Abstract：
:The use of smoked marijuana as a therapeutic agent is presently a matter of considerable debate in the United States. Many people suffering from a variety of disorders maintain that it is necessary for their adequate treatment. Yet, the evidence to support claims is insufficient for FDA approval. An interim solution is proposed which would allow patients referred by their physicians to participate in a 6-month program of legal marijuana availability, similar to the 'compassionate IND' program of a number of years ago. A technique similar to that used for post-marketing surveillance is proposed for obtaining quantitative data for a limited number of potential indications. These are: (1) nausea and vomiting associated with cancer chemotherapy or other causes, (2) weight loss associated with debilitating illnesses, (3) spasticity secondary to neurological diseases, and (4) chronic pain syndromes.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Hollister LEdoi
10.1016/s0376-8716(99)00076-9keywords:
subject
Has Abstractpub_date
2000-02-01 00:00:00pages
3-7issue
1-2eissn
0376-8716issn
1879-0046pii
S0376-8716(99)00076-9journal_volume
58pub_type
杂志文章abstract：BACKGROUND:Legal difficulties and cocaine use are prevalent in methadone maintenance patients, and they are related to one another, as well as to poor response to methadone treatment. Contingency management (CM) is efficacious for decreasing cocaine use, but the relation of CM treatment to criminal activities has rarel...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2017.08.014
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Kratom (Mitragyna speciosa) preparations have been traditionally used in Southeast Asia for its medicinal properties. Lately, Kratom use has spread to Europe and the US, where abuse potential and health hazards increasingly emerge. This study is the first to measure systematically Kratom dependence, withdraw...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2014.03.017
更新日期：2014-06-01 00:00:00
abstract：:Ninety alcoholic patients with the secondary affective disorders (anxiety, depression) were divided into four groups. Patients in the first group received GABAB receptor ligands (baclofen), those in the second group, diazepam, those in the third group, amitriptyline and those in the fourth group, placebo. The results ...
journal_title：Drug and alcohol dependence
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0376-8716(93)90057-w
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND:Many young adults engage in simultaneous alcohol and marijuana (SAM) use so that their effects overlap. Little is known about motivations for dual substance use and associations with use and consequences. This study examined daily-level associations between cross-fading motives and levels of alcohol and mari...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.108077
更新日期：2020-05-24 00:00:00
abstract：BACKGROUND:As part of a randomized controlled trial, problem drinkers who recently initiated natural recovery on their own were offered access to an interactive voice response (IVR) self-monitoring (SM) system as a sobriety maintenance tool during early recovery when relapse risk is high. Because observed IVR utilizati...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2012.04.022
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Gamma-Hydroxybutyric acid (GHB) is a drug of abuse associated with increasing numbers of GHB-dependent patients and emergency attendances often related to GHB-induced coma. Animal studies suggest that GHB induces oxidative stress in the hippocampus, resulting in memory impairments. However, the consequences ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.05.019
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Patients with prescription opioid use disorder commonly report relief of chronic pain as the chief reason for first opioid use; indeed, the prevalence of chronic pain is high in this population. Understanding the association between pain severity and subsequent opioid use is crucial for understanding how to ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2016.04.023
更新日期：2016-06-01 00:00:00
abstract：AIMS:The aims of the present study were to determine the direct effect of DRD2 and DRD4, as well as their interaction with parenting (i.e. rejection, overprotection and emotional warmth), on the development of regular alcohol and cannabis use in 1192 Dutch adolescents from the general population. METHODS:Information w...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2010.10.008
更新日期：2011-05-01 00:00:00
abstract：:The results of chronological and a daily drinking record are compared. The chronological record was completed by interviewers who probed for information on all drinking episodes during the last week. The daily record covered only the last day and was completed by the respondent without interviewer assistance. Because ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(80)90018-6
更新日期：1980-12-01 00:00:00
abstract：RATIONALE:Two previous studies have utilized diffusion tensor imaging (DTI) to examine microstructural integrity in cocaine abuse and found evidence of brain abnormalities in white matter. OBJECTIVE:Using anatomical magnetic resonance imaging (MRI), DTI, and clinical evaluation, the macrostructural and microstructural...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2007.07.019
更新日期：2008-01-01 00:00:00
abstract：INTRODUCTION:Evidence-based treatments for tobacco dependence are significantly less effective for smokers of lower socioeconomic status which contributes to socioeconomic disparities in smoking prevalence rates and health. We aimed to reduce the socioeconomic gradient in treatment outcomes by systematically adapting e...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2017.09.015
更新日期：2017-12-01 00:00:00
abstract：:The drug habits for 78 confirmed opiate addicts were studied on eight scales from the Process Association Test of Addiction (PATA) for many drug names. Through cluster analysis eight stages of addiction were defined: "to be clean", "to learn about drugs", "to hustle", "to chip" (also "to be high"), to be psychological...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(80)90144-1
更新日期：1980-06-01 00:00:00
abstract：BACKGROUND:Health-related quality of life (HRQOL) is a more powerful predictor of health services use and mortality than many objective measures of health. However, in older adults the association between main alcohol drinking patterns and HRQOL is uncertain. METHODS:A prospective cohort with 2163 community-dwelling i...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2015.12.012
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:India has an estimated 177,000 injection drug users (IDU) with a national HIV prevalence of 7.14%. Reliable estimates of HIV incidence are not available for this population. METHODS:We report HIV incidence in a cohort of male, HIV-negative IDUs recruited through peer-referral, targeted outreach and as walk-...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2014.03.021
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:This study investigated the applicability of the Chinese versions of Drug Abuse Screening Test (DAST) to detect illicit substance use in college students. METHODS:The data arising from a campus prevention program, Screening for Illicit Substance Use in College (SISUC), were utilized to explore the psychomet...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.108184
更新日期：2020-10-01 00:00:00
abstract：:The behavioral pharmacology of tandospirone (SM 3997), a novel anxiolytic/antidepressant pyrimidinylpiperazine compound with selective pharmacological effects at the 5-HT1A binding site, was investigated in baboons. Animals administered 50 mg/kg/day i.g. tandospirone, showed few behavioral changes (lip droop, ataxia),...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(93)90084-4
更新日期：1993-05-01 00:00:00
abstract：:Despite extensive evidence that selective dopamine antagonists attenuate the reinforcing effects of stimulants in laboratory animals, there is little evidence that dopamine antagonists block the positive subjective effects of stimulants in humans. However, recent evidence suggests that the subjective effects of stimul...
journal_title：Drug and alcohol dependence
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0376-8716(02)00104-7
更新日期：2002-09-01 00:00:00
abstract：:Two studies examined the abuse potential of the N-methyl-D-aspartate (NMDA) non-competitive antagonist eliprodil [(+/-)-alpha-(4-chlorophenyl)-4-[(fluorophenyl)methyl]-1- piperidineethanol] by evaluating its reinforcing effects in rhesus monkeys and its phencyclidine (PCP)-like discriminative stimulus effects in rats....
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(94)90076-0
更新日期：1994-06-01 00:00:00
abstract：:The availability of increasingly sophisticated drug formulations and delivery devices has created new opportunities in drug development. These newer approaches can result in improved drug bioavailability, or they can alter key pharmacokinetic parameters in such a way as to decrease dosing interval, decrease variabilit...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2005.10.018
更新日期：2006-06-01 00:00:00
abstract：:4-MTA (p-methylthioamphetamine) is a new synthetic sulphur derivative of amphetamine that has been associated with six deaths since it was first identified in Europe in 1997. Sold as 'ecstasy' or 'Flatliners', the drug like MDMA is a potent serotonin releaser. Using a self-nominated sampling methodology we accessed ov...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(02)00018-2
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND:Many studies have investigated how cognitive control may be compromised in cocaine addiction. Here, we extend this literature by employing spatial Independent Component Analysis (ICA) to describe circuit dysfunction in relation to impairment in response inhibition in cocaine addiction. METHODS:Fifty-five co...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.07.037
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Providing needles to people who inject drugs is a well-proven public health response to the transmission of HIV and other blood borne viruses. Despite over a quarter of a century of research, new concerns about potential unintended negative consequences of needle distribution continue to emerge. Specifically...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2014.11.022
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Despite harmful consequences of drug addiction, it is common for individuals with substance use disorders to deny having problems with drugs. Emerging evidence suggests that some drug users lack insight into their behavior due to neurocognitive dysfunction, but little research has examined potential neurocog...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2015.03.004
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVE:The present study examined the dimensionality of DSM-IV Alcohol Use Disorder (AUD) criteria using Item Response Theory (IRT) methods and tested the validity of the proposed DSM-V AUD guidelines in a sample of college students. METHOD:Participants were 396 college students who reported any alcohol use in the ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2011.03.021
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Betel quid is a substance that commonly used among male labor in Taiwan, and the dependence potential has been reported in some studies, but no instrument has been developed specifically to assess areca/betel quid dependence. OBJECTIVE:To develop a reliable and valid research instrument/screening tool for t...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2011.07.027
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Despite the high rates of comorbidity of post-traumatic stress disorder (PTSD) and alcohol dependence (AD) in clinical and epidemiological samples, little is known about the prevalence, clinical presentation, course, risk factors and patterns of treatment-seeking of co-occurring PTSD-AD among the general pop...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.04.016
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Young men who have sex with men (YMSM) continue to be at elevated risk for substance use; however, models explaining this phenomenon have often focused on a limited array of explanatory constructs. This study examined the longitudinal relationship of contextual risk factors, social cognitive processes, menta...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2012.06.007
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Cocaine addiction continues to be a significant healthcare issue, yet there are no FDA approved medications for the treatment of cocaine use disorder within the United States. METHODS:This 12-week, prospective, double-blind, randomized, placebo-controlled study examined the effectiveness of quetiapine (Sero...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2014.12.037
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Social relationships have been demonstrated as a key predictor of relapse among addicted persons and are likely to be important determinants of HIV risk behaviors also. However, the degree to which this population can reliably and consistently identify important people (IPs) in retrospect has been understudi...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2017.03.038
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:In recent decades, smoking has become an increasingly non-normative behavior. Because deviant behaviors are associated with greater clinical and genetic risks, current-generation smokers may have greater concentrations of psychiatric comorbidity than previous generations. We examined this question empiricall...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.08.025
更新日期：2013-12-01 00:00:00
