Abstract:
:The distribution of synaptic zinc after short-term (up to 48 h) tactile deprivation of vibrissae was investigated in the barrel cortex of mice using histochemical staining. In adult mice, 12 h after trimming selected rows of vibrissae, an increase in zinc staining in the deprived barrels was observed. This increase was still present 48 h after trimming. These results indicate that the level of synaptic zinc is rapidly regulated by neuronal activity in adult mice. In young (8-day-old) mice, the short-term deprivation did not alter zinc staining and only chronic sensory deprivation produced an increase in zinc staining. However, after long-term deprivation no changes were found in adult mice. These results suggest that different mechanisms might be involved in functional reorganization of zinc containing terminals in young and fully mature cerebral cortex.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Czupryn A,Skangiel-Kramska Jdoi
10.1007/s00221-001-0923-6keywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
567-72issue
4eissn
0014-4819issn
1432-1106journal_volume
141pub_type
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