Cancer: A turbulence problem.

Abstract:

:Cancers are complex, adaptive ecosystems. They remain the leading cause of disease-related death among children in North America. As we approach computational oncology and Deep Learning Healthcare, our mathematical models of cancer dynamics must be revised. Recent findings support the perspective that cancer-microenvironment interactions may consist of chaotic gene expressions and turbulent protein flows during pattern formation. As such, cancer pattern formation, protein-folding and metastatic invasion are discussed herein as processes driven by chemical turbulence within the framework of complex systems theory. To conclude, cancer stem cells are presented as strange attractors of the Waddington landscape.

journal_name

Neoplasia

authors

Uthamacumaran A

doi

10.1016/j.neo.2020.09.008

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

759-769

issue

12

eissn

1522-8002

issn

1476-5586

pii

S1476-5586(20)30154-8

journal_volume

22

pub_type

杂志文章,评审
  • A nonhomologous end-joining pathway is required for protein phosphatase 2A promotion of DNA double-strand break repair.

    abstract::Protein phosphatase 2A (PP2A) functions as a potent tumor suppressor, but its mechanism(s) remains enigmatic. Specific disruption of PP2A by either expression of SV40 small tumor antigen or depletion of endogenous PP2A/C by RNA interference inhibits Ku DNA binding and DNA-PK activities, which results in suppression of...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.09720

    authors: Wang Q,Gao F,Wang T,Flagg T,Deng X

    更新日期:2009-10-01 00:00:00

  • Neoplasia: the second decade.

    abstract::This issue marks the end of the 10-year anniversary of Neoplasia where we have seen exciting growth in both number of submitted and published articles in Neoplasia. Neoplasia was first published in 1999. During the past 10 years, Neoplasia has dynamically adapted to the needs of the cancer research community as techno...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.81372

    authors: Rehemtulla A

    更新日期:2008-12-01 00:00:00

  • Defining characteristics of Types I and II apoptotic cells in response to TRAIL.

    abstract::Type I cells have been defined to be independent of mitochondria for the induction of Fas death receptor-mediated apoptosis, whereas Type II cells are mitochondria-dependent. Knock-out studies in mice show that thymocytes are Type I and liver cells are Type II. We have previously shown that primary human hepatocytes a...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1038/sj.neo.7900270

    authors: Ozören N,El-Deiry WS

    更新日期:2002-11-01 00:00:00

  • Glutamate receptor GRIA3--target of CUX1 and mediator of tumor progression in pancreatic cancer.

    abstract::Previously, we identified the transcription factor CUX1 as an important modulator of invasion and resistance to apoptosis. Expression profiles suggested that CUX1 regulates a complex transcriptional program mediating tumor progression. We aimed to identify functionally relevant targets of CUX1 by using RNA interferenc...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.10486

    authors: Ripka S,Riedel J,Neesse A,Griesmann H,Buchholz M,Ellenrieder V,Moeller F,Barth P,Gress TM,Michl P

    更新日期:2010-08-01 00:00:00

  • Cellular basis of antiproliferative and antitumor activity of the novel camptothecin derivative, gimatecan, in bladder carcinoma models.

    abstract::To investigate the cellular/molecular basis of the activity of a novel lipophilic camptothecin, gimatecan (ST1481), against slowly proliferating cells, we performed a comparative study of topotecan and gimatecan in human bladder cancer models (HT1376 and MCR). Gimatecan was significantly more effective than topotecan ...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.04397

    authors: Ulivi P,Zoli W,Fabbri F,Brigliadori G,Ricotti L,Tesei A,Rosetti M,De Cesare M,Beretta GL,Corna E,Supino R,Zunino F

    更新日期:2005-02-01 00:00:00

  • Distinct patterns of structural and numerical chromosomal instability characterize sporadic ovarian cancer.

    abstract::Sporadic ovarian cancer is a particularly aggressive tumor characterized by highly abnormal karyotypes exhibiting many features of genomic instability. More complex genomic changes in tumors arise as a consequence of chromosomal instability (CIN), which can generate both numerical [(N)-CIN] and structural chromosomal ...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.08584

    authors: Bayani J,Paderova J,Murphy J,Rosen B,Zielenska M,Squire JA

    更新日期:2008-10-01 00:00:00

  • Paradoxically augmented anti-tumorigenic action of proton pump inhibitor and GastrininAPCMin/+ intestinal polyposis model.

    abstract::Though long-term administration of proton pump inhibitor (PPI) imposed the risk of gastrointestinal track tumorigenesis by accompanied hypergastrinemia, no overt increases of colon cancer risk were witnessed after a long-term cohort study. Our recent investigation revealed that PPI prevented colitis-associated carcino...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.131510

    authors: Han YM,Hahm KB,Park JM,Hong SP,Kim EH

    更新日期:2014-01-01 00:00:00

  • Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of a novel histone deacetylase inhibitor, LAQ824, in human colon carcinoma cells and xenografts.

    abstract::The aim of this work was to use phosphorus magnetic resonance spectroscopy ((31)P MRS) to investigate the pharmacodynamic effects of LAQ824, a histone deacetylase (HDAC) inhibitor. Human HT29 colon carcinoma cells were examined by (31)P MRS after treatment with LAQ824 and another HDAC inhibitor, suberoylanilide hydrox...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.07834

    authors: Chung YL,Troy H,Kristeleit R,Aherne W,Jackson LE,Atadja P,Griffiths JR,Judson IR,Workman P,Leach MO,Beloueche-Babari M

    更新日期:2008-04-01 00:00:00

  • Nilotinib Enhances Tumor Angiogenesis and Counteracts VEGFR2 Blockade in an Orthotopic Breast Cancer Xenograft Model with Desmoplastic Response.

    abstract::Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)-targeted therapies predominantly affect nascent, immature tumor vessels. Since platelet-derived growth factor receptor (PDGFR) blockade inhibits vessel maturation and thus increases the amount of immature tumor vessels, we evaluated whether the combined P...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2017.08.009

    authors: Zafarnia S,Bzyl-Ibach J,Spivak I,Li Y,Koletnik S,Doleschel D,Rix A,Pochon S,Tardy I,Koyadan S,van Zandvoort M,Palmowski M,Kiessling F,Lederle W

    更新日期:2017-11-01 00:00:00

  • ZEB-1, a repressor of the semaphorin 3F tumor suppressor gene in lung cancer cells.

    abstract::SEMA3F is a secreted semaphorin with potent antitumor activity, which is frequently downregulated in lung cancer. In cancer cell lines, SEMA3F overexpression decreases hypoxia-induced factor 1alpha protein and vascular endothelial growth factor mRNA, and inhibits multiple signaling components. Therefore, understanding...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.81074

    authors: Clarhaut J,Gemmill RM,Potiron VA,Ait-Si-Ali S,Imbert J,Drabkin HA,Roche J

    更新日期:2009-02-01 00:00:00

  • The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells.

    abstract::p300/CBP-associated factor (PCAF) is a coactivator of the tumor suppressor, p53. PCAF participates in p53's transactivation of target genes through acetylation of both bound p53 and histones within p53 target promoters. Using microarrays, we discovered that PCAF itself is induced by p53 in a panel of breast tumor cell...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.3292

    authors: Watts GS,Oshiro MM,Junk DJ,Wozniak RJ,Watterson S,Domann FE,Futscher BW

    更新日期:2004-05-01 00:00:00

  • Generation and characterization of novel local and metastatic human neuroblastoma variants.

    abstract::Neuroblastoma (NB) is the most commonly occurring solid tumor in children. The disease usually arises in the adrenal medulla, and it is characterized by a remarkable heterogeneity in its progression. Most NB patients with an advanced disease have massive bone marrow infiltration at diagnosis. Lung metastasis represent...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.08402

    authors: Nevo I,Sagi-Assif O,Edry Botzer L,Amar D,Maman S,Kariv N,Leider-Trejo LE,Savelyeva L,Schwab M,Yron I,Witz IP

    更新日期:2008-08-01 00:00:00

  • Ras-mediated suppression of TGFbetaRII expression in intestinal epithelial cells involves Raf-independent signaling.

    abstract::Ras-transformed intestinal epithelial cells are resistant to the growth inhibitory actions of TGFbeta and have a marked decrease in expression of the TGFbeta type II receptor (TGFbetaRII). Rat intestinal epithelial cells (RIE) were stably transfected with activated Ras, Sos and Raf constructs and tested for expression...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1038/sj.neo.7900099

    authors: Bulus NM,Sheng HM,Sizemore N,Oldham SM,Barnett JV,Coffey RJ,Beauchamp DR,Barnard JA

    更新日期:2000-07-01 00:00:00

  • Circulating endothelial cells, endothelial progenitor cells, and endothelial microparticles in cancer.

    abstract::Cancer, a proliferative disease hallmarked by abnormal cell growth and spread, is largely dependent on tumor neoangiogenesis, with evidence of vascular endothelial dysfunction. Novel ways to assess vascular function in cancer include measuring levels of circulating endothelial cells (CEC). Rare in healthy individuals,...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章,评审

    doi:10.1593/neo.05592

    authors: Goon PK,Lip GY,Boos CJ,Stonelake PS,Blann AD

    更新日期:2006-02-01 00:00:00

  • Merlin-deficient human tumors show loss of contact inhibition and activation of Wnt/β-catenin signaling linked to the PDGFR/Src and Rac/PAK pathways.

    abstract::Neurofibromatosis type 2 (NF2) is an inherited predisposition cancer syndrome characterized by the development of multiple benign tumors in the nervous system including schwannomas, meningiomas, and ependymomas. Using a disease model comprising primary human schwannoma cells, we previously demonstrated that adherens j...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.111060

    authors: Zhou L,Ercolano E,Ammoun S,Schmid MC,Barczyk MA,Hanemann CO

    更新日期:2011-12-01 00:00:00

  • The roles of telomerase in the generation of polyploidy during neoplastic cell growth.

    abstract::Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies. It has been shown that telomere deprotection in p53-deficient mouse embryonic fibroblasts leads to high rates of polyploidization. We now sho...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.121398

    authors: Christodoulidou A,Raftopoulou C,Chiourea M,Papaioannou GK,Hoshiyama H,Wright WE,Shay JW,Gagos S

    更新日期:2013-02-01 00:00:00

  • FOXF1 Induces Epithelial-Mesenchymal Transition in Colorectal Cancer Metastasis by Transcriptionally Activating SNAI1.

    abstract::Forkhead Box F1 (FOXF1) has been recently implicated in cancer progression and metastasis of lung cancer and breast cancer. However, the biological functions and underlying mechanisms of FOXF1 in the regulation of the progression of colorectal cancer (CRC) are largely unknown. We showed that FOXF1 was up-regulated in ...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2018.08.004

    authors: Wang S,Yan S,Zhu S,Zhao Y,Yan J,Xiao Z,Bi J,Qiu J,Zhang D,Hong Z,Zhang L,Huang C,Li T,Liang L,Liao W,Jiao H,Ding Y,Ye Y

    更新日期:2018-10-01 00:00:00

  • Chromosomal localization of DNA amplifications in neuroblastoma tumors using cDNA microarray comparative genomic hybridization.

    abstract::Conventional comparative genomic hybridization (CGH) profiling of neuroblastomas has identified many genomic aberrations, although the limited resolution has precluded a precise localization of sequences of interest within amplicons. To map high copy number genomic gains in clinically matched stage IV neuroblastomas, ...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/s1476-5586(03)80017-9

    authors: Beheshti B,Braude I,Marrano P,Thorner P,Zielenska M,Squire JA

    更新日期:2003-01-01 00:00:00

  • CXCR4 regulates the early extravasation of metastatic tumor cells in vivo.

    abstract::Recent studies have demonstrated that the chemokine receptor CXCR4 plays a crucial role in organ-specific metastasis formation. Although a variety of studies showed the expression of chemokine receptors, in particular, CXCR4, by gastrointestinal tumors, the precise mechanisms of chemokine receptor-mediated homing of c...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.09272

    authors: Gassmann P,Haier J,Schlüter K,Domikowsky B,Wendel C,Wiesner U,Kubitza R,Engers R,Schneider SW,Homey B,Müller A

    更新日期:2009-07-01 00:00:00

  • A Pre-Clinical Assessment of the Pan-ERBB Inhibitor Dacomitinib in Pediatric and Adult Brain Tumors.

    abstract::Glioblastoma in adults, and medulloblastoma and pineoblastoma that mainly affect children, are aggressive brain tumors. The survival for patients with glioblastoma remains dismal. While the cure rate for medulloblastoma exceeds 70%, this figure has stagnated over the past few decades and survivors still contend with s...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2018.02.004

    authors: Endersby R,Whitehouse J,Hii H,Greenall SA,Johns TG,Gottardo NG

    更新日期:2018-05-01 00:00:00

  • Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma.

    abstract::Although medulloblastoma is the most common pediatric malignant brain tumor, its molecular underpinnings are largely unknown. We have identified rare, recurrent homozygous deletions of Kruppel-like Factor 4 (KLF4) in medulloblastoma using high-resolution single nucleotide polymorphism arrays, digital karyotyping, and ...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.91122

    authors: Nakahara Y,Northcott PA,Li M,Kongkham PN,Smith C,Yan H,Croul S,Ra YS,Eberhart C,Huang A,Bigner D,Grajkowska W,Van Meter T,Rutka JT,Taylor MD

    更新日期:2010-01-01 00:00:00

  • Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells.

    abstract::Increases in the levels and/or activity of nonreceptor tyrosine kinases c-Src and c-Yes are often associated with colorectal carcinogenesis. The physiological consequences of increased c-Yes activity during the early and late stages of tumorigenesis, in addition to the degree of redundancy between c-Yes and c-Src in c...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.07442

    authors: Barraclough J,Hodgkinson C,Hogg A,Dive C,Welman A

    更新日期:2007-09-01 00:00:00

  • An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity.

    abstract::Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence. Introduction of the telomerase (hTERT) cDNA is sufficient to produce telomerase activity and immortal...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1038/sj.neo.7900113

    authors: Yi X,White DM,Aisner DL,Baur JA,Wright WE,Shay JW

    更新日期:2000-09-01 00:00:00

  • Gene expression signature for spontaneous cancer regression in melanoma pigs.

    abstract::Incomplete spontaneous regression of melanoma is common. However, complete melanoma regression is still a very rare phenomenon. Because melanoma is the most immunogenic human malignancy, the mechanisms leading to regression, based on accumulative evidence, are the host's immune responses. Unfortunately, therapies aimi...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.08344

    authors: Rambow F,Piton G,Bouet S,Leplat JJ,Baulande S,Marrau A,Stam M,Horak V,Vincent-Naulleau S

    更新日期:2008-07-01 00:00:00

  • Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production.

    abstract::Signaling events leading to Schwann cell tumor initiation have been extensively characterized in the context of neurofibromatosis (NF). Similar tumors are also observed in patients with the endocrine neoplasia syndrome Carney complex, which results from inactivating mutations in PRKAR1A. Loss of PRKAR1A causes enhance...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.08652

    authors: Jones GN,Tep C,Towns WH 2nd,Mihai G,Tonks ID,Kay GF,Schmalbrock PM,Stemmer-Rachamimov AO,Yoon SO,Kirschner LS

    更新日期:2008-11-01 00:00:00

  • Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478.

    abstract::PX-478 is a new agent known to inhibit the hypoxia-responsive transcription factor, HIF-1alpha, in experimental tumors. The current study was undertaken in preparation for clinical trials to determine which noninvasive imaging endpoint(s) is sensitive to this drug's actions. Dynamic contrast-enhanced (DCE) and diffusi...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.04628

    authors: Jordan BF,Runquist M,Raghunand N,Baker A,Williams R,Kirkpatrick L,Powis G,Gillies RJ

    更新日期:2005-05-01 00:00:00

  • Up-regulation of FOXM1 by E6 oncoprotein through the MZF1/NKX2-1 axis is required for human papillomavirus-associated tumorigenesis.

    abstract:PURPOSE:Foxhead box M1 (FOXM1) expression has been shown to be linked with human papillomavirus (HPV) 16/18-infected cervical cancer. However, the mechanism underlying the induction of FOXM1 in HPV 16/18-infected cancers remains elusive. EXPERIMENTAL DESIGN:The mechanistic actions of FOXM1 induced by the E6/NKX2-1 axi...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2014.09.010

    authors: Chen PM,Cheng YW,Wang YC,Wu TC,Chen CY,Lee H

    更新日期:2014-11-20 00:00:00

  • Hepatitis B virus X protein inhibits tumor suppressor miR-205 through inducing hypermethylation of miR-205 promoter to enhance carcinogenesis.

    abstract::The infection of hepatitis B virus (HBV) is closely associated with the development of hepatocellular carcinoma (HCC), in which HBV X protein (HBx) plays crucial roles. MicroRNAs are involved in diverse biologic functions and in carcinogenesis by regulating gene expression. In the present study, we aim to investigate ...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.131362

    authors: Zhang T,Zhang J,Cui M,Liu F,You X,Du Y,Gao Y,Zhang S,Lu Z,Ye L,Zhang X

    更新日期:2013-11-01 00:00:00

  • A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16.

    abstract::The Wilms tumor gene (WT1) is mutated or deleted in patients with heredofamilial syndromes associated with the development of Wilms tumors, but is infrequently mutated in sporadic Wilms tumors. By comparing the microarray profiles of syndromic versus sporadic Wilms tumors and WT1-inducible Saos-2 osteosarcoma cells, w...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.07869

    authors: Kim MK,Mason JM,Li CM,Berkofsky-Fessler W,Jiang L,Choubey D,Grundy PE,Tycko B,Licht JD

    更新日期:2008-01-01 00:00:00

  • SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.

    abstract::SIRT3 is a major mitochondrial deacetylase, which regulates various metabolic pathways by deacetylation; however, the effect of SIRT3 on proline metabolism is not reported. Pyrroline-5-carboxylate reductase 1 (PYCR1) participates in proline synthesis process by catalyzing the reduction of P5C to proline with concomita...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2019.04.008

    authors: Chen S,Yang X,Yu M,Wang Z,Liu B,Liu M,Liu L,Ren M,Qi H,Zou J,Vucenik I,Zhu WG,Luo J

    更新日期:2019-07-01 00:00:00