Abstract：
:Background Sjögren's syndrome (SS) is an autoimmune connective tissue disease affecting the body's moisture-producing glands. Some studies have linked SS to adverse maternal/neonatal outcomes, but sample sizes have tended to be small, with few outcomes examined. The purpose of this study was to evaluate the effect of SS on pregnancy outcomes for mother and neonate using a large dataset. Methods We carried out a retrospective cohort study of women who delivered between 1999 and 2014 using data from the Nationwide Inpatient Sample from the United States. SS categorization is based on ICD-9 coding. Baseline characteristics were compared in both groups and multivariate logistic regression was used to compare maternal and fetal outcomes of pregnancies in women with and without SS. Results The prevalence of SS in our population was 1.34 cases/10,000 births, with the rate increasing over the study period. Women with SS tended to be older, Caucasian and to have pre-existing comorbidities. Births to women with SS were at greater risk of pre-eclampsia [odds ratio (OR) 1.63, 95% confidence interval (CI) 1.34-1.99]; premature rupture of membranes (OR 1.28, 95% CI 1.04-1.57); preterm delivery (OR 1.56, 95% CI 1.34-1.81); cesarean delivery (OR 1.29, 95% CI 1.17-1.41); and venous thromboembolic events (OR 3.71, 95% CI 2.57-5.35). Infants of women with SS were more likely to have intrauterine growth restriction (IUGR) (OR 3.00, 95% CI 2.46-3.65); and congenital malformations (OR 3.26, 95% CI 2.30-4.62). Conclusion SS is a high-risk pregnancy condition associated with significant comorbidities and adverse maternal and fetal outcomes. Women with SS may benefit from increased surveillance during their pregnancies.
journal_name
J Perinat Medjournal_title
Journal of perinatal medicineauthors
Elliott B,Spence AR,Czuzoj-Shulman N,Abenhaim HAdoi
10.1515/jpm-2019-0034subject
Has Abstractpub_date
2019-08-27 00:00:00pages
637-642issue
6eissn
0300-5577issn
1619-3997pii
/j/jpme.ahead-of-print/jpm-2019-0034/jpm-2019-0034journal_volume
47pub_type
杂志文章abstract：:Objectives Coronavirus (COVID-19) is a new respiratory disease that is spreading widely throughout the world. The aim of this study was to evaluate the psychological impact of COVID-19 pandemic on pregnant women in Italy. Methods We considered 200 pregnancies attending our antenatal clinic. A questionnaire was sent to...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpm-2020-0182
更新日期：2020-07-28 00:00:00
abstract：AIM:To examine the gestational age-specific distribution of twin birth weight discordance. METHODS:We analyzed all liveborn twin sets between 28 and 40 weeks' gestation from the United States 1995-1998 Multiple Matched Birth Data Set compiled by the National Center for Health Statistics. We calculated the 50th and 95t...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/JPM.2005.022
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVE:To analyze the characteristics and trends of maternal deaths due to obstetric hemorrhage in urban and rural areas during the period of 1996-2005 in China, and to provide evidence for decision-making for further reducing the national maternal mortality ratio (MMR). METHODS:We analyzed national maternal mortal...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpm.2010.115
更新日期：2011-01-01 00:00:00
abstract：:The aim of the study was to compare a variety of neonatal outcome variables of growth concordant twin gestations (CT) to that of growth discordant twins (DT). Maternal and neonatal charts of live, non-anomalous twins > 25 weeks' gestation from 1984-2000 with no evidence of twin-twin transfusion syndrome were reviewed ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/JPM.2003.047
更新日期：2003-01-01 00:00:00
abstract：:The renin-angiotensin system and dietary sodium have been repeatedly implicated in the pathogenesis of pregnancy induced hypertension (PIH). Mechanisms responsible for increased vascular responsiveness to angiotensin II (A-II) observed in PIH are not completely understood. Plasma A-II levels and blood pressure are fun...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1984.12.4.167
更新日期：1984-01-01 00:00:00
abstract：:The blood flow pattern in the common umbilical vein is under normal conditions nonpulsatile in contrast to the flow in the fetal inferior vena cava. We observed pulsatile flow patterns in the common umbilical vein of fetal lambs during changes in the fetal hemodynamic equilibrium. These pulsations may influence the mi...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1986.14.1.19
更新日期：1986-01-01 00:00:00
abstract：:The effect of hypertonic glucose infusion on the maternal and fetal acid-base equilibrium was studied in 20 clinically normal parturients and their concepts. Samples of maternal peripheral venous blood and fetal capillary blood were collected before and after intravenous infusion of 25 g of glucose into the mother at ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1982.10.2.99
更新日期：1982-01-01 00:00:00
abstract：OBJECTIVE:we investigated whether ascites samples obtained from pregnant women during cesarean sections contained antithrombin because it is unknown whether antithrombin escapes from the blood and passes into the interstitial space during pregnancy. METHODS:the concentration and activity levels of antithrombin were de...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpm.2010.106
更新日期：2010-11-01 00:00:00
abstract：:The aim of this experimental ultrasound study on six fetal lambs was to evaluate how blood flow variables and vessel diameters of the descending aorta and the common carotid artery change during fetal asphyxia in the acute preparation. When acute asphyxia was induced by obstructing the maternal aortic blood flow all f...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVES:to assess the relationship between maternal and umbilical serum concentrations of matrix metalloproteinases (MMP)-2,8,9, the soluble receptor for advanced glycation end products (sRAGE) and IL-10 and premature delivery and fetal inflammation. METHODS:maternal serum levels of MMPs, sRAGE, IL-10 and C-reactiv...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpm.2010.092
更新日期：2010-11-01 00:00:00
abstract：:FHR monitoring and microanalysis of fetal blood are mutually complementary procedures, and optimal knowledge of the fetal state is achieved by making use of both, the former for the preliminary screening of all cases at risk and the latter for the purpose of deciding on obstetric management where pathological changes ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1975.3.1.53
更新日期：1975-01-01 00:00:00
abstract：AIMS:To investigate the incidence of severe fetal-to-maternal transfusion after delivery and to identify risk factors. MATERIAL AND METHODS:In a prospective study at the Department of Obstetrics, Charité, Campus Virchow-Klinikum, Berlin, Germany, we analyzed the incidence of severe fetal-to-maternal transfusion (>10 m...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/JPM.2004.047
更新日期：2004-01-01 00:00:00
abstract：AIM:To explore whether the Groningen Protocol is clinically necessary, scientific, and ethically justified. RESULTS:The Groningen Protocol is clinically unnecessary because the withdrawal of life-sustaining treatment from seriously ill infants is already ethically accepted globally without the need for the Protocol an...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/JPM.2009.058
更新日期：2009-01-01 00:00:00
abstract：AIM:To evaluate the short-term effects of blood transfusion on iron status [hemoglobin, ferritin, soluble transferrin receptor (sTfR), and reticulocyte count], hepcidin, and erythropoietin in stable preterm infants. METHOD:Sixty-three preterm infants treated with red blood cell transfusions (RBCTs) were included. Veno...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpm-2015-0361
更新日期：2016-10-01 00:00:00
abstract：AIMS:inflammatory processes are present during preeclampsia and in normal pregnancy. Maternal inflammatory reactions may change towards term. Our objective was to evaluate genome signaling in blood during preeclampsia and towards term using microarrays. METHODS:RNA microarrays (Illumina) were conducted on blood from p...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpm.2010.095
更新日期：2010-11-01 00:00:00
abstract：AIM:To identify cardiotocography (CTG) patterns associated with increased risk of intrapartum fetal acidemia. METHODS:A prospective observational cohort study of 1070 women with fetal scalp blood sampling (FBS) during labor was conducted at Karolinska University Hospital, Stockholm, Sweden. Women with a nonreassuring ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpm-2014-0105
更新日期：2015-07-01 00:00:00
abstract：OBJECTIVE:In cohorts of infants with proven neonatal alloimmune thrombocytopenia (NAIT) an unusual high rate of preterm infants has been reported, raising the question of whether NAIT contributes to the high rate of intracranial hemorrhage in preterm infants. METHODS:We genotyped the HPA-1-allele in a large cohort of ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/JPM.2002.023
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:To assess whether there is a difference in the behavior of fetuses of pregnant women with diabetes under treatment with insulin, compared to fetuses of pregnant women without diabetes. MATERIALS AND METHODS:Kurjak's antenatal neurodevelopmental test (KANET) - a method that, by application of four-dimensional...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpm-2016-0394
更新日期：2017-08-28 00:00:00
abstract：OBJECTIVES:Our two objectives were to evaluate the feasibility of fetal brain magnetic resonance imaging (MRI) using a fast spin echo sequence at 3.0T field strength with low radio frequency (rf) energy deposition (as measured by specific absorption rate: SAR) and to compare image quality, tissue contrast and conspicui...
journal_title：Journal of perinatal medicine
pub_type： 临床试验,杂志文章
doi：10.1515/jpm-2014-0268
更新日期：2015-03-01 00:00:00
abstract：:Glycosylated hemoglobin (HbA1) was determined in three subject groups: 69 non-diabetic mothers who were delivered of normal weight infants at term (Group I), 33 non-diabetic mothers who were delivered of macrosomic infants (greater than 4000 g) at term (Group II), 51 gestational diabetics in the 3rd trimester--before ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1984.12.3.137
更新日期：1984-01-01 00:00:00
abstract：:The influence of perinatal asphyxia in the secretion of atrial natriuretic factor (ANF) during the first 6 days of life, and its renal consequences are discussed. Comparison between 20 healthy term neonates and 19 with first--or second--degree hypoxic-ischemic encephalopathy (HIE) is made. Daily controls were performe...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：UNLABELLED:The authors present the results of their follow-up studies of data from the last four years on patients with congenital ventriculomegaly. OBJECTIVE:To study the psychomotor and mental developmental outcome of neonates with congenital ventriculomegaly diagnosed prenatally. In addition, patients were also cla...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/JPM.1999.067
更新日期：1999-01-01 00:00:00
abstract：:Monitoring of spontaneous brain electrical activity (EEG) has three purposes: Detecting sudden loss of background activity as an early sign of brain hypoxia/ischaemia, detection of silent seizures, and helping to diagnose brain damage. Tape-recording allows storage of upto 8 channels of standard EEG for prolonged peri...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：:The validity of the assessment of the fetal age and pulmonary maturity was evaluated on 369 patients at various stages of normal pregnancy and complicated by diabetes, toxemia and fetal anencephaly. Gestational maturity was assessed by ultrasonic measurement of the fetal biparietal diameter and by analysing constituen...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1975.3.2.105
更新日期：1975-01-01 00:00:00
abstract：:Serum calcium and 25-OH-D3 in mothers of newborns with craniotabes. The aim of this study was to investigate whether calcium or vitamin D balance during late pregnancy have influence on the outcome of newborn craniotabes. 27 mothers and their fullterm newborns with craniotabes in two series were studied for clinical f...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1983.11.2.127
更新日期：1983-01-01 00:00:00
abstract：:The placenta secretes large amounts of the hypothelamic hormone, corticotropin releasing hormone (CRH) into the maternal and fetal circulation during pregnancy. We and other investigators have shown that during normal pregnancy, maternal plasma CRH levels begin to rise in the second trimester with a dramatic increase ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1990.18.1.39
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Influenza presents with increased morbidity and mortality in children ≤5 months of age. Vaccination of caregivers is indicated, but immunization rates are estimated at only 30%. The 2009 New York State Neonatal Influenza Protection Act (NIPA) mandated offering of influenza vaccine to caregivers during the po...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpm-2014-0248
更新日期：2014-11-01 00:00:00
abstract：:A patient was admitted to the hospital in the 31st week of gestation because of reduced sensation of fetal movements and a pathologic fetal heart rate tracing (Fig. 1). At first no underlying pathology could be found. After a week she developed a polyhydramnios. After repeated ultrasonographic examinations an atresia ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1984.12.6.325
更新日期：1984-01-01 00:00:00
abstract：:Preterm infants fed fortified human milk (HM) in standard (STD) fashion grow slower than preterm formula fed infants. Recently, low protein intake has been proven to be the primary limiting factor responsible for this growth failure. The main reason of protein undernutrition despite fortification is that STD fortifica...
journal_title：Journal of perinatal medicine
pub_type： 指南,杂志文章
doi：10.1515/jpm.2010.073
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:To evaluate whether uterotrophic agents increase the risk of fatal hemorrhagic brain stroke. METHODS:Between 1991 and 1992, there were 230 maternal deaths among 2,420,000 pregnant women in Japan and the causes of these deaths was investigated in 1994. Using information provided in this report, we identified ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpm.2010.116
更新日期：2011-01-01 00:00:00
