Tracking the migration of dendritic cells by in vivo optical imaging.

abstract：:Type I cells have been defined to be independent of mitochondria for the induction of Fas death receptor-mediated apoptosis, whereas Type II cells are mitochondria-dependent. Knock-out studies in mice show that thymocytes are Type I and liver cells are Type II. We have previously shown that primary human hepatocytes a...

journal_title：Neoplasia (New York, N.Y.)

authors： Ozören N,El-Deiry WS

更新日期：2002-11-01 00:00:00

abstract：:The expression of N-cadherin (NCAD) has been shown to correlate with increased tumor cell motility and metastasis. However, NCAD-mediated adhesion is a robust phenomenon and therefore seems to be inconsistent with the "release" from intercellular adhesion required for invasion. We show that in the most invasive melano...

journal_title：Neoplasia (New York, N.Y.)

authors： Maret D,Gruzglin E,Sadr MS,Siu V,Shan W,Koch AW,Seidah NG,Del Maestro RF,Colman DR

更新日期：2010-12-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common malignant primary tumor of the central nervous system. With no effective therapy, the prognosis for patients is terrible poor. It is highly heterogeneous and EGFR amplification is its most frequent molecular alteration. In this light, we aimed to examine the genetic heterogeneity ...

journal_title：Neoplasia (New York, N.Y.)

authors： Muñoz-Hidalgo L,San-Miguel T,Megías J,Monleón D,Navarro L,Roldán P,Cerdá-Nicolás M,López-Ginés C

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Well-differentiated gastroenteropancreatic neuroendocrine neoplasms are rare tumors with a slow proliferation. They are virtually resistant to many DNA-damaging therapeutic approaches, such as chemo- and external beam therapy, which might be overcome by DNA damage inhibition induced by proteasome inhibitors ...

journal_title：Neoplasia (New York, N.Y.)

authors： Briest F,Koziolek EJ,Albrecht J,Schmidt F,Bernsen MR,Haeck J,Kühl AA,Sedding D,Hartung T,Exner S,Welzel M,Fischer C,Grötzinger C,Brenner W,Baum RP,Grabowski P

更新日期：2021-01-01 00:00:00

abstract：:The benefits of inhibiting vascular endothelial growth factor (VEGF) signaling in cancer patients are predominantly attributed to effects on tumor endothelial cells. Targeting non-endothelial stromal cells to further impact tumor cell growth and survival is being pursued through the inhibition of additional growth fac...

journal_title：Neoplasia (New York, N.Y.)

authors： Duignan IJ,Corcoran E,Pennello A,Plym MJ,Amatulli M,Claros N,Iacolina M,Youssoufian H,Witte L,Samakoglu S,Schwartz J,Surguladze D,Tonra JR

更新日期：2011-01-01 00:00:00

abstract：:We determined whether the implantation of human pancreatic cancer cells into the pancreas of nude mice can be used to select variants with increasing metastatic potential. COLO 357 line fast-growing cells were injected into the spleen or pancreas of nude mice. Hepatic metastases were harvested, and tumor cells were re...

journal_title：Neoplasia (New York, N.Y.)

authors： Bruns CJ,Harbison MT,Kuniyasu H,Eue I,Fidler IJ

更新日期：1999-04-01 00:00:00

abstract：:Since loss of VHL is frequently detected early phase genetic event in human renal cell carcinoma, pVHL is assumed to be indispensable for suppression of tumor initiation step. However, induction of HIF-1α, target of pVHL E3 ligase, is more adequate to angiogenesis step after tumor mass formation. Concerning this, it h...

journal_title：Neoplasia (New York, N.Y.)

authors： Jung YS,Chun HY,Yoon MH,Park BJ

更新日期：2014-12-01 00:00:00

abstract：:This issue marks the end of the 10-year anniversary of Neoplasia where we have seen exciting growth in both number of submitted and published articles in Neoplasia. Neoplasia was first published in 1999. During the past 10 years, Neoplasia has dynamically adapted to the needs of the cancer research community as techno...

journal_title：Neoplasia (New York, N.Y.)

authors： Rehemtulla A

更新日期：2008-12-01 00:00:00

abstract：:In this study, a new compound, 4-(N)-docosahexaenoyl 2', 2'-difluorodeoxycytidine (DHA-dFdC), was synthesized and characterized. Its antitumor activity was evaluated in cell culture and in mouse models of pancreatic cancer. DHA-dFdC is a poorly soluble, pale yellow waxy solid, with a molecular mass of 573.3Da and a me...

journal_title：Neoplasia (New York, N.Y.)

authors： Naguib YW,Lansakara-P D,Lashinger LM,Rodriguez BL,Valdes S,Niu M,Aldayel AM,Peng L,Hursting SD,Cui Z

更新日期：2016-01-01 00:00:00

abstract：:Upper urinary tract transitional cell carcinoma (UUT-TCC) is quite an uncommon disease, and its prognosis differs among individuals irrespective of tumor stage. DNA repair gene polymorphisms are reported to result in the modulation of the repair capacity and might influence the prognosis of UUT-TCC. We examined the as...

journal_title：Neoplasia (New York, N.Y.)

authors： Sasaki M,Sakano S,Okayama N,Akao J,Hara T,Kawai Y,Ohmi C,Hinoda Y,Naito K

更新日期：2008-03-01 00:00:00

abstract：:Head and neck squamous cell carcinomas (HNSCC) are frequently characterized by chemotherapy and radiation resistance, and by overexpression of Bcl-XL, an antiapoptotic member of the Bcl-2 protein family. In this report we examined whether cell-permeable peptides derived from the BH3 domains of proapoptotic Bax, Bad, o...

journal_title：Neoplasia (New York, N.Y.)

authors： Li R,Boehm AL,Miranda MB,Shangary S,Grandis JR,Johnson DE

更新日期：2007-10-01 00:00:00

abstract：:We report that daurinol, a novel arylnaphthalene lignan, is a promising potential anticancer agent with adverse effects that are less severe than those of etoposide, a clinical anticancer agent. Despite its potent antitumor activity, clinical use of etoposide is limited because of its adverse effects, including myelos...

journal_title：Neoplasia (New York, N.Y.)

authors： Kang K,Oh SH,Yun JH,Jho EH,Kang JH,Batsuren D,Tunsag J,Park KH,Kim M,Nho CW

更新日期：2011-11-01 00:00:00

abstract：:Cancers are complex, adaptive ecosystems. They remain the leading cause of disease-related death among children in North America. As we approach computational oncology and Deep Learning Healthcare, our mathematical models of cancer dynamics must be revised. Recent findings support the perspective that cancer-microenvi...

journal_title：Neoplasia (New York, N.Y.)

authors： Uthamacumaran A

更新日期：2020-12-01 00:00:00

abstract：:SAG (Sensitive to Apoptosis Gene), also known as RBX2 or ROC2, is a RING component of CRL (Cullin-RING ligase), required for its activity. Our previous studies showed that Sag/Rbx2 co-operated with Kras or Pten loss to promote tumorigenesis in the lung and prostate, respectively, but antagonized Kras to inhibit skin t...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhang Q,Wei D,Tan M,Li H,Morgan MA,Sun Y

更新日期：2020-04-24 00:00:00

abstract：:Preclinical studies have shown that gefitinib, licofelone, atorvastatin, and α-difluoromethylornithine (GLAD) are promising colon cancer chemopreventive agents. Because low-dose combination regimens can offer potential additive or synergistic effects without toxicity, GLAD combination was tested for toxicity and chemo...

journal_title：Neoplasia (New York, N.Y.)

authors： Mohammed A,Janakiram NB,Brewer M,Vedala K,Steele VE,Rao CV

更新日期：2013-05-01 00:00:00

abstract：:The bcl-2 and c-myc oncogenes cooperate to transform multiple cell types. In the pediatric malignancy NB(2), Bcl-2 is highly expressed. In tumors with a poor prognosis, N-Myc, a protein homologous to c-Myc, is overexpressed as a result of gene amplification. The present study was designed to determine whether Bcl-2 co...

journal_title：Neoplasia (New York, N.Y.)

authors： Jasty R,van Golen C,Lin HJ,Solomon G,Heidelberger K,Polverini P,Opipari A,Feldman E,Castle VP

更新日期：2001-07-01 00:00:00

abstract：:The human gyrovirus derived protein Apoptin (HGV-Apoptin) a homologue of the chicken anemia virus Apoptin (CAV-Apoptin), a protein with high cancer cells selective toxicity, triggers apoptosis selectively in cancer cells. In this paper, we show that HGV-Apoptin acts independently from the death receptor pathway as it ...

journal_title：Neoplasia (New York, N.Y.)

authors： Chaabane W,Cieślar-Pobuda A,El-Gazzah M,Jain MV,Rzeszowska-Wolny J,Rafat M,Stetefeld J,Ghavami S,Los MJ

更新日期：2014-09-01 00:00:00

abstract：:SEMA3F is a secreted semaphorin with potent antitumor activity, which is frequently downregulated in lung cancer. In cancer cell lines, SEMA3F overexpression decreases hypoxia-induced factor 1alpha protein and vascular endothelial growth factor mRNA, and inhibits multiple signaling components. Therefore, understanding...

journal_title：Neoplasia (New York, N.Y.)

authors： Clarhaut J,Gemmill RM,Potiron VA,Ait-Si-Ali S,Imbert J,Drabkin HA,Roche J

更新日期：2009-02-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a neoplasia characterized by proliferation of a myeloid cell lineage and chromosome translocation t(9;22) (q34;q11.2). As in the case of most cancers, the average telomere length in CML cells is shorter than that in normal blood cells. However, there are currently no data available co...

journal_title：Neoplasia (New York, N.Y.)

authors： Samassekou O,Ntwari A,Hébert J,Yan J

更新日期：2009-11-01 00:00:00

abstract：:Pancreatic invasive ductal adenocarcinoma (PDAC) is a representative intractable malignancy under the current cancer therapies, and is considered a scirrhous carcinoma because it develops dense stroma. Both PODXL1, a member of CD34 family molecules, and C5aR, a critical cell motility inducer, have gained recent attent...

journal_title：Neoplasia (New York, N.Y.)

authors： Saito K,Iioka H,Maruyama S,Sumardika IW,Sakaguchi M,Kondo E

更新日期：2019-12-01 00:00:00

abstract：:Adenosine monophosphate-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis, has emerged as a promising molecular target in the prevention of breast cancer. Clinical trials using the United States Food and Drug Administration (FDA)-approved, AMPK-activating, antidiabetic drug metformin a...

journal_title：Neoplasia (New York, N.Y.)

authors： Buac D,Kona FR,Seth AK,Dou QP

更新日期：2013-12-01 00:00:00

abstract：:Incomplete spontaneous regression of melanoma is common. However, complete melanoma regression is still a very rare phenomenon. Because melanoma is the most immunogenic human malignancy, the mechanisms leading to regression, based on accumulative evidence, are the host's immune responses. Unfortunately, therapies aimi...

journal_title：Neoplasia (New York, N.Y.)

authors： Rambow F,Piton G,Bouet S,Leplat JJ,Baulande S,Marrau A,Stam M,Horak V,Vincent-Naulleau S

更新日期：2008-07-01 00:00:00

abstract：:Bone morphogenetic protein 7 (BMP-7) belongs to the superfamily of transforming growth factor β-like cytokines, which can act either as tumor suppressors or as tumor promoters depending on cell type and differentiation. Our investigations focused on analyzing the effects of BMP-7 during glioma cell proliferation in vi...

journal_title：Neoplasia (New York, N.Y.)

authors： Klose A,Waerzeggers Y,Monfared P,Vukicevic S,Kaijzel EL,Winkeler A,Wickenhauser C,Löwik CW,Jacobs AH

更新日期：2011-03-01 00:00:00

abstract：:A theoretical model for the intraperitoneal (i.p.) delivery of cisplatin and heat to tumor metastases in tissues adjacent to the peritoneal cavity is presented. The penetration distance (the depth to which drug diffuses directly from the cavity into tissues) is predicted to be on the order of 0.5 mm. The model shows t...

journal_title：Neoplasia (New York, N.Y.)

authors： El-Kareh AW,Secomb TW

更新日期：2004-03-01 00:00:00

abstract：:We have demonstrated that modifying the tumor microenvironment through intratumoral administration of adenoviral vectors (Ad) encoding the conditional cytotoxic molecule, i.e., HSV1-TK and the immune-stimulatory cytokine, i.e., fms-like tyrosine kinase 3 ligand (Flt3L) leads to T-cell-dependent tumor regression in rod...

journal_title：Neoplasia (New York, N.Y.)

authors： Candolfi M,Curtin JF,Yagiz K,Assi H,Wibowo MK,Alzadeh GE,Foulad D,Muhammad AK,Salehi S,Keech N,Puntel M,Liu C,Sanderson NR,Kroeger KM,Dunn R,Martins G,Lowenstein PR,Castro MG

更新日期：2011-10-01 00:00:00

abstract：:NF-kappaB and the upstream kinase PKB/Akt are highly expressed in chemoresistance tumor cells and may hamper the apoptotic pathway. CF101, a specific agonist to the A3 adenosine receptor (A3AR), inhibits the development of colon carcinoma growth in cell cultures and xenograft murine models. Because CF101 has been show...

journal_title：Neoplasia (New York, N.Y.)

authors： Bar-Yehuda S,Madi L,Silberman D,Gery S,Shkapenuk M,Fishman P

更新日期：2005-01-01 00:00:00

abstract：:Originally identified as an oncogene activated by amplification in squamous cell carcinomas, several lines of evidence now suggest that squamous cell carcinoma-related oncogene (SCCRO; aka DCUN1D1) may play a role in the pathogenesis of a wide range of human cancers including gliomas. SCCRO's oncogenic function is sub...

journal_title：Neoplasia (New York, N.Y.)

authors： Broderick SR,Golas BJ,Pham D,Towe CW,Talbot SG,Kaufman A,Bains S,Huryn LA,Yonekawa Y,Carlson D,Hambardzumyan D,Ramanathan Y,Singh B

更新日期：2010-06-01 00:00:00

abstract：:Previously, we identified the transcription factor CUX1 as an important modulator of invasion and resistance to apoptosis. Expression profiles suggested that CUX1 regulates a complex transcriptional program mediating tumor progression. We aimed to identify functionally relevant targets of CUX1 by using RNA interferenc...

journal_title：Neoplasia (New York, N.Y.)

authors： Ripka S,Riedel J,Neesse A,Griesmann H,Buchholz M,Ellenrieder V,Moeller F,Barth P,Gress TM,Michl P

更新日期：2010-08-01 00:00:00

abstract：:One of the puzzles in cancer predisposition is that women carrying BRCA-1 mutations preferentially develop tumors in epithelial tissues of the breast and ovary. Moreover, sporadic breast tumors contain lower levels of BRCA-1 in the absence of mutations in the BRCA-1 gene. The problem of tissue specificity requires ana...

journal_title：Neoplasia (New York, N.Y.)

authors： Jeffy BD,Hockings JK,Kemp MQ,Morgan SS,Hager JA,Beliakoff J,Whitesell LJ,Bowden GT,Romagnolo DF

更新日期：2005-09-01 00:00:00

abstract：:Adenomatous polyposis coli (APC) is a multifunctional protein having diverse cellular functions including cell migration, cell-cell adhesion, cell cycle control, chromosomal segregation, and apoptosis. Recently, we found a new role of APC in base excision repair (BER) and showed that it interacts with DNA polymerase β...

journal_title：Neoplasia (New York, N.Y.)

authors： Jaiswal AS,Panda H,Pampo CA,Siemann DW,Gairola CG,Hromas R,Narayan S

更新日期：2013-04-01 00:00:00