A ligand for peroxisome proliferator activated receptor gamma inhibits cell growth and induces apoptosis in human liver cancer cells.

abstract：BACKGROUND:In a previous hospital based study, we suggested that undiagnosed coeliac disease has a prevalence, among pregnant women, of 1:80, and is a cause of unfavourable outcome of pregnancy. AIMS:In order to confirm or dismiss this hypothesis, which has significant public health implications, we carried out a larg...

journal_title：Gut

authors： Greco L,Veneziano A,Di Donato L,Zampella C,Pecoraro M,Paladini D,Paparo F,Vollaro A,Martinelli P

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Cirrhotic patients with hepatocellular carcinoma (HCC) frequently have impaired glucose metabolism. AIMS:To investigate whether impaired glucose metabolism affects the growth rate of the tumour. PATIENTS AND METHODS:Tumour doubling time (DT), assessed by ultrasound imaging analysis, was measured in 60 pati...

journal_title：Gut

authors： Saito K,Inoue S,Saito T,Kiso S,Ito N,Tamura S,Watanabe H,Takeda H,Misawa H,Togashi H,Matsuzawa Y,Kawata S

更新日期：2002-07-01 00:00:00

abstract：:Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two isoforms (COX-1 and COX-2). COX-1 is constitutively expressed in the gastrointestinal tract in large quantities and has been suggested to maintain mucosal integrity through continuous generation of prostaglandins. COX-2 is induced pred...

journal_title：Gut

authors： Halter F,Tarnawski AS,Schmassmann A,Peskar BM

更新日期：2001-09-01 00:00:00

abstract：:It has been demonstrated that cardiac output and pulmonary, gastroduodenal, pancreatic, and splenic blood flow increases after portacaval shunt operations. This report concerns a study of cerebral haemodynamics and metabolism in eight patients with cirrhosis of the liver, examined both before and after portacaval surg...

journal_title：Gut

authors： Bianchi Porro G,Maiolo AT,Della Porta P

更新日期：1969-11-01 00:00:00

abstract：:It is well known that chronic encephalopathy may be a major complication after the establishment of a surgical portal caval shunt for an episode of variceal haemorrhage. In an effort to minimise this problem Warren and colleagues developed the distal splenorenal shunt where the portal and mesenteric blood flow to the ...

journal_title：Gut

authors： Bleasel AF,Waugh RC,McCaughan GW

更新日期：1989-10-01 00:00:00

abstract：:Recent reports have indicated a possible role for 111Indium leucocyte scintigraphy in the management of patients with acute inflammatory bowel disease. Our experience with this technique in 15 patients (nine with ulcerative colitis, six with Crohn's disease) is described. Perfect agreement was not obtained between sci...

journal_title：Gut

authors： Buxton-Thomas MS,Dickinson RJ,Maltby P,Hunter JO,Wraight EP

更新日期：1984-12-01 00:00:00

abstract：:Proximal diversion has commonly been used for severe perianal Crohn's disease in an attempt to relieve local symptoms, whether the primary intestinal disease is in the colon or small bowel. Two patients are presented in whom diversion led to severe symptomatic disease in the previously normal defunctioned bowel. In ea...

journal_title：Gut

authors： Williamson ME,Hughes LE

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Independent component analysis (ICA) of the electroencephalogram (EEG) overcomes many of the classical problems in EEG analysis. We used ICA to determine the brain responses to painful stimulation of the oesophagus. METHODS:Twelve subjects with a median age of 41 years were included. With a nasal e...

journal_title：Gut

authors： Drewes AM,Sami SA,Dimcevski G,Nielsen KD,Funch-Jensen P,Valeriani M,Arendt-Nielsen L

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Fer kinase is activated by a number of growth factors and cytokines, and phosphorylates cortactin during cell shape change induced cortical actin reorganisation. In addition, Fer participates in cytoskeletal interactions mediated by cadherins, platelet endothelial cell adhesion molecule 1 (PECAM-1),...

journal_title：Gut

authors： Qi W,Ebbert KV,Craig AW,Greer PA,McCafferty DM

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:Lesogaberan (AZD3355) is a novel γ-aminobutyric acid B-type receptor agonist designed to treat gastro-oesophageal reflux disease (GERD) by inhibiting transient lower oesophageal sphincter relaxations. A randomised, double-blind, placebo-controlled, multi-centre phase IIb study was performed to assess the effi...

journal_title：Gut

authors： Shaheen NJ,Denison H,Björck K,Karlsson M,Silberg DG

更新日期：2013-09-01 00:00:00

abstract：:Sex differences exist in the site specific incidences of colorectal cancer. The increased incidence of colonic cancer in women with breast cancer and the protective effect of increasing parity suggest a role for sex hormones. To explore the molecular basis, the expression of messenger RNA for oestrogen and progesteron...

journal_title：Gut

authors： Singh S,Sheppard MC,Langman MJ

更新日期：1993-05-01 00:00:00

abstract：:A 45 year old man is described with Whipple's disease who presented with weight loss, lethargy, and ascites. He subsequently developed fever and a mass in the neck, but died despite antibiotic treatment and nutritional support. Necropsy showed extraintestinal lymphoma. ...

journal_title：Gut

authors： Gillen CD,Coddington R,Monteith PG,Taylor RH

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:Treatments with sequential therapy (SEQ) or bismuth quadruple (QUAD) therapy have been proposed as empirical firstline regimens for Helicobacter pylori. We compared the efficacy and tolerability of 10 day SEQ with 10 day modified QUAD as both firstline and secondline treatments for H pylori in a randomised cr...

journal_title：Gut

authors： Liu KS,Hung IF,Seto WK,Tong T,Hsu AS,Lam FY,But DY,Wong SY,Leung WK

更新日期：2014-09-01 00:00:00

abstract：:A cohort of 123 patients with coeliac disease, diagnosed in the first three years of life and followed up for at least 10 years, was reevaluated during the teenage period in terms of compliance with the diet and clinical state. Mucosal structure and lymphocytes were assessed in small intestinal biopsy specimens obtain...

journal_title：Gut

authors： Mayer M,Greco L,Troncone R,Auricchio S,Marsh MN

更新日期：1991-08-01 00:00:00

abstract：:For the first time the endoscopist has more than one option for the management of gastro-oesophageal varices. It is now feasible to select the appropriate therapy on the basis of the clinical setting. Acute injection sclerotherapy remains a quick and simple technique for the control of active bleeding from oesophageal...

journal_title：Gut

authors： Williams SG,Westaby D

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:The pre-malignant gastric lesions atrophic gastritis (AG), intestinal metaplasia (IM) and dysplasia (DYS) have long been identified as principal risk factors for gastric cancer. OBJECTIVE:To evaluate epidemiological time trends of pre-malignant gastric lesions in the Netherlands. METHODS:Patients with a fi...

journal_title：Gut

authors： de Vries AC,Meijer GA,Looman CW,Casparie MK,Hansen BE,van Grieken NC,Kuipers EJ

更新日期：2007-12-01 00:00:00

abstract：:Lymphocytes obtained after enzymatic digestion of intestinal biopsies from patients with coeliac disease were examined for the presence of gliadin specific antibody secreting cells by means of the ELISPOT technique. This technique permits enumeration of gliadin antibody secreting immunocytes, differentiated with regar...

journal_title：Gut

authors： Lycke N,Kilander A,Nilsson LA,Tarkowski A,Werner N

更新日期：1989-01-01 00:00:00

abstract：:Big differences in the prevalence of peptic ulcer are known to exist in different parts of India. This paper reports a high incidence in Assam and records certain differences with peptic ulcers found in south India. ...

journal_title：Gut

authors： MALHOTRA SL,MAJUMDAR CT,BARDOLOI PC

更新日期：1964-08-01 00:00:00

abstract：:Synchronous cancers of the oesophagus and stomach diagnosed in a patient showing pronounced leucocytosis were examined for production of granulocyte colony stimulating factor (G-CSF) and expression of G-CSF receptor. Whereas enzyme immunoassay of tissue extracts showed that the oesophageal carcinoma produced G-CSF, th...

journal_title：Gut

authors： Ichiishi E,Yoshikawa T,Kogawa T,Yoshida N,Kondo M

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:The diagnosis and classification of oesophageal motility disorders is currently based on assessment of the phasic contractile activity of the oesophagus. Tonic muscular contraction of the oesophageal body (oesophageal tone) has not been well characterised. AIM:To quantify oesophageal tonic activity in healt...

journal_title：Gut

authors： González M,Mearin F,Vasconez C,Armengol JR,Malagelada JR

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Pigment epithelium-derived factor (PEDF), a non-inhibitory SERPIN with potent antiangiogenic activity, has been recently implicated in metabolism and adipogenesis, both of which are known to influence pancreatic cancer progression. Increased pancreatic fat in human pancreatic tumour correlates with ...

journal_title：Gut

authors： Grippo PJ,Fitchev PS,Bentrem DJ,Melstrom LG,Dangi-Garimella S,Krantz SB,Heiferman MJ,Chung C,Adrian K,Cornwell ML,Flesche JB,Rao SM,Talamonti MS,Munshi HG,Crawford SE

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori affects gastric epithelium integrity by acceleration of apoptosis. However, it remains unclear what product of the bacteria causes apoptosis, or whether or not the apoptosis is involved in the development of ulcers. AIMS:To elucidate the factor from H pylori that causes acceleration of a...

journal_title：Gut

authors： Kohda K,Tanaka K,Aiba Y,Yasuda M,Miwa T,Koga Y

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that up to 0.5% of the Caucasian population is homozygous for the HFE gene C282Y mutation. High prevalence values have been reported in Northern Europe. To what extent the presence of this mutation is associated with overt clinical haemochromatosis is unclear. AIM:To determine th...

journal_title：Gut

authors： Distante S,Berg JP,Lande K,Haug E,Bell H

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Inflammatory bowel disease (IBD) is initiated and perpetuated by a dysregulated immune response to unknown environmental antigens such as luminal bacteria in genetically susceptible hosts. SR-PSOX/CXCL16, a scavenger receptor that binds phosphatidylserine and oxidised lipoprotein, has both phagocyti...

journal_title：Gut

authors： Uza N,Nakase H,Yamamoto S,Yoshino T,Takeda Y,Ueno S,Inoue S,Mikami S,Matsuura M,Shimaoka T,Kume N,Minami M,Yonehara S,Ikeuchi H,Chiba T

更新日期：2011-11-01 00:00:00

abstract：:p53 mutations are a common genetic finding in hepatocellular carcinoma from areas of high aflatoxin exposure. Recent small studies have shown that p53 gene mutations may be less common in areas with a low prevalence of hepatocellular carcinoma such as Great Britain. The protein product of mutant p53 can be detected im...

journal_title：Gut

authors： Collier JD,Carpenter M,Burt AD,Bassendine MF

更新日期：1994-01-01 00:00:00

abstract：:Psychological treatments are increasingly being used to help patients with the irritable bowel syndrome (IBS), but the efficacy of such treatments is still debated. This review indicates that there are three ways in which they might have been effective in published studies to date; relating bowel symptoms to stress, s...

journal_title：Gut

authors： Creed F,Guthrie E

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Colonoscopy is the current reference standard for the detection of colorectal neoplasia, but nevertheless adenomas remain undetected. The Endocuff, an endoscopic cap with plastic projections, may improve colonic visualisation and adenoma detection. The aim of this study was to compare the mean numbe...

journal_title：Gut

authors： van Doorn SC,van der Vlugt M,Depla A,Wientjes CA,Mallant-Hent RC,Siersema PD,Tytgat K,Tuynman H,Kuiken SD,Houben G,Stokkers P,Moons L,Bossuyt P,Fockens P,Mundt MW,Dekker E

更新日期：2017-03-01 00:00:00

abstract：:Jejunal biopsies from 15 Greenlandic and three Danish patients with adult type hypolactasia and nine Greenlandic and 15 Danish patients with normal lactase activity were analysed quantitatively for lactase protein by crossed immunoelectrophoresis. A constant correlation between the amount of lactase activity and immun...

journal_title：Gut

authors： Skovbjerg H,Gudmand-Høyer E,Fenger HJ

更新日期：1980-05-01 00:00:00

abstract：:The spectrum of clinical disease associated with specific defects in jejunal brush border membrane sodium/proton exchange is poorly defined and only two patients have been described so far. Jejunal brush border membrane transport studies were performed in a boy who presented with lethal familial protracted diarrhoea i...

journal_title：Gut

authors： Keller KM,Wirth S,Baumann W,Sule D,Booth IW

更新日期：1990-10-01 00:00:00

abstract：:Bile acid pool size and kinetics were determined in 17 patients with cirrhosis and 11 patients without liver disease and correlated with the severity of liver disease as determined by the usual clinical and laboratory criteria. In order to assess the severity of liver disease, a grading system was devised which assign...

journal_title：Gut

authors： McCormick WC 3rd,Bell CC Jr,Swell L,Vlahcevic ZR

更新日期：1973-11-01 00:00:00