Therapeutic drug monitoring of tacrolimus in pediatric liver transplant patients.

abstract：:HSCT-associated thrombotic microangiopathy (TA-TMA) is a severe complication with a poor prognosis. Recently, it has been reported that complement system dysregulation, such as CFH autoantibodies and deletions CFH-related genes 3 and 1, induced TA-TMA. In addition, C4d-positive renal arterioles are both a good marker ...

journal_title：Pediatric transplantation

authors： Sakamoto K,Imamura T,Osone S,Nishimura A,Nishida M,Ishida H,Hosoi H

更新日期：2015-06-01 00:00:00

abstract：UNLABELLED:The Latin American Pediatric Nephrology Association (ALANEPE) reports the first regional kidney transplant registry in Latin America. A mean range of 75%, 30% to 100% renal transplant recipients under 21 yr old were included. Out of 20 countries invited to participate, 14 performed renal transplant, 11 had u...

journal_title：Pediatric transplantation

authors： Latin American Pediatric Nephrology Association.,Latin American Pediatric Renal Transplant Cooperative Study.

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:No previous paediatric study has evaluated the frequency of diagnostic disagreement between clinical standard histopathological assessment (CSHA) and retrospective, independent, histopathological assessment (RIHA) of gastrointestinal Graft-Versus-Host Disease (GI-GVHD) METHODS: In a retrospective cohort stud...

journal_title：Pediatric transplantation

authors： Mårtensson T,Szakos A,Mellgren K,Toporski J,Arvidson J,Mattsson J,Gustafsson B,Casswall TH

更新日期：2020-12-01 00:00:00

abstract：:Injuries sustained by major vessels during procurement pose a major threat to organ viability. Aortic and inferior vena cava lacerations produce rapid hemorrhage associated with hypoperfusion and ischemic damage. We describe a technique that will prevent such damage in the event of vascular mishaps. ...

journal_title：Pediatric transplantation

authors： Molmenti EP,Molmenti H,Marubashi S,Sanchez EQ,Gogel B,Goldstein RM,Levy MF,Fasola CG,Gonwa TA,Klintmalm GB

更新日期：2001-10-01 00:00:00

abstract：:This study analyzes the data reported to the Korean Cord Blood Registry between 1994 and 2008, involving children and adolescents with non-malignant diseases. Sixty-five patients were evaluated in this study: SAA (n = 24), iBMFS, (n = 16), and primary immune deficiency/inherited metabolic disorder (n = 25). The CI of ...

journal_title：Pediatric transplantation

authors： Park M,Lee YH,Kang HR,Lee JW,Kang HJ,Park KD,Shin HY,Ahn HS,Baek HJ,Kook H,Hwang TJ,Lee JW,Chung NG,Cho B,Kim HK,Lee SH,Yoo KH,Sung KW,Koo HH,Koh KN,Im HJ,Seo JJ,Park JE,Lim YJ,Lyu CJ,Lee JM,Hah JO,K

更新日期：2014-03-01 00:00:00

abstract：:Retransplantation is often a necessity for children with end-stage renal disease (ESRD), as kidney graft survival is still not infinite. If a suitable live donor is present, the current policy is to use the live donor first, in order to obtain excellent long-term outcome and to prevent human leucocyte antigen (HLA) se...

journal_title：Pediatric transplantation

authors： De Meester J,Smits JM,Offner G,Persijn GG

更新日期：2001-06-01 00:00:00

abstract：:Small bowel transplantation has become a life-saving procedure for selected adults and children with intestinal failure who are intolerant to parental nutrition. There are few pediatric data available on the results of this procedure. In this article we review the background of intestinal transplantation, present the ...

journal_title：Pediatric transplantation

authors： Atkison P,Chatzipetrou M,Tsaroucha A,Lehmann R,Tzakis A,Grant D

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:The optimal conditioning regimen for alloHCT in children with myeloid malignancies remains undefined. PROCEDURE:We performed a retrospective review of children undergoing alloHCT for AML and MDS over a 10-year period (2008-2018) at our institution, comparing the outcomes of recipients of either a myeloablat...

journal_title：Pediatric transplantation

authors： Oshrine B,Adams L,Nguyen ATH,Amankwah E,Shyr D,Hale G,Petrovic A

更新日期：2020-06-01 00:00:00

abstract：:Live viral vaccines have historically been avoided in children after solid organ transplantation. Multiple reports of safety and immunogenicity, largely in the pediatric liver transplant population, have led to a reconsideration of this recommendation. Here, we report the case of a 4-year-old boy who inadvertently rec...

journal_title：Pediatric transplantation

authors： Bobrowski AE,Muller WJ

更新日期：2020-06-01 00:00:00

abstract：:Hypogammaglobulinemia is common after pediatric SCT and IgG replacement is recommended. Some children will have a prolonged hypogammaglobulinemia but may have poor venous access which impedes further iv IgG replacement. In primary antibody deficiencies, sc IgG replacement, performed by parents at home, has been shown ...

journal_title：Pediatric transplantation

authors： Sundin M,Nordin K,Jostemyr Y,Winiarski J

更新日期：2012-12-01 00:00:00

abstract：:Children and adolescents with renal disease experience daily social, emotional, and medical challenges. Renal transplantation can help to improve quality of life but requires a lifelong regimen of immunosuppressant medication to maintain health. Adherence to a daily complex regimen can be difficult, particularly for a...

journal_title：Pediatric transplantation

authors： Kraenbring MM,Zelikovsky N,Meyers KEC

更新日期：2019-03-01 00:00:00

abstract：:Pneumatosis intestinalis is an uncommon finding beyond the neonatal period, but it has been reported in immunocompromized pediatric patients. The association of pneumatosis intestinalis in children following renal transplantation has to the best of our knowledge been only reported once in children. We describe a 4-yea...

journal_title：Pediatric transplantation

authors： Chelimsky G,Blanchard S,Sivit C,Davis I,Czinn S

更新日期：2003-06-01 00:00:00

abstract：:Primary graft dysfunction following HTx is associated with significant morbidity and mortality. This study aimed to assess the incidence of, risk factors for, and outcomes of children requiring ECMO within 24 hours of HTx. This study utilized a linked PHIS/SRTR database of pediatric HTx recipients (2002-2016). Post-HT...

journal_title：Pediatric transplantation

authors： Godown J,Bearl DW,Thurm C,Hall M,Feingold B,Soslow JH,Mettler BA,Smith AH,Profita EL,Singh TP,Dodd DA

更新日期：2019-06-01 00:00:00

abstract：:Although TEG directs effective resuscitation in adult surgical patients, pediatric data are lacking. We performed a retrospective comparative review of the effect of TEG on blood product utilization and outcomes following pediatric liver transplantation in 38 patients between 2008 and 2014. Diagnoses, laboratory value...

journal_title：Pediatric transplantation

authors： Sujka J,Gonzalez KW,Curiel KL,Daniel J,Fischer RT,Andrews WS,Wicklund BM,Hendrickson RJ

更新日期：2018-06-01 00:00:00

abstract：:Stenosis of the HJ is a common complication of pediatric split LT with high morbidity and possible evolution to secondary biliary cirrhosis and re-transplantation if not treated. Because the endoscopy is generally infeasible in the Roux-en-Y, percutaneous interventional radiology management is usually the safest and m...

journal_title：Pediatric transplantation

authors： Paolantonio G,Pietrobattista A,Parapatt GK,Liccardo D,Natali GL,Candusso M,Spada M,Rollo M,Tomà P

更新日期：2018-12-01 00:00:00

abstract：:There is currently no way to diagnose a rejection before a change in serum creatinine. This had led some to start doing SB, but little data exist on the utility and safety of SB in pediatric patients. There is also little known on practice patterns of pediatric nephrologists. A retrospective review of pediatric kidney...

journal_title：Pediatric transplantation

authors： Nazario M,Nicoara O,Becton L,Self S,Hill J,Mack E,Evans M,Twombley K

更新日期：2018-06-01 00:00:00

abstract：:The prospective cross-sectional study investigated the 6MWT performance in pediatric group of liver transplant recipients (6-17 yr, median post-transplantation time of 22 months) and compared to the normal values obtained in healthy children as well as evaluated the reproducibility of the 6MWT. We analyzed the relatio...

journal_title：Pediatric transplantation

authors： Maria da Silva R,Brunow de Carvalho W,Johnston C,Borba de Castro M,Manta Ferreira I,Patti CL,Anthero de Azevedo R,Miziara Gonzalez A,Moura Linhares M,Augusto Salzedas-Netto A

更新日期：2014-09-01 00:00:00

abstract：:Abdominal wall closure after pediatric liver transplantation (pLT) in infants may be hampered by graft-to-recipient size discrepancy. Herein, we describe the use of a porcine dermal collagen acellular graft (PDCG) as a biological mesh (BM) for abdominal wall closure in pLT recipients. Patients <2 years of age, who und...

journal_title：Pediatric transplantation

authors： Gül-Klein S,Dziodzio T,Martin F,Kästner A,Witzel C,Globke B,Jara M,Ritschl PV,Henning S,Gratopp A,Bufler P,Schöning W,Schmelzle M,Pratschke J,Öllinger R

更新日期：2020-05-01 00:00:00

abstract：:Graft-vs-host disease (GVHD) is one of the most difficult problems in stem cell transplantation. It is best considered in the context of the normal immune response. The role of the immune system is to identify and eliminate foreign antigens. In the case of GVHD, the antigens are minor histocompatibility antigens (mHA)...

journal_title：Pediatric transplantation

authors： Antin JH

更新日期：2005-12-01 00:00:00

abstract：:IHHE as the most common vascular tumor of the liver in infancy can present with acute postnatal liver and congestive heart failure. LTx may be a lifesaving option, but can be complicated by extrahepatic involvement and bleeding complications, especially in neonates. Here we discuss the benefit of LTx in cases of acute...

journal_title：Pediatric transplantation

authors： Grabhorn E,Richter A,Fischer L,Krebs-Schmitt D,Ganschow R

更新日期：2009-08-01 00:00:00

abstract：:Post-transplant anemia is a widespread problem among pediatric renal transplant recipients. Many clinicians treat post-transplant anemia in a manner similar to treatment of anemia in dialysis patients, including the use of intravenous iron, such as sodium ferric gluconate (SFG). Data on pediatric dosing of SFG are lim...

journal_title：Pediatric transplantation

authors： Gillespie RS,Symons JM

更新日期：2005-02-01 00:00:00

abstract：:We reviewed 112 pediatric renal transplant recipients to document the rate of medication non-adherence (NA) and to examine the relationships between NA, comorbid psychiatric illness, and the outcome variables of acute and chronic rejection and graft loss. A total of 32.5% of subjects had clinically significant NA with...

journal_title：Pediatric transplantation

authors： Shaw RJ,Palmer L,Blasey C,Sarwal M

更新日期：2003-12-01 00:00:00

abstract：:Few studies have identified the psychosocial characteristics of those children and their families associated with future non-adherence to immunosuppressive medications following a heart or lung transplant. UNOS data and medical records information were used to test the association between patient and family psychosoci...

journal_title：Pediatric transplantation

authors： Killian MO

更新日期：2017-06-01 00:00:00

abstract：:A generic version of tacrolimus was approved for use in the USA in August 2009. These narrow therapeutic index generics are tested for bioequivalence only in adults. No data are available on generic tacrolimus levels in children with allografts. Four patients with stable renal allografts in our pediatric program were ...

journal_title：Pediatric transplantation

authors： Abdulnour HA,Araya CE,Dharnidharka VR

更新日期：2010-12-01 00:00:00

abstract：:Antibody-mediated rejection (AMR) has recently been recognized as a significant and unique form of rejection that is not amenable to treatment with standard immunosuppressive medications aimed at modification of T-cell function. Recent interest in AMR and the role of B cells in rejection has been aided by the concomit...

journal_title：Pediatric transplantation

authors： Jordan SC,Vo AA,Tyan D,Nast CC,Toyoda M

更新日期：2005-06-01 00:00:00

abstract：:MCs are important effector cells in a broad range of immune responses. Their role in liver allograft rejection is not clear. Twenty-one liver transplant recipients (mean age +/- s.d.; 10.2 +/- 4.1 yr) who experienced a rejection episode are included in this study. Biopsy specimens from normal livers (allograft biopsy ...

journal_title：Pediatric transplantation

authors： Arikan C,Nart D,Kilic M,Yuksekkaya HA,Aydogdu S

更新日期：2008-05-01 00:00:00

abstract：:This review details the indications for heart transplantation in children. Contraindications have evolved from absolute to relative. Controversial issues remain and this paper represents a consensus of more than a dozen centers that have programs that remain active performing pediatric heart transplants. ...

journal_title：Pediatric transplantation

authors： Fricker FJ,Addonizio L,Bernstein D,Boucek M,Boucek R,Canter C,Chinnock R,Chin C,Kichuk M,Lamour J,Pietra B,Morrow R,Rotundo K,Shaddy R,Schuette EP,Schowengerdt KO,Sondheimer H,Webber S

更新日期：1999-11-01 00:00:00

abstract：:Thrombosis is a major postoperative complication in pediatric liver transplantation. There is marked heterogeneity in prophylactic antithrombotic therapies used, without established guidelines. This review summarizes current worldwide incidence of thrombotic events and compares antithrombotic therapies in children pos...

journal_title：Pediatric transplantation

authors： Flynn E,Huang JY,Hardikar W,Herd L,Hodgson A,Monagle P

更新日期：2019-06-01 00:00:00

abstract：:Children who undergo heart transplantation are at risk for long-term neurodevelopmental sequelae secondary to heart disease and its treatment. Detailed neuropsychological profiles in clinical sample status post-pediatric heart transplantation are sparse in the literature, and there is little information regarding pred...

journal_title：Pediatric transplantation

authors： Wolfe KR,Kelly SL,Steinberg E,Pliego J,Everitt MD

更新日期：2020-02-01 00:00:00

abstract：:We studied restoration of the coagulation and fibrinolysis system in pediatric patients following liver transplantation and biomarkers of blood coagulation and fibrinolysis for suspecting the occurrence of acute cellular rejection. Coagulation activity recovered rapidly within two days following transplantation, but i...

journal_title：Pediatric transplantation

authors： Mimuro J,Mizuta K,Kawano Y,Hishikawa S,Hamano A,Kashiwakura Y,Ishiwata A,Ohmori T,Madoiwa S,Kawarasaki H,Sakata Y

更新日期：2010-05-01 00:00:00