Abstract：
:Drosophila ovo/svb (dovo) is required for epidermal cuticle/denticle differentiation and is genetically downstream of the wg signaling pathway. Similarly, a mouse homolog of dovo, movo1, is required for the proper formation of hair, a mammalian epidermal appendage. Here, we provide biochemical evidence that movo1 encodes a nuclear DNA binding protein (mOvo1a) that binds to DNA sequences similar to those that dOvo binds to, further supporting the notion that mOvo1a and dOvo are genetically and biochemically homologous proteins. Additionally, we show that the movo1 promoter is activated by the lymphoid enhancer factor 1 (LEF1)/beta-catenin complex, a transducer of wnt signaling. Collectively, our findings suggest that movo1 is a developmental target of wnt signaling during hair morphogenesis in mice, and that the wg/wnt-ovo link in epidermal appendage regulatory pathways has been conserved between mice and flies.
journal_name
Proc Natl Acad Sci U S Aauthors
Li B,Mackay DR,Dai Q,Li TW,Nair M,Fallahi M,Schonbaum CP,Fantes J,Mahowald AP,Waterman ML,Fuchs E,Dai Xdoi
10.1073/pnas.092137099keywords:
subject
Has Abstractpub_date
2002-04-30 00:00:00pages
6064-9issue
9eissn
0027-8424issn
1091-6490pii
99/9/6064journal_volume
99pub_type
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更新日期：2018-05-22 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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更新日期：2002-07-23 00:00:00
