Baclofen administration for the treatment of affective disorders in alcoholic patients.

abstract：BACKGROUND:In cocaine-dependent individuals, executive function (EF) deficits are associated with poor treatment outcomes. Psychological interventions and pharmacological approaches have produced only modest effect sizes. To date, studies of this topic have been few and limited. The aim of this study was to examine the...

journal_title：Drug and alcohol dependence

authors： Gonçalves PD,Ometto M,Bechara A,Malbergier A,Amaral R,Nicastri S,Martins PA,Beraldo L,dos Santos B,Fuentes D,Andrade AG,Busatto GF,Cunha PJ

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The DSM specifies categorical criteria for psychiatric disorders. In contrast, a dimensional approach considers variability in symptom severity and can significantly improve statistical power. The current study tested whether a categorical, DSM-defined diagnosis of Alcohol Dependence (AD) was a better fit th...

journal_title：Drug and alcohol dependence

authors： Fazzino TL,Rose GL,Burt KB,Helzer JE

更新日期：2014-03-01 00:00:00

abstract：:While current psychiatric taxonomies recognise a classification of amphetamine dependence, derived from the notion of an alcohol dependence syndrome, little research has validated that such a condition exists for this drug. Current amphetamine users (N = 331), were interviewed using the World Health Organization opera...

journal_title：Drug and alcohol dependence

authors： Topp L,Darke S

更新日期：1997-11-25 00:00:00

abstract：BACKGROUND:This study seeks to identify changes in perceived barriers to alcohol treatment and predictors of treatment use between 1991-92 and 2001-02, to potentially help understand reported reductions in treatment use at this time. Social, economic, and health trends during these 10 years provide a context for the st...

journal_title：Drug and alcohol dependence

authors： Chartier KG,Miller K,Harris TR,Caetano R

更新日期：2016-03-01 00:00:00

abstract：:This study examined the predictors of self-reported health status at follow-up in the Drug Abuse Treatment Outcomes Study (DATOS), a longitudinal study of drug abuse treatment programs and patients in 1991-1993. Baseline and follow-up interviews of 2966 patients in 75 programs were performed. The follow-up assessment ...

journal_title：Drug and alcohol dependence

authors： Friedmann PD,Lemon SC,Anderson BJ,Stein MD,Drug Abuse Treatment Outcome Study (DATOS.

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:To improve measures of monthly tobacco cigarette smoking among non-daily smokers, predictive of future non-daily monthly and daily smoking. METHODS:Data from United States National Longitudinal Study of Adolescent to Adult Health, tracking adolescents, ages 12-21, over 14 years were analyzed. At baseline, 6...

journal_title：Drug and alcohol dependence

authors： Saddleson ML,Kozlowski LT,Giovino GA,Homish GG,Mahoney MC,Goniewicz ML

更新日期：2016-05-01 00:00:00

abstract：:Ethanol stimulates the spontaneous transmitter release from motor nerve endings, as shown by the increase of miniature end plate potential (m.e.p.p.) frequency at the neuro-muscular junction. The stimulation of acetylcholine spontaneous quantal release by ethanol is greater in regenerating than in mature nerve endings...

journal_title：Drug and alcohol dependence

authors： Bruno C,Cuppini R,Cuppini C

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Few studies of the natural history of DSM-IV inhalant substance use disorders (I-SUDs) have been conducted. This investigation examined the prevalence, timing, and predictors of transitions from inhalant use to formal I-SUDs among inhalant users within a nationally representative sample. METHODS:Participant...

journal_title：Drug and alcohol dependence

authors： Perron BE,Howard MO,Maitra S,Vaughn MG

更新日期：2009-03-01 00:00:00

abstract：:To characterize prescription opioid dependent patients in a methadone maintenance treatment (MMT) program, a detailed retrospective chart review of new admissions (1997-1999, n=178, mean age=34.5+/-0.7 years, 65% male) was conducted. At admission most patients (83%) had been using prescription opioids (+/-heroin). Fou...

journal_title：Drug and alcohol dependence

authors： Brands B,Blake J,Sproule B,Gourlay D,Busto U

更新日期：2004-02-07 00:00:00

abstract：:In this paper, we examine the effects of age at first substance use, and history of psychiatric disorders, on the development of substance use disorder (SUD) by age 16. We use a prospective, longitudinal design to disaggregate the effects of age at first use and time since first use on the development of adolescent SU...

journal_title：Drug and alcohol dependence

authors： Sung M,Erkanli A,Angold A,Costello EJ

更新日期：2004-09-06 00:00:00

abstract：:The effects of morphine on extracellular dopamine levels in brain have never been studied over a wide range of doses within a single study. This has made it difficult to make definitive interpretations of drug interactions with morphine. An inhibition of morphine-induced increases in dopamine could be interpreted as e...

journal_title：Drug and alcohol dependence

authors： Maisonneuve IM,Warner LM,Glick SD

更新日期：2001-12-01 00:00:00

abstract：AIMS:This study aimed at examining a possible association between cannabis use in adolescence and future disability pension (DP). DP can be granted to any person in Sweden aged 16-65 years if working capacity is judged to be permanently reduced due to long-standing illness or injury. METHODS:Data were obtained from a ...

journal_title：Drug and alcohol dependence

authors： Danielsson AK,Agardh E,Hemmingsson T,Allebeck P,Falkstedt D

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:This study assessed whether the Nationwide Emergency Department Sample (NEDS) could reliably fill the national drug surveillance gap caused by the discontinuation of the Drug Abuse Warning Network (DAWN). METHODS:Estimates of the drug-related emergency department (ED) visits derived from DAWN (2004-2011) an...

journal_title：Drug and alcohol dependence

authors： Sevigny EL,Caces MF

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Stress is thought to contribute to both initiation and relapse to drug abuse. However, the mechanisms by which stress influences drug use are unclear. Interestingly, responses to acute administration of stimulant drugs resemble certain neuronal and hormonal responses to acute stress, and there is accumulatin...

journal_title：Drug and alcohol dependence

authors： Hamidovic A,Childs E,Conrad M,King A,de Wit H

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Approximately 700,000 Social Security beneficiaries in the U.S. with psychiatric disabilities have been assigned a representative payee to manage their funds but it is unclear how those judged to need a payee differ from others and whether payee assignment improves clinical outcomes, especially substance abu...

journal_title：Drug and alcohol dependence

authors： Rosen MI,McMahon TJ,Rosenheck R

更新日期：2007-01-12 00:00:00

abstract：INTRODUCTION:Evidence-based treatments for tobacco dependence are significantly less effective for smokers of lower socioeconomic status which contributes to socioeconomic disparities in smoking prevalence rates and health. We aimed to reduce the socioeconomic gradient in treatment outcomes by systematically adapting e...

journal_title：Drug and alcohol dependence

authors： Sheffer CE,Bickel WK,Franck CT,Panissidi L,Pittman JC,Stayna H,Evans S

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Mental health diagnoses (MHD) are common among those with opioid use disorders (OUD). Methadone/buprenorphine are effective medication-assisted treatment (MAT) strategies; however, treatment receipt is low among those with dual MHDs. Medicaid expansions have broadly increased access to OUD and mental health ...

journal_title：Drug and alcohol dependence

authors： Pro G,Utter J,Haberstroh S,Baldwin JA

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Although drug use is common in the population, drug users are sometimes excluded from research without justification. Two models of individualized study matching were compared for effectiveness in enrolling people who "endorsed current drug use" and those who "did not" into appropriate research. METHODS:Par...

journal_title：Drug and alcohol dependence

authors： Cottler LB,Striley CW,Elliott AL,Zulich AE,Kwiatkowski E,Nelson DR

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:To provide information on the clinical relevance of a reduction in the World Health Organization (WHO) drinking risk categories, we examined their relationship to an important indicator of how individuals feel and function: drug use disorders (DUDs), i.e., those involving substances other than alcohol. METH...

journal_title：Drug and alcohol dependence

authors： Knox J,Wall M,Witkiewitz K,Kranzler HR,Falk DE,Litten R,Mann K,O'Malley SS,Scodes J,Anton R,Hasin DS,Alcohol Clinical Trials (ACTIVE) Workgroup.

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Many Pacific Island countries are in social and epidemiological transition, but there are little population data about drug and alcohol usage among adolescents in this region. METHODS:Random samples of school students aged 11-17 years completed surveys in three populations: Pohnpei State in the Federated St...

journal_title：Drug and alcohol dependence

authors： Smith BJ,Phongsavan P,Bauman AE,Havea D,Chey T

更新日期：2007-04-17 00:00:00

abstract：:This paper examines official published statistics for various causes of death in the United Kingdom between 1970 and 1985. The variables selected were mainly those that had been linked to alcohol or cigarette use. In particular, changes in mortality due to acute myocardial infarction, cancer of trachea, bronchus and l...

journal_title：Drug and alcohol dependence

authors： Sales J,Duffy J,Plant M,Peck D

更新日期：1989-10-01 00:00:00

abstract：OBJECTIVES:To determine HIV prevalence and potential associations with sociodemographic and behavioral factors among injection drug users (IDUs) in Tashkent, Uzbekistan. METHODS:Subjects in this cross-sectional study provided sociodemographic and risk behavior data and were tested for HIV antibody with a saliva-based ...

journal_title：Drug and alcohol dependence

authors： Sanchez JL,Todd CS,Bautista CT,Botros BA,Khakimov MM,Giyasova GM,Yakubov SK,Abdulaeva MA,Saad MD,Graham RR,Carr JK,Earhart KC

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Previous studies have examined associations between alcohol use in pregnancy and offspring birth size but evidence on whether associations persist during childhood is limited. METHODS:We examined the association between maternal drinking during pregnancy and trajectories of offspring weight and height from ...

journal_title：Drug and alcohol dependence

authors： O'Keeffe LM,Kearney PM,Greene RA,Zuccolo L,Tilling K,Lawlor DA,Howe LD

更新日期：2015-08-01 00:00:00

abstract：:The sensitivity and specificity of several screening instruments including the CAGE, brief MAST, AUDIT, TWEAK, RAPS, and Trauma Scale, were evaluated against both ICD-10 and DSM-IV criteria for alcohol dependence and for harmful drinking and abuse in a probability sample of 586 Hispanic emergency department patients. ...

journal_title：Drug and alcohol dependence

authors： Cherpitel CJ

更新日期：1999-01-07 00:00:00

abstract：:Self-reports of drug use frequency are central to treatment outcome evaluations, estimates of the prevalence of heavy use, estimates of treatment need, and other questions with direct relevance to drug policies. Nevertheless, surprisingly little is known about the validity of these self-reports. This study examines th...

journal_title：Drug and alcohol dependence

authors： Morral AR,McCaffrey D,Iguchi MY

更新日期：2000-01-01 00:00:00

abstract：:Little research is available on brief screening instruments for identify those meeting diagnostic criteria for drug dependence or abuse. A brief, four-item screening instrument, called the rapid drug problems screen (RDPS), was developed from a similar instrument for alcohol use disorders, the rapid alcohol problems s...

journal_title：Drug and alcohol dependence

authors： Cherpitel CJ,Borges G

更新日期：2004-05-10 00:00:00

abstract：:The oral administration of single doses (0.5-6.0 g/kg) of ethanol to rats, shortly before injecting them with a large dose (3.0 mg base/kg) of epinephrine subcutaneously, significantly reduced the severity of the myocardial damage produced by the epinephrine. The larger the dose of ethanol, the greater was the protect...

journal_title：Drug and alcohol dependence

authors： Mallov S,Gilmour RF

更新日期：1977-09-01 00:00:00

abstract：:A series of beta-carbolines were prepared and their affinities for imidazoline (I(1) and I(2)) sites evaluated. Selected compounds were also examined at alpha(2)-adrenoceptors. Some of the beta-carbolines were found to bind with high affinity to I(2)-sites and this affinity was dependent on both the planarity of the m...

journal_title：Drug and alcohol dependence

authors： Husbands SM,Glennon RA,Gorgerat S,Gough R,Tyacke R,Crosby J,Nutt DJ,Lewis JW,Hudson AL

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Metabolomics allows the high-throughput analysis of low molecular mass compounds in biofluids, which can reflect the metabolic response of the body to heroin exposure and potentially reveal biomarkers of heroin abuse. METHODS:Heroin was administered to Sprague-Dawley rats in increasing doses from 3 to 16.5 ...

journal_title：Drug and alcohol dependence

authors： Zheng T,Liu L,Aa J,Wang G,Cao B,Li M,Shi J,Wang X,Zhao C,Gu R,Zhou J,Xiao W,Yu X,Sun R,Zhou Y,Zuo Y,Zhu X

更新日期：2013-01-01 00:00:00

abstract：:Despite the fact that tobacco and marihuana are often used together, relatively little is known about the effects of this combination. In order to investigate the effects of the principal psychoactive component in tobacco smoke, nicotine, on marihuana-induced intoxication, we conducted a double blind, cross-over exper...

journal_title：Drug and alcohol dependence

authors： Penetar DM,Kouri EM,Gross MM,McCarthy EM,Rhee CK,Peters EN,Lukas SE

更新日期：2005-08-01 00:00:00