The dual-specificity protein phosphatase Yvh1p acts upstream of the protein kinase mck1p in promoting spore development in Saccharomyces cerevisiae.

Abstract:

:Diploid Saccharomyces cerevisiae cells induce YVH1 expression and enter the developmental pathway, leading to sporulation when starved for nitrogen. We show that yvh1 disruption causes a defect in spore maturation; overexpression of MCK1 or IME1 suppresses this yvh1 phenotype. While mck1 mutations are epistatic to those in yvh1 relative to spore maturation, overexpression of MCK1 does not suppress the yvh1 slow-vegetative-growth phenotype. We conclude that (i) Yvh1p functions earlier than Mck1p and Ime1p in the signal transduction cascade that regulates sporulation and is triggered by nitrogen starvation and (ii) the role of Yvh1p in gametogenesis can be genetically distinguished from its role in vegetative growth.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Beeser AE,Cooper TG

doi

10.1128/JB.181.17.5219-5224.1999

keywords:

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

5219-24

issue

17

eissn

0021-9193

issn

1098-5530

journal_volume

181

pub_type

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