated on for stage IB non-small cell lung cancer (NSCLC) and to assess the impact on survival of the number of lymph nodes removed. PATIENTS AND METHOD:We studied 300 patients operated on for stage IB NSCLC. Only palpable or visible lymph node...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Cerón J,Peñalver JC,Jordá C,Padilla J

    更新日期:2009-02-01 00:00:00

  • [Effectiveness and tolerance of antituberculosis treatment regimens without isoniazid and rifampicin: analysis of 85 cases].

    abstract:OBJECTIVE:To determine if isoniazid- and/or rifampicin-free antituberculosis treatment regimens are safe and effective and to identify any factors that might require changes in the regimens. PATIENTS AND METHODS:We carried out a retrospective study of patients treated with isoniazid- and/or rifampicin-free regimens be...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Tost JR,Vidal R,Maldonado J,Caylà JA

    更新日期:2008-09-01 00:00:00

  • Characteristics of asthma patients admitted to an intermediate respiratory care unit.

    abstract:INTRODUCTION:Intermediate respiratory care units (IRCU) provide continuous monitoring and non-invasive mechanical ventilation (NIMV) in patients with severe respiratory failure who are usually admitted to intensive care units (ICU). The usefulness of IRCU in managing severe asthma exacerbations has never been evaluated...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Núñez B,Fiorentino F,Kersul A,Belda S,García S,Gutiérrez C,Sala E,Cosío B

    更新日期:2013-04-01 00:00:00

  • [Videothoracoscopy in the surgical treatment of pneumothorax: report of 46 cases].

    abstract::We report our 3-years experience with video-thoracoscopy for pneumothorax. Forty-six endoscopies (34 men, 12 women; mean age 27 +/- 9 years) were performed. Patients were under general anesthesia and intubation was selective. The conventional approach was used, with 3 incisions through which the camera and endoscopic ...

    journal_title:Archivos de bronconeumologia

    pub_type: 临床试验,杂志文章


    authors: Izquierdo JM,Pac J,Casanova J,Mariñán M,Rojo R,Rumbero JC,Vara F

    更新日期:1996-02-01 00:00:00

  • [Impact of anemia on COPD].

    abstract::The frequency of anemia may be higher than expected in patients with chronic obstructive pulmonary disease (COPD). Some studies have detected a prevalence of 33%, contrasting with the common idea that associates COPD with secondary polyglobulia. Among the risk factors associated with the development of anemia in these...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: de Miguel Díez Jde M,Martín MJ,Bailón MM,Alvarez-Sala JL

    更新日期:2009-01-01 00:00:00

  • Prevalence and Mortality of Patients with Palliative Needs in an Acute Respiratory Setting.

    abstract:INTRODUCTION:NECPAL is a tool for identification of patients with advanced chronic disease in need of palliative care. The main objective of the study is to know the prevalence of patients with palliative needs in an acute respiratory ward in a Spanish tertiary hospital using NECPAL. A second objective of the study is ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Tabernero Huguet E,Ortiz de Urbina Antia B,González Quero B,Garay Llorente E,Andia Iturrate J,Pérez Fernández S,Gómez Larrauri A,Iriberri Pascual M

    更新日期:2020-09-25 00:00:00

  • [Perfusion of donor tissue improves the preservation of graft in heterotopic tracheal transplantation].

    abstract::To assess the effect on tracheal graft preservation of perfusion of donor tissue with a Collins solution before extraction and immunosuppression of the recipient. An experimental study was performed in 36 albino rabbits with revascularized heterotopic cervical reconstruction of the trachea with omentum. The animals we...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Jiménez MF,Gómez-Alonso A,Varela G,Ludeña MD,García-Criado J

    更新日期:1997-12-01 00:00:00

  • [Vascular endothelial growth factor in benign and malignant pleural effusions].

    abstract:OBJECTIVE:Vascular endothelial growth factor (VEGF) is a potent inducer of capillary permeability and its role as a crucial mediator in pleural fluid formation has been established. This study was conducted to assess the usefulness of VEGF for diagnosing malignant and non-malignant pleural effusions of various causes. ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Kaya A,Poyraz B,Celik G,Ciledag A,Gulbay BE,Savas H,Savas I

    更新日期:2005-07-01 00:00:00

  • [COPD and alpha-1-antitrypsin deficiency].

    abstract::Alpha-1-antitrypsin deficiency (AATD) is the main genetic factor related to the development of emphysema. This protein has numerous variants, some of which are clinically relevant because their anomalous conformation implies that they fail to reach the target organs as they are polymerized in the hepatocyte. The main ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Lara B

    更新日期:2010-01-01 00:00:00

  • [Hookwire localization of pulmonary nodules for video-thorascopic surgical resection].

    abstract:OBJECTIVES:To assess the usefulness of a technique for inserting hookwires guided by computed tomography to locate and resect pulmonary nodules by video-assisted thoracoscopy. To describe the procedure and its complications. PATIENTS AND METHODS:Nine pulmonary nodules were located in nine patients. All were

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Soleto MJ,Olivera MJ,Pun YW,Moreno R,Nieto S,Caballero P

    更新日期:2002-09-01 00:00:00

  • [The evaluation of lung vascular compliance by the dobutamine stress test in patients who are candidates for extensive lung resections].

    abstract::This prospective descriptive study evaluated the utility of dobutamine in studying pulmonary vascular compliance in patients with lung neoplasms who are high risk candidates for lung resection. Seventeen consecutive patients meeting one of the following inclusion criteria were enrolled: FEV1 < 60% of theoretical value...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Rubia MV,Gandía F,Duque JL

    更新日期:1997-05-01 00:00:00

  • [Analysis of proliferating cell nuclear antigen (PCNA) expression in 24 cases of primary non-small cell pulmonary carcinomas and correlation with survival].

    abstract::Proliferating cell nuclear antigen (PCNA) is a 36 kD nuclear protein involved in DNA replication that is believed to provide an indication of proliferation in some neoplasms. This study analyzes PCNA expression in 24 cases of primary non-small cell lung cancer using monoclonal PC-10 antibodies in paraffin embedded mat...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Castellano VM,Sotelo T,Ballestín C,López-Encuentra A,Varela G

    更新日期:1996-03-01 00:00:00

  • [Diagnosis and treatment of bronchiectasis. Spanish Society of Pneumology and Thoracic Surgery].

    abstract::Bronchiectasis is the end result of several different diseases that share principles of management. The clinical course usually involves chronic bronchial infection and inflammation, which are associated with progression. The cause of bronchiectasis should always be investigated, particularly when it can be treated. W...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,实务指引


    authors: Vendrell M,de Gracia J,Olveira C,Martinez-Garcia MA,Girón R,Máiz L,Cantón R,Coll R,Escribano A,Solé A

    更新日期:2008-11-01 00:00:00

  • Systemic Inflammatory Marker CRP Was Better Predictor of Readmission for AECOPD Than Sputum Inflammatory Markers.

    abstract:INTRODUCTION:Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) readmission contributes considerably to the worse outcomes for COPD patients. Predictors for readmission include some socio-demographic variables and the severity of the underlying disease, however, few evidence suggested whether persiste...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Jing Z,Chun C,Ning S,Hong Z,Bei H,Wan-Zhen Y

    更新日期:2016-03-01 00:00:00

  • Myeloid-Derived Suppressor Cells: Possible Link Between Chronic Obstrucive Pulmonary Disease and Lung Cancer.

    abstract::Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are prevalent diseases and are a leading cause of morbidity and mortality worldwide. There is strong evidence to show that COPD is an independent risk factor for LC. Chronic inflammation plays a significant pathogenic role in COPD comorbidities, particu...

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    pub_type: 杂志文章,评审


    authors: Scrimini S,Pons J,Sauleda J

    更新日期:2016-01-01 00:00:00

  • [Predictors of outcome in blunt chest trauma].

    abstract:INTRODUCTION:Thoracic trauma is often associated with polytrauma. Because mortality is high, the search for prognostic tools is useful. PATIENTS AND METHODS:A total of 108 patients with blunt thoracic trauma, 73 of whom had multiple injuries, were studied in an intensive care unit (ICU). The variables named as potenti...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Virgós Señor B,Nebra Puertas AC,Sánchez Polo C,Broto Civera A,Suárez Pinilla MA

    更新日期:2004-11-01 00:00:00

  • Human papillomavirus in non-small-cell lung cancer: the impact of EGFR mutations and the response to erlotinib.

    abstract::It has been suggested that human papillomavirus (HPV) could participate in the development of non-small-cell lung cancer (NSCLC). A higher HPV infection rate has been reported in the NSCLC samples from Asian non-smoker patients, with adenocarcinomas or responders to EGFR tyrosine kinase inhibitors (EGFR-TKI). We explo...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Márquez-Medina D,Gasol-Cudós A,Taberner-Bonastre MT,Samamé Pérez-Vargas JC,Salud-Salvia A,Llombart-Cussac A

    更新日期:2013-02-01 00:00:00

  • [Lung cancer risk in shoe manufacturing].

    abstract:OBJECTIVE:Workers in shoe manufacturing have been reported to be at a greater relative risk for bronchogenic carcinoma. Given the implications for our practice setting, we carried out a study to a) clarify whether working in shoe manufacturing is a risk factor for lung cancer and b) detect histological differences betw...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Galán Dávila A,Romero Candeira S,Sánchez Payá J,Orts Giménez D,Llorca Martínez E

    更新日期:2005-04-01 00:00:00

  • [Pulmonary mucormycosis: a case report and review of the literature].

    abstract::Mucormycosis is an opportunistic mycotic infection, the frequency of pulmonary infection is 22% and the associated mortality rates were 83% for pulmonary. We present a case of pulmonary mucormycosis survived after the therapy with amphotericin B and surgery. ...

    journal_title:Archivos de bronconeumologia

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    authors: Escobar Sacristán JA,de Granda Orive JI,Ramírez García JR,Ortiz de Villajos E,López Perales M,Barberán López J

    更新日期:1996-01-01 00:00:00

  • Can pulse transit time be useful for detecting hypertension in patients in a sleep unit?

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    pub_type: 杂志文章


    authors: Gómez García MT,Troncoso Acevedo MF,Rodriguez Guzmán M,Alegre de Montaner R,Fernández Fernández B,del Río Camacho G,González-Mangado N

    更新日期:2014-07-01 00:00:00

  • [Clinical efficacy of moxifloxacin in the treatment of exacerbations of chronic bronchitis: a systematic review and meta-analysis].

    abstract:OBJECTIVE:As the research undertaken to date on the efficacy of the new antibiotics in the treatment of exacerbations of chronic bronchitis has taken the form of trials designed to demonstrate equivalence, we have no data on the advantages associated with the use of these new drugs with greater bactericidal activity. O...

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    authors: Miravitlles M,Molina J,Brosa M

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    pub_type: 杂志文章


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    更新日期:2003-02-01 00:00:00

  • [Risk factors in bronchogenic carcinoma surgery].

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    pub_type: 杂志文章


    authors: Duque JL,Rami-Porta R,Almaraz A,Castanedo M,Freixinet J,Fernández de Rota A,López Encuentra A,Grupo Cooperativo del Carcinoma Broncogénico SEPAR.

    更新日期:2007-03-01 00:00:00

  • [Prognostic factors and outcome of thymectomy in 80 cases of myasthenia gravis].

    abstract:OBJECTIVES:To analyze the results of thymectomy in our series of patients with myasthenia gravis (MG) and to study the influence of the most common prognostic factors. MATERIAL AND METHODS:Eighty MG patients over a period of 23 years underwent thymectomy consecutively in our hospital. Preoperative assessment included ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Vázquez-Pelillo J,Gil Alonso J,Díaz-Agero P,García Sánchez-Girón J,Roca Serrano R,Díez Tejedor E,Casillas Pajuelo M

    更新日期:2001-04-01 00:00:00

  • [Usefulness of chest sonography in a respiratory medicine unit].

    abstract::Chest ultrasound, a diagnostic technique used mainly by radiologists, is useful for managing pleural effusion. Sonography and computed tomography (CT) are complementary, although the former is more accessible to clinicians because it is safe and easy to use and because results are available quickly. We evaluated the u...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Hidalgo Ramírez M,Cases Viedma E,Sanchis Aldás JL

    更新日期:2003-06-01 00:00:00

  • [Diffuse interstitial lung disease related to peribronchiolar metaplasia].

    abstract::Peribronchiolar metaplasia is a histologic lesion characterized by fibrosis and bronchiolar epithelial proliferation, affecting peribronchiolar alveolar septa and terminal bronchioles. It has been considered a nonspecific tissue reaction secondary to the action of external factors, such as tobacco smoke and microbes, ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Cano-Jiménez E,Molina-Molina M,Ramírez J,Sánchez M,Aliaga JL,Xaubet A

    更新日期:2009-01-01 00:00:00

  • [Split-night versus full-night polysomnography: comparison of the first and second parts of the night].

    abstract:BACKGROUND AND OBJECTIVE:In a split-night study, the first part consists of standard polysomnography (PSG) for the diagnosis of obstructive sleep apnea syndrome while the second part is used to establish a suitable level of continuous positive airway pressure. The aim of our study was to compare the sleep and respirato...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Ciftci B,Ciftci TU,Guven SF

    更新日期:2008-01-01 00:00:00