Nonalcoholic steatohepatitis.

Abstract:

:Nonalcoholic steatohepatitis (NASH) is a liver disease that, until recently, has been underrecognized as a common cause of elevated liver enzymes. This distinct clinical entity is characterized by liver biopsy findings similar to those seen in alcoholic hepatitis but in the absence of alcohol consumption sufficient to cause such changes. Patients with NASH are often middle-aged and obese, with coexisting diabetes or hyperlipidemia, but NASH also occurs in younger lean, otherwise healthy individuals and even in children. Although NASH is generally a benign disorder, it may be progressive, leading to cirrhosis and complications of portal hypertension. Liver biopsy remains the gold standard for diagnosis. Therapy for NASH remains poorly defined, although weight reduction and ursodeoxycholic acid may have a beneficial effect.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Kumar KS,Malet PF

doi

10.4065/75.7.733

keywords:

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

733-9

issue

7

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(11)64621-1

journal_volume

75

pub_type

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