Peroxisome biogenesis and degradation in yeast: a structure/function analysis.

Abstract:

:In yeast, peroxisomes are the site of specific catabolic pathways that characteristically include hydrogen peroxide producing oxidases and catalase. During the last 10 years, much progress has been made in unravelling the molecular mechanisms involved in the biogenesis of this organelle. At present, 23 different genes (PEX genes) have been identified that are involved in different aspects of peroxisome biogenesis (e.g., proliferation, formation of the peroxisomal membrane, import of matrix proteins). The principles of peroxisome degradation are still much less understood. Recently, the first yeast mutants affected in this process have become available and used to clone corresponding genes by functional complementation. In this paper, an overview is presented of the research on yeast peroxisomes, focusing on recent achievements in the molecular aspects of peroxisome development, function, and turnover.

journal_name

Microsc Res Tech

authors

Veenhuis M,Salomons FA,Van Der Klei IJ

doi

10.1002/1097-0029(20001215)51:6<584::AID-JEMT8>3.0

keywords:

subject

Has Abstract

pub_date

2000-12-15 00:00:00

pages

584-600

issue

6

eissn

1059-910X

issn

1097-0029

pii

10.1002/1097-0029(20001215)51:6<584::AID-JEMT8>3.0

journal_volume

51

pub_type

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