Abstract:
:Angiogenesis is a fundamental component of normal development and pathologic processes within the eye. Complications due to abnormal ocular neovascularization remain the leading cause of visual loss throughout the world today. Neovascularization and the associated increase in vascular permeability are the underlying threats to vision in such diverse conditions as diabetic retinopathy, retinal vein occlusion, retinopathy of prematurity, exudative age-related macular degeneration, sickle cell retinopathy, radiation retinopathy, and numerous others. Although it has been appreciated for nearly one-half century that the clinical findings associated with ocular neovascularization suggest an etiology involving the elaboration of growth factors, the exact molecules involved and their mechanisms of action have remained incompletely understood. Recent developments in this rapidly evolving field have begun to elucidate the major factors responsible for modulating the neovascularization common to these conditions and have significant theoretic implications for the development of novel, nondestructive, pharmacologic treatment modalities.
journal_name
Curr Opin Ophthalmoljournal_title
Current opinion in ophthalmologyauthors
Aiello LPdoi
10.1097/00055735-199706000-00005keywords:
subject
Has Abstractpub_date
1997-06-01 00:00:00pages
19-31issue
3eissn
1040-8738issn
1531-7021journal_volume
8pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Corneal transplantation is the most commonly performed solid organ transplantation in the world. Despite a glorious history of more than a 100 years, the success of conventional corneal transplantation surgery is marred by problems like graft rejection,graft infection and associated glaucoma due to lo...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:
更新日期:2010-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Tubulointerstitial nephritis and uveitis syndrome (TINU) is a specific form of intraocular inflammation (uveitis) combined with kidney disease that was first described in two patients by Dobrin et al. in 1975. Since then, approximately 200 more cases have been published. The cause of the disease is st...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3283318f9a
更新日期:2009-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Corneal collagen cross-linking has recently emerged as a novel approach for management of ectasia. This article reviews the literature published in the past 3 years about the expanding spectrum of cross-linking as a therapeutic modality and its complications. RECENT FINDINGS:Recent studies have confi...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e328354865e
更新日期:2012-07-01 00:00:00
abstract::Macular translocation is a term used to describe any surgical procedure that involves the deliberate detachment of the retina with subsequent repositioning of the macula to a new location relative to the underlying retinal pigment epithelium. By moving the fovea away from abnormal pigment epithelium and/or choroid and...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200006000-00001
更新日期:2000-06-01 00:00:00
abstract::There have been many recent advances in the diagnosis and management of children with retinoblastoma. Regarding diagnosis, the judicial use of ancillary studies, particularly B-scan ultrasonography, has been instrumental in supplementing the diagnosis when opaque media preclude a clear view of the underlying neoplasm...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199406000-00014
更新日期:1994-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe the emerging applications of deep learning in ophthalmology. RECENT FINDINGS:Recent studies have shown that various deep learning models are capable of detecting and diagnosing various diseases afflicting the posterior segment of the eye with high accuracy. Most of the initial studies hav...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000470
更新日期:2018-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Many causes of toxic optic neuropathy have been described to date and novel causes of toxicity are continuously being added to the current literature. The pathophysiological basis for the toxicity or a direct causal relationship is yet to be determined for many of these agents. This review highlights ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000001
更新日期:2013-11-01 00:00:00
abstract::Porous high-density polyethylene implants have become well accepted for the repair of orbital wall fractures, delayed orbital reconstruction, orbital rim and malar bony onlay augmentation, and volume replacement as orbital spherical implants for the treatment of anophthalmos. Medpor (Porex Surgical, Inc. College Park,...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199710000-00012
更新日期:1997-10-01 00:00:00
abstract::Both classic descriptions and new findings in human anatomy have been limited in the past to cadaveric dissections. Although dissection still supplies most of new information, refinements in technique and the advent of high-resolution soft tissue imaging available with magnetic resonance have certainly provided a new ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199510000-00010
更新日期:1995-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The introduction of hydrogel socket and orbital expanders has modified the approach towards the rehabilitation of congenital anophthalmia. This study highlights the most recent advances for the treatment of congenital anophthalmia based on personal experience and the review of recent literature. RECE...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e328349948a
更新日期:2011-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Optical coherence tomography has assumed an important role in the management of numerous ocular conditions. With regard to ocular oncology, optical coherence tomography can illustrate retinal changes overlying choroidal tumors. Some of these features include photoreceptor loss, intraretinal edema, and...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000158258.01681.40
更新日期:2005-06-01 00:00:00
abstract::Sjögren syndrome is a chronic systemic disease characterized by polyglandular tissue destruction leading to keratoconjunctivitis sicca (KCS) and xerostomia. Patients with primary Sjögren syndrome show evidence of KCS and xerostomia, whereas patients with secondary Sjögren syndrome suffer from KCS, xerostomia, and an a...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200012000-00011
更新日期:2000-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The concept of neuroprotective therapy for glaucoma is that damage to retinal ganglion cells (RGCs) may be prevented by intervening in neuronal death pathways. This review focuses on strategies for neuroprotection and summarizes preclinical studies that have investigated potential agents over the last...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32834372ec
更新日期:2011-03-01 00:00:00
abstract::Retinopathy of prematurity is a disease that manifests soon after birth in the premature infant and may lead to a lifelong disability. More infants at risk for developing the retinopathy are surviving, and the ophthalmologist must be aware of possible vision abnormalities, such as decreased acuity, strabismus, nystagm...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199606000-00009
更新日期:1996-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Topography-guided laser refractive surgery regularizes the front corneal surface irregularities to achieve the desired refractive outcome. This is particularly applicable in highly aberrated corneas, where wavefront aberrometry is often not possible. This article aims to review the recently published ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3283622a59
更新日期:2013-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The Charles Bonnet syndrome is a disorder of visual hallucinations typically occurring in older persons with vision impairment or deafferentation of the visual cortex. This review cites recent studies on Charles Bonnet syndrome and discusses treatment options. The numbers of affected persons will incr...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000193100.13551.ac
更新日期:2006-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Update on controversies in the surgical management of rhegmatogenous retinal detachment. RECENT FINDINGS:There are multiple new reports regarding the development and management of retinal detachment. Current use of oral fluoroquinolones may be associated with onset of retinal detachment, although the...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32835f8e6b
更新日期:2013-05-01 00:00:00
abstract::This review of recent articles on ocular toxicology concentrates on undesirable effects on the eye induced by systemically used xenobiotics. These include color vision deficiencies or visual field deterioration related to antiepileptic drugs, elevated intraocular pressure associated with inhaled corticosteroids, retin...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199712000-00016
更新日期:1997-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to examine current trends in vision screening for children. RECENT FINDINGS:Literature within the past year regarding children's vision screening has been dominated by clinical validation studies of autorefractors or photoscreeners that allow the detection of amblyogenic...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000136112.48664.62
更新日期:2004-10-01 00:00:00
abstract:PURPOSE OF REVIEW:A variety of options exist for perioperative, intraoperative, and postoperative medications in cataract surgery. This article reviews some of the more timely literature on "controversial" subjects in this area. RECENT FINDINGS:Recent literature may support the rationale for intracameral vancomycin at...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200402000-00010
更新日期:2004-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to describe the current clinical landscape of potential future therapies for both nonexudative (dry) and exudative (wet) age-related macular degeneration (AMD). We highlight some of the more promising treatments that are furthest along in development. RECENT FINDINGS:Pat...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000657
更新日期:2020-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The history, pharmacology, indications, complications, and success rates of botulinum administration are discussed in this review as they relate to strabismus and associated conditions. RECENT FINDINGS:Botulinum has been used to treat strabismus and a variety of other ocular conditions for over three...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000243018.97627.4c
更新日期:2006-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To review recent studies on potential neurodevelopmental impacts on the pediatric population through general anesthesia events or intravitreal anti-vascular endothelial growth factor (VEGF) injection. RECENT FINDINGS:Studies on this topic have been extensive with varied reported neurodevelopmental ou...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000598
更新日期:2019-09-01 00:00:00
abstract::Human amniotic membrane (AM) is composed of three layers: a single epithelial layer, a thick basement membrane, and an avascular stroma. Amniotic membrane has anti-adhesive properties and is felt to promote epithelialization and decrease inflammation, neovascularization, and fibrosis. Amniotic membrane transplantation...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200108000-00006
更新日期:2001-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss current knowledge of global risk assessment in ocular hypertension. RECENT FINDINGS:The ophthalmologist treating patients with ocular hypertension is frequently faced with the clinical dilemma of which patients to treat and how vigorous treatment should be. The goal of risk assessment for ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32808373a2
更新日期:2007-03-01 00:00:00
abstract::In the past year, as in recent years, most of the research on the development of refraction has focused on the following: 1) mechanisms whereby the eye can maintain coordinated growth to achieve emmetropia and 2) disruptions of emmetropization resulting in myopia or hyperopia. Preterm children and those with Down synd...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199910000-00002
更新日期:1999-10-01 00:00:00
abstract::Three problems exist when assessing the effectiveness of treatment for normal-tension glaucoma. Firstly, it is a common type of primary open-angle glaucoma. Secondly, the extent to which it is a pressure-sensitive disease remains to be seen. Thirdly, it is possible that normal-tension glaucoma is a collection of diffe...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199504000-00011
更新日期:1995-04-01 00:00:00
abstract:PURPOSE OF REVIEW:We assess the studies on vector systems for delivery of transgenes to the cornea that have been published over the last year and summarize new work on the identification of specific transgenes for corneal diseases. RECENT FINDINGS:Adeno-associated viral vectors are increasingly being successfully app...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3283541eb6
更新日期:2012-07-01 00:00:00
abstract::Giant cell arteritis is a systemic disease that can have devastating ophthalmic consequences. New insights into the epidemiology and pathophysiology of the disease may improve early diagnosis and treatment. ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199812000-00013
更新日期:1998-12-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an unstructured review of the recent literature on the role of optical coherence tomography (OCT) in cataract surgery with specific focus on cystoid macular edema (CME) on the basis of expert opinion of the authors. RECENT FINDINGS:OCT appears to be a useful method to reveal clinically rel...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/icu.0b013e3283199162
更新日期:2009-01-01 00:00:00