Ceramide-induced apoptosis in fas-resistant Hodgkin's disease cell lines is caspase independent.

abstract：:In this study we demonstrated that neural rosettes derived from human ES cells can give rise either to neural crest precursors, following expansion in presence of bFGF and EGF, or to dopaminergic precursors after exposure to ventralizing factors Shh and FGF8. Both regionalised precursors are capable of extensive proli...

journal_title：Experimental cell research

authors： Colleoni S,Galli C,Giannelli SG,Armentero MT,Blandini F,Broccoli V,Lazzari G

更新日期：2010-04-15 00:00:00

abstract：:The expression of human cellular fibronectin (HFN) was analyzed in relation to the differentiation process of the human enterocyte-like cell line Caco-2. A single approximately 290-kDa form of HFN, corresponding to a 10.0-kb mRNA species, was observed in Caco-2 cells. The expression levels of both protein and mRNA wer...

journal_title：Experimental cell research

authors： Vachon PH,Simoneau A,Herring-Gillam FE,Beaulieu JF

更新日期：1995-01-01 00:00:00

abstract：:Malignant melanoma (MM) remains the leading cause of skin cancer related death, which has very poor prognosis because of locoregional recurrence and distant metastasis. DEPDC1B (DEP domain-containing protein 1B), has been proved to be associated with some types of malignant tumors. However, the role of DEPDC1B in MM i...

journal_title：Experimental cell research

authors： Xu Y,Sun W,Zheng B,Liu X,Luo Z,Kong Y,Xu M,Chen Y

更新日期：2019-06-01 00:00:00

abstract：:Mechanisms involved in establishing the organization and numbers of fibres in a muscle are not completely understood. During Drosophila indirect flight muscle (IFM) formation, muscle growth is achieved by both incorporating hundreds of nuclei, and hypertrophy. As a result, IFMs provide a good model with which to under...

journal_title：Experimental cell research

authors： Rai M,Nongthomba U

更新日期：2013-10-15 00:00:00

abstract：:Phosphorylation of types III and IV intermediate filaments (IFs) is known to regulate their organization and function. Phosphorylation of the amino-terminal head domain sites on types III and IV IF proteins plays a key role in the assembly/disassembly of IF subunits into 10 nm filaments, and influences the phosphoryla...

journal_title：Experimental cell research

authors： Sihag RK,Inagaki M,Yamaguchi T,Shea TB,Pant HC

更新日期：2007-06-10 00:00:00

abstract：:Resistance of cancer cells to apoptosis is dependent on a balance of multiple genetic and epigenetic mechanisms, which up-regulate efficacy of the surviving growth factor-receptor signaling pathways and suppress death-receptor signaling pathways. The Insulin-like Growth Factor-1 Receptor (IGF-1R) signaling pathway is ...

journal_title：Experimental cell research

authors： Karasic TB,Hei TK,Ivanov VN

更新日期：2010-07-15 00:00:00

abstract：:Mip130/LIN-9 is part of a large complex that includes homologs of the Drosophila dREAM (drosophila RB-like, E2F, and Myb) and C. elegans DRM complexes. This complex also includes proteins such as Mip40/LIN-37, Mip120/LIN-54, and LIN-52. In mammalian cells, Mip130/LIN-9 specifically associates with the p107/p130-E2F4 r...

journal_title：Experimental cell research

authors： Sandoval R,Pilkinton M,Colamonici OR

更新日期：2009-10-15 00:00:00

abstract：:Senescent human diploid fibroblasts, TIG-1, had labelling indices of about 0.5-3% when labelled with [3H]thymidine for 3 days in fresh medium containing 10% fetal bovine serum. When these cells were infected with SV40, the percentage of nuclei incorporating [3H]thymidine increased by about 10-fold. The frequency of T-...

journal_title：Experimental cell research

authors： Tsuji Y,Ide T,Ishibashi S

更新日期：1983-03-01 00:00:00

abstract：:The tumor suppressor protein p16INK4a (inhibitor of CDK4) is one of the most direct links between cell-cycle control and cancer. The p16INK4a gene is frequently inactivated in human tumors, and inheritance of mutant alleles results in susceptibility to several types of cancer. p16INK4a is part of a cell-cycle regulato...

journal_title：Experimental cell research

authors： Serrano M

更新日期：1997-11-25 00:00:00

abstract：:Culture and UV (254 nm) irradiation conditions that are suggested as appropriate for a study of the effect of UV on the limited in vitro lifespan of a normal human diploid fibroblast (HDF) strain are first described. An inoculation density at each subcultivation of 1.8 x 10(4) viable cells/cm-2 permits the decline in ...

journal_title：Experimental cell research

authors： Kantor GJ,Mulkie JR,Hull DR

更新日期：1978-05-01 00:00:00

abstract：:Analyses of mice with targeted deletions in the genes for alpha3 and beta1 integrin suggest that the alpha3beta1 integrin heterodimer likely determines the organization of the extracellular matrix within the basement membrane of skin. Here we tested this hypothesis using keratinocytes derived from alpha3 integrin-null...

journal_title：Experimental cell research

authors： deHart GW,Healy KE,Jones JC

更新日期：2003-02-01 00:00:00

abstract：:Metastatic progression is a major cause of mortality in cervical cancers, but factors regulating migratory and pre-metastatic cell populations remain poorly understood. Here, we sought to assess whether a SUV39H1-low chromatin state promotes migratory cell populations in cervical cancers, using meta-analysis of data f...

journal_title：Experimental cell research

authors： Rodrigues C,Pattabiraman C,Vijaykumar A,Arora R,Narayana SM,Kumar RV,Notani D,Varga-Weisz P,Krishna S

更新日期：2019-05-15 00:00:00

abstract：:UNC5H receptors (UNC5H1, UNC5H2, UNC5H3) are putative tumor suppressors whose expression is lost in numerous cancers. These receptors have been shown to belong to the so-called family of dependence receptors. Such receptors induce apoptosis when their ligand netrin-1 is absent, thus conferring a state of cellular depe...

journal_title：Experimental cell research

authors： Maisse C,Rossin A,Cahuzac N,Paradisi A,Klein C,Haillot ML,Hérincs Z,Mehlen P,Hueber AO

更新日期：2008-08-15 00:00:00

abstract：:Rat peritoneal mast cells (RPMC) and rat basophilic leukemia (RBL) cells are representative of connective tissue-type (CTMC) and mucosal-type (MMC) mast cells, respectively. Using polyethylene glycol, we have fused RPMC with 6-thioguanine resistant, HAT (hypoxanthine, aminopterin, thymidine) sensitive RBL-CA10.7 or RB...

journal_title：Experimental cell research

authors： Zheng YL,Chan BM,Rector ES,Berczi I,Froese A

更新日期：1991-06-01 00:00:00

abstract：:The importance of mononuclear leukocyte (MO) adhesion to dysfunctional endothelium and migration to the subendothelial space in the early phases of atherogenesis is well established. Few studies have addressed the relevance of polymorphonuclear leukocytes (PMNs) in the context of evolving lesions, and nothing is known...

journal_title：Experimental cell research

authors： Donetti E,Baetta R,Comparato C,Altana C,Sartore S,Paoletti R,Castano P,Gabbiani G,Corsini A

更新日期：2002-04-01 00:00:00

abstract：:This study was designed to elucidate the mechanisms involved in elevated cell death arising from an altered endogenous oxidant state. Increased levels of cell death were detected in cells lacking Gpx1 following the addition of exogenous H2O2. This increased apoptosis correlated with a down-regulation in the activation...

journal_title：Experimental cell research

authors： Taylor JM,Crack PJ,Gould JA,Ali U,Hertzog PJ,Iannello RC

更新日期：2004-11-01 00:00:00

abstract：:There are a number of low-abundance small nuclear RNAs (snRNAs) in eukaryotic cells. Many of them have been assigned functions in the biogenesis of cellular RNAs, such as splicing and 3' end processing. Here, we present the sequence of Xenopus U12 snRNA and compare the secondary structures of the low-abundance U11 and...

journal_title：Experimental cell research

authors： Yu YT,Tarn WY,Yario TA,Steitz JA

更新日期：1996-12-15 00:00:00

abstract：:RalGPS2 is a Ras-independent Guanine Nucleotide Exchange Factor (GEF) for RalA containing a PH domain and an SH3-binding region and it is involved in several cellular processes, such as cytokinesis, control of cell cycle progression, differentiation, cytoskeleton organization and rearrangement. Up to now, few data hav...

journal_title：Experimental cell research

authors： D'Aloia A,Berruti G,Costa B,Schiller C,Ambrosini R,Pastori V,Martegani E,Ceriani M

更新日期：2018-01-15 00:00:00

abstract：:Cholesterol and related compounds can give rise to oxygenated sterol molecules (oxysterols) which are potent regulators of lymphoid cell growth. Oxysterols added exogenously cause cell death of several lines of cultured cells, and on the basis of limited criteria, it has been suggested that this death is apoptosis. In...

journal_title：Experimental cell research

authors： Ayala-Torres S,Moller PC,Johnson BH,Thompson EB

更新日期：1997-08-25 00:00:00

abstract：:Rat IPC-81 promyelocytic leukemia cells responded to cAMP analog by undergoing apoptotic cell death both when anchored to fibronectin and when free in the medium. The protein kinase C stimulator 12-O-tetradecanoylphorbol 13-acetate enhanced the anchoring to substratum without impeding cAMP-induced cell death. The immo...

journal_title：Experimental cell research

authors： Vintermyr OK,Gjertsen BT,Lanotte M,Døskeland SO

更新日期：1993-05-01 00:00:00

abstract：:A monoclonal antibody Pr-28 was prepared, which recognized an antigen present only in proliferating cells. Immunofluorescence analysis of Pr-28 antigen showed that the antigen was localized mainly in perinuclear cytoplasm. Although Pr-28 antibody was produced against a chicken cell antigen, it reacts not only with chi...

journal_title：Experimental cell research

authors： Matsuhashi S,Watanabe T,Hori K

更新日期：1987-06-01 00:00:00

abstract：:The giant protein hFat1, a member of the cadherin superfamily, has been proposed to play roles in cerebral development, glomerular slit formation, and also to act as a tumor suppressor, but its mechanisms of action have not been elucidated. To examine functions of the transmembrane and cytoplasmic domains, they were e...

journal_title：Experimental cell research

authors： Magg T,Schreiner D,Solis GP,Bade EG,Hofer HW

更新日期：2005-07-01 00:00:00

abstract：:UDP-glucose dehydrogenase (UGDH) catalyzes oxidation of UDP-glucose to yield UDP-glucuronic acid, a precursor of hyaluronic acid (HA) and other glycosaminoglycans (GAGs) in extracellular matrix. Although association of extracellular matrix with cell proliferation and migration has been well documented, the importance ...

journal_title：Experimental cell research

authors： Wang TP,Pan YR,Fu CY,Chang HY

更新日期：2010-10-15 00:00:00

abstract：OBJECTIVES:Our purpose was to investigate the role of the nitric oxide (NO) signaling pathway in the regulation of ciliary beat frequency (CBF) in mouse nasal and tracheal epithelial cells. METHODS:We studied the effects of the NO donor l-arginine (L-Arg) and specific inhibitors of the NO signaling pathway on CBF of b...

journal_title：Experimental cell research

authors： Jiao J,Wang H,Lou W,Jin S,Fan E,Li Y,Han D,Zhang L

更新日期：2011-10-15 00:00:00

abstract：:Recent studies have provided evidence that apoptosis of pancreatic beta-cells is important in the early etiology of both type I and type II diabetes mellitus. The mechanisms responsible for induction of apoptosis are unknown, but we present evidence that the signal transduction pathway controlling the process in pancr...

journal_title：Experimental cell research

authors： Loweth AC,Williams GT,Scarpello JH,Morgan NG

更新日期：1996-11-25 00:00:00

abstract：:HALF1 (human activator of liver function 1) is a closed DNA duplex implicated in reversion of rat dedifferentiated C2 hepatoma cells to a well-differentiated state. A copy of HALF1 is found in high-molecular-weight DNA in the human genome. The genomic equivalent of HALF1 and its flanking sequences [gH(5'-3') fragment]...

journal_title：Experimental cell research

authors： Boccaccio C,Meunier-Rotival M,Deschatrette J

更新日期：1994-07-01 00:00:00

abstract：:ADAMs (a disintegrin and metalloprotease) comprise a family of cell surface proteins with protease and cell-binding activities. Using different forms and fragments of ADAM12 as substrates in cell adhesion and spreading assays, we demonstrated that alpha9beta1 integrin is the main receptor for ADAM12. However, when alp...

journal_title：Experimental cell research

authors： Thodeti CK,Fröhlich C,Nielsen CK,Holck P,Sundberg C,Kveiborg M,Mahalingam Y,Albrechtsen R,Couchman JR,Wewer UM

更新日期：2005-10-01 00:00:00

abstract：:Differentiation of endoderm into intestinal epithelium is initiated at E13.5 of mouse development when there are significant changes in morphology resulting in the conversion of undifferentiated stratified epithelium into a mature epithelial monolayer. Here we demonstrate that monolayer formation is associated with th...

journal_title：Experimental cell research

authors： Abud HE,Watson N,Heath JK

更新日期：2005-02-15 00:00:00

abstract：:KRIT1 is a disease gene responsible for Cerebral Cavernous Malformations (CCM). It encodes for a protein containing distinct protein-protein interaction domains, including three NPXY/F motifs and a FERM domain. Previously, we isolated KRIT1B, an isoform characterized by the alternative splicing of the 15th coding exon...

journal_title：Experimental cell research

authors： Francalanci F,Avolio M,De Luca E,Longo D,Menchise V,Guazzi P,Sgrò F,Marino M,Goitre L,Balzac F,Trabalzini L,Retta SF

更新日期：2009-01-15 00:00:00

abstract：:Prenucleolar bodies (PNBs) are transitory structures which serve as building blocks for nucleoli at the transition mitosis/interphase. The assembly of PNBs and their pathway are not clearly understood. To better understand these events, the behavior of the PNB-containing PM-Scl 100 protein was compared with that of ot...

journal_title：Experimental cell research

authors： Fomproix N,Hernandez-Verdun D

更新日期：1999-09-15 00:00:00