Pathological and biochemical consequences of acute and chronic neuroinflammation within the basal forebrain cholinergic system of rats.

abstract：:Parkinson's disease (PD) is a progressive aging disorder that affects millions worldwide, thus, disease-modifying-therapies are urgently needed. PD pathology includes α-synuclein (aSyn) accumulation as synucleinopathy. Loss of GM1 gangliosides occurs in PD brain, which is modeled in GM2 synthase transgenic mice. GM2+/...

journal_title：Neuroscience

authors： Vidal-Martinez G,Najera K,Miranda JD,Gil-Tommee C,Yang B,Vargas-Medrano J,Diaz-Pacheco V,Perez RG

更新日期：2019-07-15 00:00:00

abstract：:Factors involved in the production of long-term potentiation in the CA1 region of rat hippocampal slices were examined using whole-cell voltage clamp recordings. The pairing of postsynaptic membrane depolarization with tetanic stimulation produced a reliable long-lasting enhancement of synaptic currents provided that ...

journal_title：Neuroscience

authors： Kato K,Clifford DB,Zorumski CF

更新日期：1993-03-01 00:00:00

abstract：:Ascending projections from the several nuclei of the medullary reticular formation were examined using the autoradiographic method. The majority of fibers labeled after injections of [3H]leucine into nucleus gigantocellularis ascended within Forel's tractus fasciculorum tegmenti which is located ventrolateral to the m...

journal_title：Neuroscience

authors： Vertes RP,Martin GF,Waltzer R

更新日期：1986-11-01 00:00:00

abstract：:alpha-Calcitonin gene-related peptide expression in alpha-motoneurons is regulated by spinal cord transection, axotomy and testosterone, but to date there are no studies which examine the regulation of cholecystokinin expression in motoneurons. In the present study, we compared the regulation of preprocholecystokinin ...

journal_title：Neuroscience

authors： Popper P,Abelson L,Micevych PE

更新日期：1992-11-01 00:00:00

abstract：:The paraventricular nucleus of the hypothalamus is increasingly being viewed as an important site for cardiovascular integration because of its connections to regions in the brain and spinal cord which are known to be important in cardiovascular control. Like the vasomotor neurons of the rostral ventrolateral medulla,...

journal_title：Neuroscience

authors： Pyner S,Coote JH

更新日期：1999-01-01 00:00:00

abstract：:Dopamine is a neurotransmitter crucial for motor, motivational, and reward-related functions. Our aim was to determine the effect of a palatable maternal diet on the transcriptional regulation of dopaminergic-related genes during perinatal development of rat offspring. For that, female offspring from dams fed with a c...

journal_title：Neuroscience

authors： Rossetti MF,Schumacher R,Gastiazoro MP,Lazzarino GP,Andreoli MF,Stoker C,Varayoud J,Ramos JG

更新日期：2020-01-01 00:00:00

abstract：:Despite a long history of interrogation, the functional organization of motor cortex remains obscure. A major barrier has been the inability to measure and perturb activity with sufficient resolution to reveal clear functional elements within motor cortex and its associated circuits. Increasingly, the mouse has been e...

journal_title：Neuroscience

authors： Warriner CL,Fageiry SK,Carmona LM,Miri A

更新日期：2020-12-01 00:00:00

abstract：:Peripheral and central diabetic neuropathies were studied in streptozotocin-diabetic rats, using behavioral, biochemical and electrophysiological techniques. Diabetic rats showed thermal hypoalgesia and decreasing motor nerve conduction velocity at 4 and 8 weeks of diabetes. In addition, amplitude of the evoked potent...

journal_title：Neuroscience

authors： Piriz J,Torres-Aleman I,Nuñez A

更新日期：2009-05-05 00:00:00

abstract：:Exercise has been shown to impact brain plasticity and function by involving the action of brain-derived neurotrophic factor (BDNF); however, mechanisms involved are poorly understood. Two types of BDNF coexist in the brain, the precursor (proBDNF) and its mature product (mBDNF), which preferentially bind specific rec...

journal_title：Neuroscience

authors： Ding Q,Ying Z,Gómez-Pinilla F

更新日期：2011-09-29 00:00:00

abstract：:It is becoming clear that the detection and integration of synaptic input and its conversion into an output signal in cortical neurons are strongly influenced by background synaptic activity or "noise." The majority of this noise results from the spontaneous release of synaptic transmitters, interacting with ligand-ga...

journal_title：Neuroscience

authors： Greenhill SD,Jones RS

更新日期：2007-07-29 00:00:00

abstract：:The contributions of several Ca(2+)-dependent processes to neurotoxicity were examined in primary cultures of rat cortical neurons. The Ca2+ ionophore ionomycin induced a rapid loss of axonal morphology and concomitant release of inositol phosphates that preceded morphological alterations of neuronal cell bodies, chol...

journal_title：Neuroscience

authors： Castillo MR,Babson JR

更新日期：1998-10-01 00:00:00

abstract：:Novel approaches are required in the clinical management of peripheral nerve injuries because current surgical techniques result in deficient sensory recovery. Microsurgery alone fails to address extensive cell death in the dorsal root ganglia (DRG), in addition to poor axonal regeneration. Incorporation of cultured c...

journal_title：Neuroscience

authors： Reid AJ,Sun M,Wiberg M,Downes S,Terenghi G,Kingham PJ

更新日期：2011-12-29 00:00:00

abstract：:It has been suggested that the brain adopts a simplified strategy to coordinate a large number of degrees of freedom in motor control. Synergies have been proposed as a strategy to produce movements by recruitment of a small number of fixed modular patterns. However, there is no direct support for a synergistic organi...

journal_title：Neuroscience

authors： Hao Y,Zhang S,Zhang Q,Li G,Chen W,Zheng X

更新日期：2017-08-15 00:00:00

abstract：:Three closely-linked clusters of protocadherin (Pcdh) genes (alpha, beta, and gamma) encoding more than 50 distinct mRNAs have been identified in humans and mice, and proposed to play important roles in neuronal connectivity in the CNS. The human and mouse Pcdh alpha and gamma clusters each span a region of about 300 ...

journal_title：Neuroscience

authors： Zou C,Huang W,Ying G,Wu Q

更新日期：2007-01-19 00:00:00

abstract：:The topographical organization of amygdaloid projections to the caudatoputamen, nucleus accumbens, and lateral portions of the bed nucleus of the stria terminalis and central amygdaloid nucleus was investigated, in the rat, using the retrograde transport of wheat germ agglutinin-conjugated horseradish peroxidase. Alth...

journal_title：Neuroscience

authors： McDonald AJ

更新日期：1991-01-01 00:00:00

abstract：:The gp130 cytokines leukemia inhibitory factor and interleukin-6 are neuroactive cytokines associated with peripheral nerve injury. Here we show that exogenous administration of these factors selectively regulates neuropeptide phenotype in intact sensory neurons in a manner consistent with their role as injury-induced...

journal_title：Neuroscience

authors： Thompson SW,Priestley JV,Southall A

更新日期：1998-06-01 00:00:00

abstract：:The cochlear nucleus is the first central pathway involved in the processing of peripheral auditory activity. The anterior ventral cochlear nucleus (AVCN), posterior ventral cochlear nucleus (PVCN) and dorsal cochlear nucleus (DCN) each contain predominant populations of neurons that have been well characterized regar...

journal_title：Neuroscience

authors： Friedland DR,Popper P,Eernisse R,Cioffi JA

更新日期：2006-10-27 00:00:00

abstract：:A study has been made at the ultrastructural level of the effects of denervation and axotomy on the synapse population of the rat superior cervical ganglion. Superior cervical ganglia were subjected unilaterally to acute (survival, 48 h) or chronic preganglionic denervation (survival, 41-189 days) by cutting the cervi...

journal_title：Neuroscience

authors： Ramsay DA,Matthews MR

更新日期：1985-12-01 00:00:00

abstract：:Vagal afferents ascending from the gastrointestinal tract synapse on neurons in the nucleus of the solitary tract. Although these neurons constitute a significant proportion of solitary tract cells their firing behaviour and synaptic properties are not documented. Since gastrointestinal tract afferent termination site...

journal_title：Neuroscience

authors： Paton JF,Li YW,Deuchars J,Kasparov S

更新日期：2000-01-01 00:00:00

abstract：:The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. Here we report the first phenotypic analysis of a Dcdc2 knockout mouse. Comparisons between Dcdc2 knockout mice and wild-type (wt) littermates revealed no significant ...

journal_title：Neuroscience

authors： Wang Y,Yin X,Rosen G,Gabel L,Guadiana SM,Sarkisian MR,Galaburda AM,Loturco JJ

更新日期：2011-09-08 00:00:00

abstract：:The spinal cord is innervated by brainstem serotonergic neurons, some of which contain substance P and/or thyrotropin-releasing hormone in addition to serotonin. These neurons project at least three types of axons to the spinal cord: those containing both substance P and thyrotropin-releasing hormone, those containing...

journal_title：Neuroscience

authors： Wu W,Elde R,Wessendorf MW

更新日期：1993-07-01 00:00:00

abstract：:Ionotropic glutamate receptors in the substantia nigra pars compacta regulate the activity of dopamine neurons. We have used dual-label immunofluoresence and confocal laser microscopy to study the localization of subunits of two types of ionotropic receptors within the substantia nigra pars compacta of the rat. Immuno...

journal_title：Neuroscience

authors： Albers DS,Weiss SW,Iadarola MJ,Standaert DG

更新日期：1999-03-01 00:00:00

abstract：:In the hippocampus, chelatable zinc is accumulated in vesicles of glutamatergic presynaptic terminals, abounding specially in the mossy fibers, from where it is released with activity and can exert a powerful inhibitory action upon N-methyl-D-aspartate receptors. Zinc is therefore in a strategic situation to control o...

journal_title：Neuroscience

authors： Domínguez MI,Blasco-Ibáñez JM,Crespo C,Marqués-Marí AI,Martínez-Guijarro FJ

更新日期：2003-01-01 00:00:00

abstract：:The daily light dark cycle is the most salient entraining factor for the circadian system. However, in modern society, darkness at night is vanishing as light pollution steadily increases. The impact of brighter nights on wild life ecology and human physiology is just now being recognized. In the present study, we tes...

journal_title：Neuroscience

authors： Shuboni D,Yan L

更新日期：2010-11-10 00:00:00

abstract：:Nuclear factor-kappa B (NF-κB) is a ubiquitous transcription factor that regulates immune and cell-survival signaling pathways. NF-κB has been reported to be present in neurons wherein it reportedly responds to immune and toxic stimuli, glutamate, and synaptic activity. However, because the brain contains many cell ty...

journal_title：Neuroscience

authors： Listwak SJ,Rathore P,Herkenham M

更新日期：2013-10-10 00:00:00

abstract：:Three-dimensional changes in the angular orientation of the head were monitored during galvanic vestibular stimulation (GVS) delivered through electrodes implanted bilaterally in the tensor tympani muscle of the guinea-pig middle ear. Bilateral GVS was delivered by passing current between both ears with the anode situ...

journal_title：Neuroscience

authors： Kim J

更新日期：2013-12-03 00:00:00

abstract：:Alternative splicing is an important mechanism for expanding proteome diversity from a limited number of genes, especially in higher vertebrates. Brain-specific splicing factors play an important role in establishing specific patterns of alternative splicing in the brain and thereby contribute to its complex architect...

journal_title：Neuroscience

authors： Jelen N,Ule J,Zivin M

更新日期：2010-08-25 00:00:00

abstract：:The interaction between the dopaminergic and glutamatergic systems governs normal behavior and is perturbed in many psychiatric disorders including schizophrenia. Hypofunction of the D1 family of receptors, to which the D(1) and D(5) subtypes belong, is a typical feature of schizophrenia. Here we have used confocal li...

journal_title：Neuroscience

authors： Kruusmägi M,Kumar S,Zelenin S,Brismar H,Aperia A,Scott L

更新日期：2009-12-01 00:00:00

abstract：:Approximately 50% of patients who survived after aneurysmal subarachnoid hemorrhage (SAH) have cognitive or neurobehavioral dysfunction. The mechanisms are not known. NR2B, one of the subunits of N-methyl-d-aspartate (NMDA) receptors, has been proved to be an important factor for synapse function and behavior cognitio...

journal_title：Neuroscience

authors： Chen G,Li Q,Feng D,Hu T,Fang Q,Wang Z

更新日期：2013-02-12 00:00:00

abstract：:Human Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32kDa (DARPP-32, also known as PPP1R1B) gene codes for different transcripts that are mainly translated into two DARPP-32 protein isoforms, full length (fl)-DARPP-32 and truncated (t)-DARPP. The t-DARPP lacks the first 36 residues at the N-terminal,...

journal_title：Neuroscience

authors： Straccia M,Carrere J,Rosser AE,Canals JM

更新日期：2016-10-01 00:00:00