Protective effect of folinic acid on low-dose methotrexate genotoxicity.

abstract：:Conventional radiography, ultrasonography (US), magnetic resonance imaging (MRI), computed tomography, and scintigraphy are imaging techniques in use for rheumatoid arthritis (RA). Conventional radiography of the hands and the forefeet should be performed every 6 to 12 months in the first two years, and every 12 to 24...

journal_title：Zeitschrift fur Rheumatologie

authors： Kellner H,Schmidt W,Rau R

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is characterized by heterogeneous clinical symptoms. Peripheral skin fibrosis can be a common symptom. Nevertheless, a variety of diseases with different etiologies are associated with a thickening of the skin and make the initial diagnosis of systemic sclerosis more difficult. OBJE...

journal_title：Zeitschrift fur Rheumatologie

authors： Jendrek ST,Kahle B,Riemekasten G

更新日期：2019-02-01 00:00:00

abstract：:Tocilizumab, a monoclonal humanized antibody against IL-6, was licensed in January 2009 in combination with Methotrexate for the treatment of adult patients with moderately to severely active rheumatoid arthritis and inadequate response to one or more DMARDs or TNF antagonists. Tocilizumab is given once every 4 weeks ...

journal_title：Zeitschrift fur Rheumatologie

authors： Roll P,Rubbert-Roth A,Tony HP

更新日期：2010-09-01 00:00:00

abstract：:A female patient developed systemic rash, lung edema, electrocardiogram (ECG) abnormalities and fulminant hepatitis with partial liver failure 4 weeks after the start of sulfasalazine treatment. Peripheral T-cell activation, a positive PCR test for human herpesvirus (HHV) 6 as well as eosinophilia in bronchial lavage ...

journal_title：Zeitschrift fur Rheumatologie

authors： Pirklbauer M,Gruber J

更新日期：2014-03-01 00:00:00

abstract：:In order to measure therapeutic effects or assess disease course, outcomes measurement parameters are commonly used in patients with rheumatoid arthritis. From the patient's perspective, possibly the most important outcome measurement parameter is quality of life (QoL). QoL may be defined in terms of "health status" a...

journal_title：Zeitschrift fur Rheumatologie

authors： Stamm T

更新日期：2010-05-01 00:00:00

abstract：:The case of a 36-year old man with Behçet's disease (BS) for 16 years had low back pain and stiffness in the cervical and lumbar spine. He was diagnosed as having ankylosing spondylitis (AS). In this report we wish to emphasize the clinically occult co-existence of AS in BS and revelation of AS after a long time of BS...

journal_title：Zeitschrift fur Rheumatologie

authors： Cimen OB,Sahin G,Biçer A,Erdoğan C

更新日期：2002-08-01 00:00:00

abstract：AIM:To explore the circadian rhythm of serum interleukin (IL)-6 in collagen-induced arthritis (CIA) rats and compare the safety and effectiveness of methotrexate (MTX) administered traditionally and via chronotherapy. METHODS:CIA rat models were immunized with bovine type II collagen. Serum IL-6 levels in normal and C...

journal_title：Zeitschrift fur Rheumatologie

authors： Wang X,Yan X,Wang F,Ge F,Li Z

更新日期：2018-04-01 00:00:00

abstract：:The difference between mofebutazone and phenylbutazone is shown by means of toxicological, pharmacological and pharmacokinetic studies as well as by the protein binding. In spite of a certain chemical similarity both substances differ distinctly. Mofebutazone is approx. 5-6 times less toxic than phenylbutazone but its...

journal_title：Zeitschrift fur Rheumatologie

authors： Loew D,Schuster O,Knoell HE,Graul EH

更新日期：1985-07-01 00:00:00

abstract：:Polyarthralgias are widely common complaints. In earlier stages it might be difficult to state the right diagnosis. Differential diagnosis is absolutely necessary for starting in time with the right treatment. Out of a great clinical material the following diseases causing mono-, oligo- or polyarthralgia were discusse...

journal_title：Zeitschrift fur Rheumatologie

authors： Singer F

更新日期：1982-01-01 00:00:00

abstract：:Autoinflammatory syndromes are characterized by periodic febrile attacks in combination with increased inflammatory markers. The dysregulation of different cellular signaling pathways leads to an excessive immune response, which can in turn promote multisystemic inflammatory processes. Due to overlapping symptoms, var...

journal_title：Zeitschrift fur Rheumatologie

authors： Schnappauf O

更新日期：2020-09-01 00:00:00

abstract：:A 74-year-old female patient with rheumatoid arthritis was diagnosed with Pneumocystis jiroveci pneumonia (PcP) following therapy with methotrexate and prednisone. Although bactrim treatment was initiated and PcP was not detected by a control bronchoalveolar lavage, the patient died. The precise cause of death remains...

journal_title：Zeitschrift fur Rheumatologie

authors： Bertisch B,Ruef C

更新日期：2006-02-01 00:00:00

abstract：:Antibodies to double-stranded DNA (anti-dsDNA, dsDNA-Ab) are frequently found in systemic lupus erythematosus (SLE), especially during active disease and differ with respect to immunoglobulin class and avidity. The detection of anti-dsDNA is one of the diagnostic criteria for SLE according to the American College of R...

journal_title：Zeitschrift fur Rheumatologie

authors： Wigand R,Gottschalk R,Falkenbach A,Matthias T,Kaltwasser JP,Hoelzer D

更新日期：1997-03-01 00:00:00

abstract：UNLABELLED:We report on a 6-year-old Romanian girl with recently diagnosed hyper-IgD-syndrome. The leading symptom of this rare disease are periodic pyrexia, joint involvements (arthralgias/arthritis) and swollen lymph nodes. A permanent increase of alpha 1-acid glycoprotein fucosylation indicates persisting inflammati...

journal_title：Zeitschrift fur Rheumatologie

authors： Suschke J,Walther JU

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Familial Mediterranean fever (FMF) in Germany is a rare, genetically linked disease of childhood and adolescence, which is characterized by recurrent febrile episodes and clinical signs of peritonitis, pleuritis and arthritis. Treatment with colchicine is effective and well-tolerated in the majority of patie...

journal_title：Zeitschrift fur Rheumatologie

authors： Kallinich T,Blank N,Braun T,Feist E,Kiltz U,Neudorf U,Oommen PT,Weseloh C,Wittkowski H,Braun J

更新日期：2019-02-01 00:00:00

abstract：:The duration and severity of rheumatic diseases of the shoulder correlate with symptom frequency, structural changes and associated functional limitations. The multifactorial character of the underlying rheumatic disease requires a multimodal therapeutic concept including interaction of surgical and non-surgical disci...

journal_title：Zeitschrift fur Rheumatologie

authors： Heers G,Grifka J,Springorum HR,Craiovan B,Anders S

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Clinical observation suggests a frequent coincidence of back pain (BP) and fibromyalgia (FMA). Based on data from a population survey on back pain we studied the hypothesis of FMA being a frequent underlying condition of BP. We additionally studied the association of the severity of back pain and both chroni...

journal_title：Zeitschrift fur Rheumatologie

authors： Hüppe A,Brockow T,Raspe H

更新日期：2004-02-01 00:00:00

abstract：:1436 young men were investigated clinically and radiologically for rheumatic sacro iliitis. In two men (1.4%) definite bilateral sacro iliitis was diagnosed. In 18 cases (12.5%) the signs were not sufficient to make a definite diagnosis. They were regarded as suspected iliitis. For comparison the cards of 6138 patient...

journal_title：Zeitschrift fur Rheumatologie

authors： Yenal O,Usman ON,Yassa K,Uyar A,Agbaba S

更新日期：1977-09-01 00:00:00

abstract：:Twelve patients with osteoarthrosis were locally treated with Felbinac Gel (biphenyl acetic acid (BPAA) 3%) three times daily for 14 days (five patients), 28 days (six patients) or 42 days (one patient) before elective knee joint surgery. BPAA plasma concentrations as of the seventh day of treatment were steady at bet...

journal_title：Zeitschrift fur Rheumatologie

authors： Bolten W,Waldorf-Bolten E,Sarfert D,Lehmann W,Miehlke W

更新日期：1990-11-01 00:00:00

abstract：:278 patients with ankylosing spondylitis have been studied in order to find a basis for prognosis by setting a mobility function index of the vertebral column. This index does not depend on manifestation age or on the blood sedimentation rate. It increases with progression of x-ray findings. A coincidence of impaired ...

journal_title：Zeitschrift fur Rheumatologie

authors： Schöffel J,Pohl W

更新日期：1975-11-01 00:00:00

abstract：:Interstitial nephritis is responsible for about 12 % of end-stage renal disease in Germany. It comprises an etiologically heterogenous group of inflammatory renal disorders which primarily affect the renal interstitium and tubuli. Drugs, predominantly antibiotics, nonsteroidal anti-inflammatory drugs and proton pump i...

journal_title：Zeitschrift fur Rheumatologie

authors： Korsten P,Müller GA

更新日期：2015-05-01 00:00:00

abstract：:Heavy physical work load is a known determinant of osteoarthritis of the hip, which may account for the high risk observed among farmers. On the other hand, the data on influence of heavy manual work in the pathogenesis of hand osteoarthritis are still controversial. We examined 25 retired farm laborers who strenuousl...

journal_title：Zeitschrift fur Rheumatologie

authors： Schmid L,Dreier D,Muff B,Allgayer B,Schlumpf U

更新日期：1999-12-01 00:00:00

abstract：:Within the group of inflammatory rheumatic diseases, spondyloarthropathy is the most common diagnosis after rheumatoid arthritis. Its prevalence was long underestimated. Ankylosing spondylitis (AS) and undifferentiated spondyloathropathy (uSpA) are the most common subgroups in western countries. There are still diffic...

journal_title：Zeitschrift fur Rheumatologie

authors： Haibel H,Rudwaleit M,Braun J,Sieper J

更新日期：2002-02-01 00:00:00

abstract：:Due to the wide range of positive effects and the clear evidence of effectiveness, physical activity is one of the most important treatments for inflammatory rheumatic diseases. Because of the frequent overlap of disease and age-related aspects in older patients, the implementation of the German national physical acti...

journal_title：Zeitschrift fur Rheumatologie

authors： Golla A,Mattukat K,Mau W

更新日期：2019-03-01 00:00:00

abstract：:Heberden nodes affect mainly middle-aged women. Inheritance is autosomal dominant in female and autosomal recessive in male patients. We report the case of a young man who presented already with 12 years of age with pain in the distal finger joints. There were no other clinical or serological signs for other rheumatoi...

journal_title：Zeitschrift fur Rheumatologie

authors： Rascu A,Kraetsch HG,Grünke M,Kalden JR,Manger B

更新日期：1999-04-01 00:00:00

abstract：:Various rheumatic symptoms can occur in association with malignancies and are termed the so-called paraneoplastic arthropathy. The clinical picture is often similar to primary inflammatory rheumatic diseases. At present there exist no epidemiological data on this disease entity. The case of a patient with tibial pain ...

journal_title：Zeitschrift fur Rheumatologie

authors： Lange U,Bachmann G,Müller-Ladner U

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Up to now indirect immunofluorescence (IIF) followed by an antigen-specific assay specific for proteinase 3 (PR3) or myeloperoxidase (MPO) has been the standard method for the detection of antineutrophil cytoplasmic antibodies (ANCA). The development of more sensitive and highly specific PR3-ANCA and MPO-ANC...

journal_title：Zeitschrift fur Rheumatologie

authors： Csernok E,Kempiners N,Hellmich B

更新日期：2017-03-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-beta superfamily. Their potential for organ and tissue regeneration and repair has been intensively investigated in recent years. Studies on fetal development have demonstrated the important role of these proteins for the development and diffe...

journal_title：Zeitschrift fur Rheumatologie

authors： Bramlage CP,Häupl T,Kaps C,Bramlage P,Müller GA,Strutz F

更新日期：2005-09-01 00:00:00

abstract：:Our aim is to present a new method to examine spinal mobility and spine shape excluding torsional scoliosis. In comparison to measuring devices of the spine used so far, this noninvasive and easy to use method documents altered patterns of intervertebral mobility of the lumbar and thoracic spine. This may lead to a br...

journal_title：Zeitschrift fur Rheumatologie

authors： Hauns B,Ovenhausen K,Hase P,Lorenzen W,Mennet P,Stratz T,Müller W

更新日期：1994-05-01 00:00:00

abstract：:Chondral or osteochondral lesions are typical injuries in orthopaedics and traumatology. Since there is no regeneration of damaged articular cartilage, these lesions can lead to premature osteoarthritis. Therefore, an adequate therapy for these injuries is an important goal. Nowadays, common methods in cartilage thera...

journal_title：Zeitschrift fur Rheumatologie

authors： Vogt S,Braun S,Imhoff AB

更新日期：2007-10-01 00:00:00

abstract：:In fibromyalgia as well as in low back pain we frequently find disturbances of the posture of vertebral column clinically and radiologically. Also, reduction in the mobility of whole spine and localized movement impairments in both conditions was present. It is likely that the disturbances are responsible for the firs...

journal_title：Zeitschrift fur Rheumatologie

authors： Müller W,Kelemen J,Stratz T

更新日期：1998-01-01 00:00:00