Abstract：
:The backbone or vertebral column is the defining feature of vertebrates and is clearly metameric. Given that vertebrae arise from segmented paraxial mesoderm in the embryo, this metamerism is not surprising. Fate mapping studies in a variety of species have shown that ventromedial sclerotome cells of the differentiated somite contribute to the developing vertebrae and ribs. Nevertheless, extensive studies in amniote embryos have produced conflicting data on exactly how embryonic segments relate to those of the adult. To date, much attention has focused on the derivatives of the somites, while relatively little is known about the contribution of other tissues to the formation of the vertebral column. In particular, while it is clear that signals from the notochord induce and maintain proliferation of the sclerotome, and later promote chondrogenesis, the role of the notochord in vertebral segmentation has been largely overlooked. Here, we review the established role of the notochord in vertebral development, and suggest an additional role for the notochord in the segmental patterning of the vertebral column.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Fleming A,Keynes RJ,Tannahill Ddoi
10.1046/j.1469-7580.2001.19910177.xkeywords:
subject
Has Abstractpub_date
2001-07-01 00:00:00pages
177-80issue
Pt 1-2eissn
0021-8782issn
1469-7580journal_volume
199pub_type
杂志文章,评审abstract：:Neural stem cells are a multipotent population of tissue-specific stem cells with a broad but limited differentiation potential. However, recent studies have shown that over-expression of the pluripotency gene, Oct4, alone is sufficient to initiate a process by which these can form 'induced pluripotent stem cells' (iP...
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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doi：
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journal_title：Journal of anatomy
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doi：
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pub_type： 杂志文章
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journal_title：Journal of anatomy
pub_type： 杂志文章
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2000.19730461.x
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1979-09-01 00:00:00
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journal_title：Journal of anatomy
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doi：
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：1994-10-01 00:00:00
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：1988-08-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
