Abstract：
AIM:To clarify the prognosis of melanotic schwannoma. This is a rare tumour which is generally considered as a benign lesion, reported in many cases with a short follow-up only. METHODS AND RESULTS:Five cases of spinal melanotic schwannoma were retrospectively studied. The tumours were examined using standard histological, immunohistochemical and ultrastructural methods. No features of malignancy (high mitotic count, atypia or necrosis) were found in the primary tumours. The follow-up period ranged from 3 to 7 years. Malignant clinical behaviour was clear-cut in four cases: three patients died from metastases to various sites and one presented several discrete spinal tumours of the same type seven years after the first operation. Only one patient presented no recurrence and was free of disease 6 years after initial diagnosis. The review of 57 cases of the literature (including our cases), showed that 15% of the cases had recurrences and 26.3% were complicated by metastasis. Only 53% of the cases followed for more than 5 years, were free of disease vs. 67.5% of the cases with shorter follow-up. Twenty additional cases had no follow-up. CONCLUSION:Appropriate long-term follow-up is required for all melanotic schwannomas, as it may recur or metastasize after more than 5 years, even in the absence of overt malignant histological features.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Vallat-Decouvelaere AV,Wassef M,Lot G,Catala M,Moussalam M,Caruel N,Mikol Jdoi
10.1046/j.1365-2559.1999.00786.xkeywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
558-66issue
6eissn
0309-0167issn
1365-2559pii
his786journal_volume
35pub_type
杂志文章相关文献
HISTOPATHOLOGY文献大全abstract：AIMS:Cluster of differentiation 103 (CD103), a marker of tissue resident memory T cells, is expressed on subsets of CD8+ T lymphocytes. We investigated the prognostic significance of CD103+ intra-epithelial tumour-infiltrating lymphocytes (iTILs) in invasive breast cancer (IBC). METHODS AND RESULTS:Immunohistochemistr...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/his.14126
更新日期：2020-10-01 00:00:00
abstract：:S-100 positive epidermal dendritic cells were counted in skin biopsies from 48 Kveim tests and four known foreign-body reactions. Counts in histologically positive Kveim biopsies (mean 11.3 per 200 basal cells) were significantly higher than in either negative biopsies (5.1; P less than 0.001) or foreign-body reaction...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1991.tb01457.x
更新日期：1991-02-01 00:00:00
abstract：:Adenomatous hyperplasia, defined as a sizable parenchymal nodule in cirrhosis, was examined morphologically. Ninety-seven nodules of adenomatous hyperplasia were obtained from 47 cirrhotic livers and were divided into 'ordinary' (44 nodules) and 'atypical' (53 nodules) types. The former consisted of hepatocytes simila...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1990.tb00660.x
更新日期：1990-07-01 00:00:00
abstract：:In view of the critical role of dendritic cells in immune mediated skin diseases, we have investigated the membrane antigen patterns and ultrastructure of cutaneous dendritic cells in eight patients with chronic discoid lupus erythematosus and five with subacute cutaneous lupus erythematosus. In the lesional epidermis...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1994.tb00531.x
更新日期：1994-04-01 00:00:00
abstract：:An immunocytochemical and cytophotometrical analysis of 30 renal cell carcinomas was carried out in order to investigate the expression of cytokeratin and vimentin in relation to the ploidy and mitotic index. Thirty renal cell carcinomas were studied using monoclonal antibodies CAM 5.2 and anti-vimentin in a biotin-st...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1991.tb00852.x
更新日期：1991-04-01 00:00:00
abstract：AIMS:Survivin, a newly discovered member of the inhibitor of apoptosis protein family, is suggested to be involved in liver carcinogenesis. The aim was to investigate the clinical significance of survivin expression in resected hepatocellular carcinoma (HCC) and paired adjacent non-tumour tissue. METHODS AND RESULTS:I...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.2007.02738.x
更新日期：2007-08-01 00:00:00
abstract：:Calcitonin is a hypocalcaemia producing hormone and is secreted by C-cells of the thyroid. The current study was undertaken on a hypothesis that C-cell hyperplasia may develop in the secondary hyperparathyroidism of chronic renal failure in response to sustained hypercalcaemia. With an immunoperoxidase staining method...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1992.tb00433.x
更新日期：1992-11-01 00:00:00
abstract：AIMS:To investigate the expression of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptors and decoy receptors, including osteoprotegerin (OPG) in infantile haemangioma (IH). METHODS AND RESULTS:Immunostaining, Western blotting and quantitative reverse transcription-polymerase chain react...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.2011.03970.x
更新日期：2011-09-01 00:00:00
abstract：:A retrospective histopathological study was undertaken to determine the prevalence of mucin filled ducts and their associated mucinous proliferation in 962 breast cancers and 335 benign lesions. A total of 38 (3%) cases with mucin filled ducts was identified and 27 (2%) of these showed mucin extravasation into the adj...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1046/j.1365-2559.1996.d01-535.x
更新日期：1996-12-01 00:00:00
abstract：AIMS:Pseudosarcomatous myofibroblastic proliferations (PSMPs) of the urinary bladder are diagnostically challenging. Diagnostic difficulties are mainly due to frequent cytokeratin expression, variable ALK expression and worrisome morphological features suggestive of malignancy. Conversely, sarcomatoid urothelial carcin...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/his.14206
更新日期：2020-12-01 00:00:00
abstract：AIMS:Littoral cell angioma (LCA) is a rare primary splenic tumour that is frequently associated with internal malignancies. Immunohistochemistry can demonstrate a distinct hybrid endothelial-histiocytic phenotype of littoral cells, and is a helpful adjunct for making the correct diagnosis. The aims of this study were t...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/his.13026
更新日期：2016-11-01 00:00:00
abstract：AIMS:Angiogenesis is essential for tumour growth and metastasis and tumour necrosis factor (TNF)-alpha is a potent angiogenic factor. Invasive micropapillary carcinoma of the breast (IMPC), a rare subtype of breast cancer, possesses a lymphotropic nature with a high incidence of lymph node metastasis and poor prognosis...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.2008.03128.x
更新日期：2008-10-01 00:00:00
abstract：AIMS:Calcific aortic stenosis is a progressive disease characterized by massive fibrosis andmineralization of the valve leaflets. The aim of this study was to determine whether the onset of native calcific aortic stenosis is associated primarily with matrix remodelling events, and particularly with elastin degradation....
journal_title：Histopathology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2559.2011.03977.x
更新日期：2011-09-01 00:00:00
abstract：AIMS:In order to develop efficient digital pathology workstations, we studied the navigation patterns of pathologists diagnosing whole-slide images. To gain a better understanding of these patterns, we built a conceptual model based on observations. We also determined whether or not new navigation patterns have emerged...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/his.12629
更新日期：2015-08-01 00:00:00
abstract：:Wilms' tumour (nephroblastoma) has been associated with chromosomal abnormalities at the 11p13, 11p15 and 16q regions. A study into the possibility of mutations occurring within p53, the ubiquitous adult tumour suppressor gene, in Wilms' tumour was carried out. Thirty-eight cases were studied. Of these 36 were categor...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1046/j.1365-2559.1996.d01-384.x
更新日期：1996-01-01 00:00:00
abstract：AIMS:To survey current European practices in handling and reporting of radical prostatectomy (RP) specimens. METHODS AND RESULTS:A European Network of Uropathology (ENUP) was organized for the dissemination of information, survey studies and research collaborations. Contact data of uropathologists were collected from ...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.2008.03102.x
更新日期：2008-09-01 00:00:00
abstract：AIMS:The diagnosis of polymorphous low-grade adenocarcinoma (PLGA) remains difficult for general pathologists, particularly in cases of small biopsy samples. We aimed to characterize the histopathological spectrum and immunohistochemical aspects by using an accessible immunohistochemical panel of cytoskeletal proteins ...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/his.12880
更新日期：2016-06-01 00:00:00
abstract：:A review of 76 endomyocardial biopsies and 54 autopsies of patients with dilated cardiomyopathy (DCM) revealed features of hypertrophy and degenerative changes associated with long-standing hypertrophy. Long-term survivors had significantly heavier heart weights. Short-term survivors had heavier than normal right vent...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1985.tb02821.x
更新日期：1985-04-01 00:00:00
abstract：:A male infant was diagnosed as having diabetes mellitus 1 d after birth and died on the third day. Histological examination of the pancreas showed small and inconspicuous islets of Langerhans that were completely devoid of insulin-secreting cells. There was no evidence of insulitis. ...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1988.tb01974.x
更新日期：1988-05-01 00:00:00
abstract：AIMS:Despite increasing interest in the recently established immunoglobulin 4-related disease (IgG4-RD), its pathogenesis and aetiology remain largely unclear. Characteristic histopathological features are one of the key elements of diagnosis, including 'storiform' fibrosis, obliterative phlebitis, increased lymphoplas...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/his.13965
更新日期：2020-01-01 00:00:00
abstract：AIMS:To investigate the role of BNIP3, a 19-kDa interacting protein of the Bcl-2 family, alongside Bcl-2 in follicular lymphoma in comparison with reactive lymphoid hyperplasia. The results were compared with those from p53 and caspase-3 (apoptotic markers) and Ki67 (proliferation marker). METHODS AND RESULTS:Immunohi...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.2007.02657.x
更新日期：2007-04-01 00:00:00
abstract：:Two cases of tubulovillous adenoma and adjacent colonic mucosa were studied in which intestinal spirochaetosis had heavily colonized the non-neoplastic but not the neoplastic epithelium. Ultrastructural and histochemical studies were performed and we postulate that the reason for this disparity is the normal microvill...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1995.tb01530.x
更新日期：1995-10-01 00:00:00
abstract：:One hundred and eighty-seven operable lung tumours were immunostained with the monoclonal antibody Ki-67 and divided into groups of high, moderate or low proliferation. Patients have been followed clinically for up to 7 years to ascertain whether this immunocytochemical measurement reflected tumour behaviour in terms ...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1991.tb01503.x
更新日期：1991-12-01 00:00:00
abstract：:In this study breast tissue that contained ultrastructural dense core granules has been examined from 24 patients. The possible neuroendocrine characteristics of the granules were studied using the uranaffin reaction and an ultrastructural argyrophil stain. The tissue included 15 breast carcinomas and nine benign samp...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1987.tb01855.x
更新日期：1987-11-01 00:00:00
abstract：:We have reviewed 60 liver specimens from 47 patients with the diagnosis of incomplete septal cirrhosis observed between 1968 and 1987. In reaching this diagnosis evaluation of the following histological features appeared to be helpful: parenchymal nodularity, thin incomplete septa, hypoplastic portal tracts, increased...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1988.tb02091.x
更新日期：1988-12-01 00:00:00
abstract：AIMS:p16, a tumour suppressor gene located at 9p21 chromosome and involved in cell cycle regulation, is often inactivated in lung carcinoma. Inactivation is also supported by the loss of p16 protein, a strong inhibitor of cyclin-dependent kinase (CDK) 4 and 6. The aim of this study was to examine alterations of p16 bot...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.2008.02969.x
更新日期：2008-03-01 00:00:00
abstract：:A case of visceral botryomycosis of the liver in a 50-year-old man is reported. The clinical diagnosis was hepatocellular carcinoma. Pathological examination of the surgically resected specimen demonstrated microabscesses containing gram- positive microorganisms with surrounding fibrosis replacing liver parenchyma. An...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1995.tb00294.x
更新日期：1995-07-01 00:00:00
abstract：:The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation sponsored by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Association of Pathologists in association with the Canadian Partnership Against Cancer, ...
journal_title：Histopathology
pub_type： 杂志文章,评审
doi：10.1111/his.13877
更新日期：2019-10-01 00:00:00
abstract：AIMS:It is still not clear whether oval cells demonstrate diverse morphology, immunophenotype or quantity in different human liver diseases. The aim of this study was to investigate these differences in hepatitis B virus (HBV)-positive and hepatitis C virus (HCV)-positive human liver cirrhosis (HLC). METHODS AND RESUL...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.2006.02372.x
更新日期：2006-04-01 00:00:00
abstract：AIMS:Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is a downstream effector of Ras signalling, and is overexpressed in several types of human malignancy. However, its role in gastric cancer remains unclear. The aim of this study was to investigate the prognostic significance of G3BP1 in gastric can...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/his.12695
更新日期：2015-11-01 00:00:00
