Abstract:
BACKGROUND:Experimental evidence indicates that statins might have direct vascular effects independently from low-density lipoprotein (LDL) cholesterol reduction and we reported that the reduction in urinary albumin excretion rate during Simvastatin treatment in type 2 diabetic patients was not correlated with LDL-cholesterol decrease. However in humans there are no data regarding possible additional effects of Simvastatin on blood pressure and urinary albumin excretion beyond its capacity to lower serum cholesterol. PATIENTS AND METHODS:Twenty-six microalbuminuric hypertensive type 2 diabetic patients (diastolic blood pressure - after four months wash-out from the previous antihypertensive therapy - consistently > 90 and < 100 mmHg; plasma LDL-cholesterol > 3.9 and < 6.5 mmol L-1) were enrolled in the study. In random order, these patients received Simvastatin (20 mg day-1) or Cholestyramine (6 g three times a day) for a period of 10 months and after three months of wash-out (cross-over) the sequence was reversed for an additional 10 months. Blood pressure, lipid parameters, glycated haemoglobin and urinary albumin excretion were measured during the study. Additionally, in eight patients, urinary glycosaminoglycan excretion (GAG) was also measured during the study. RESULTS:Simvastatin and Cholestyramine were equally effective in reducing total and LDL cholesterol. Only during Simvastatin treatment a significant reduction in diastolic blood pressure and both 24 h urinary albumin and GAG excretion rates were observed, while no significant changes were seen with Cholestyramine treatment. CONCLUSIONS:Our results clearly show for the first time that the reduction of blood pressure, together with 24 h urinary albumin excretion rate - two established cardiovascular risk factors, obtained during Simvastatin therapy in hypertensive type 2 diabetic patients - is in large part independent from the reduction of LDL Cholesterol.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Tonolo G,Melis MG,Formato M,Angius MF,Carboni A,Brizzi P,Ciccarese M,Cherchi GM,Maioli Mdoi
10.1046/j.1365-2362.2000.00735.xkeywords:
subject
Has Abstractpub_date
2000-11-01 00:00:00pages
980-7issue
11eissn
0014-2972issn
1365-2362pii
eci735journal_volume
30pub_type
临床试验,杂志文章abstract::The aim of the study was to compare the changes in plasma renin activity induced by a vasodilator in normal dogs and in dogs with an impaired cardiac reserve. In normal conscious dogs, a 60-min nitroprusside infusion increased plasma renin activity from 1.05 +/- 0.26 to 8.35 +/- 1.20 ng, angiotensin I ml-1 h-1 (P less...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1983.tb00109.x
更新日期:1983-08-01 00:00:00
abstract:BACKGROUND:Renal impairment and type 2 diabetes mellitus (DM) are well-known independent risk factors for mortality. The evidence of their combined effects on mortality is unclear, but of importance because it may determine aggressiveness of treatment. This study sought to assess and quantify the effect modification of...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/eci.12035
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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doi:10.1046/j.1365-2362.2000.00717.x
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1984.tb02100.x
更新日期:1984-04-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1046/j.1365-2362.1996.2550586.x
更新日期:1996-11-01 00:00:00
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journal_title:European journal of clinical investigation
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更新日期:2018-09-01 00:00:00
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journal_title:European journal of clinical investigation
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更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Lipoprotein(a) [Lp(a)] is an important cardiovascular risk factor in the general population. However, prospective data on the vascular risk conferred by Lp(a) in patients with diabetes mellitus are scarce and controversial. It is not known whether the diabetic state affects the association of Lp(a) with vasc...
journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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更新日期:2004-06-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1990-04-01 00:00:00
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doi:10.1046/j.1365-2362.2000.0300s3001.x
更新日期:2000-12-01 00:00:00
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journal_title:European journal of clinical investigation
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pub_type: 杂志文章,meta分析
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journal_title:European journal of clinical investigation
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2012-10-01 00:00:00
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journal_title:European journal of clinical investigation
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更新日期:2012-08-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.2007.01780.x
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journal_title:European journal of clinical investigation
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doi:10.1111/j.1365-2362.2004.01345.x
更新日期:2004-05-01 00:00:00