Plant hormone ethylene is a Norrish type II product from enzymically generated triplet 1-butanal.

abstract：:McKay et al. [(1996) Science 273, 924-930] suggested that carbonate globules in the meteorite ALH84001 contained the fossil remains of Martian microbes. We have characterized a subpopulation of magnetite (Fe(3)O(4)) crystals present in abundance within the Fe-rich rims of these carbonate globules. We find these Martia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas-Keprta KL,Clemett SJ,Bazylinski DA,Kirschvink JL,McKay DS,Wentworth SJ,Vali H,Gibson EK Jr,McKay MF,Romanek CS

更新日期：2001-02-27 00:00:00

abstract：:Osteocalcin, a bone-specific protein and marker of the mature osteoblast, is expressed only in nonproliferating osteoblasts in a mineralizing extracellular matrix, while type I collagen is expressed in proliferating cells. The nuclear proteins encoded by the c-fos and c-jun protooncogenes are expressed during the prol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Owen TA,Bortell R,Yocum SA,Smock SL,Zhang M,Abate C,Shalhoub V,Aronin N,Wright KL,van Wijnen AJ

更新日期：1990-12-01 00:00:00

abstract：:Optical imaging of individual vesicle exocytosis is providing new insights into the mechanism and regulation of secretion by cells. To study calcium-triggered secretion from astrocytes, we used acridine orange (AO) to label vesicles. Although AO is often used for imaging exocytosis, we found that imaging vesicles labe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaiswal JK,Fix M,Takano T,Nedergaard M,Simon SM

更新日期：2007-08-28 00:00:00

abstract：:A 1-hr exposure of bovine lenses in organ culture to H2O2 concentrations in the range found in the aqueous fluid of patients with cataracts inhibits 86Rb+ influx. At 1 mM H2O2, complete inhibition was observed and further investigated. Membrane permeability is slightly decreased. Although lactate concentrations increa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garner WH,Garner MH,Spector A

更新日期：1983-04-01 00:00:00

abstract：:AB5 bacterial toxins and polyomaviruses induce membrane curvature as a mechanism to facilitate their entry into host cells. How membrane bending is accomplished is not yet fully understood but has been linked to the simultaneous binding of the pentameric B subunit to multiple copies of glycosphingolipid receptors. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kabbani AM,Raghunathan K,Lencer WI,Kenworthy AK,Kelly CV

更新日期：2020-06-30 00:00:00

abstract：:In this study, we demonstrate that fluid shear stress (FSS)-induced actin cytoskeletal reorganization and junctional formation in renal epithelial cells are nearly completely opposite the corresponding changes in vascular endothelial cells (ECs) [Thi MM et al. (2004) Proc Natl Acad Sci USA 101:16483-16488]. Mouse prox...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duan Y,Gotoh N,Yan Q,Du Z,Weinstein AM,Wang T,Weinbaum S

更新日期：2008-08-12 00:00:00

abstract：:The transcription factors that act in hepatocyte-specific gene expression include proteins that are present mainly in liver cells (HNF-1/LFB1, C/EBP, HNF-3, HNF-4) (HNF, hepatocyte nuclear factor; C/EBP, rat enhancer binding protein) and proteins that are widely distributed (AP-1, NF-1, NF-Y/ACF). We show here that th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xanthopoulos KG,Prezioso VR,Chen WS,Sladek FM,Cortese R,Darnell JE Jr

更新日期：1991-05-01 00:00:00

abstract：:Cell fate determination depends in part on the establishment of specific transcriptional programs of gene expression. These programs result from the interpretation of the genomic cis-regulatory information by sequence-specific factors. Decoding this information in sequenced genomes is an important issue. Here, we deve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rouault H,Mazouni K,Couturier L,Hakim V,Schweisguth F

更新日期：2010-08-17 00:00:00

abstract：:We report light-induced electron paramagnetic resonance triplet spectra from samples of chloroplasts or digitonin photosystem I particles that depend upon the dark redox state of the bound acceptors of photosystem I. If the reaction centers are prepared in the redox state P-700 A X- FdB-FdA-, then upon illumination at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frank HA,McLean MB,Sauer K

更新日期：1979-10-01 00:00:00

abstract：:The spleen is the lymphoid organ that induces immune responses toward blood-borne pathogens. Specialized macrophages in the splenic marginal zone are strategically positioned to phagocytose pathogens and cell debris, but are not known to play a role in the activation of T-cell responses. Here we demonstrate that splen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Backer R,Schwandt T,Greuter M,Oosting M,Jüngerkes F,Tüting T,Boon L,O'Toole T,Kraal G,Limmer A,den Haan JM

更新日期：2010-01-05 00:00:00

abstract：:The requirement and influence of the peripheral nervous system on tissue replacement in mammalian appendages remain largely undefined. To explore this question, we have performed genetic lineage tracing and clonal analysis of individual cells of mouse hind limb tissues devoid of nerve supply during regeneration of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rinkevich Y,Montoro DT,Muhonen E,Walmsley GG,Lo D,Hasegawa M,Januszyk M,Connolly AJ,Weissman IL,Longaker MT

更新日期：2014-07-08 00:00:00

abstract：:For decades, scientists have debated whether supercooled liquids stop flowing below a glass transition temperature [Formula: see text] or whether motion continues to slow gradually down to zero temperature. Answering this question is challenging because human time scales set a limit on the largest measurable viscosity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jadhao V,Robbins MO

更新日期：2017-07-25 00:00:00

abstract：:Loss of function of CDKN2A/B, also known as INK4/ARF [encoding p16INK4A, p15INK4B, and p14ARF (mouse p19Arf)], confers susceptibility to cancers, whereas its up-regulation during organismal aging provokes cellular senescence and tissue degenerative disorders. To better understand the transcriptional regulation of p16 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Hyle J,Wright S,Shao Y,Zhao X,Zhang H,Li C

更新日期：2019-12-09 00:00:00

abstract：:Members of the polo subfamily of protein kinases play pivotal roles in cell-cycle control and proliferation. In addition to a high degree of sequence similarity in the kinase domain, polo kinases contain a strikingly conserved motif termed "polo-box" in the noncatalytic C-terminal domain. We have previously shown that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee KS,Song S,Erikson RL

更新日期：1999-12-07 00:00:00

abstract：:Mesencephalic dopamine neurons from the embryonic mouse brain were dissociated, aggregated in vitro in the presence of dissociated cells from appropriate or inappropriate target neuron areas, and visualized by the Falck-Hillarp histofluorescence technique after exposure to 1 microM exogenous dopamine. When aggregated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hemmendinger LM,Garber BB,Hoffmann PC,Heller A

更新日期：1981-02-01 00:00:00

abstract：:Children who are treated for congenital cataracts later exhibit impairments in configural face analysis. This has been explained in terms of a critical period for the acquisition of normal face processing. Here, we consider a more parsimonious account according to which deficits in configural analysis result from the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vogelsang L,Gilad-Gutnick S,Ehrenberg E,Yonas A,Diamond S,Held R,Sinha P

更新日期：2018-10-30 00:00:00

abstract：:The remarkable capacity of the adult olfactory epithelium (OE) to regenerate fully both neurosensory and nonneuronal cell types after severe epithelial injury depends on life-long persistence of two stem cell populations: the horizontal basal cells (HBCs), which are quiescent and held in reserve, and mitotically activ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herrick DB,Lin B,Peterson J,Schnittke N,Schwob JE

更新日期：2017-07-11 00:00:00

abstract：:Here we test the hypothesis that high-altitude native resident Tibetan women with genotypes for high oxygen saturation of hemoglobin, and thus less physiological hypoxic stress, have higher Darwinian fitness than women with low oxygen saturation genotypes. Oxygen saturation and genealogical data were collected from re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beall CM,Song K,Elston RC,Goldstein MC

更新日期：2004-09-28 00:00:00

abstract：:We describe here a third region of variability in human fibronectin (FN) due to alternative RNA splicing. Two other positions of alternative splicing have been reported previously (ED and IIICS). The third region involves a 273-nucleotide exon encoding exactly one 91-amino acid repeat of type III homology, located bet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gutman A,Kornblihtt AR

更新日期：1987-10-01 00:00:00

abstract：:Cell couples have been formed by mixing an antigen- and Ia-specific cloned helper T-cell line with a B-cell hybridoma presenting the antigen. By immunofluorescence observations, we have shown that the microtubule-organizing center (MTOC) inside the helper T cell, but not in the bound antigen-presenting cell, becomes o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kupfer A,Swain SL,Janeway CA Jr,Singer SJ

更新日期：1986-08-01 00:00:00

abstract：:Alpha-actinin-4 is a widely expressed protein that employs an actin-binding site with two calponin homology domains to crosslink actin filaments (F-actin) in a Ca(2+)-sensitive manner in vitro. An inherited, late-onset form of kidney failure is caused by point mutations in the alpha-actinin-4 actin-binding domain. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weins A,Schlondorff JS,Nakamura F,Denker BM,Hartwig JH,Stossel TP,Pollak MR

更新日期：2007-10-09 00:00:00

abstract：:CrAs was observed to possess the bulk superconductivity under high-pressure conditions. To understand the superconducting mechanism and explore the correlation between the structure and superconductivity, the high-pressure structural evolution of CrAs was investigated using the angle-dispersive X-ray diffraction (XRD)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu Z,Wu W,Hu Q,Zhao J,Li C,Yang K,Cheng J,Luo J,Wang L,Mao HK

更新日期：2015-12-01 00:00:00

abstract：:Molecular modeling and two-dimensional NMR techniques enable us to identify structural features in the third variable region (V3) loop of the human immunodeficiency virus (HIV) surface glycoprotein gp120, in particular the principal neutralizing determinant (PND), that remain conserved despite the sequence variation. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fontenot JD,Gatewood JM,Mariappan SV,Pau CP,Parekh BS,George JR,Gupta G

更新日期：1995-01-03 00:00:00

abstract：:Inteins are intervening protein sequences that undergo self-excision from a precursor protein with concomitant joining of the flanking sequences. Here, we demonstrate intein trans-splicing in Nicotiana tabacum chloroplasts by using the naturally split Ssp DnaE intein. Trans-splicing occurred whether both intein fragme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chin HG,Kim GD,Marin I,Mersha F,Evans TC Jr,Chen L,Xu MQ,Pradhan S

更新日期：2003-04-15 00:00:00

abstract：:The pharmacokinetic analysis of dynamic-contrast-enhanced (DCE) MRI data yields K(trans) and k(ep), two parameters independently measuring the capillary wall contrast reagent transfer rate. The almost universally used standard model (SM) embeds the implicit assumption that equilibrium transcytolemmal water exchange is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang W,Li X,Morris EA,Tudorica LA,Seshan VE,Rooney WD,Tagge I,Wang Y,Xu J,Springer CS

更新日期：2008-11-18 00:00:00

abstract：:Activation of the c-abl protooncogene occurs in Abelson murine leukemia virus, in Hardy-Zuckerman 2 feline sarcoma virus, and during the chromosomal translocations that generate BCR-ABL gene fusion products. To study the molecular mechanism involved in the c-abl activation, we have created a series of modifications in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shore SK,Bogart SL,Reddy EP

更新日期：1990-09-01 00:00:00

abstract：:Chronic stress is known to promote inflammatory bowel disease (IBD), but the underlying mechanism remains largely unresolved. Here, we found chronic stress to sensitize mice to dextran sulfate sodium (DSS)-induced colitis; to increase the infiltration of B cells, neutrophils, and proinflammatory ly6Chi macrophages in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao X,Cao Q,Cheng Y,Zhao D,Wang Z,Yang H,Wu Q,You L,Wang Y,Lin Y,Li X,Wang Y,Bian JS,Sun D,Kong L,Birnbaumer L,Yang Y

更新日期：2018-03-27 00:00:00

abstract：:Somatostatin (somatotropin release-inhibiting factor; SRIF) is a tetradecapeptide present in brain, pancreas, gastrointestinal tract, and thyroid that inhibits the secretion or action of several hormones in these tissues. We observed that the toad urinary bladder contains concentrations of endogenous somatostatin (8.0...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Forrest JN Jr,Reichlin S,Goodman DB

更新日期：1980-08-01 00:00:00

abstract：:Significant efforts have been directed to understanding the factors that influence the lineage commitment of stem cells. This paper demonstrates that cell shape, independent of soluble factors, has a strong influence on the differentiation of human mesenchymal stem cells (MSCs) from bone marrow. When exposed to compet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kilian KA,Bugarija B,Lahn BT,Mrksich M

更新日期：2010-03-16 00:00:00

abstract：:The principal sequence feature responsible for intrinsic DNA curvature is generally assumed to be runs of adenines. However, according to the wedge model of DNA curvature, each dinucleotide step is associated with a characteristic deflection of the local helix axis. Thus, an important test of a more general view of se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bolshoy A,McNamara P,Harrington RE,Trifonov EN

更新日期：1991-03-15 00:00:00