Abstract:
:The transcription factors that act in hepatocyte-specific gene expression include proteins that are present mainly in liver cells (HNF-1/LFB1, C/EBP, HNF-3, HNF-4) (HNF, hepatocyte nuclear factor; C/EBP, rat enhancer binding protein) and proteins that are widely distributed (AP-1, NF-1, NF-Y/ACF). We show here that the genes encoding each of these liver-enriched factors exhibit different patterns of transcriptional control in different tissues. In addition, there were several instances in which transcription was detected (e.g., for HNF-1) when no mRNA or specific DNA binding protein was found, suggesting the importance of posttranscriptional control in some instances for these factors. These experiments identify C/EBP, HNF-3, and HNF-4, and perhaps also HNF-1, as targets for the study of cascades of transcriptionally controlled transcription factors in differentiated cells.
journal_name
Proc Natl Acad Sci U S Aauthors
Xanthopoulos KG,Prezioso VR,Chen WS,Sladek FM,Cortese R,Darnell JE Jrdoi
10.1073/pnas.88.9.3807subject
Has Abstractpub_date
1991-05-01 00:00:00pages
3807-11issue
9eissn
0027-8424issn
1091-6490journal_volume
88pub_type
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