Extracellular matrix components of the wall of umbilical cord vein and their alterations in pre-eclampsia.

Abstract:

:Pre-eclampsia--edema, proteinuria, hypertension (EPH-gestosis) is one of the more common complications observed during pregnancy. The umbilical cord vein walls were taken from newborns delivered by healthy mothers (control material) and by mothers with polysymptomatic pre-eclampsia (investigated material). Normal saphenous vein walls were collected from adult subjects undergoing varicose vein surgery. The collagen content was measured by the assay of hydroxyproline. Elastin was determined according to Fastin Elastin Assay and gravimetrically. Glycosaminoglycans content was determined by uronic acids assay. The collagen content decreased in the pre-eclampsia material. The amount of soluble elastin increased in the investigated material. The insoluble elastin content decreased in the umbilical cord veins of newborns delivered by mothers with pre-eclampsia. Reconstructing the umbilical cord vein wall may disturb fetal blood flow and affect the vascular system in adulthood.

journal_name

J Perinat Med

authors

Romanowicz L,Sobolewski K

doi

10.1515/JPM.2000.019

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

140-6

issue

2

eissn

0300-5577

issn

1619-3997

journal_volume

28

pub_type

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