Abstract:
:The placenta secretes large amounts of the hypothelamic hormone, corticotropin releasing hormone (CRH) into the maternal and fetal circulation during pregnancy. We and other investigators have shown that during normal pregnancy, maternal plasma CRH levels begin to rise in the second trimester with a dramatic increase in CRH levels during the 5-6 weeks preceding the onset of labor. This rise in maternal plasma CRH is parallel to the rise of placental CRH mRNA which has been reported to occur with gestational maturation. Mechanisms underlying the control of CRH secretion by the placenta have not yet been determined. In twin gestation, increased fetal-placental mass has been shown to be associated with elevated maternal levels of several placental hormones as compared to singleton gestation. We measured maternal plasma CRH in both twin and singleton gestation to investigate whether the larger size of the fetal-placental unit in twin gestation is associated with elevated maternal CRH levels. Seventy-six serial venous blood samples were collected from 20 women with twin gestation and 40 samples were obtained from 27 women with uncomplicated singleton gestation. Gestational age was determined by history of a known last menstrual period and first trimester clinical examination and confirmed by ultrasound examination. CRH was extracted from 1-2 ml plasma with SEP-Pak C18 cartridges and eluted with triethylamine-formic-acid propranolol. CRH was measured by radioimmunoassay (RIA) with human CRH standard and antiserum to human CRH raised in our laboratory. Mean CRH levels were calculated for four week intervals. In both singleton and twin gestation, the maternal plasma CRH levels increased with advancing gestational age. After 29 weeks of gestation, maternal plasma CRH levels in twin gestation were significantly higher than those in singleton gestation (p less than 0.01). At 37 to 40 weeks of gestation, mean maternal CRH was 1167 +/- 237 pg/ml in singleton gestation as compared to 6927 +/- 1725 pg/ml in twin gestation (p less than 0.05). In addition, the rapid rise in plasma CRH levels which occurs near term in singleton gestation, occurred earlier in twin gestation. This early rise in maternal CRH levels persisted when the data from twin pregnancies complicated by preterm labor were removed from the analysis.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Perinat Medjournal_title
Journal of perinatal medicineauthors
Warren WB,Goland RS,Wardlaw SL,Stark RI,Fox HE,Conwell IMdoi
10.1515/jpme.1990.18.1.39subject
Has Abstractpub_date
1990-01-01 00:00:00pages
39-44issue
1eissn
0300-5577issn
1619-3997journal_volume
18pub_type
杂志文章abstract::Objective To compare myocardial strain and mechanical dyssynchrony in fetuses with congenital heart disease (CHD) to normal controls using speckle tracking echocardiography (STE). Methods In this comparative cross-sectional study 23 fetuses with CHD and 105 normal controls between 19 and 41 weeks of gestation were ass...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2019-0073
更新日期:2019-08-27 00:00:00
abstract::Plasma lipoprotein, cholesterol and triglycerides were determined in 34 hypertensive pregnant patients and in 17 healthy full term pregnant women. Pregnancy induced hypertension was diagnosed in 21 patients and chronic hypertension in the remaining 13 women. Serum triglyceride levels were significantly elevated in the...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1990.18.6.473
更新日期:1990-01-01 00:00:00
abstract::Current approaches to the detection of patients at risk for preterm delivery (PTD) have focused on the diagnosis of preterm labor. However, these approaches are complicated by treatment biases and our inability to convincingly differentiate preterm labor from Braxton-Hicks contractions. Moreover, preterm labor with in...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/jpme.1993.21.6.441
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate cisterna magna size of the fetuses between 16 and 24 weeks of gestation, and to establish a normogram for cisterna magna measurements during gestation. METHODS:A prospective study of normal singleton pregnancies was established. Measurement of the fetal cisterna magn...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2007.060
更新日期:2007-01-01 00:00:00
abstract::Objective To determine whether the risk of intra-amniotic infection/inflammation and spontaneous preterm delivery (SPTD) varies as a function of the concentration of cervical fetal fibronectin (fFN) in patients with preterm labor and intact membranes. Methods This prospective study included 180 patients with preterm l...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2018-0351
更新日期:2019-04-24 00:00:00
abstract::The validity of the assessment of the fetal age and pulmonary maturity was evaluated on 369 patients at various stages of normal pregnancy and complicated by diabetes, toxemia and fetal anencephaly. Gestational maturity was assessed by ultrasonic measurement of the fetal biparietal diameter and by analysing constituen...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1975.3.2.105
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVE:Our objective was to evaluate whether using a standardized shoulder dystocia delivery form improved documentation. A standardized delivery form was added to our institution's obstetrical record in August 2003. METHODS:A retrospective cohort study was conducted comparing 100 vaginal deliveries complicated by ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2011.112
更新日期:2011-10-24 00:00:00
abstract::This paper reviews data that support the effectiveness of the French approach of using risk scoring for evaluating the risk of preterm delivery. This approach, which was developed in 1969 and spread to obstetricians and midwives throughout France in the early 1970s, includes systematic information about the recognitio...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/JPM.1999.002
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To compare obstetrical and neonatal outcomes of vaginal deliveries complicated by shoulder dystocia, according to the length of second stage of labor. METHODS:We conducted a retrospective cohort study of 177 shoulder dystocia cases that were divided into three categories according to second stage duration (1...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2011-0253
更新日期:2012-03-29 00:00:00
abstract::During pregnancy the role of the cervix shifts between two opposing functions. Throughout most of gestation, the cervix is rigid and resists tension in order to maintain the products of conception inside the uterus. At term, however, cervical function changes drastically in order to accommodate stretch and delivery. T...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.1999.026
更新日期:1999-01-01 00:00:00
abstract:AIM:The aim of the study was to investigate the most frequent causes of perinatal mortality in Bosnia and Herzegovina. METHODS:We analyzed in a retrospective study over a one year period (1999) the following cantons: Sarajevo, Mostar, Tuzla, Bihać, Gorazde, Travnik, Zenica, which represent about one half of the popula...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/JPM.2001.035
更新日期:2001-01-01 00:00:00
abstract::Large epidemiological studies with over 5000 cases have the advantage of providing sufficient case numbers for the statistical evaluation of sub-groups. They are associated with a higher error rate in data collection and the influence of differences in judgment on part of the collaborators. In order to quantitatively ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1981.9.2.79
更新日期:1981-01-01 00:00:00
abstract::Background Monocytes, after neutrophils, are the most abundant white blood cells found in the amniotic cavity of women with intra-amniotic inflammation/infection. However, the origin of such cells has not been fully investigated. Herein, we determined (1) the origin of amniotic fluid monocytes/macrophages from women w...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2019-0262
更新日期:2019-10-25 00:00:00
abstract::Fetuses show various facial expressions, such as blinking, yawning, sucking, mouthing, tongue expulsion, scowling, and smiling, assessed by four-dimensional ultrasound from the early second trimester of pregnancy. Moreover, some fetuses demonstrate emotion-like behaviors as noted in infants, children, and adults. Sele...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/jpm-2016-0377
更新日期:2017-08-28 00:00:00
abstract::A new design of vacuum extractor cup--'the New Generation cup'--has recently been introduced into clinical practice. Its major modification is a traction cord which passes around the rim of the cup for 180 degrees and is free to slide within the rim. Claims that this design 'enables the operator to pull obliquely with...
journal_title:Journal of perinatal medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1515/jpme.1986.14.2.95
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Gestational weight gain (GWG) above the recently recommended ranges is likely to be related to adverse pregnancy outcomes and therefore a challenge in industrialized countries. AIMS:We conducted a systematic review on observational studies in order to gain more evidence on whether diets with lower caloric/p...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/jpm.2010.127
更新日期:2011-03-01 00:00:00
abstract::Continuous transcutaneous carbon dioxide partial pressure (tcPco2) was monitored in 40 spontaneous labors. The electrode was attached by glue fixation. An interpretable tracing was obtained in 36 cases. All cases but 2 were normal pregnancies. Thirty-two patients had epidural analgesia while the others had no analgesi...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1987.15.4.390
更新日期:1987-01-01 00:00:00
abstract::Background We examined the influence of companionship and the use of complementary therapies on adverse outcomes in parturients under regional analgesia. Methods This study is a single-center retrospective cohort of 986 term pregnant women, and it was based on data from medical records (hospitalization period: Novembe...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2019-0366
更新日期:2020-06-25 00:00:00
abstract::The fetal electrocardiogram (FECG) has been recorded from 155 women in labor using a fetal scalp electrode and a minicomputerized enhanced averaging technique. Fetal hypoxia, acidosis, and stress have been diagnosed by analysis of blood from the fetal scalp, and post delivery from full gas analysis from blood taken fr...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1986.14.6.399
更新日期:1986-01-01 00:00:00
abstract::An easily applicable score to predict the risk of prematurity (Tab. I) (defined by weight) is examined prospectively (scoring during 6 th month of pregnancy) in 431 and retrospectively (obtained after delivery) in 1183 pregnancies. In the prospective study (Tab. II) 71.4% of all pregnancies resulting in babies below 2...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1976.4.1.38
更新日期:1976-01-01 00:00:00
abstract:AIMS:To investigate localization and concentration of adhesion molecules in the human lower uterine segment during preterm parturition. METHODS:In a prospective study biopsy specimens from the lower uterine segment of 43 patients undergoing cesarean section at 24 + 0 to 36 + 4 weeks' gestation were immunostained for i...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2001.069
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:We examined the causes of death amongst full term stillbirths and early neonatal deaths. METHODS:Our cohort includes women in the Region of Southern Denmark, who gave birth at full term to a stillborn infant or a neonate who died within the first 7 days from 2010 through 2014. Demographic, biometric and clin...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2017-0171
更新日期:2018-02-23 00:00:00
abstract:AIM:The aim of this study was to review prenatally diagnosed tumors of the head and neck in the fetus and to report antenatal and postnatal outcomes. METHODS:PubMed/Medline, EMBASE/SCOPUS, Cochrane database and Google Scholar were reviewed over the last 20 years. No language or article type restriction was used. RESU...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/jpm-2016-0074
更新日期:2017-02-01 00:00:00
abstract::Viability means "the quality or state of being able to live, grow and develop." Limit of viability has been changed along with the advancement of perinatal and neonatal medicine. The viability limit defined in the Japanese Motherhood Protection Act was amended from 24 to 22 completed weeks of gestation in 1991 based o...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/JPM.2009.112
更新日期:2009-01-01 00:00:00
abstract::Objective To evaluate fetal behavioral differences between singleton and twin fetuses before 20 weeks of gestation using four-dimensional (4D) ultrasound. Methods 4D ultrasound was used to examine fetal movements in 58 singleton and 48 twin normal fetuses at 12-19 weeks. The frequencies of eight fetal movements were a...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2017-0158
更新日期:2018-10-25 00:00:00
abstract:OBJECTIVE:Infection has been implicated in the pathogenesis of preeclampsia, yet the association between microbial invasion of the amniotic cavity (MIAC) and preeclampsia has not been determined. The aim of this study was to determine the prevalence, and microbial diversity associated with MIAC, as well as the nature o...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2010.078
更新日期:2010-09-01 00:00:00
abstract::We report on an exceptional therapy with epidural anesthesia and tunnelling of the peridural catheter over a time period of 2-14 days in patients with threatening early preterm labor, intact membranes and vaginal engagement of the infants (4 singleton, 8 twin and 2 triplet pregnancies). A combination of bupivacaine (0...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2008.081
更新日期:2008-01-01 00:00:00
abstract:AIM:To compare the growth attainment of preterm children and their cardiovascular risk factors at adolescence with the values measured in term children in Germany. METHODS:About 17,641 children aged 0 to <18 years were studied between 2003 and 2006 in the population representative German KiGGS survey ("German Health I...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2016-0294
更新日期:2017-07-26 00:00:00
abstract::Fluorescence polarization of the amniotic fluid from 39 high risk pregnancies requiring preterm delivery was measured in order to assess the maturity of the fetal lung. The study population included 15 cases of intrauterine growth retardation, ten maternal hypertension, five maternal Hodgkin's disease, three placenta ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1993.21.5.349
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:Determine social factors related to pregnancy among young adolescents. METHODS:We obtained socio-demographic data from early adolescent nulliparas aged < or = 15 years. RESULTS:During the study period at the Enrique C. Sotomayor Obstetrics and Gynecology Hospital, Guayaquil-Ecuador 201 early adolescent null...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2004.063
更新日期:2004-01-01 00:00:00