Polymorphism of apoprotein E (APOE), methylenetetrahydrofolate reductase (MTHFR) and paraoxonase (PON1) genes in patients with cerebrovascular disease.

abstract：BACKGROUND:Efficient laboratory service is the cornerstone of modern health care systems. Scientific innovations have contributed to substantial improvements in the field of laboratory science, but errors still prevail. These errors are classified as preanalytical, analytical and postanalytical, depending upon the time...

journal_title：Clinical chemistry and laboratory medicine

authors： Goswami B,Singh B,Chawla R,Mallika V

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Mid-regional pro-adrenomedullin (MR-proADM) and endothelin-1 have been shown to predict mortality of patients with acute myocardial infarction. However, the prognostic value of both biomarkers in predicting long-term clinical events after acute myocardial infarction remains unclear. METHODS:In a prospective...

journal_title：Clinical chemistry and laboratory medicine

authors： Behnes M,Papassotiriou J,Walter T,Fiedler E,Sauer T,Lang S,Elmas E,Hoffmann U,Borggrefe M,Brueckmann M

更新日期：2008-01-01 00:00:00

abstract：:Congenital disorders of glycosylation (CDG) are genetic multisystemic diseases due to various defects in the biosynthesis or processing of glycoproteins. Our aim is to present our experience in the selective screening of CDG syndrome in a paediatric population (421 patients) with clinical suspicion of the disease, ana...

journal_title：Clinical chemistry and laboratory medicine

authors： Colomé C,Ferrer I,Artuch R,Vilaseca MA,Pineda M,Briones P

更新日期：2000-10-01 00:00:00

abstract：:This study was designed to test the hypothesis that impaired neutrophil function might contribute to the development of bacterial pneumonia in patients with HIV-infection. Numbers of inflammatory cells and immunoglobulin G Fcgamma receptor (IgG FcgammaR) I, II, III levels were investigated in bronchoalveolar lavage (B...

journal_title：Clinical chemistry and laboratory medicine

authors： Armbruster C,Krugluger W,Huber M,Stephan K

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Neutrophil gelatinase-associated lipocalin (NGAL) has been suggested as the most promising biomarker of acute kidney injury. However, there are no reliable data on analytical sensitivity and reference limits of urinary NGAL (uNGAL) assay in pediatric age. The aim of the present study is to evaluate the analy...

journal_title：Clinical chemistry and laboratory medicine

authors： Cangemi G,Storti S,Cantinotti M,Fortunato A,Emdin M,Bruschettini M,Bugnone D,Melioli G,Clerico A

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:The purpose of an external quality assessment (EQA) is to evaluate the analytical capability of clinical laboratories, identify differences among the laboratories and improve analytical quality. Our EQA results show that the rates of unsatisfactory performance for thyroid hormone tests were the highest in al...

journal_title：Clinical chemistry and laboratory medicine

authors： Zhou Q,Li S,Li X,Wang W,Wang Z

更新日期：2006-01-01 00:00:00

abstract：:A questionable scientific approach to measuring at low concentrations and inappropriate censoring of results below certain cut-offs have resulted in the dichotomous classification of troponin assays based on their so-called analytical sensitivity. The definition of "high-sensitivity" cardiac troponin is flawed. Eviden...

journal_title：Clinical chemistry and laboratory medicine

authors： Ungerer JPJ,Pretorius CJ

更新日期：2017-10-26 00:00:00

abstract：BACKGROUND:Squamous cell carcinoma antigen-immunoglobulin M (SCCA-IgM) is a useful biomarker for the risk of development of hepatocellular carcinoma (HCC) in patients with cirrhosis due to its progressive increase associated to HCC evolution. In patients with cirrhosis, other assays have been affected by interfering re...

journal_title：Clinical chemistry and laboratory medicine

authors： Zuin J,Veggiani G,Pengo P,Gallotta A,Biasiolo A,Tono N,Gatta A,Pontisso P,Toth R,Cerin D,Frecer V,Meo S,Gion M,Fassina G,Beneduce L

更新日期：2010-02-01 00:00:00

abstract：:Since PSA is supposed to play an active role in the progression of prostate cancer, we applied a quantitative RT-PCR to measure the absolute levels of prostate-specific antigen (PSA) mRNA expression in benign and malignant prostatic tissue. Consecutive fine needle prostate biopsy material from 59 patients (43 with pro...

journal_title：Clinical chemistry and laboratory medicine

authors： Gelmini S,Tricarico C,Petrone L,Forti G,Amorosi A,Dedola GL,Serio M,Pazzagli M,Orlando C

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:The discovery of mutations in the epidermal growth factor receptor gene (EGFR) related to the clinical response to tyrosine kinase inhibitors, has transformed the management of non-small cell lung cancer (NSCLC). Several methods have been developed for determination of mutations in EGFR, with different sensi...

journal_title：Clinical chemistry and laboratory medicine

authors： Martínez-Carretero C,Pascual FI,Rus A,Bernardo I

更新日期：2017-10-26 00:00:00

abstract：BACKGROUND:The Sysmex DI-60 system (DI-60, Sysmex, Kobe, Japan) is a new automated digital cell imaging analyzer. We explored the performance of DI-60 in comparison with Sysmex XN analyzer (XN, Sysmex) and manual count. METHODS:In a total of 276 samples (176 abnormal and 100 normal samples), white blood cell (WBC) dif...

journal_title：Clinical chemistry and laboratory medicine

authors： Kim HN,Hur M,Kim H,Kim SW,Moon HW,Yun YM

更新日期：2017-11-27 00:00:00

abstract：:There is currently no well-established biomarker for Parkinson's disease. The need to better diagnose the condition, define the subtypes of disease, and follow its course independent of any symptomatic drug effects is well-established. In this review, we will begin by reviewing the evidence for biological fluid biomar...

journal_title：Clinical chemistry and laboratory medicine

authors： Breen DP,Michell AW,Barker RA

更新日期：2011-03-01 00:00:00

abstract：:Total prostate-specific antigen (PSA) and complexed PSA were determined in venous blood from 12 patients with prostate cancer before and after radical prostatectomy by using Immuno 1 PSA assays. The elimination kinetics of complexed PSA were compared with that of total PSA. Nearly constant concentrations of complexed ...

journal_title：Clinical chemistry and laboratory medicine

authors： Stephan C,Jung K,Brux B,Lein M,Sinha P,Schnorr D,Loening SA

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Low back pain (LBP) is a very frequent condition, affecting most people at some point throughout their life. This cross-sectional study was aimed to investigate a selected panel of cytokines and inflammatory biomarkers in patients with or without LBP. METHODS:The study population consisted of 104 patients d...

journal_title：Clinical chemistry and laboratory medicine

authors： Lippi G,Dagostino C,Buonocore R,Aloe R,Bonaguri C,Fanelli G,Allegri M

更新日期：2017-08-28 00:00:00

abstract：BACKGROUND:It has been proposed that only anti-thyroid-peroxidase (TPOAb) and not anti-thyroglobulin (TgAb) antibodies should be assayed in the diagnosis of autoimmune thyroid disease (AITD). METHODS:We analyzed the thyroid autoantibody profile with a multiplex bead array system, which allows simultaneous measurement ...

journal_title：Clinical chemistry and laboratory medicine

authors： Tozzoli R,Villalta D,Kodermaz G,Bagnasco M,Tonutti E,Bizzaro N

更新日期：2006-01-01 00:00:00

abstract：:Increased expression of sialyl Lewis X or A antigens on metastatic cancer cells leads to their selectin-mediated extravasation. Profound fucosylation of the serum microenvironment may be a factor that interrupts adhesion and influences the formation of metastases. In this study we quantitatively analyzed fucosylation ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kossowska B,Ferens-Sieczkowska M,Gancarz R,Passowicz-Muszyńska E,Jankowska R

更新日期：2005-01-01 00:00:00

abstract：:Background The increasing number of multi-drug resistant (MDR) bacteria provides enormous challenges for choosing an appropriate antibiotic therapy in the early phase of sepsis. While bacterial identification has been greatly accelerated by the introduction of matrix-assisted laser desorption ionization-time of flight...

journal_title：Clinical chemistry and laboratory medicine

authors： Kittel M,Findeisen P,Ghebremedhin B,Miethke T,Grundt A,Ahmad-Nejad P,Neumaier M

更新日期：2019-07-26 00:00:00

abstract：:The present article proposes personal suggestions to improve determinations and clinical interpretation of results of lipoprotein(a) assays. Methods and procedures for sampling and quantification of the various isoforms of lipoprotein(a) in serum, plasma and urine are reviewed with the aim of improving the reliability...

journal_title：Clinical chemistry and laboratory medicine

authors： Lippi G,Guidi G

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Paraoxonases (PON) are members of an enzyme family involved in preventing low-density lipoprotein oxidation and therefore protecting against atherosclerotic plaque formation. METHODS:We studied the Met55Leu and Gln192Arg PON1 polymorphisms in 712 patients (437 Caucasian- and 275 African-Brazilians) who unde...

journal_title：Clinical chemistry and laboratory medicine

authors： Rios DL,D'Onofrio LO,Cerqueira CC,Bonfim-Silva R,Carvalho HG,Santos-Filho A,Galvão-Castro B

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Whereas N-terminal pro-brain natriuretic peptide (NT-proBNP) is approved for risk stratification of patients with acute coronary syndromes (ACS), short-term temporal changes in NT-proBNP concentrations and the optimal time points for sampling are not clear. The purpose of this study was to better define the ...

journal_title：Clinical chemistry and laboratory medicine

authors： Buchner S,Debl K,Barlage S,Griese D,Fredersdorf S,Jeron A,Lubnow M,Müller T,Muders F,Holmer S,Riegger GA,Luchner A

更新日期：2010-06-01 00:00:00

abstract：:Betaine serves as a methyl donor in a reaction converting homocysteine to methionine, catalysed by the enzyme betaine-homocysteine methyltransferase. It has been used for years to lower the concentration of plasma total homocysteine (tHcy) in patients with homocystinuria, and has recently been shown to reduce fasting ...

journal_title：Clinical chemistry and laboratory medicine

authors： Ueland PM,Holm PI,Hustad S

更新日期：2005-01-01 00:00:00

abstract：:Microsatellite typing is frequently used in disease diagnosis and in genetic association studies. Inter-study consistency and comparability is essential in both applications. In this study, we show that the interlaboratory comparison of microsatellite sizes is often discrepant and misleading. This is a matter of great...

journal_title：Clinical chemistry and laboratory medicine

authors： Rossouw M,Warren R,Hoal EG

更新日期：2002-09-01 00:00:00

abstract：:There are large differences in the use of laboratory tests between hospitals in Sweden. These differences are not only due to differences between the patients treated but also to differences in practice. Use of laboratory test seems to reflect local traditions to a large extent. These large variations in practice are ...

journal_title：Clinical chemistry and laboratory medicine

authors： Larsson A,Palmer M,Hultén G,Tryding N

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Certain genetic polymorphisms can lead to differences in immunity function, resulting in different clinical outcomes for hepatitis B virus (HBV) patients. The aim of this study was to investigate the association between apolipoprotein E (ApoE) gene polymorphisms and HBV infection status in northern Chinese i...

journal_title：Clinical chemistry and laboratory medicine

authors： Yin Z,Xiong C,Wang Y,Zhou X,Yan SK

更新日期：2010-12-01 00:00:00

abstract：:Introduction Element-tagged immunoassay coupled with inductively coupled plasma-mass spectrometry (ICP-MS) detection has the potential to revolutionize immunoassay analysis in clinical detection; however, a systematic evaluation with the standard guidelines of the assay is needed to ensure its performance meets the re...

journal_title：Clinical chemistry and laboratory medicine

authors： Jiang W,Sun G,Wen X,Men S,Cui W,Jing M,Jia X,Hu Z,Pu D,Zhang S,Yuan X,Liu X,Zhang X,Wang C

更新日期：2020-06-25 00:00:00

abstract：:Background Biochemical bone turnover markers (BTM) are useful tools to assess bone remodeling at the cellular level. N-terminal propeptide of type I procollagen (PINP) has been recommended as a reference marker for bone formation in research studies. Methods We describe the results of a multicenter study for routine c...

journal_title：Clinical chemistry and laboratory medicine

authors： Cavalier E,Eastell R,Rye Jørgensen N,Makris K,Tournis S,Vasikaran S,Kanis JA,Cooper C,Pottel H,Morris HA,IFCC-IOF Joint Committee for Bone Metabolism (C-BM).

更新日期：2019-09-25 00:00:00

abstract：:In our efforts to develop diagnostic tests for complex multifactorial disorders, and to assist the research community in evaluating genetic markers for predisposition to cardiovascular disease, we have developed a prototype assay to genotype up to 35 variable sites among 15 genes. The candidate markers in this panel w...

journal_title：Clinical chemistry and laboratory medicine

authors： Cheng S,Pallaud C,Grow MA,Scharf SJ,Erlich HA,Klitz W,Pullinger CR,Malloy MJ,Kane JP,Siest G,Visvikis S

更新日期：1998-08-01 00:00:00

abstract：:The effects of the time of the day and breakfast on the outcome of interleukin-6 and its soluble receptor in serum were studied on 22 subjectively health volunteers. We collected blood specimens at 8.00 a.m. after an overnight fast, at 9.30 a.m. after usual breakfast, and at 11.30 a.m. A second group of volunteers (n ...

journal_title：Clinical chemistry and laboratory medicine

authors： Dugué B,Leppänen E

更新日期：1998-05-01 00:00:00

abstract：:Human protein 1/Clara cell Mr 10,000 protein consists of two identical subunits of seventy amino acid residues each. In the present study, eight clones of monoclonal antibodies against native protein 1 were prepared and their respective epitopes were immunochemically and immunohistochemically characterized using nativ...

journal_title：Clinical chemistry and laboratory medicine

authors： Yamaguchi T,Yamada T,Okutani R,Shijubo N,Singh G,Itoh Y

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Reference laboratories providing reference services recognized by the Joint Committee for Traceability in Laboratory Medicine (JCTLM) must be accredited as calibration laboratories according to ISO 17025 and ISO 15195. These standards require laboratories to establish an uncertainty budget, in which the unce...

journal_title：Clinical chemistry and laboratory medicine

authors： Rami L,Canalias F

更新日期：2015-04-01 00:00:00