The fibronectin binding proteins of Staphylococcus aureus are required for adhesion to and invasion of bovine mammary gland cells.

Abstract:

:We recently described adhesion to and invasion of bovine mammary gland cells by Staphylococcus aureus in vitro. Here, we show that the levels of adhesion and invasion are dependent on the bacterial growth phase and are controlled by the agr locus. Incubation of exponential growth phase cells of S. aureus with mammary gland cells resulted in bacterial cell clumping. Strains of S. aureus deficient in expression of the fibronectin binding proteins (FnBPA and FnBPB) failed to clump and their ability to adhere to and to invade the bovine mammary gland cells is strongly reduced. This indicates that the fibronectin binding proteins are essential for S. aureus adhesion to and invasion of bovine mammary gland cells.

journal_name

FEMS Microbiol Lett

authors

Lammers A,Nuijten PJ,Smith HE

doi

10.1111/j.1574-6968.1999.tb08783.x

keywords:

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

103-9

issue

1

eissn

0378-1097

issn

1574-6968

pii

S0378-1097(99)00470-X

journal_volume

180

pub_type

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