Individual telomere lengths in chronic myeloid leukemia.

abstract：:Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)-targeted therapies predominantly affect nascent, immature tumor vessels. Since platelet-derived growth factor receptor (PDGFR) blockade inhibits vessel maturation and thus increases the amount of immature tumor vessels, we evaluated whether the combined P...

journal_title：Neoplasia (New York, N.Y.)

authors： Zafarnia S,Bzyl-Ibach J,Spivak I,Li Y,Koletnik S,Doleschel D,Rix A,Pochon S,Tardy I,Koyadan S,van Zandvoort M,Palmowski M,Kiessling F,Lederle W

更新日期：2017-11-01 00:00:00

abstract：:Angiogenesis is a central cancer hallmark, necessary for supporting tumor growth and metastasis. In vivo imaging of angiogenesis is commonly applied, to understand dynamic processes in cancer development and treatment strategies. However, most radiological modalities today assess angiogenesis based on indirect mechani...

journal_title：Neoplasia (New York, N.Y.)

authors： Omar M,Schwarz M,Soliman D,Symvoulidis P,Ntziachristos V

更新日期：2015-02-01 00:00:00

abstract：:Mouse models are powerful tools to study lung cancer initiation and progression in vivo and have contributed significantly to recent advances in therapy. Using micro-computed tomography to monitor and study parenchymal and extra-parenchymal metastases in existing murine models of lung cancer is challenging owing to a ...

journal_title：Neoplasia (New York, N.Y.)

authors： Viswanath P,Peng S,Singh R,Kingsley C,Balter PA,Johnson FM

更新日期：2018-10-01 00:00:00

abstract：:Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies. It has been shown that telomere deprotection in p53-deficient mouse embryonic fibroblasts leads to high rates of polyploidization. We now sho...

journal_title：Neoplasia (New York, N.Y.)

authors： Christodoulidou A,Raftopoulou C,Chiourea M,Papaioannou GK,Hoshiyama H,Wright WE,Shay JW,Gagos S

更新日期：2013-02-01 00:00:00

abstract：:It is widely accepted that a deranged immune system plays a key role in the onset and evolution of classic Kaposi sarcoma (CKS). Nevertheless, the usage of the T-cell receptor (TCR) β-variable (BV) chain repertoire expressed by peripheral blood lymphocytes in patients with CKS is still unknown. With the aim of providi...

journal_title：Neoplasia (New York, N.Y.)

authors： Galleu A,Fozza C,Simula MP,Contini S,Virdis P,Corda G,Pardini S,Cottoni F,Pruneddu S,Angeloni A,Ceccarelli S,Longinotti M

更新日期：2012-06-01 00:00:00

abstract：:The biologic plausibility of an association between type 2 diabetes mellitus (T2D) and lung cancer has received increasing attention, but the results of investigations remain largely inconclusive. In the present study we investigated the influence of the anti-diabetic drug metformin on the cytotoxic effects of EGFR ta...

journal_title：Neoplasia (New York, N.Y.)

authors： Xiao Z,Gaertner S,Morresi-Hauf A,Genzel R,Duell T,Ullrich A,Knyazev PG

更新日期：2017-05-01 00:00:00

abstract：:BRAF is the most frequently mutated gene in melanoma. Constitutive activation of mutant BRAFV600E leads to aberrant Ras-independent MAPK signaling and cell transformation. Inhibition of mutant BRAF is a current frontline therapy for such cases, with improved survival compared with chemotherapy. Unfortunately, reactiva...

journal_title：Neoplasia (New York, N.Y.)

authors： Mologni L,Costanza M,Sharma GG,Viltadi M,Massimino L,Citterio S,Purgante S,Raman H,Pirola A,Zucchetti M,Piazza R,Gambacorti-Passerini C

更新日期：2018-05-01 00:00:00

abstract：:To investigate the cellular/molecular basis of the activity of a novel lipophilic camptothecin, gimatecan (ST1481), against slowly proliferating cells, we performed a comparative study of topotecan and gimatecan in human bladder cancer models (HT1376 and MCR). Gimatecan was significantly more effective than topotecan ...

journal_title：Neoplasia (New York, N.Y.)

authors： Ulivi P,Zoli W,Fabbri F,Brigliadori G,Ricotti L,Tesei A,Rosetti M,De Cesare M,Beretta GL,Corna E,Supino R,Zunino F

更新日期：2005-02-01 00:00:00

abstract：:Several observations suggest a potential role of T-cell-mediated immunity in the control of neuroblastoma (NB). However, the generation of NB-specific cytotoxic T lymphocytes (CTL) on T-cell priming with tumor mRNA-transfected dendritic cells (DC) has never been investigated before. In the present study, the feasibili...

journal_title：Neoplasia (New York, N.Y.)

authors： Morandi F,Chiesa S,Bocca P,Millo E,Salis A,Solari M,Pistoia V,Prigione I

更新日期：2006-10-01 00:00:00

abstract：:This review covers the diverse topic of neuroendocrine neoplasms (NENs), a relatively rare and heterogeneous tumor type, comprising ~2% of all malignancies, with a prevalence of <200,000 in the United States, which makes it an orphan disease (Basu et al., 2010).1 For functional purposes, NENs are divided into two grou...

journal_title：Neoplasia (New York, N.Y.)

authors： Oronsky B,Ma PC,Morgensztern D,Carter CA

更新日期：2017-12-01 00:00:00

abstract：:c-Cbl, a RING-type ubiquitin E3 ligase, downregulates various receptor tyrosine kinases (e.g., epidermal growth factor receptor (EGFR)), leading to inhibition of cell proliferation. Moreover, patients with myeloid neoplasm frequently harbor c-Cbl mutations, implicating the role of c-Cbl as a tumor suppressor. Recently...

journal_title：Neoplasia (New York, N.Y.)

authors： Seong MW,Ka SH,Park JH,Park JH,Yoo HM,Yang SW,Park JM,Park D,Lee ST,Seol JH,Chung CH

更新日期：2015-06-01 00:00:00

abstract：:Approximately 50% of prostate cancers harbor the TMPRSS2:ERG fusion, resulting in elevated expression of the ERG transcription factor. Despite the identification of this subclass of prostate cancers, no personalized therapeutic strategies have achieved clinical implementation. Kinases are attractive therapeutic target...

journal_title：Neoplasia (New York, N.Y.)

authors： Lee RS,Zhang L,Berger A,Lawrence MG,Song J,Niranjan B,Davies RG,Lister NL,Sandhu SK,Rubin MA,Risbridger GP,Taylor RA,Rickman DS,Horvath LG,Daly RJ

更新日期：2019-04-01 00:00:00

abstract：:Recent studies have established that a significant fraction of prostate cancers harbor a signature gene fusion between the 5' region of androgen-regulated TMPRSS2 and an ETS family transcription factor, most commonly ERG. Studies on the molecular mechanisms and functional consequences of this important chromosomal rea...

journal_title：Neoplasia (New York, N.Y.)

authors： Mertz KD,Setlur SR,Dhanasekaran SM,Demichelis F,Perner S,Tomlins S,Tchinda J,Laxman B,Vessella RL,Beroukhim R,Lee C,Chinnaiyan AM,Rubin MA

更新日期：2007-03-01 00:00:00

abstract：:Previously, we identified the transcription factor CUX1 as an important modulator of invasion and resistance to apoptosis. Expression profiles suggested that CUX1 regulates a complex transcriptional program mediating tumor progression. We aimed to identify functionally relevant targets of CUX1 by using RNA interferenc...

journal_title：Neoplasia (New York, N.Y.)

authors： Ripka S,Riedel J,Neesse A,Griesmann H,Buchholz M,Ellenrieder V,Moeller F,Barth P,Gress TM,Michl P

更新日期：2010-08-01 00:00:00

abstract：:The purposes of this study were 1) to investigate the feasibility of using optical tomography in the near-infrared (NIR) spectrum combined with ultrasound (US) localization (NIR/US) in monitoring tumor vascular changes and assessing tumor pathological response during chemotherapy and 2) to compare the accuracy of NIR/...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhu Q,Tannenbaum S,Hegde P,Kane M,Xu C,Kurtzman SH

更新日期：2008-10-01 00:00:00

abstract：:Pro-inflammatory conditions have long been associated with mammary carcinogenesis and breast cancer progression. The underlying mechanisms are incompletely understood but signaling of pro-inflammatory cytokine TNFα through its receptors TNFR1 and TNFR2 is a major mediator of inflammation in both obesity and in the res...

journal_title：Neoplasia (New York, N.Y.)

authors： He L,Bhat K,Duhacheck-Muggy S,Ioannidis A,Zhang L,Nguyen NT,Moatamed NA,Pajonk F

更新日期：2021-02-01 00:00:00

abstract：:With the recent approval of 3 new antibody drug conjugates (ADCs) for solid tumors, this class of drugs is gaining momentum for the targeted treatment of cancer. Despite significant investment, there are still fundamental issues that are incompletely understood. Three of the recently approved ADCs contain payloads exh...

journal_title：Neoplasia (New York, N.Y.)

authors： Khera E,Cilliers C,Smith MD,Ganno ML,Lai KC,Keating TA,Kopp A,Nessler I,Abu-Yousif AO,Thurber GM

更新日期：2021-02-01 00:00:00

abstract：:Fbw7 is a tumor suppressor that regulates the degradation of oncogenic substrates such as c-Jun, c-Myc, Notch1 intracellular domain (ICD), and cyclin E by functioning as the substrate recognition protein in the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex. Consequently, low expression or loss of FBXW7 in breast ca...

journal_title：Neoplasia (New York, N.Y.)

authors： Meyer AE,Furumo Q,Stelloh C,Minella AC,Rao S

更新日期：2020-11-01 00:00:00

abstract：:PX-478 is a new agent known to inhibit the hypoxia-responsive transcription factor, HIF-1alpha, in experimental tumors. The current study was undertaken in preparation for clinical trials to determine which noninvasive imaging endpoint(s) is sensitive to this drug's actions. Dynamic contrast-enhanced (DCE) and diffusi...

journal_title：Neoplasia (New York, N.Y.)

authors： Jordan BF,Runquist M,Raghunand N,Baker A,Williams R,Kirkpatrick L,Powis G,Gillies RJ

更新日期：2005-05-01 00:00:00

abstract：:The benefits of inhibiting vascular endothelial growth factor (VEGF) signaling in cancer patients are predominantly attributed to effects on tumor endothelial cells. Targeting non-endothelial stromal cells to further impact tumor cell growth and survival is being pursued through the inhibition of additional growth fac...

journal_title：Neoplasia (New York, N.Y.)

authors： Duignan IJ,Corcoran E,Pennello A,Plym MJ,Amatulli M,Claros N,Iacolina M,Youssoufian H,Witte L,Samakoglu S,Schwartz J,Surguladze D,Tonra JR

更新日期：2011-01-01 00:00:00

abstract：:DBD* is a novel gene encoding an 89 amino acid peptide that is constitutively lethal to leukemic cells. DBD* was derived from the DNA binding domain of the human glucocorticoid receptor by a frameshift that replaces the final 21 C-terminal amino acids of the domain. Previous studies suggested that DBD* no longer acted...

journal_title：Neoplasia (New York, N.Y.)

authors： Ji YS,Johnson BH,Webb MS,Thompson EB

更新日期：2002-09-01 00:00:00

abstract：:We characterized the molecular genetic consequences of a balanced chromosome translocation t(8;22)(p21;q12), which occurred as the sole cytogenetic aberration in short-term cultured cells from an intrathoracic mature teratoma in a 15-year-old girl. Fluorescence in situ hybridization and reverse transcription-polymeras...

journal_title：Neoplasia (New York, N.Y.)

authors： Jin Y,Mertens F,Kullendorff CM,Panagopoulos I

更新日期：2006-05-01 00:00:00

abstract：:Metastatic dissemination of primary tumors is responsible for 90% of colorectal cancer (CRC) deaths. The presence of positive lymph nodes, which separates stage I/II from stage III CRC, is a particularly key factor in patient management. Here, we describe results of a quantitative proteomic survey to identify molecula...

journal_title：Neoplasia (New York, N.Y.)

authors： Lin Y,Buckhaults PJ,Lee JR,Xiong H,Farrell C,Podolsky RH,Schade RR,Dynan WS

更新日期：2009-09-01 00:00:00

abstract：:We used the standard comet assay successfully to generate in vitro dose-response curves under oxic and hypoxic conditions. We then made mixtures of cells that had been irradiated with 3 and 9 Gy of X-rays to simulate two subpopulations in a tumor, but efforts to accurately detect and quantify the subpopulations using ...

journal_title：Neoplasia (New York, N.Y.)

authors： Wang J,Klem J,Wyrick JB,Ozawa T,Cunningham E,Golinveaux J,Allen MJ,Lamborn KR,Deen DF

更新日期：2003-07-01 00:00:00

abstract：:It has been proposed that the structural and numerical chromosome abnormalities recorded in breast cancer could be the result of telomere dysfunction and that telomerase is activated de novo to provide a survival mechanism curtailing further chromosomal aberrations. However, recent in vivo and in vitro data show that ...

journal_title：Neoplasia (New York, N.Y.)

authors： Papadopoulou A,Trangas T,Teixeira MR,Heim S,Dimitriadis E,Tsarouha H,Andersen JA,Evangelou E,Ioannidis P,Agnantis NJ,Pandis N

更新日期：2003-03-01 00:00:00

abstract：:Gemcitabine is widely used as first-line chemotherapeutic drug in the treatment of pancreatic cancer. Our previous experimental chemotherapy studies have shown that treatment of human pancreatic carcinoma cells with 5-fluorouracil (5-FU) alters the cellular transporter expression profile and that modulation of the exp...

journal_title：Neoplasia (New York, N.Y.)

authors： Hagmann W,Jesnowski R,Löhr JM

更新日期：2010-09-01 00:00:00

abstract：:The cancer stem cell paradigm postulates that dysregulated tissue-specific stem cells or progenitor cells are precursors for cancer biogenesis. Consequently, identifying cancer stem cells is crucial to our understanding of cancer progression and for the development of novel therapeutic agents. In this study, we demons...

journal_title：Neoplasia (New York, N.Y.)

authors： Vesuna F,Lisok A,Kimble B,Raman V

更新日期：2009-12-01 00:00:00

abstract：:Cancer cells can undergo stress-induced premature senescence, which is considered to be a desirable outcome of anticancer treatment. However, the escape from senescence and cancer cell repopulation give rise to some doubts concerning the effectiveness of the senescence-induced anticancer therapy. Similarly, it is post...

journal_title：Neoplasia (New York, N.Y.)

authors： Mosieniak G,Sliwinska MA,Alster O,Strzeszewska A,Sunderland P,Piechota M,Was H,Sikora E

更新日期：2015-12-01 00:00:00

abstract：:Peritoneal metastasis (PM) is a very serious complication of gastrointestinal and gynecological malignancies which is poorly documented. Modified mesothelial cell layer and their microenvironments can favor fibrin deposition for cancer cell adhesion. Scanning and transmission electron microscopy of peritoneal surface ...

journal_title：Neoplasia (New York, N.Y.)

authors： Shahid S,Iman A,Matti U,Rachid K,Assaf A,Eveno C,Marc P,Massoud M

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) kinase is overexpressed in various tumors and has been linked to poor prognosis. Its role as proto-oncogene is based on several Pim-1 target proteins involved in pivotal cellular processes. Here, we explore the functional relevance of Pim...

journal_title：Neoplasia (New York, N.Y.)

authors： Weirauch U,Beckmann N,Thomas M,Grünweller A,Huber K,Bracher F,Hartmann RK,Aigner A

更新日期：2013-07-01 00:00:00