Nondrug costs of therapy in acute care--are they important?

abstract：:Despite continuous advances in technologic and pharmacologic management, the mortality rate from septic shock remains high. Care of patients with sepsis includes measures to support the circulatory system and treat the underlying infection. There is a substantial body of knowledge indicating that fluid resuscitation, ...

journal_title：Critical care (London, England)

authors： Waxman AB,Ward N,Thompson T,Lilly CM,Lisbon A,Hill N,Nasraway SA,Heard S,Corwin H,Levy M

更新日期：2005-08-20 00:00:00

abstract：:Considerable progress has been made in the past few years in the development of therapeutic interventions that can reduce mortality in sepsis. However, encouraging physicians to put the results of new studies into practice is not always simple. A roundtable was thus convened to provide guidance for clinicians on the i...

journal_title：Critical care (London, England)

authors： Vincent JL,Abraham E,Annane D,Bernard G,Rivers E,Van den Berghe G

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Biomarkers can be of help to understand critical illness and to identify and stratify sepsis. Adrenomedullin is a vasoactive hormone, with reported prognostic and potentially therapeutic value in sepsis. The primary aim of this study was to investigate the association of circulating bioactive adrenomedullin ...

journal_title：Critical care (London, England)

authors： Lundberg OHM,Lengquist M,Spångfors M,Annborn M,Bergmann D,Schulte J,Levin H,Melander O,Frigyesi A,Friberg H

更新日期：2020-11-04 00:00:00

abstract：:Disagreements between the perceptions of nurses and physicians regarding end-of-life (EOL) decisions are frequent. In a survey carried out in 13 Brazilian ICUs, Fumis and Deheinzelin reported that the majority of nurses, physicians and family members are in favor of limiting life-sustaining therapies in terminally ill...

journal_title：Critical care (London, England)

authors： Soares M

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:During septic shock, resistance to the haemodynamic effects of catecholamine vasopressors and inotropes is a well-recognised marker of mortality risk. However, the specific cardiovascular or metabolic response elements that are most closely associated with outcome have not been well defined. The objective ...

journal_title：Critical care (London, England)

authors： Kumar A,Schupp E,Bunnell E,Ali A,Milcarek B,Parrillo JE

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Diclofenac, a nonsteroidal antiinflammatory drug, is commonly used as antipyretic therapy in intensive care. The purpose of this study was to investigate the effects of parenteral diclofenac infusion on brain homeostasis, including brain-tissue oxygen tension (PbtO2) and brain metabolism after aneurysmal s...

journal_title：Critical care (London, England)

authors： Schiefecker AJ,Pfausler B,Beer R,Sohm F,Sabo J,Knauseder V,Fischer M,Dietmann A,Hackl WO,Thomé C,Schmutzhard E,Helbok R

更新日期：2013-05-12 00:00:00

abstract：INTRODUCTION:The aim of this study was to determine whether the degree of fluid responsiveness in critically ill septic patients is related to baseline mixed venous oxygen saturation (SvO2) levels. We also sought to define whether fluid responsiveness would be less likely in the presence of a high SvO2 (>70%). METHODS...

journal_title：Critical care (London, England)

authors： Velissaris D,Pierrakos C,Scolletta S,De Backer D,Vincent JL

更新日期：2011-07-26 00:00:00

abstract：:In an effort to reduce the complications related to invasive ventilation, the use of noninvasive ventilation (NIV) has increased over the last years in patients with acute respiratory failure. However, failure rates for NIV remain high in specific patient categories. Several studies have identified factors that contri...

journal_title：Critical care (London, England)

authors： Oppersma E,Doorduin J,van der Heijden EH,van der Hoeven JG,Heunks LM

更新日期：2013-12-05 00:00:00

abstract：:Assessment of vasomotor tone is essential in defining appropriate resuscitation strategies for the hypotensive patient. Although changes in mean arterial pressure to cardiac output define arterial resistance, resistance is only one component of vasomotor tone. Compliance is the other component. The reciprocal of compl...

journal_title：Critical care (London, England)

authors： Pinsky MR

更新日期：2011-01-01 00:00:00

abstract：:Glucocorticoid use in sepsis is controversial. In contrast to other extracellular signaling molecules, glucocorticoid receptors (GRs) are intra-cytoplasmic. Several GR isoforms have been identified. A study in Critical Care Forum suggests that sepsis alters the abundance of the dominant negative GRβ. Here we discuss G...

journal_title：Critical care (London, England)

authors： Deutschman CS

更新日期：2013-06-27 00:00:00

abstract：INTRODUCTION:Despite recent interest in measurement of central venous oxygen saturation (ScvO2), there are no published data describing the pattern of ScvO2 changes after major general surgery or any relationship with outcome. METHODS:ScvO2 and other biochemical, physiological and demographic data were prospectively m...

journal_title：Critical care (London, England)

authors： Pearse R,Dawson D,Fawcett J,Rhodes A,Grounds RM,Bennett ED

更新日期：2005-01-01 00:00:00

abstract：:The Surviving Sepsis Campaign guidelines for the management of severe sepsis and septic shock recommend that the initial hemodynamic resuscitation be done according to the protocol used by Rivers and colleagues in their well-known early goal-directed therapy (EGDT) study. However, it may well be that their patients we...

journal_title：Critical care (London, England)

authors： Perel A

更新日期：2008-01-01 00:00:00

abstract：:Cardiogenic shock is a lethal condition. Physicians are searching for hemodynamic markers which could help risk-stratification of patients in this picture. Torgersen and coworkers present an hourly time integral of the cardiac power index and cardiac index drops to predict outcomes in the setting of cardiogenic shock....

journal_title：Critical care (London, England)

authors： Yilmaz MB,Mebazaa A

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Patients with acute-on-chronic liver failure show an aggravated hyperdynamic circulation. We evaluated, in a controlled manner, potential changes in systemic haemodynamics induced by the molecular adsorbent recirculating system (MARS) and the Prometheus system liver detoxification devices in a group of pat...

journal_title：Critical care (London, England)

authors： Laleman W,Wilmer A,Evenepoel P,Elst IV,Zeegers M,Zaman Z,Verslype C,Fevery J,Nevens F

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:For patients who survive a critical illness and have their oral endotracheal tube removed, dysphagia is highly prevalent, and without intervention, it may persist far beyond hospital discharge. This pre- and post-intervention study with historical controls tested the effects of a swallowing and oral care (SO...

journal_title：Critical care (London, England)

authors： Wu CP,Xu YJ,Wang TG,Ku SC,Chan DC,Lee JJ,Wei YC,Hsiao TY,Chen CC

更新日期：2019-11-09 00:00:00

abstract：INTRODUCTION:The aetiology of lower respiratory tract infections in young children admitted to the paediatric intensive care unit (PICU) is often difficult to establish. However, most infections are believed to be caused by respiratory viruses. A diagnostic study was performed to compare conventional viral tests with t...

journal_title：Critical care (London, England)

authors： van de Pol AC,Wolfs TF,Jansen NJ,van Loon AM,Rossen JW

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Impaired skeletal muscle function has important clinical outcome implications for survivors of critical illness. Previous studies employing volitional manual muscle testing for diagnosing intensive care unit-acquired weakness (ICU-AW) during the early stages of critical illness have only provided limited d...

journal_title：Critical care (London, England)

authors： Connolly BA,Jones GD,Curtis AA,Murphy PB,Douiri A,Hopkinson NS,Polkey MI,Moxham J,Hart N

更新日期：2013-10-10 00:00:00

abstract：:The future of critical care medicine will be shaped not only by the evidence-validated foundations of science, but also by innovations based on unproven and, in many cases, untested concepts and thoughtful visions of scientists and clinicians familiar with the complex problems actually faced in clinical practice. Clin...

journal_title：Critical care (London, England)

authors： Marini JJ,Vincent JL,Wischmeyer P,Singer M,Gattinoni L,Ince C,Gan TJ

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:The study objectives were to evaluate septic shock-induced alterations in skeletal muscle hemoglobin oxygenation saturation (StO2) using near-infrared spectroscopy (NIRS) and forearm skin blood flow velocity using laser Doppler (LD) to determine the relationship of macroperfusion and microperfusion paramet...

journal_title：Critical care (London, England)

authors： Payen D,Luengo C,Heyer L,Resche-Rigon M,Kerever S,Damoisel C,Losser MR

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Critical illness following head injury is associated with a hypermetabolic state but there are insufficient epidemiological data describing acute nutrition delivery to this group of patients. Furthermore, there is little information describing relationships between nutrition and clinical outcomes in this pop...

journal_title：Critical care (London, England)

authors： Chapple LA,Chapman MJ,Lange K,Deane AM,Heyland DK

更新日期：2016-01-07 00:00:00

abstract：INTRODUCTION:Prognosis in patients suffering out-of-hospital cardiac arrest is poor. Higher survival rates have been observed only in patients with ventricular fibrillation who were fortunate enough to have basic and advanced life support initiated soon after cardiac arrest. An ability to predict cardiac arrest outcome...

journal_title：Critical care (London, England)

authors： Kolar M,Krizmaric M,Klemen P,Grmec S

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Hemorrhagic shock induced O2 deficit triggers inflammation and multiple organ failure (MOF). Endogenous H2S has been proposed to be involved in MOF since plasma H2S concentration appears to increase in various types of shocks and to predict mortality. We tested the hypothesis that H2S increases during hemo...

journal_title：Critical care (London, England)

authors： Van de Louw A,Haouzi P

更新日期：2012-10-02 00:00:00

abstract：:There has been a lot of debate about the concept of relative adrenocortical insufficiency (often defined as a reduced response to corticotropin) as a pathophysiological explanation of steroid effects in septic shock. Less is known about the prevalence of absolute adrenocortical insufficiency based on more usual defini...

journal_title：Critical care (London, England)

authors： Bollaert PE

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Dehydroepiandrosterone (DHEA) improves survival after trauma and sepsis, while mechanisms of action are not yet fully understood. Therefore, we investigated the influence of DHEA on local cytokine expression in a two-hit model. METHODS:Male NMRI mice were subjected to femur fracture/hemorrhagic shock and ...

journal_title：Critical care (London, England)

authors： Barkhausen T,Hildebrand F,Krettek C,van Griensven M

更新日期：2009-01-01 00:00:00

abstract：:Heart rate variability in the frequency domain can now be obtained at the bedside in the ICU. Promising data suggest that it may help to characterize a patient response to a spontaneous breathing trial. Refinement of the analysis could even help to predict the outcome of extubation or at least help to detect early pat...

journal_title：Critical care (London, England)

authors： Brochard L

更新日期：2014-03-31 00:00:00

abstract：INTRODUCTION:Patients admitted to intensive care following surgery for faecal peritonitis present particular challenges in terms of clinical management and risk assessment. Collaborating surgical and intensive care teams need shared perspectives on prognosis. We aimed to determine the relationship between dynamic asses...

journal_title：Critical care (London, England)

authors： Tridente A,Clarke GM,Walden A,Gordon AC,Hutton P,Chiche JD,Holloway PA,Mills GH,Bion J,Stüber F,Garrard C,Hinds C,GenOSept Investigators.

更新日期：2015-05-05 00:00:00

abstract：BACKGROUND:In hospitalised patients, anaemia increases the risk of developing acute kidney injury (AKI). Our aim was to determine whether anaemia also has an impact on the risk of progression from early AKI to more severe AKI in critically ill patients. METHODS:We retrospectively analysed the data of patients admitted...

journal_title：Critical care (London, England)

authors： Powell-Tuck J,Crichton S,Raimundo M,Camporota L,Wyncoll D,Ostermann M

更新日期：2016-03-08 00:00:00

abstract：INTRODUCTION:Fractalkine is a chemokine implicated as a mediator in a variety of inflammatory conditions. Knowledge of fractalkine release in patients presenting with infection to the Intensive Care Unit (ICU) is highly limited. The primary objective of this study was to establish whether plasma fractalkine levels are ...

journal_title：Critical care (London, England)

authors： Hoogendijk AJ,Wiewel MA,van Vught LA,Scicluna BP,Belkasim-Bohoudi H,Horn J,Zwinderman AH,Klein Klouwenberg PM,Cremer OL,Bonten MJ,Schultz MJ,van der Poll T,MARS consortium.

更新日期：2015-11-25 00:00:00

abstract：: ...

journal_title：Critical care (London, England)

authors： Virk HS,Wiersinga WJ

更新日期：2019-02-13 00:00:00

abstract：INTRODUCTION:Admission blood glucose (BG) level is a predictor of mortality in patients with ST-segment elevation myocardial infarction (STEMI). However, limited data are available relating admission BG to mortality in patients with STEMI complicated by cardiogenic shock, and it is not known whether diabetic status has...

journal_title：Critical care (London, England)

authors： Yang JH,Song PS,Song YB,Hahn JY,Choi SH,Choi JH,Lee SH,Jeong MH,Kim YJ,Gwon HC

更新日期：2013-10-03 00:00:00