Abstract：
:Spermiogenesis pursues three major objectives: (1) The safeguard of the male genome within the confines of a compact nucleus. (2) The accumulation of enzymes in the acrosome of be released at fertilization. (3) The development of a sperm propelling tail consisting of an axoneme surrounded by a scaffold of keratin-containing outer dense fibers and a fibrous sheath. Recent experimental data indicate that three keratins-Sak57, 0df1 and 0df2-and other proteins (the 26S proteasome and the 0df1-binding protein Spag4) are temporarily stored in the manchette before being sorted to the developing sperm tail. These findings support a general model for the manchette as an ephemeral structure timely developed and strategically positioned to provide a transient storage to both structural and signaling proteins. Some of the proteins are later sorted to the developing tail; others may participate in the reciprocal nuclear-cytoplasmic signaling pathways as the gene activity of the male genome gradually becomes silent. Mol. Reprod. Dev. 59: 347-349, 2001.
journal_name
Mol Reprod Devjournal_title
Molecular reproduction and developmentauthors
Kierszenbaum ALdoi
10.1002/mrd.1040keywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
347-9issue
4eissn
1040-452Xissn
1098-2795journal_volume
59pub_type
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journal_title：Molecular reproduction and development
pub_type： 评论,杂志文章
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journal_title：Molecular reproduction and development
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pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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更新日期：2000-12-01 00:00:00
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journal_title：Molecular reproduction and development
pub_type： 杂志文章,评审
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