Variation in the PaO2/FiO2 ratio with FiO2: mathematical and experimental description, and clinical relevance.

abstract：INTRODUCTION:Early multimodal treatment of severe sepsis, including the use of drotrecogin alfa (activated) (DrotAA) when indicated, is considered essential for optimum outcome. However, predicting which infected patients will progress to severe sepsis and the need for aggressive intervention continues to be problemati...

journal_title：Critical care (London, England)

authors： Hodder RV,Hall R,Russell JA,Fisher HN,Lee B

更新日期：2009-01-01 00:00:00

abstract：:COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it can progress into severe pneumonia and acute respiratory distress syndrome (ARDS). Inflammation is known to play a crucial role in the pathogenesis of severe infe...

journal_title：Critical care (London, England)

authors： van de Veerdonk FL,Netea MG

更新日期：2020-07-18 00:00:00

abstract：:Institutionally based research ethics review is a form of peer review that has - for better or worse - become the norm throughout the world. The vast majority of research ethics review takes the form of protocol review alone, conducted in advance of the research. Although oversight and monitoring in clinical research ...

journal_title：Critical care (London, England)

authors： Lavery JV,Van Laethem ML,Slutsky AS

更新日期：2004-12-01 00:00:00

abstract：INTRODUCTION:The aim of the present study was to investigate the relationship between the blood IL-6 level, the blood glucose level, and glucose control in septic patients. METHODS:This retrospective observational study in a general ICU of a university hospital included a total of 153 patients with sepsis, severe seps...

journal_title：Critical care (London, England)

authors： Nakamura M,Oda S,Sadahiro T,Watanabe E,Abe R,Nakada TA,Morita Y,Hirasawa H

更新日期：2012-12-12 00:00:00

abstract：:The 21st International Symposium on Intensive Care and Emergency Medicine was dominated by the results of recent clinical trials in sepsis and acute respiratory distress syndrome (ARDS). The promise of extracorporeal liver replacement therapy and noninvasive ventilation were other areas of interest. Ethical issues als...

journal_title：Critical care (London, England)

authors： Ball J,Venn R

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Optimal glycaemic targets in traumatic brain injury (TBI) remain unclear. We performed a systematic review and meta-analysis of randomised controlled trials (RCTs) comparing intensive with conventional glycaemic control in TBI requiring admission to an intensive care unit (ICU). METHODS:We systematically se...

journal_title：Critical care (London, England)

authors： Hermanides J,Plummer MP,Finnis M,Deane AM,Coles JP,Menon DK

更新日期：2018-01-19 00:00:00

abstract：INTRODUCTION:Patients with sepsis often demonstrate severely impaired immune responses. The hallmark of this state of immunoparalysis is monocytic deactivation characterized by decreased human leukocyte antigen (HLA)-DR expression and reduced production of proinflammatory cytokines. Recently, diminished numbers of dend...

journal_title：Critical care (London, England)

authors： Poehlmann H,Schefold JC,Zuckermann-Becker H,Volk HD,Meisel C

更新日期：2009-01-01 00:00:00

abstract：:An influenza pandemic threatens to be the most lethal public health crisis to confront the world. Physicians will have critical roles in diagnosis, containment and treatment of influenza, and their commitment to treat despite increased personal risks is essential for a successful public health response. The obligation...

journal_title：Critical care (London, England)

authors： Anantham D,McHugh W,O'Neill S,Forrow L

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Sedation is widely used in intensive care unit (ICU) patients to limit the risk of pulmonary barotrauma and to decrease oxygen needs. However, adverse effects of cc5128sedation have not been fully evaluated; in particular, effects of benzodiazepine and opiates on microcirculation have not been extensively ...

journal_title：Critical care (London, England)

authors： Lamblin V,Favory R,Boulo M,Mathieu D

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The frequency and clinical significance of polymicrobial aetiology in community-acquired pneumonia (CAP) patients admitted to the ICU have been poorly studied. The aim of the present study was to describe the prevalence, clinical characteristics and outcomes of severe CAP of polymicrobial aetiology in pati...

journal_title：Critical care (London, England)

authors： Cillóniz C,Ewig S,Ferrer M,Polverino E,Gabarrús A,Puig de la Bellacasa J,Mensa J,Torres A

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Postoperative atrial fibrillation (POAF) is commonplace after cardiothoracic surgery. A rate control strategy using short-acting beta blockers is recommended as a first-line therapy in patients without hemodynamic instability. Microcirculatory effects of POAF and esmolol have not yet been investigated. We hy...

journal_title：Critical care (London, England)

authors： Fornier W,Jacquet-Lagrèze M,Collenot T,Teixeira P,Portran P,Schweizer R,Ovize M,Fellahi JL

更新日期：2017-12-12 00:00:00

abstract：INTRODUCTION:Between 1 and 31% of patients suffering out-of-hospital cardiac arrest (OHCA) survive to discharge from hospital. International studies have shown that the level of care provided by the admitting hospital determines survival for patients suffering from OHCA. These data may only be partially transferable to...

journal_title：Critical care (London, England)

authors： Wnent J,Seewald S,Heringlake M,Lemke H,Brauer K,Lefering R,Fischer M,Jantzen T,Bein B,Messelken M,Gräsner JT

更新日期：2012-09-12 00:00:00

abstract：BACKGROUND:Renal perfusion status remains poorly studied at the bedside during septic shock. We sought to measure cortical renal perfusion in patients with septic shock during their first 3 days of care using renal contrast enhanced ultrasound (CEUS). METHODS:We prospectively included 20 ICU patients with septic shock...

journal_title：Critical care (London, England)

authors： Harrois A,Grillot N,Figueiredo S,Duranteau J

更新日期：2018-06-15 00:00:00

abstract：INTRODUCTION:The choice of invasive systemic haemodynamic monitoring in critically ill patients remains controversial as no multicentre comparative clinical data exist. Accordingly, we sought to study and compare the features and outcomes of patients who receive haemodynamic monitoring with either the pulmonary artery ...

journal_title：Critical care (London, England)

authors： Uchino S,Bellomo R,Morimatsu H,Sugihara M,French C,Stephens D,Wendon J,Honore P,Mulder J,Turner A,PAC\/PiCCO Use and Likelihood of Success Evaluation PULSE Study Group.

更新日期：2006-01-01 00:00:00

abstract：:Prior to 2001 there was no standard for early management of severe sepsis and septic shock in the emergency department. In the presence of standard or usual care, the prevailing mortality was over 40-50 %. In response, a systems-based approach, similar to that in acute myocardial infarction, stroke and trauma, called ...

journal_title：Critical care (London, England)

authors： Nguyen HB,Jaehne AK,Jayaprakash N,Semler MW,Hegab S,Yataco AC,Tatem G,Salem D,Moore S,Boka K,Gill JK,Gardner-Gray J,Pflaum J,Domecq JP,Hurst G,Belsky JB,Fowkes R,Elkin RB,Simpson SQ,Falk JL,Singer DJ,Rivers EP

更新日期：2016-07-01 00:00:00

abstract：:An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic. Both SARS-CoV-2 and SARS-CoV enter host cells via the angiotensin-converting enzyme 2 (ACE2) receptor, which is expressed in various human organ...

journal_title：Critical care (London, England)

authors： Ni W,Yang X,Yang D,Bao J,Li R,Xiao Y,Hou C,Wang H,Liu J,Yang D,Xu Y,Cao Z,Gao Z

更新日期：2020-07-13 00:00:00

abstract：INTRODUCTION:Hemorrhagic shock induced O2 deficit triggers inflammation and multiple organ failure (MOF). Endogenous H2S has been proposed to be involved in MOF since plasma H2S concentration appears to increase in various types of shocks and to predict mortality. We tested the hypothesis that H2S increases during hemo...

journal_title：Critical care (London, England)

authors： Van de Louw A,Haouzi P

更新日期：2012-10-02 00:00:00

abstract：INTRODUCTION:We conducted an ultrasound study to investigate echocardiographic artifacts in mechanically ventilated patients with lung pathology. METHODS:A total of 205 mechanically ventilated patients who exhibited lung atelectasis and/or pleural effusion were included in this 36-month study. The patients underwent l...

journal_title：Critical care (London, England)

authors： Karabinis A,Saranteas T,Karakitsos D,Lichtenstein D,Poularas J,Yang C,Stefanadis C

更新日期：2008-01-01 00:00:00

abstract：:Even more than in previous disasters, Katrina has proven itself to be a testing ground for a plethora of new technologies. Although not all of these technologies did immediately save lives, in this regard a number of them exhibited considerable potential for the future, and hence there is a need to include them in fut...

journal_title：Critical care (London, England)

authors： Leitl E

更新日期：2006-02-01 00:00:00

abstract：INTRODUCTION:The gut is often considered as the motor of critical illness through bacterial translocation, which amplifies the inflammatory response and alters the immune status. However, systemic bacterial translocation was rarely proven and endotoxin measurement only reflects translocation of Gram-negative-derived pr...

journal_title：Critical care (London, England)

authors： Kim OY,Monsel A,Bertrand M,Cavaillon JM,Coriat P,Adib-Conquy M

更新日期：2009-01-01 00:00:00

abstract：:Determine the effectiveness of decontamination, and perform thorough dry or wet decontamination, depending on the circumstances. Always remain cognizant of the fact that, even after decontamination has been completed, contamination may not have been completely eliminated. Perform periodic monitoring to determine wheth...

journal_title：Critical care (London, England)

authors： Okumura S,Okumura T,Ishimatsu S,Miura K,Maekawa H,Naito T

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:Economic evaluations of interventions in the hospital setting often rely on the estimated long-term impact on patient survival. Estimates of mortality rates and long-term outcomes among patients discharged alive from the intensive care unit (ICU) are lacking from lower- and middle-income countries. This st...

journal_title：Critical care (London, England)

authors： Luangasanatip N,Hongsuwan M,Lubell Y,Limmathurotsakul D,Teparrukkul P,Chaowarat S,Day NP,Graves N,Cooper BS

更新日期：2013-10-03 00:00:00

abstract：BACKGROUND:Candidemia is an opportunistic infection associated with high morbidity and mortality in patients hospitalized both inside and outside intensive care units (ICUs). Identification of patients at risk is crucial to ensure prompt antifungal therapy. We sought to assess risk factors for candidemia and death, bot...

journal_title：Critical care (London, England)

authors： Poissy J,Damonti L,Bignon A,Khanna N,Von Kietzell M,Boggian K,Neofytos D,Vuotto F,Coiteux V,Artru F,Zimmerli S,Pagani JL,Calandra T,Sendid B,Poulain D,van Delden C,Lamoth F,Marchetti O,Bochud PY,FUNGINOS.,Allfun F

更新日期：2020-03-18 00:00:00

abstract：:Drug acquisition costs are only a proportion of the total costs associated with drug therapy. The relevance of these costs are often not appreciated. However, they impact on the Intensive Care Unit via resources and quality of care. Increased indirect care by medical and nursing staff has the potential to adversely af...

journal_title：Critical care (London, England)

authors： Edbrooke DL,Bourne RS

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:The shock index (SI), defined as heart rate (HR) divided by systolic blood pressure (SBP), is reported to be a more sensitive marker of shock than traditional vital signs alone. In previous literature, use of the reverse shock index (rSI), taken as SBP divided by HR, is recommended instead of SI for hospital...

journal_title：Critical care (London, England)

authors： Kimura A,Tanaka N

更新日期：2018-04-11 00:00:00

abstract：BACKGROUND:Coagulation can be visualised using whole blood coagulation analyses such as thromboelastometry and platelet aggregation tests; however, the role of temperature in the analyses is ambiguous. The aim was to examine whether temperature influences the whole blood coagulation tests. METHODS:We included 40 patie...

journal_title：Critical care (London, England)

authors： Jeppesen AN,Kirkegaard H,Ilkjær S,Hvas AM

更新日期：2016-04-30 00:00:00

abstract：:BACKGROUND: In recent years, rural hospitals have expanded their scope of specialized services, which has led to the development and staffing of rural intensive care units (ICUs). There is little information about the breadth, quality or outcomes of these services. This is particularly true for specialized ICU service...

journal_title：Critical care (London, England)

authors： Fieselmann JF,Bock MJ,Hendryx MS,Wakefield D,Helms CM,Bentler SE

更新日期：1999-01-01 00:00:00

abstract：INTRODUCTION:Correct bedside measurement of intra-abdominal pressure (IAP) is important. The bladder method is considered as the gold standard for indirect IAP measurement, but the instillation volumes reported in the literature vary substantially. The aim of this study was to evaluate the effect of instillation volume...

journal_title：Critical care (London, England)

authors： Malbrain ML,Deeren DH

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Effects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described. METHODS:Experimental endotoxemia (2 ng/kg Escherichia coli lipopolysaccharide [LPS]) was induced in 15 subjects, whereas 10 ser...

journal_title：Critical care (London, England)

authors： van den Boogaard M,Ramakers BP,van Alfen N,van der Werf SP,Fick WF,Hoedemaekers CW,Verbeek MM,Schoonhoven L,van der Hoeven JG,Pickkers P

更新日期：2010-01-01 00:00:00

abstract：:Recent interest in transfusion management of trauma patients has heightened expectation in the role of blood component therapy in improving patient outcome. Optimal transfusion support in supplementation with fibrinogen has not been defined by high-quality evidence. Current evidence comes mainly from case series and u...

journal_title：Critical care (London, England)

authors： Stanworth SJ,Hunt BJ

更新日期：2011-01-01 00:00:00