Gene expression signature for spontaneous cancer regression in melanoma pigs.

abstract：:The maspin gene functions as a tumor suppressor in human breasts, and its expression is frequently lost during breast cancer progression. In vitro models of human breast cancer indicate that the loss of maspin expression is closely linked to aberrant methylation of the maspin promoter. We conducted a study on 30 archi...

journal_title：Neoplasia (New York, N.Y.)

authors： Futscher BW,O'Meara MM,Kim CJ,Rennels MA,Lu D,Gruman LM,Seftor RE,Hendrix MJ,Domann FE

更新日期：2004-07-01 00:00:00

abstract：:Inhibitors of histone deacetylases have been shown to enhance the sensitivity of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand TRAIL-mediated cytotoxicity. Valproic acid (VA), a commonly used antiepileptic agent whose pharmacokinetics and toxicity profiles are well described, is a histone dea...

journal_title：Neoplasia (New York, N.Y.)

authors： Ziauddin MF,Yeow WS,Maxhimer JB,Baras A,Chua A,Reddy RM,Tsai W,Cole GW Jr,Schrump DS,Nguyen DM

更新日期：2006-06-01 00:00:00

abstract：:During normal sympathetic nervous system (SNS) development, cells of the ganglionic lineage can malignantly transform and develop into the childhood tumor neuroblastoma. Hypoxia-inducible transcription factors (HIFs) mediate cellular responses during normal development and are central in the adaptation to oxygen short...

journal_title：Neoplasia (New York, N.Y.)

authors： Mohlin S,Hamidian A,Påhlman S

更新日期：2013-03-01 00:00:00

abstract：:Although Chk1 kinase inhibitors are currently under clinical investigation as effective cancer cell sensitizers to the cytotoxic effects of numerous chemotherapeutics, there is still a considerable uncertainty regarding their role in modulation of anticancer potential of platinum-based drugs. Here we newly demonstrate...

journal_title：Neoplasia (New York, N.Y.)

authors： Herůdková J,Paruch K,Khirsariya P,Souček K,Krkoška M,Vondálová Blanářová O,Sova P,Kozubík A,Hyršlová Vaculová A

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) kinase is overexpressed in various tumors and has been linked to poor prognosis. Its role as proto-oncogene is based on several Pim-1 target proteins involved in pivotal cellular processes. Here, we explore the functional relevance of Pim...

journal_title：Neoplasia (New York, N.Y.)

authors： Weirauch U,Beckmann N,Thomas M,Grünweller A,Huber K,Bracher F,Hartmann RK,Aigner A

更新日期：2013-07-01 00:00:00

abstract：:Angiogenesis is a central cancer hallmark, necessary for supporting tumor growth and metastasis. In vivo imaging of angiogenesis is commonly applied, to understand dynamic processes in cancer development and treatment strategies. However, most radiological modalities today assess angiogenesis based on indirect mechani...

journal_title：Neoplasia (New York, N.Y.)

authors： Omar M,Schwarz M,Soliman D,Symvoulidis P,Ntziachristos V

更新日期：2015-02-01 00:00:00

abstract：:Substantial heterogeneity exists within cervical cancer that is generally infected by human papillomavirus (HPV). However, the most common histological subtype of cervical cancer, cervical squamous cell carcinoma (CSCC), is poorly characterized regarding the association between its heterogeneity and HPV oncoprotein ex...

journal_title：Neoplasia (New York, N.Y.)

authors： Lu X,Jiang L,Zhang L,Zhu Y,Hu W,Wang J,Ruan X,Xu Z,Meng X,Gao J,Su X,Yan F

更新日期：2019-06-01 00:00:00

abstract：:SAG (Sensitive to Apoptosis Gene), also known as RBX2 or ROC2, is a RING component of CRL (Cullin-RING ligase), required for its activity. Our previous studies showed that Sag/Rbx2 co-operated with Kras or Pten loss to promote tumorigenesis in the lung and prostate, respectively, but antagonized Kras to inhibit skin t...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhang Q,Wei D,Tan M,Li H,Morgan MA,Sun Y

更新日期：2020-04-24 00:00:00

abstract：:p300/CBP-associated factor (PCAF) is a coactivator of the tumor suppressor, p53. PCAF participates in p53's transactivation of target genes through acetylation of both bound p53 and histones within p53 target promoters. Using microarrays, we discovered that PCAF itself is induced by p53 in a panel of breast tumor cell...

journal_title：Neoplasia (New York, N.Y.)

authors： Watts GS,Oshiro MM,Junk DJ,Wozniak RJ,Watterson S,Domann FE,Futscher BW

更新日期：2004-05-01 00:00:00

abstract：:Fbw7 is a tumor suppressor that regulates the degradation of oncogenic substrates such as c-Jun, c-Myc, Notch1 intracellular domain (ICD), and cyclin E by functioning as the substrate recognition protein in the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex. Consequently, low expression or loss of FBXW7 in breast ca...

journal_title：Neoplasia (New York, N.Y.)

authors： Meyer AE,Furumo Q,Stelloh C,Minella AC,Rao S

更新日期：2020-11-01 00:00:00

abstract：:Mouse models are powerful tools to study lung cancer initiation and progression in vivo and have contributed significantly to recent advances in therapy. Using micro-computed tomography to monitor and study parenchymal and extra-parenchymal metastases in existing murine models of lung cancer is challenging owing to a ...

journal_title：Neoplasia (New York, N.Y.)

authors： Viswanath P,Peng S,Singh R,Kingsley C,Balter PA,Johnson FM

更新日期：2018-10-01 00:00:00

abstract：:Pancreatic carcinoma has an extremely bad prognosis due to lack of early diagnostic markers and lack of effective therapeutic strategies. Recently, we have established an in vitro model recapitulating the first steps in the carcinogenesis of the pancreas. SV40 large T antigen-immortalized bovine pancreatic duct cells ...

journal_title：Neoplasia (New York, N.Y.)

authors： Jesnowski R,Zubakov D,Faissner R,Ringel J,Hoheisel JD,Lösel R,Schnölzer M,Löhr M

更新日期：2007-02-01 00:00:00

abstract：:Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence. Introduction of the telomerase (hTERT) cDNA is sufficient to produce telomerase activity and immortal...

journal_title：Neoplasia (New York, N.Y.)

authors： Yi X,White DM,Aisner DL,Baur JA,Wright WE,Shay JW

更新日期：2000-09-01 00:00:00

abstract：:Epidemiological studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) significantly reduce the risk and mortality from colorectal cancer, in part by inhibiting prostaglandin (PG) synthesis. Cyclooxygenase (COX), the rate-limiting enzyme in PG biosynthesis, exists in two isoforms, COX-1 and COX-2. Genetic...

journal_title：Neoplasia (New York, N.Y.)

authors： Tong BJ,Tan J,Tajeda L,Das SK,Chapman JA,DuBois RN,Dey SK

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:Inflammatory breast cancer (IBC) is arguably the deadliest form of breast cancer due to its rapid onset and highly invasive nature. IBC carries 5- and 10-year disease-free survival rates of ~45% and <20%, respectively. Multiple studies demonstrate that in comparison with conventional breast cancer, IBC has a un...

journal_title：Neoplasia (New York, N.Y.)

authors： Joglekar-Javadekar M,Van Laere S,Bourne M,Moalwi M,Finetti P,Vermeulen PB,Birnbaum D,Dirix LY,Ueno N,Carter M,Rains J,Ramachandran A,Bertucci F,van Golen KL

更新日期：2017-07-01 00:00:00

abstract：:BRAF is the most frequently mutated gene in melanoma. Constitutive activation of mutant BRAFV600E leads to aberrant Ras-independent MAPK signaling and cell transformation. Inhibition of mutant BRAF is a current frontline therapy for such cases, with improved survival compared with chemotherapy. Unfortunately, reactiva...

journal_title：Neoplasia (New York, N.Y.)

authors： Mologni L,Costanza M,Sharma GG,Viltadi M,Massimino L,Citterio S,Purgante S,Raman H,Pirola A,Zucchetti M,Piazza R,Gambacorti-Passerini C

更新日期：2018-05-01 00:00:00

abstract：:We previously reported that overexpression of an O-type glycosyltransferase, GALNT6 (polypeptide N-acetylgalactosaminyltransferase 6) played critical roles in mammary carcinogenesis. To further investigate the biological function of GALNT6, we screened a substrate protein(s) of GALNT6 using a VVA (Vicia villosa agglut...

journal_title：Neoplasia (New York, N.Y.)

authors： Lin J,Chung S,Ueda K,Matsuda K,Nakamura Y,Park JH

更新日期：2017-01-01 00:00:00

abstract：:Since loss of VHL is frequently detected early phase genetic event in human renal cell carcinoma, pVHL is assumed to be indispensable for suppression of tumor initiation step. However, induction of HIF-1α, target of pVHL E3 ligase, is more adequate to angiogenesis step after tumor mass formation. Concerning this, it h...

journal_title：Neoplasia (New York, N.Y.)

authors： Jung YS,Chun HY,Yoon MH,Park BJ

更新日期：2014-12-01 00:00:00

abstract：:We present an in vivo fluorescence microscopic evaluation of intratumor distribution of the photosensitizer mono-L-aspartylchlorin-e6 (NPe6) in an intradermal mouse EMT6 tumor model. Although the identification of favorable photophysical and pharmacological properties has led to the development of new photosensitizers...

journal_title：Neoplasia (New York, N.Y.)

authors： Mitra S,Foster TH

更新日期：2008-05-01 00:00:00

abstract：:About 10% to 30% of patients with ataxia-telangiectasia (A-T) develop leukemias or lymphomas. There is considerable interpatient variation in the age of onset and leukemia/lymphoma type. The incomplete penetrance and variable age of onset may be attributable to several factors. These include competing mortality from o...

journal_title：Neoplasia (New York, N.Y.)

authors： Genik PC,Bielefeldt-Ohmann H,Liu X,Story MD,Ding L,Bush JM,Fallgren CM,Weil MM

更新日期：2014-02-01 00:00:00

abstract：:Numerous human tumor types, including ovarian cancer, display a significant expression of the CD44 family of cell surface proteoglycans. To develop tumor-targeted drugs, we have initially evaluated whether the CD44 ligand hyaluronic acid (HA) could serve as a backbone for paclitaxel (TXL) prodrugs. HA-TXL was prepared...

journal_title：Neoplasia (New York, N.Y.)

authors： Auzenne E,Ghosh SC,Khodadadian M,Rivera B,Farquhar D,Price RE,Ravoori M,Kundra V,Freedman RS,Klostergaard J

更新日期：2007-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths in America. Nearly two thirds of newly diagnosed CRC cases include lymph node (LN) involvement, and LN metastasis is one of the strongest negative prognostic factors for CRC. It is thought that CRC tumors ...

journal_title：Neoplasia (New York, N.Y.)

authors： Margolin DA,Silinsky J,Grimes C,Spencer N,Aycock M,Green H,Cordova J,Davis NK,Driscoll T,Li L

更新日期：2011-09-01 00:00:00

abstract：:Heparanase-1 (HPR1), an endoglycosidase that specifically degrades heparan sulfate (HS) proteoglycans, is overexpressed in a variety of malignancies. Our present study sought to determine whether oncogene BRAF and RAS mutations lead to increased HPR1 expression. Reverse transcription-polymerase chain reaction analysis...

journal_title：Neoplasia (New York, N.Y.)

authors： Rao G,Liu D,Xing M,Tauler J,Prinz RA,Xu X

更新日期：2010-11-01 00:00:00

abstract：:The MEK-ERK growth signaling pathway is important in human hepatocellular carcinoma (HCC). To evaluate the targeting of this pathway in HCC, we characterized a novel, orally-active MEK inhibitor, PD184161, using human HCC cells (HepG2, Hep3B, PLC, and SKHep) and in vivo human tumor xenografts. PD184161 inhibited MEK a...

journal_title：Neoplasia (New York, N.Y.)

authors： Klein PJ,Schmidt CM,Wiesenauer CA,Choi JN,Gage EA,Yip-Schneider MT,Wiebke EA,Wang Y,Omer C,Sebolt-Leopold JS

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Well-differentiated gastroenteropancreatic neuroendocrine neoplasms are rare tumors with a slow proliferation. They are virtually resistant to many DNA-damaging therapeutic approaches, such as chemo- and external beam therapy, which might be overcome by DNA damage inhibition induced by proteasome inhibitors ...

journal_title：Neoplasia (New York, N.Y.)

authors： Briest F,Koziolek EJ,Albrecht J,Schmidt F,Bernsen MR,Haeck J,Kühl AA,Sedding D,Hartung T,Exner S,Welzel M,Fischer C,Grötzinger C,Brenner W,Baum RP,Grabowski P

更新日期：2021-01-01 00:00:00

abstract：:The expression of N-cadherin (NCAD) has been shown to correlate with increased tumor cell motility and metastasis. However, NCAD-mediated adhesion is a robust phenomenon and therefore seems to be inconsistent with the "release" from intercellular adhesion required for invasion. We show that in the most invasive melano...

journal_title：Neoplasia (New York, N.Y.)

authors： Maret D,Gruzglin E,Sadr MS,Siu V,Shan W,Koch AW,Seidah NG,Del Maestro RF,Colman DR

更新日期：2010-12-01 00:00:00

abstract：:The extracellular matrix (ECM) is critical for mammary ductal development and differentiation, but how mammary fibroblasts regulate ECM remodeling remains to be elucidated. Herein, we used a mouse genetic model to activate platelet derived growth factor receptor-alpha (PDGFRα) specifically in the stroma. Hyperactivati...

journal_title：Neoplasia (New York, N.Y.)

authors： Hammer AM,Sizemore GM,Shukla VC,Avendano A,Sizemore ST,Chang JJ,Kladney RD,Cuitiño MC,Thies KA,Verfurth Q,Chakravarti A,Yee LD,Leone G,Song JW,Ghadiali SN,Ostrowski MC

更新日期：2017-06-01 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy originating from T-cell precursors. The genetic landscape of T-ALL has been largely characterized by next-generation sequencing. Yet, the transcriptome of miRNAs (miRNome) of T-ALL has been less extensively studied. Using small RNA sequencing, we ...

journal_title：Neoplasia (New York, N.Y.)

authors： Dawidowska M,Jaksik R,Drobna M,Szarzyńska-Zawadzka B,Kosmalska M,Sędek Ł,Machowska L,Lalik A,Lejman M,Ussowicz M,Kałwak K,Kowalczyk JR,Szczepański T,Witt M

更新日期：2019-03-01 00:00:00

abstract：:Gemcitabine is widely used as first-line chemotherapeutic drug in the treatment of pancreatic cancer. Our previous experimental chemotherapy studies have shown that treatment of human pancreatic carcinoma cells with 5-fluorouracil (5-FU) alters the cellular transporter expression profile and that modulation of the exp...

journal_title：Neoplasia (New York, N.Y.)

authors： Hagmann W,Jesnowski R,Löhr JM

更新日期：2010-09-01 00:00:00

abstract：:Recent studies have demonstrated that the chemokine receptor CXCR4 plays a crucial role in organ-specific metastasis formation. Although a variety of studies showed the expression of chemokine receptors, in particular, CXCR4, by gastrointestinal tumors, the precise mechanisms of chemokine receptor-mediated homing of c...

journal_title：Neoplasia (New York, N.Y.)

authors： Gassmann P,Haier J,Schlüter K,Domikowsky B,Wendel C,Wiesner U,Kubitza R,Engers R,Schneider SW,Homey B,Müller A

更新日期：2009-07-01 00:00:00