Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America.

abstract：:To explore the pathogenic mechanism of dominant mutations affecting the carboxyl terminus of rhodopsin that cause retinitis pigmentosa, we generated five lines of transgenic mice carrying the proline-347 to serine (P347S) mutation. The severity of photoreceptor degeneration correlated with the levels of transgene expr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li T,Snyder WK,Olsson JE,Dryja TP

更新日期：1996-11-26 00:00:00

abstract：:The improvement of motor behavior, based on experience, is a form of learning that is critically dependent on the cerebellum. A well studied example of cerebellar motor learning is short-term saccadic adaptation (STSA). In STSA, information on saccadic errors is used to improve future saccades. The information optimiz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Catz N,Dicke PW,Thier P

更新日期：2008-05-20 00:00:00

abstract：:A posttranslational protein O-mannosylation process resembling that found in fungi and animals has been reported in the major human pathogen Mycobacterium tuberculosis (Mtb) and related actinobacteria. However, the role and incidence of this process, which is essential in eukaryotes, have never been explored in Mtb. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu CF,Tonini L,Malaga W,Beau M,Stella A,Bouyssié D,Jackson MC,Nigou J,Puzo G,Guilhot C,Burlet-Schiltz O,Rivière M

更新日期：2013-04-16 00:00:00

abstract：:Trypanosomatid RNA editing is a unique process and essential for these organisms. It therefore represents a drug target for a group of protozoa that includes the causative agents for African sleeping sickness and other devastating tropical and subtropical diseases. Here, we present drug-like inhibitors of a key enzyme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amaro RE,Schnaufer A,Interthal H,Hol W,Stuart KD,McCammon JA

更新日期：2008-11-11 00:00:00

abstract：:Escherichia coli cells lacking the histone-like protein HU form filaments and have an abnormal number of anucleate cells. Furthermore, their phenotype resembles that of rfa mutants, the well-characterized deep-rough phenotype, as they show an enhanced permeability that renders them hypersensitive to chloramphenicol, n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Painbeni E,Caroff M,Rouviere-Yaniv J

更新日期：1997-06-24 00:00:00

abstract：:Antibodies to DNA in the left-handed (Z) conformation bind to acid-fixed polytene chromosomes of both Chironomus thummi and Drosophila melanogaster, as shown by direct and indirect immunofluorescence. Comparison of the phase-contrast, immunofluorescence, and DNA staining patterns shows a predominant localization of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arndt-Jovin DJ,Robert-Nicoud M,Zarling DA,Greider C,Weimer E,Jovin TM

更新日期：1983-07-01 00:00:00

abstract：:Saccharomyces cerevisiae strain PP5 has a phosphodiesterase (PDE) deficiency that results in heat-shock sensitivity due to the intracellular accumulation of cAMP. This strain also carries the cam mutation, which confers permeability to cAMP and, as shown here, to other compounds. Expression of rat type IV PDE in these...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pillai R,Kytle K,Reyes A,Colicelli J

更新日期：1993-12-15 00:00:00

abstract：:The sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) is a P-type ATPase that transports Ca2+ from the cytosol into the sarco(endo)plasmic reticulum (SR/ER) lumen, driven by ATP. This primary transport activity depends on tight coupling between movements of the transmembrane helices forming the two Ca2+-binding sites a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geurts MMG,Clausen JD,Arnou B,Montigny C,Lenoir G,Corey RA,Jaxel C,Møller JV,Nissen P,Andersen JP,le Maire M,Bublitz M

更新日期：2020-12-08 00:00:00

abstract：:Various reconstructive procedures have been attempted to restore a cosmetically acceptable phallus that would allow normal reproductive, sexual, and urinary function in patients requiring penile reconstruction. However, these procedures are limited by a shortage of native penile tissue. We previously demonstrated that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen KL,Eberli D,Yoo JJ,Atala A

更新日期：2010-02-23 00:00:00

abstract：:Mixed-metal oxides play a very important role in many areas of chemistry, physics, materials science, and geochemistry. Recently, there has been a strong interest in understanding phenomena associated with the deposition of oxide nanoparticles on the surface of a second (host) oxide. Here, scanning tunneling microscop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park JB,Graciani J,Evans J,Stacchiola D,Ma S,Liu P,Nambu A,Sanz JF,Hrbek J,Rodriguez JA

更新日期：2009-03-31 00:00:00

abstract：:Phytochrome photoreceptors control plant growth, development, and the shade avoidance response that limits crop yield in high-density agricultural plantings. Cyanobacteriochromes (CBCRs) are distantly related photosensory proteins that control cyanobacterial metabolism and behavior in response to light. Photoreceptors...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lim S,Yu Q,Gottlieb SM,Chang CW,Rockwell NC,Martin SS,Madsen D,Lagarias JC,Larsen DS,Ames JB

更新日期：2018-04-24 00:00:00

abstract：:OLE (ornate, large, extremophilic) RNAs comprise a class of structured noncoding RNAs (ncRNAs) found in many extremophilic bacteria species. OLE RNAs constitute one of the longest and most widespread bacterial ncRNA classes whose major biochemical function remains unknown. In the Gram-positive alkaliphile Bacillus hal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris KA,Zhou Z,Peters ML,Wilkins SG,Breaker RR

更新日期：2018-07-03 00:00:00

abstract：:We have evaluated the effect of ligand binding on expression of the receptor for IgE on rat basophilic leukemia (RBL) cells. RBL cells were grown in the presence or absence of 131I-labeled IgE and sometimes were also surface labeled with 125I. We found that cells grown in the presence of IgE continued to accumulate re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furuichi K,Rivera J,Isersky C

更新日期：1985-03-01 00:00:00

abstract：:Natural killer (NK) cells form three functionally distinct populations of effectors: competent cytolytic effectors able to bind and kill target cells and two subsets of nonlytic effectors, one able and the other unable to bind target cells. A flow cytometric method was developed, based on size and two-color fluorescen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lebow LT,Bonavida B

更新日期：1990-08-01 00:00:00

abstract：:CD11c, also known as integrin alpha X, is the most widely used defining marker for dendritic cells (DCs). CD11c can bind complement iC3b and mediate phagocytosis in vitro, for which it is also referred to as complement receptor 4. However, the functions of this prominent marker protein in DCs, especially in vivo, rema...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu J,Wu H,An J,Ballantyne CM,Cyster JG

更新日期：2018-06-26 00:00:00

abstract：:When a fast-moving drop impacts onto a smooth substrate, splashing will be produced at the edge of the expanding liquid sheet. This ubiquitous phenomenon lacks a fundamental understanding. Combining experiment with model, we illustrate that the ultrathin air film trapped under the expanding liquid front triggers splas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Tan P,Xu L

更新日期：2015-03-17 00:00:00

abstract：:Recent technical advances allow detection of several hundred volatile organic compounds (VOCs) in human exhaled air, many of which reflect unidentified endogenous pathways. Our group has previously estimated plasma glucose levels in healthy adults during a standard oral glucose tolerance test via exhaled VOC analysis....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Novak BJ,Blake DR,Meinardi S,Rowland FS,Pontello A,Cooper DM,Galassetti PR

更新日期：2007-10-02 00:00:00

abstract：:We have previously reported the cloning, sequencing, and partial characterization of Kid-1, a zinc finger-encoding cDNA from the rat kidney. The Kid-1 protein and approximately one-third of all other zinc finger proteins contain a highly conserved region of approximately 75 amino acids at their NH2 terminus named Krüp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Witzgall R,O'Leary E,Leaf A,Onaldi D,Bonventre JV

更新日期：1994-05-10 00:00:00

abstract：:Cell cycle progression is tightly regulated by cyclin-dependent kinases (CDKs). The ankyrin-repeat protein p19INK4d functions as a key regulator of G1/S transition; however, its molecular mode of action is unknown. Here, we combine cell and structural biology methods to unravel the mechanism by which p19INK4d controls...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumar A,Gopalswamy M,Wolf A,Brockwell DJ,Hatzfeld M,Balbach J

更新日期：2018-03-27 00:00:00

abstract：:In characterizing mice with targeted disruption of the SerpinB2 gene, we observed animals that were small at birth with delayed growth and decreased life expectancy. Although this phenotype cosegregated with homozygosity for the inactive SerpinB2 allele, analysis of homozygous SerpinB2-deficient mice derived from two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Westrick RJ,Mohlke KL,Korepta LM,Yang AY,Zhu G,Manning SL,Winn ME,Dougherty KM,Ginsburg D

更新日期：2010-09-28 00:00:00

abstract：:Utrophin levels have recently been shown to be more abundant in slow vs. fast muscles, but the nature of the molecular events underlying this difference remains to be fully elucidated. Here, we determined whether this difference is due to the expression of utrophin A or B, and examined whether transcriptional regulato...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chakkalakal JV,Stocksley MA,Harrison MA,Angus LM,Deschenes-Furry J,St-Pierre S,Megeney LA,Chin ER,Michel RN,Jasmin BJ

更新日期：2003-06-24 00:00:00

abstract：:The expression of a number of genes encoding products involved in copper ion uptake in yeast is specifically inhibited by copper ions. We show here that copper metalloregulation occurs through Cu-dependent repression of the transactivation activity of Mac1p. A segment of the yeast transcription factor Mac1p was identi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graden JA,Winge DR

更新日期：1997-05-27 00:00:00

abstract：:The genome of the defective avian tumor virus MH2 was identified as a RNA of 5.7 kilobases by its presence in different MH2-helper virus complexes and its absence from pure helper virus, by its unique fingerprint pattern of RNase T1-resistant (T1) oligonucleotides that differed from those of two helper virus RNAs, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duesberg PH,Vogt PK

更新日期：1979-04-01 00:00:00

abstract：:In 1950, John Nash contributed a remarkable one-page PNAS article that defined and characterized a notion of equilibrium for n- person games. This notion, now called the "Nash equilibrium," has been widely applied and adapted in economics and other behavioral sciences. Indeed, game theory, with the Nash equilibrium as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holt CA,Roth AE

更新日期：2004-03-23 00:00:00

abstract：:Ubiquitin E3 ligases are crucial for eliminating misfolded proteins before they form cytotoxic aggregates that threaten cell fitness and survival. However, it remains unclear how emerging misfolded proteins in the cytoplasm can be selectively recognized and eliminated by E3 ligases in plants. We found that Misfolded P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim JH,Cho SK,Oh TR,Ryu MY,Yang SW,Kim WT

更新日期：2017-11-14 00:00:00

abstract：:Some strains of Bradyrhizobium japonicum produce rhizobitoxine, a phytotoxin that causes foliar chlorosis on susceptible host plants. We have previously obtained Tn5-induced rhizobitoxine null mutants of B. japonicum. DNA sequence analysis of the region surrounding two Tn5 insertions identifies two overlapping open re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruan X,Zhang C,Peters NK

更新日期：1993-04-01 00:00:00

abstract：:Xenopus oocytes express a gene encoding bovine rhodopsin as well as its SP6 RNA polymerase-derived transcripts and total retinal mRNA. The opsin produced is in unglycosylated (30 kDa) and two glycosylated (35 kDa and 41 kDa) forms. Incubation of the cells expressing the above proteins with 11-cis-retinal generates rho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khorana HG,Knox BE,Nasi E,Swanson R,Thompson DA

更新日期：1988-11-01 00:00:00

abstract：:RNA interfering is a eukaryote-specific gene silencing by 20∼23-nucleotide (nt) microRNAs and small interfering RNAs that recruit Argonaute proteins to complementary RNAs for degradation. In humans, Argonaute2 (AGO2) has been known as the only slicer while Argonaute3 (AGO3) barely cleaves RNAs. Therefore, the intrinsi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park MS,Sim G,Kehling AC,Nakanishi K

更新日期：2020-11-17 00:00:00

abstract：:Histone methyltransferase G9a has critical roles in promoting cancer-cell growth and gene suppression, but whether it is also associated with the DNA damage response is rarely studied. Here, we report that loss of G9a impairs DNA damage repair and enhances the sensitivity of cancer cells to radiation and chemotherapeu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Q,Zhu Q,Lu X,Du Y,Cao L,Shen C,Hou T,Li M,Li Z,Liu C,Wu D,Xu X,Wang L,Wang H,Zhao Y,Yang Y,Zhu WG

更新日期：2017-07-25 00:00:00

abstract：:Tetrahymena ribozymes hold promise for repairing genetic disorders but are largely limited by their modest splicing efficiency and low production of final therapeutic proteins. Ribozyme evolution in intact living mammalian cells would greatly facilitate the discovery of new ribozyme variants with high in vivo activity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hasegawa S,Jackson WC,Tsien RY,Rao J

更新日期：2003-12-09 00:00:00