Abstract:
:Adenomatous polyposis coli (APC) is a multifunctional protein having diverse cellular functions including cell migration, cell-cell adhesion, cell cycle control, chromosomal segregation, and apoptosis. Recently, we found a new role of APC in base excision repair (BER) and showed that it interacts with DNA polymerase β and 5'-flap endonuclease 1 and interferes in BER. Previously, we have also reported that cigarette smoke condensate (CSC) increases expression of APC and enhances the growth of normal human breast epithelial (MCF10A) cells in vitro. In the present study, using APC overexpression and knockdown systems, we have examined the molecular mechanisms by which CSC and its major component, Benzo[α]pyrene, enhances APC-mediated accumulation of abasic DNA lesions, which is cytotoxic and mutagenic in nature, leading to enhanced neoplastic transformation of MCF10A cells in an orthotopic xenograft model.
journal_name
Neoplasiajournal_title
Neoplasia (New York, N.Y.)authors
Jaiswal AS,Panda H,Pampo CA,Siemann DW,Gairola CG,Hromas R,Narayan Sdoi
10.1593/neo.13176subject
Has Abstractpub_date
2013-04-01 00:00:00pages
454-60issue
4eissn
1522-8002issn
1476-5586journal_volume
15pub_type
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