Abstract:
:Surface properties of poly (D,L-lactide) (PDLLA) were modified by combining plasma treatment and collagen modification. The changes of surface properties were characterized by contact angles, surface energy, X-ray photoelectron spectra and scanning electron microscopy. The mouse 3T3 fibroblasts were used as model cells to evaluate the cell affinity of PDLLA before and after modification. Effects of different modification methods including plasma treatment, collagen coating and combining plasma treatment with collagen anchorage were investigated and compared. The results showed that the hydrophilicity and surface-free energy were improved and reduced, respectively, after each modification. Plasma pre-treatment could improve the roughness as it incorporated the polar groups and positively charged groups onto the sample surface; so the plasma pre-treated surface would benefit in anchoring more collagen tightly. As a result, cell affinity of PDLLA modified by combining plasma treatment with collagen anchorage was greatly improved. The modified materials could endure rinsing by PBS, which would facilitate further application when the modified materials were used as cells scaffold in tissue engineering.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Yang J,Bei J,Wang Sdoi
10.1016/s0142-9612(01)00400-8keywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
2607-14issue
12eissn
0142-9612issn
1878-5905pii
S0142-9612(01)00400-8journal_volume
23pub_type
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