Abstract：
:Von Hippel-Lindau disease (VHL) is a hereditary cancer syndrome caused by germline mutations of the VHL tumor suppressor gene. Major progress has been made in the last decade in both clinical and fundamental aspects of VHL. The VHL gene product, pVHL, has major and multiple functions: pVHL regulates not only first angiogenesis but also extracellular matrix formation and the cell cycle. A molecular diagnosis of VHL is now available, leading to a transformation in clinical management of patients and their families. Diagnosis of VHL has to be suspected in patients with a VHL-related tumor without familial history and especially in case of hemangioblastoma or endolymphatic sac tumors. Such patients should be systematically investigated for clinical and molecular evidence of VHL disease. Treatment of symptomatic hemangioblastomas remains mainly neurosurgical, often in emergency, but stereotactic radiosurgery is emerging as an alternative therapeutic procedure. In the future, antiangiogenic drugs could represent a potential medical treatment of CNS hemangioblastomas in view of their highly vascular structure. Lastly, visceral manifestations of VHL disease are also of critical importance and require early detection for effective treatment.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Richard S,David P,Marsot-Dupuch K,Giraud S,Béroud C,Resche Fdoi
10.1007/s101430050024keywords:
subject
Has Abstractpub_date
2000-03-01 00:00:00pages
1-22; discussion 23-4issue
1eissn
0344-5607issn
1437-2320journal_volume
23pub_type
杂志文章,评审abstract：:Colloid cysts of the third ventricle are considered as benign lesions. The clinical manifestations are not clear in most of cases. Many treatment options are available and endoscopic removal of the cysts proves to be a very successful method especially if the lateral ventricles are moderately or severely dilated. Some...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-018-0956-y
更新日期：2019-03-01 00:00:00
abstract：:Spinal cord or cauda equina compression (SCC) is an increasing challenge in clinical oncology due to a higher prevalence of long-term cancer survivors. Our aim was to determine the clinical relevance of SCC regarding patient outcome depending on different tumor entities and their anatomical localization (extradural/in...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-016-0790-z
更新日期：2017-07-01 00:00:00
abstract：:Paraffin-embedded surgical specimens from 55 meningiomas were immunostained after microwave processing using the streptavidin/peroxidase method and the monoclonal antibody (moAb) MIB-1 to the Ki-67 antigen. The authors assessed proliferative labelling index (LI) from a series of surgically removed meningiomas using im...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-003-0261-1
更新日期：2003-07-01 00:00:00
abstract：:The endoscopic third ventriculostomy (ETV) success score (ETVSS) was developed to predict the success rate of ETV at 6 months. In this study, the authors assessed the performance of this score for > 6 months, i.e., at 12 months, and provided external validation in Brazilian children. All children undergoing first ETV ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-020-01461-6
更新日期：2021-01-03 00:00:00
abstract：:Between 1987 and 1991 we performed a unilateral or bilateral frontoorbital advancement to correct trigono- or plagiocephaly in 10 children: Three-dimensional CT provides an exact basis for operation planning. Titanium miniplates allow an already primarily rather stable osteosynthesis. The best time for this interventi...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF00345936
更新日期：1992-01-01 00:00:00
abstract：:Growing evidence from recent studies have revealed that long non-coding RNA (lncRNA) might be a useful prognostic biomarker for glioma; we therefore conducted the current meta-analysis to evaluate prognostic and clinicopathological predictive value of lncRNA expression for glioma patients. Eligible studies were identi...
journal_title：Neurosurgical review
pub_type： 杂志文章,meta分析
doi：10.1007/s10143-018-0965-x
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Trigeminal neuralgia (TN) is characterized by jolts of pain along the distribution of the trigeminal nerve. If patients fail conservative management, microvascular decompression (MVD) is the next step in treatment. MVD is largely done by placing implant pads between the nerve and compressing vessels. We cond...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-019-01187-0
更新日期：2020-02-01 00:00:00
abstract：:Functional activity, metabolism and blood flow are locally heterogeneous in the brain, but tightly coupled. This adjustment occurs in two different ways: 1. Short-term, dynamic coupling mediated by local vasoactive factors that ensure second-to-second regulation. 2. Long-term, static coupling apparently mediated by ca...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/BF00310651
更新日期：1991-01-01 00:00:00
abstract：:A nonchordomatous solitary lesion of the clival bone is an exceptionally rare pathological entity, which represents a diagnostic and a therapeutic challenge. Many diseases with extremely different biological behavior, and requiring a dedicated treatment strategy, may result in similar clinical patterns. The approach t...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-013-0463-0
更新日期：2013-10-01 00:00:00
abstract：:In 112 comatose patients somatosensory, visual and auditory evoked potentials were registered within 36 hours after the onset of coma or admission. Main causes of coma were head injury, and intracerebral and subarachnoid haemorrhage. The initial bilateral loss of any evoked potential was associated with a mortality of...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/BF00383655
更新日期：1990-01-01 00:00:00
abstract：:We present 78 patients with spinal cord injuries. Operation is not indicated in cord contusion, extended bleeding into the spinal canal or severe fracture dislocation. However, it would seem advisable to operate on patients with vertebral fractures, particularly at the lower thoracic and lumbar levels, if intraspinal ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01790702
更新日期：1989-01-01 00:00:00
abstract：:Surgical approaches for medically refractory mesial temporal lobe epilepsy (MTLE) that previously have been reported include anterior temporal lobectomy (ATL), transcortical selective amygdalohippocampectomy, transsylvian amygdalohippocampectomy, and subtemporal amygdalohippocampectomy. Each approach has its advantage...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-015-0657-8
更新日期：2016-01-01 00:00:00
abstract：:Traumatic bifrontal contusions (TBC) form a recognised clinical entity among patients with traumatic brain injury (TBI). This study aims to systematically review current literature on demographics, management, and predictors of outcomes of patients with TBC. A multi-database literature search (PubMed, Cochrane, OVID M...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-019-01098-0
更新日期：2020-06-01 00:00:00
abstract：:We did a prospective study of 70 adults with chronic subdural hematomas. We looked at the correlation between some aetiological, clinical, and radiological factors and outcome. The present analysis found a significant positive correlation of cephalea, isodense aspect of the hematoma at CT scan, and pulsatance of the e...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF00383875
更新日期：1995-01-01 00:00:00
abstract：:Hemangiopericytomas represent rare intracranial tumors that have a tendency to recur locally and have the unique characteristic of giving extracranial metastases. Our current communication reviews a series of patients diagnosed with hemangiopericytoma who were treated in our facility. Eleven patients with a mean age o...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-005-0001-9
更新日期：2006-04-01 00:00:00
abstract：:The management of posterior cranial fossa meningioma [PCFM] is challenging and many neurosurgeons advise gamma knife radiosurgery [GKRS] as a modality for its upfront or adjuvant treatment. Due to the varying radiosurgical response based on lesion location, tumor biology, and radiation dosage, we performed a pioneer a...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-019-01144-x
更新日期：2020-08-01 00:00:00
abstract：:We aimed to evaluate whether bypass of the external carotid artery (ECA) to the middle cerebral artery (MCA) can be established by a short saphenous vein graft in order to increase the anastomosis patency. The method was performed to ten adult cadaver sides. We described a modified technique for bypass of the ECA to t...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-008-0138-4
更新日期：2008-07-01 00:00:00
abstract：:Multilevel discectomy and inter-vertebral body fusion combined with anterior plate-screw fixation is the common procedure in cervical spine surgery. The correct placement of the screws is an important factor for the outcome of these operations. Yet no systematic approach has been undertaken to optimize the geometry of...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-005-0386-5
更新日期：2005-10-01 00:00:00
abstract：:Pediatric cortical ependymomas (CEs) are rare; the clinical features and optimal treatment remain ill-defined. We aimed to clarify the clinical characteristics and outcome of pediatric CEs based on institutional series and literature review. Thirteen children with CEs from our department were included in the present s...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-020-01336-w
更新日期：2020-06-30 00:00:00
abstract：:Stereotactic biopsies represent a routine neurosurgical procedure for the diagnosis of intracranial lymphomas and selected diffusely infiltrating gliomas. Acquisition of tissue samples that do not allow correct tumor typing and grading is, however, not uncommon. Five-aminolevulinic acid (5-ALA) has been shown to accum...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-012-0374-5
更新日期：2012-07-01 00:00:00
abstract：:Patients infected with the human immunodeficiency virus (HIV) or suffering from acquired immunodeficiency syndrome (AIDS) are now surviving for longer periods of time secondary to improvements in medical management. As the classical causes of morbidity and mortality in this patient population have come under better co...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-004-0371-4
更新日期：2005-04-01 00:00:00
abstract：:Glial tumors are the most common tumors of the nervous system, affecting individuals at any age. Since understanding of the molecular pathologies underlying human gliomas is still very poor, the treatment and therefore prognosis of this malignancy could not yet be improved. In order to determine whether different glio...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-003-0279-4
更新日期：2004-01-01 00:00:00
abstract：:The present study aimed to determine the clinical presentation, the multimodal interdisciplinary treatment strategies and outcome of posterior fossa arterio-venous malformations (AVMs) in our neurovascular centre. Fifty-three patients with a posterior fossa AVM were seen between 1998 and 2012 and analysed retrospectiv...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-014-0551-9
更新日期：2014-10-01 00:00:00
abstract：:80-90% of individuals suffering from aneurysmal bone cyst (ABC) are children or adolescents. Primary ABC is a non-neoplastic lesion. Diagnostic assessment and detection of recurrence demands repeated plain x-rays or CT scans. These repeated radiographic examinations expose these young patients to large doses of ionizi...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF00383659
更新日期：1990-01-01 00:00:00
abstract：:Stroke therapy has been revolutionized in the past two decades with the widespread implementation of chemical thrombolysis for acute stroke. However, chemical thrombolysis continues to be limited in its efficacy secondary to relatively short time windows and a high associated risk of hemorrhage. In an attempt to minim...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-010-0294-1
更新日期：2011-01-01 00:00:00
abstract：:Optic pathway glioma (OPG) encompasses a spectrum of findings ranging from lesions confined to the optic nerve only, lesions affecting the optic chiasm and hypothalamus, and lesions with diffuse involvement of a large part of the optic pathway and neighboring structures. The majority of pediatric low-grade astrocytoma...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-016-0747-2
更新日期：2017-01-01 00:00:00
abstract：:Magnesium has neuroprotective and antivasospastic properties in the presence of subarachnoid hemorrhage (SAH). The present study investigated the effect of intracisternal administration of magnesium on cerebral vasospasm in the experimental SAH rat model. The rat double-SAH model (0.2 mL autologous blood injected twic...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-008-0122-z
更新日期：2008-04-01 00:00:00
abstract：:Direct electrical stimulation (DES) of the optic radiation (OR) during an awake tumor resection has been repeatedly reported. In all cases, visual function monitoring was performed in patients with open eyes which were looking at a picture. We report a new modification of the standard method, OR stimulation in patient...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-014-0535-9
更新日期：2014-07-01 00:00:00
abstract：:The aim of this study was to analyze the long-term clinical and radiological outcomes of craniocervical decompression for patients affected by Chiari I-related syringomyelia. We performed a retrospective analysis of a group of patients affected by Chiari I-associated syringomyelia treated by craniocervical decompressi...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-010-0260-y
更新日期：2010-07-01 00:00:00
abstract：:The posteroinferior region of the thalamus is formed by the pulvinar, and it is surgically accessed through the infratentorial supracerebellar approach, between the midline and the retromastoid region. This study aimed to compare the paramedian, lateral, extreme lateral, and contralateral paramedian corridors with the...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-020-01405-0
更新日期：2020-10-24 00:00:00
