Comparative effects of dimethylbenz(a)anthacene and a 15% olive-oil diet on cellular components and expression of apoptosis-related proteins in the spleen and mammary gland tumors of rats.

abstract：:Antineoplastons are naturally occurring peptides and amino acid derivatives found in human blood and urine. antineoplastons have been shown to control neoplastic growth. In the present study, we investigated demethylation effect of the antineoplaston AS2-1 (a mixture of phenylacetylglutamine and phenylacetate in the r...

journal_title：Oncology reports

authors： Ushijima M,Ogata Y,Tsuda H,Akagi Y,Matono K,Shirouzu K

更新日期：2014-01-01 00:00:00

abstract：:Membrane-associated RING-CH (MARCH) belongs to the family of RING-CH type E3 ubiquitin ligases. MARCH1 ubiquitinates and downregulates MHC class II expression in APCs and targets major players of the immune system. However, the role of MARCH1 in ovarian cancer has not been elucidated. The present study investigated th...

journal_title：Oncology reports

authors： Meng Y,Hu J,Chen Y,Yu T,Hu L

更新日期：2016-11-01 00:00:00

abstract：:As tumor-associated antigens are not well characterized for the majority of human tumors, polyvalent vaccines prepared with whole-tumor antigens are an attractive approach for tumor vaccination. Vascular endothelial growth factor receptor-2 (VEGFR2), as a model antigen with which to...

journal_title：Oncology reports

authors： Yan HX,Cheng P,Wei HY,Shen GB,Fu LX,Ni J,Wu Y,Wei YQ

更新日期：2013-04-01 00:00:00

abstract：:Human papillomavirus (HPV) L1 capsid protein is only produced during a productive HPV infection at the end of the natural viral life cycle and is a major target of the immune response in women with HPV-related squamous intraepithelial lesions. We evaluated the usefulness of L1 detection by immunocytochemistry in high-...

journal_title：Oncology reports

authors： Norman I,Hjerpe A,Andersson S

更新日期：2013-08-01 00:00:00

abstract：:This study assessed the prediction of gastric cancer recurrence based on detection of occult neoplastic cells (ONCs) in lymph nodes, and by using criteria that were developed to identify patients with a high risk of recurrence/metastasis. The subjects were 60 patients of stage II or III gastric cancer with lymph node ...

journal_title：Oncology reports

authors： Mukai M,Sato S,Komatsu N,Kimura T,Ninomiya H,Kawada M,Nakasaki H,Ogoshi K,Makuuchi H

更新日期：2004-07-01 00:00:00

abstract：:In a human cancer cell line, we previously found a mutation in codon 322 of the extracellular signal-regulated kinase (ERK2E322K), the protein showed a faster migration when compared to wild-type in SDS-PAGE and constitutive phosphorylation. However, the reason for the faster migration, and the biochemical and biologi...

journal_title：Oncology reports

authors： Mahalingam M,Arvind R,Ida H,Murugan AK,Yamaguchi M,Tsuchida N

更新日期：2008-10-01 00:00:00

abstract：:It has been revealed that the induction of epithelial‑mesenchymal transition (EMT) is associated with drug resistance, leading to tumor recurrence and metastasis. Recent studies have shown that chemotherapeutic agents, besides their therapeutic effects, can induce EMT and enhance invasive and metastatic properties of ...

journal_title：Oncology reports

authors： Chun SY,Kim S,Nam KS

更新日期：2017-08-01 00:00:00

abstract：:In the present study, a novel signaling pathway of microRNA-141 (miR-141)/fused in sarcoma (FUS) was investigated in neuroblastoma (NB). Gene expression of miR-141 was evaluated in 6 NB cell lines. IMR-32 and SH-SY5Y cells were transduced with the miR-141 mimic lentivirus. The effects of miR-141 upregulation on cell p...

journal_title：Oncology reports

authors： Wang Z,Lei H,Sun Q

更新日期：2016-05-01 00:00:00

abstract：:Given its tumor-specific expression, including liver cancer, OY-TES-1 is a potential molecular marker for the diagnosis and immunotherapy of liver cancers. However, investigations of the mechanisms and the role of OY-TES-1 in liver cancer are rare. In the present study, based on a comprehensive bioinformatic analysis ...

journal_title：Oncology reports

authors： Hu Q,Fu J,Luo B,Huang M,Guo W,Lin Y,Xie X,Xiao S

更新日期：2015-04-01 00:00:00

abstract：:Given the important role of CXCR4 in cancer metastasis, microenvironmental factors that modulate CXCR4 may have an impact on the process of tumor expansion. Hypoxia is a common feature of solid tumors and a significant microenvironmental factor that drives aggressive behavior. CXCR4...

journal_title：Oncology reports

authors： Oh YS,Kim HY,Song IC,Yun HJ,Jo DY,Kim S,Lee HJ

更新日期：2012-12-01 00:00:00

abstract：:Mammary stem cells (MSCs) are the progenitor population for human breast epithelia. MSCs give rise during mammary gland development to estrogen receptor (ER)-negative basal cells and the ER- luminal progenitor (LP) population which maintains ER+ and ER- luminal cells. The MSC population is expanded and tumorigenic in ...

journal_title：Oncology reports

authors： Wu J,Crowe DL

更新日期：2015-07-01 00:00:00

abstract：:Cancer cells in ascites are usually exposed to a hypoxia tumor microenvironment and utilize enhanced glycolysis which produces energy and metabolizes nutrients to support proliferation. Vesicular stomatitis virus (VSV) is an oncolytic virus that relies on the host cellular metabolism for replication. We tested the eff...

journal_title：Oncology reports

authors： Zhou Y,Wen F,Zhang P,Tang R,Li Q

更新日期：2016-03-01 00:00:00

abstract：:Sedum sarmentosum Bunge, a traditional Chinese herbal medicine, has a wide range of clinical applications including antibiosis, anti-inflammation and anti-oxidation. In the present study, we identified that its extract (SSBE) exerts pancreatic anticancer activity in vitro and in vivo. In the cultured pancreatic cancer...

journal_title：Oncology reports

authors： Bai Y,Chen B,Hong W,Liang Y,Zhou M,Zhou L

更新日期：2016-05-01 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) caused by NF1 gene mutation is a commonly inherited autosomal dominant disorder. Malignant peripheral nerve sheath tumors (MPNSTs), a type of aggressive sarcoma, are a major cause of mortality in NF1 patients. The malignant transformation of benign plexiform neurofibromas (PNs) to MPNSTs...

journal_title：Oncology reports

authors： Park GH,Lee SJ,Yim H,Han JH,Kim HJ,Sohn YB,Ko JM,Jeong SY

更新日期：2014-10-01 00:00:00

abstract：:During the initial emergency operation, a temporary loop colostomy (TLC) was constructed at the oral border of the region for subsequent radical resection. Then, radical surgery was performed by hybrid 2-port HALS (Mukai's operation) using the TLC as the hand access site. Left hemicolectomy was done in three patients,...

journal_title：Oncology reports

authors： Mukai M,Sekido Y,Hoshikawa T,Yazawa N,Fukumitsu H,Okada K,Tajima T,Nakamura M,Ogoshi K

更新日期：2010-07-01 00:00:00

abstract：:Post-transcriptional modification of p53 by phosphorylation has been proposed as an important mechanism of p53 stabilization and functional regulation. However, little is known about the phosphorylation state of mutant p53 protein overexpressed in human tumors. We evaluated immunohistochemically the p53 phosphorylatio...

journal_title：Oncology reports

authors： Matsumoto M,Furihata M,Kurabayashi A,Ohtsuki Y

更新日期：2004-11-01 00:00:00

abstract：:Sesquiterpene lactones have been confirmed to have potential antitumor activity. Here, we demonstrated that Eupalinolide O (EO), a novel sesquiterpene lactone isolated from Eupatorium lindleyanum DC., showed significant anticancer activity against human MDA-MB-468 breast cancer cells. The cytotoxicity induced by EO wa...

journal_title：Oncology reports

authors： Yang B,Zhao Y,Lou C,Zhao H

更新日期：2016-11-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-mediated signaling is a newly recognized clinical target in prostate cancer, and it is hypothesized that blockade of the IGF receptor (IGF1R) will impair downstream signaling and slow tumor growth. In this study the efficacy of nordihydroguaiaretic a...

journal_title：Oncology reports

authors： Friedlander TW,Weinberg VK,Huang Y,Mi JT,Formaker CG,Small EJ,Harzstark AL,Lin AM,Fong L,Ryan CJ

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study was to look for a new medicine in diagnosing and treating of glioblastoma. Radioiodine-labeled anti-epidermal growth factor receptor (EGFR) binding nanoparticles were constructed. In vitro cell-binding assays were confirmed by confocal microscopy and flow cytometry. Cell cytotoxicity assays were ...

journal_title：Oncology reports

authors： Li C,Tan J,Chang J,Li W,Liu Z,Li N,Ji Y

更新日期：2017-11-01 00:00:00

abstract：:Apoptosis repressor with caspase recruitment domain (ARC), an inhibitor of apoptosis, is primarily expressed in terminally differentiated tissues. Recent studies have revealed that ARC is highly expressed in a variety of human cancer cell lines and epithelial-derived cancers, which suggests that ARC plays an important...

journal_title：Oncology reports

authors： Wu P,Tang Y,He J,Qi L,Jiang W,Zhao S

更新日期：2013-10-01 00:00:00

abstract：:The emergence of radioresistance is a significant issue in the treatment of squamous cell carcinoma. We recently demonstrated that post-radiogenic extracellular signal-regulated kinase (ERK) signaling might decrease radiosensitivity in this cancer type. To further elucidate how tumo...

journal_title：Oncology reports

authors： Affolter A,Schmidtmann I,Mann WJ,Brieger J

更新日期：2013-02-01 00:00:00

abstract：:MicroRNAs (miRs) have emerged as prospective tools for human cancer therapy, including hepatocellular carcinoma (HCC) therapy. Previous studies have suggested that miR-381 functions as oncogenic or tumor-suppressive miRs in other cancer types. However, the role of miR-381 in HCC remains unknown. The present study inve...

journal_title：Oncology reports

authors： Zhang Q,Zhao S,Pang X,Chi B

更新日期：2016-03-01 00:00:00

abstract：:Ovarian cancer (OC) is one of the most lethal gynecological malignancies in the world. The aim of the present study was to examine the role of microRNA (miR)-134-3p in OC. Reverse transcription-quantitative PCR was used to measure the expression levels of miR-134-3p. Cell Counting Kit-8, TUNEL, flow cytometric and col...

journal_title：Oncology reports

authors： Zhao M,Ji H,Fu Q,Cheng Q,Zhang Y,Yang Y

更新日期：2021-01-01 00:00:00

abstract：:Aquaporins (AQPs) are a family of small, integral membrane proteins that have been shown to play an important role in tumor development and metastasis. Several studies have demonstrated that expression of AQP3 contributes to the enhanced migration of epithelial cells and is related to differentiation, metastasis and v...

journal_title：Oncology reports

authors： Li A,Lu D,Zhang Y,Li J,Fang Y,Li F,Sun J

更新日期：2013-02-01 00:00:00

abstract：:The cancer stem cell hypothesis suggests that mutated melanocyte stem cells are present in skin as precursors of melanoma cells. Nestin and CD133 have been described as markers of melanocytic stem cells. The aim of this study was to establish if melanocytic stem cells could have a prognostic significance in melanoma p...

journal_title：Oncology reports

authors： Piras F,Perra MT,Murtas D,Minerba L,Floris C,Maxia C,Demurtas P,Ugalde J,Ribatti D,Sirigu P

更新日期：2010-01-01 00:00:00

abstract：:Chronic pancreatitis/pancreatic cancer (CP/PC) is characterized by fibrous connective tissue proliferation induced by activated pancreatic stellate cells (PSCs). Galectin-1 is upregulated in activated PSCs and is important for the continuing activation of PSCs. The aim of this study was to evaluate the effect of galec...

journal_title：Oncology reports

authors： Tang D,Wu Q,Zhang J,Zhang H,Yuan Z,Xu J,Chong Y,Huang Y,Xiong Q,Wang S,Tian Y,Lu Y,Ge X,Shen W,Wang D

更新日期：2018-03-01 00:00:00

abstract：:Inflammasomes can identify endogenous danger signals as an inflammatory immune response. As the most common inflammasome, the NLR pyrin family domain containing 3 (NLRP3) inflammasome is associated with the pathogenesis of different tumors. However, the function of the NLRP3 inflammasome in esophageal cancer (EC) has ...

journal_title：Oncology reports

authors： Yu S,Yin JJ,Miao JX,Li SG,Huang CZ,Huang N,Fan TL,Li XN,Wang YH,Han SN,Zhang LR

更新日期：2020-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) are reported to be involved in renal hypoxia/reoxygenation (H/R) damage. To investigate this further, human kidney (HK‑2) cells were cultured, subjected to H/R and the function of miR‑30a‑5p and glutamate dehydrogenase 1 (GLUD1) was evaluated. The results showed that, miR‑30‑5p was downregulated and...

journal_title：Oncology reports

authors： He Y,Lang X,Cheng D,Zhang T,Yang Z,Xiong R

更新日期：2020-10-01 00:00:00

abstract：:Heparanase is endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix and basement membrane. Heparanase has been thought to have an important role in the process of cancer invasion and metastasis. Recent studies have revealed that heparanase has multifunctional mo...

journal_title：Oncology reports

authors： Naomoto Y,Takaoka M,Okawa T,Nobuhisa T,Gunduz M,Tanaka N

更新日期：2005-07-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) can act as carcinogenic or cancer suppressive factors during the pathogenesis, invasion and metastasis of non‑small cell lung cancer (NSCLC). The current study explored the role of long intergenic non‑protein coding RNA 00887 (LINC00887) and competing endogenous RNAs (ceRNAs). It was rev...

journal_title：Oncology reports

authors： Tian Y,Yu M,Sun L,Liu L,Huo S,Shang W,Sheng S,Wang J,Sun J,Hu Q,Dou Y,Zhu J,Ren X,Yang S

更新日期：2019-09-01 00:00:00