Signal recognition particle components in the nucleolus.

abstract：:Transforming growth factor beta (TGF-beta)-mediated G(1) arrest previously has been shown to specifically target inactivation of cyclin D:cyclin-dependent kinase (Cdk) 4/6 complexes. We report here that TGF-beta-treated human HepG2 hepatocellular carcinoma cells arrest in G(1), but retain continued cyclin D:Cdk4/6 act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagahara H,Ezhevsky SA,Vocero-Akbani AM,Kaldis P,Solomon MJ,Dowdy SF

更新日期：1999-12-21 00:00:00

abstract：:Inbred Lewis (LEW/N) female rats develop an arthritis in response to group A streptococcal cell wall peptidoglycan polysaccharide (SCW), which mimics human rheumatoid arthritis. Histocompatible Fischer (F344/N) rats do not develop arthritis in response to the same SCW stimulus. To evaluate this difference in inflammat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sternberg EM,Hill JM,Chrousos GP,Kamilaris T,Listwak SJ,Gold PW,Wilder RL

更新日期：1989-04-01 00:00:00

abstract：:The importance of alternative splicing in regulating apoptosis has been suggested by findings of functionally antagonistic proteins generated by alternative splicing of several genes involved in apoptosis. Among these, Ich-1 (also named as caspase-2) encodes a member of the caspase family of proteases. Two forms of Ic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang ZH,Zhang WJ,Rao Y,Wu JY

更新日期：1998-08-04 00:00:00

abstract：:The content of elongation factor Tu in E. coli B has been determined both by radioimmune assay and by GDP binding. The two assays gave comparable results: cells growing at 2 doublings per hour contained about 8 molecules of Tu per ribosome, whereas those growing at 0.22 doublings per hour contained about 14 molecules ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furano AV

更新日期：1975-12-01 00:00:00

abstract：:Crystals of magnetite (Fe(3)O(4)) and periclase (MgO) in Fe-Mg-Ca carbonate in the Martian meteorite Allan Hills 84001 were studied by using transmission electron microscopy to understand their origin and evaluate claims that the magnetites were made by Martian microorganisms. In magnesian carbonate, periclase occurs ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barber DJ,Scott ER

更新日期：2002-05-14 00:00:00

abstract：:A complete description of protein metabolism requires knowledge of the rates of protein production and destruction within cells. Using an epitope-tagged strain collection, we measured the half-life of >3,750 proteins in the yeast proteome after inhibition of translation. By integrating our data with previous measureme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belle A,Tanay A,Bitincka L,Shamir R,O'Shea EK

更新日期：2006-08-29 00:00:00

abstract：:The voltage-dependent gating of the colicin channel involves a substantial structural rearrangement that results in the transfer of about 35% of the 200 residues in its pore-forming domain across the membrane. This transfer appears to represent an unusual type of protein translocation that does not depend on a large, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slatin SL,Nardi A,Jakes KS,Baty D,Duché D

更新日期：2002-02-05 00:00:00

abstract：:The radial distributions of the Calpha and side-chain atoms in a sample of 13 native proteins have been examined. It is found that there are substantial differences in behavior between different atoms of the same amino acid. In particular, the Calpha atoms of polar residues show no particular preference for being far ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rackovsky S,Scheraga HA

更新日期：1977-12-01 00:00:00

abstract：:Ducks and wild waterfowl perpetuate all strains of influenza viruses in nature. In their natural host, influenza viruses typically cause asymptomatic infection and little pathology. Ducks are often resistant to influenza viruses capable of killing chickens. Here, we show that the influenza virus sensor, RIG-I, is pres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barber MR,Aldridge JR Jr,Webster RG,Magor KE

更新日期：2010-03-30 00:00:00

abstract：:For a distribution F on R(p) and a point x in R(p) the simplicial depth D(x), which is the probability that x be inside a random simplex whose vertices are p + 1 independent observations from F, is introduced. D(x) can be viewed as a measure of depth of the point x relative to F, and its empirical version gives rise t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu RY

更新日期：1988-03-01 00:00:00

abstract：:The Snf1 protein kinase family has been conserved in eukaryotes. In the yeast Saccharomyces cerevisiae, Snf1 is essential for transcription of glucose-repressed genes in response to glucose starvation. The direct interaction between Snf1 and its activating subunit, Snf4, within the kinase complex is regulated by the g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ludin K,Jiang R,Carlson M

更新日期：1998-05-26 00:00:00

abstract：:A central tenet of evolutionary social science holds that behaviors, such as those associated with social dominance, produce fitness effects that are subject to cultural selection. However, evidence for such selection is inconclusive because it is based on short-term statistical associations between behavior and ferti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lansing JS,Watkins JC,Hallmark B,Cox MP,Karafet TM,Sudoyo H,Hammer MF

更新日期：2008-08-19 00:00:00

abstract：:We have studied androgen binding characteristics of cells for androgen insensitivity from an obligate heterozygote, who is the mother of three male pseudohermaphrodites with dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one) receptor deficiency. Specific dihydrotestosterone binding by skin fibroblasts from he...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer WJ 3rd,Migeon BR,Migeon CJ

更新日期：1975-04-01 00:00:00

abstract：:Hydrocarbon films confined between smooth mica surfaces have long provided an experimental playground for model studies of structure and dynamics of confined liquids. However, fundamental questions regarding the phase behavior and shear properties in this simple system remain unsolved. With ultrasensitive resolution i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith AM,Hallett JE,Perkin S

更新日期：2019-12-17 00:00:00

abstract：:The impact of ligand binding on nuclear receptor (NR) structure and the ability of target cells to distinguish between different receptor-ligand complexes are key determinants of the pharmacological activity of NR ligands. However, until relatively recently, these mechanistic insights have not been used in a prospecti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joseph JD,Wittmann BM,Dwyer MA,Cui H,Dye DA,McDonnell DP,Norris JD

更新日期：2009-07-21 00:00:00

abstract：:In this paper we extend the well-known Vitali-Hahn-Saks and Nikodým theorems for measures to finitely additive vector-valued set functions. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brooks JK,Jewett RS

更新日期：1970-11-01 00:00:00

abstract：:The heroin analogue 1-methyl-4-phenylpyridinium, MPP(+), both in vitro and in vivo, produces death of dopaminergic substantia nigral cells by inhibiting the mitochondrial NADH dehydrogenase multienzyme complex, producing a syndrome indistinguishable from Parkinson's disease. Similarly, a fragment of amyloid protein, A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kashiwaya Y,Takeshima T,Mori N,Nakashima K,Clarke K,Veech RL

更新日期：2000-05-09 00:00:00

abstract：:The best-studied cytoskeletal system is the inner surface of the erythrocyte membrane, which provides an erythrocyte with the structural support needed to be stable yet flexible as it passes through the circulation. Current structural models predict that the spectrin-actin-based cytoskeletal network is attached to the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stefanovic M,Markham NO,Parry EM,Garrett-Beal LJ,Cline AP,Gallagher PG,Low PS,Bodine DM

更新日期：2007-08-28 00:00:00

abstract：:Two adjacent, divergently transcribed, developmentally regulated genes of the maize chloroplast chromosome have different superhelical density/transcriptional activation profiles when transcribed in vitro by the homologous DNA-dependent RNA polymerase. Promoter-specific transcription of the gene for the beta and epsil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stirdivant SM,Crossland LD,Bogorad L

更新日期：1985-08-01 00:00:00

abstract：:Frame-shift mutations at microsatellites occur as a time-dependent function of polymerase errors followed by failure of postreplicational mismatch repair. A cell-culture system was developed that allows identification of intermediate mutant cells that carry the mutation on a single DNA strand after the initial DNA pol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gasche C,Chang CL,Natarajan L,Goel A,Rhees J,Young DJ,Arnold CN,Boland CR

更新日期：2003-02-18 00:00:00

abstract：:Recognition of a particular individual occurs when we reactivate links between current perceptual inputs and the previously formed representation of that person. This recognition can be achieved by identifying, separately or simultaneously, distinct elements such as the face, silhouette, or voice as belonging to one i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sliwa J,Duhamel JR,Pascalis O,Wirth S

更新日期：2011-01-25 00:00:00

abstract：:Converging TGF-beta and insulin-like neuroendocrine signaling pathways regulate whether Caenorhabditis elegans develops reproductively or arrests at the dauer larval stage. We examined whether neurotransmitters act in the dauer entry or recovery pathways. Muscarinic agonists promote recovery from dauer arrest induced ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tissenbaum HA,Hawdon J,Perregaux M,Hotez P,Guarente L,Ruvkun G

更新日期：2000-01-04 00:00:00

abstract：:The structures of both oxidized (HP(ox)) and reduced (HP(red)) high-potential iron protein and of oxidized ferredoxin (Fd(ox)) have been partially refined at 2.0-A resolution by methods similar to those applied to the protein rubredoxin [Watenpaugh, K. D., Sieker, L. C., Herriott, J. R. & Jensen, L. H. (1971) Cold Spr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carter CW Jr,Kraut J,Freer ST,Alden RA,Sieker LC,Adman E,Jensen LH

更新日期：1972-12-01 00:00:00

abstract：:Critical to the maintenance of circadian rhythmicity is the cyclic expression of at least some components of the central oscillator. High-amplitude cycling of mRNA and protein abundance, protein phosphorylation and nuclear/cytoplasmic shuttling have all been implicated in the maintenance of circadian period. Here we u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim WY,Geng R,Somers DE

更新日期：2003-04-15 00:00:00

abstract：:An intense (up to 20 muA/cm(2)) steady electrical current enters the anterior or nurse cell end of the growing follicle (or oocyte-nurse cell complex) of the Cecropia moth and is balanced by a more diffuse current leaving elsewhere. In late growth stages, the total transfollicular current is about 100 nA. Moreover, a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaffe LF,Woodruff RI

更新日期：1979-03-01 00:00:00

abstract：:Eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the recently identified human Dcp2 decapping enzyme cleaves the cap of dead...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Dijk E,Le Hir H,Séraphin B

更新日期：2003-10-14 00:00:00

abstract：:Brain function depends on adaptive self-organization of large-scale neural assemblies, but little is known about quantitative network parameters governing these processes in humans. Here, we describe the topology and synchronizability of frequency-specific brain functional networks using wavelet decomposition of magne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bassett DS,Meyer-Lindenberg A,Achard S,Duke T,Bullmore E

更新日期：2006-12-19 00:00:00

abstract：:Pore-forming toxins (PFTs) are a class of proteins implicated in a wide range of virulent bacterial infections and diseases. These toxins bind to target membranes and subsequently oligomerize to form functional pores that eventually lead to cell lysis. While the protein undergoes large conformational changes on the bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ponmalar II,Cheerla R,Ayappa KG,Basu JK

更新日期：2019-06-25 00:00:00

abstract：:The fdhF gene encoding the 80-kDa selenopolypeptide subunit of formate dehydrogenase H from Escherichia coli contains an in-frame TGA codon at amino acid position 140, which encodes selenocysteine. We have analyzed how this UGA "sense codon" is discriminated from a UGA codon signaling polypeptide chain termination. De...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zinoni F,Heider J,Böck A

更新日期：1990-06-01 00:00:00

abstract：:The mitotic (or spindle assembly) checkpoint system prevents premature separation of sister chromatids in mitosis. When the checkpoint is turned on, the mitotic checkpoint complex (MCC) inhibits the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). MCC is composed of the checkpoint proteins BubR1, Bub3, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eytan E,Sitry-Shevah D,Teichner A,Hershko A

更新日期：2013-06-25 00:00:00