Immunoglobulin M in Health and Diseases: How Far Have We Come and What Next?

abstract：:Natural killer (NK) cells play an important role in the containment of HIV replication during primary infection, though their functions are impaired during chronic HIV infection. Infants experience more rapid HIV disease progression than adults, but contributions of infant NK cells to containing HIV infection are unkn...

journal_title：Frontiers in immunology

authors： Slyker JA,Lohman-Payne B,John-Stewart GC,Dong T,Mbori-Ngacha D,Tapia K,Atzberger A,Taylor S,Rowland-Jones SL,Blish CA

更新日期：2012-12-31 00:00:00

abstract：:Activation of the aryl hydrocarbon receptor (AhR) by its prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mediates potent suppression of T-cell dependent immune responses. The suppressive effects of TCDD occur early during CD4(+) T-cell differentiation in the absence of effects on proliferation and have ...

journal_title：Frontiers in immunology

authors： Rohlman D,Pham D,Yu Z,Steppan LB,Kerkvliet NI

更新日期：2012-08-06 00:00:00

abstract：:An important challenge in cancer immunotherapy is to expand the number of patients that benefit from immune checkpoint inhibitors (CI), a fact that has been related to the pre-existence of an efficient anti-tumor immune response. Different strategies are being proposed to promote tumor immunity and to be used in combi...

journal_title：Frontiers in immunology

authors： Roselli E,Araya P,Núñez NG,Gatti G,Graziano F,Sedlik C,Benaroch P,Piaggio E,Maccioni M

更新日期：2019-03-20 00:00:00

abstract：:Epstein Barr virus (EBV) is a gamma herpes virus associated with certain malignancies and autoimmune diseases. EBV maintains latency in B cells with occasional reactivation, in part by overcoming the host immune response with viral homologs of several human proteins. EBV interleukin 10 (vIL-10), a lytic phase protein,...

journal_title：Frontiers in immunology

authors： Jog NR,Chakravarty EF,Guthridge JM,James JA

更新日期：2018-10-09 00:00:00

abstract：:Immunoglobulin A (IgA) is the most abundant antibody class present at mucosal surfaces. The production of IgA exceeds the production of all other antibodies combined, supporting its prominent role in host-pathogen defense. IgA closely interacts with the intestinal microbiota to enhance its diversity, and IgA has a pas...

journal_title：Frontiers in immunology

authors： Breedveld A,van Egmond M

更新日期：2019-03-22 00:00:00

abstract：:Vitamin A deficiency affects over 250 million preschool-age children worldwide and is associated with increased childhood mortality and risk of developing enteric infections. Vitamin A deficient (A-) mice developed chronic Citrobacter rodentium infection. A single oral dose of retinoic acid (RA) at d7 post-infection w...

journal_title：Frontiers in immunology

authors： Snyder LM,McDaniel KL,Tian Y,Wei CH,Kennett MJ,Patterson AD,Ross AC,Cantorna MT

更新日期：2019-01-08 00:00:00

abstract：:Neutrophil extracellular trap (NET) formation requires chromatin decondensation before nuclear swelling and eventual extracellular release of DNA, which occurs together with nuclear and cytoplasmic antimicrobial proteins. A key mediator of chromatin decondensation is protein deiminase 4 (PAD4), which catalyzes histone...

journal_title：Frontiers in immunology

authors： Clark HL,Abbondante S,Minns MS,Greenberg EN,Sun Y,Pearlman E

更新日期：2018-05-29 00:00:00

abstract：:Objectives: Regulatory T cells (Tregs) are frequently functionally impaired in patients with granulomatosis with polyangiitis (GPA). However, the mechanism underlying their impaired function is unknown. Here, we hypothesized that Treg dysfunction in GPA is due to altered microRNA (miRNA) expression. Methods: RNA isola...

journal_title：Frontiers in immunology

authors： Dekkema GJ,Bijma T,Jellema PG,Van Den Berg A,Kroesen BJ,Stegeman CA,Heeringa P,Abdulahad WH,Sanders JS

更新日期：2019-09-12 00:00:00

abstract：:Defense peptides protect multicellular eukaryotes from infections. In biomedical sciences, a dominant conceptual framework refers to defense peptides as host-defense peptides (HDPs), which are bifunctional peptides with both direct antimicrobial and immunomodulatory activities. No HDP has been reported in plants so fa...

journal_title：Frontiers in immunology

authors： Petre B

更新日期：2020-08-21 00:00:00

abstract：:Obesity-associated inflammation stems from a combination of cell-intrinsic changes of individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune cells. Although much of the focus of immune cell contributions to metabolic disease has focused on adipose tissue-associated cells, these potent...

journal_title：Frontiers in immunology

authors： Liu R,Nikolajczyk BS

更新日期：2019-07-17 00:00:00

abstract：:Leprosy serology reflects the bacillary load of patients and multidrug therapy (MDT) reduces Mycobacterium leprae-specific antibody titers of multibacillary (MB) patients. The Clinical Trial for Uniform Multidrug Therapy Regimen for Leprosy Patients in Brazil (U-MDT/CT-BR) compared outcomes of regular 12 doses MDT/R-M...

journal_title：Frontiers in immunology

authors： Hungria EM,Bührer-Sékula S,Oliveira RM,Aderaldo LC,Pontes MAA,Cruz R,de Gonçalves HS,Penna MLF,Penna GO,Stefani MMA

更新日期：2018-05-14 00:00:00

abstract：:Immunoglobulin (Ig) replacement therapy dramatically changed the clinical course of primary hypogammaglobulinemias, significantly reducing the incidence of infectious events. Over the last two decades its use has been extended to secondary antibody deficiencies, particularly those related to hematological disorders as...

journal_title：Frontiers in immunology

authors： Compagno N,Malipiero G,Cinetto F,Agostini C

更新日期：2014-12-08 00:00:00

abstract：:Humans have an innate desire to observe and subsequently dissect an event into component pieces in an effort to better characterize the event. We then examine these pieces individually and in combinations using this information to determine the outcome of future similar events and the likelihood of their recurrence. P...

journal_title：Frontiers in immunology

authors： Reed AM,Crowson CS,Dvergsten JA

更新日期：2019-04-02 00:00:00

abstract：:The dual potential to promote tolerance or inflammation to self-antigens makes dendritic cells (DCs) fundamental players in autoimmunity. Previous results have shown that stimulation of dopamine receptor D5 (DRD5) in DCs potentiates their inflammatory behaviour, favouring the development of experimental autoimmune enc...

journal_title：Frontiers in immunology

authors： Prado C,Gaiazzi M,González H,Ugalde V,Figueroa A,Osorio-Barrios FJ,López E,Lladser A,Rasini E,Marino F,Zaffaroni M,Cosentino M,Pacheco R

更新日期：2018-03-21 00:00:00

abstract：:Pertussis or whooping cough, mainly caused by Bordetella pertussis, is a severe respiratory disease that can affect all age groups but is most severe and can be life-threatening in young children. Vaccines against this disease are widely available since the 1950s. Despite high global vaccination coverage, the disease ...

journal_title：Frontiers in immunology

authors： Solans L,Locht C

更新日期：2019-01-14 00:00:00

abstract：:In this study, we identified and characterized the potential of a high ratio of bicarbonate to CO2 and a moderately alkaline pH to render neutrophils prone to undergo neutrophil extracellular trap (NET) formation. Both experimental settings increased the rate of spontaneous NET release and potentiated the NET-inducing...

journal_title：Frontiers in immunology

authors： Maueröder C,Mahajan A,Paulus S,Gößwein S,Hahn J,Kienhöfer D,Biermann MH,Tripal P,Friedrich RP,Munoz LE,Neurath MF,Becker C,Schett GA,Herrmann M,Leppkes M

更新日期：2016-12-09 00:00:00

abstract：:A major limitation to the translation of tolerogenic therapies to clinical transplantation is a lack of biomarkers that can be used as surrogate measures for predicting the successful induction of immune tolerance which would allow for the safe withdrawal of immunosuppression. We have used three different mouse models...

journal_title：Frontiers in immunology

authors： Cobbold SP,Adams E,Waldmann H

更新日期：2011-04-06 00:00:00

abstract：:The 5-year survival rate of primary anorectal malignant melanoma is less than 20%. Optimal treatment of this condition remains controversial regarding locally disease, and whether any preferential survival benefit arises from either abdominoperineal resection or wide local excision remains unknown. The majority of pat...

journal_title：Frontiers in immunology

authors： Faure M,Rochigneux P,Olive D,Taix S,Brenot-Rossi I,Gilabert M

更新日期：2018-04-19 00:00:00

abstract：:Vaccination with CD1d-binding glycolipid adjuvants and co-administered protein, lipid, and carbohydrate antigens leads to invariant natural killer T (NKT) cell-dependent enhancement of protective B cell responses. NKT cell activation boosts the establishment of protein antigen-specific B cell memory and long-lived pla...

journal_title：Frontiers in immunology

authors： Lang ML

更新日期：2018-02-22 00:00:00

abstract：:Influenza A viruses (IAVs) continue to pose major risks of morbidity and mortality during yearly epidemics and periodic pandemics. The genomic instability of IAV allows it to evade adaptive immune responses developed during prior infection. Of particular concern are pandemics which result from wholesale incorporation ...

journal_title：Frontiers in immunology

authors： Hsieh IN,De Luna X,White MR,Hartshorn KL

更新日期：2018-06-13 00:00:00

abstract：:Degenerative disc disease is associated with increased expression of pro-inflammatory cytokines in the intervertebral disc (IVD). However, it is not completely clear how inflammation arises in the IVD and which cellular compartments are involved in this process. Recently, the endoplasmic reticulum (ER) has emerged as ...

journal_title：Frontiers in immunology

authors： Krupkova O,Sadowska A,Kameda T,Hitzl W,Hausmann ON,Klasen J,Wuertz-Kozak K

更新日期：2018-08-17 00:00:00

abstract：:Prolonged low-grade inflammation or smoldering inflammation is a hallmark of cancer. Mast cells form a heterogeneous population of immune cells with differences in their ultra-structure, morphology, mediator content, and surface receptors. Mast cells are widely distributed throughout all tissues and are stromal compon...

journal_title：Frontiers in immunology

authors： Varricchi G,Galdiero MR,Loffredo S,Marone G,Iannone R,Marone G,Granata F

更新日期：2017-04-12 00:00:00

abstract：:Red blood cells (RBCs) have a well-defined lifespan, indicating a mechanism by which senescent cells of a certain age are removed from circulation. However, the specifics by which senescent cells are recognized and removed are poorly understood. There are multiple competing hypotheses for this process, perhaps the mos...

journal_title：Frontiers in immunology

authors： Hudson KE,de Wolski K,Kapp LM,Richards AL,Schniederjan MJ,Zimring JC

更新日期：2017-10-30 00:00:00

abstract：:Anemia of inflammation (AI) is the second most prevalent anemia after iron deficiency anemia and results in persistent low blood erythrocytes and hemoglobin, fatigue, weakness, and early death. Anemia of inflammation is common in people with chronic inflammation, chronic infections, or sepsis. Although several studies...

journal_title：Frontiers in immunology

authors： Bisht K,Tay J,Wellburn RN,McGirr C,Fleming W,Nowlan B,Barbier V,Winkler IG,Levesque JP

更新日期：2020-10-06 00:00:00

abstract：:A novel coronavirus, which has been designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first detected in December 2019 in Wuhan China and causes the highly infectious disease referred to as COVID-19. COVID-19 has now spread worldwide to become a global pandemic affecting over 24 million pe...

journal_title：Frontiers in immunology

authors： Sharma O,Sultan AA,Ding H,Triggle CR

更新日期：2020-10-14 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells that link innate and adaptive immunity and are critical for the induction of protective immune responses against pathogens. Proportions of these cells are markedly decreased in the blood of untreated HIV-1-infected individuals, suggesting they might be in...

journal_title：Frontiers in immunology

authors： Martin-Gayo E,Yu XG

更新日期：2019-06-06 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation of the synovial lining (synovitis). The inflammation in the RA joint is associated with and driven by immune cell infiltration, synovial hyperproliferation, and excessive production of proinflammatory mediators, such as tumor nec...

journal_title：Frontiers in immunology

authors： Roberts CA,Dickinson AK,Taams LS

更新日期：2015-11-19 00:00:00

abstract：:Infection and inflammation of the male reproductive tract are relevant causes of infertility. Inflammatory damage occurs in the special immunosuppressive microenvironment of the testis, a hallmark termed testicular immune privilege, which allows tolerance to neo-antigens from developing germ cells appearing at puberty...

journal_title：Frontiers in immunology

authors： Lustig L,Guazzone VA,Theas MS,Pleuger C,Jacobo P,Pérez CV,Meinhardt A,Fijak M

更新日期：2020-09-25 00:00:00

abstract：:Adenosine, a purine nucleoside generated by the dephosphorylation of adenine nucleotides, is a potent endogenous physiologic and pharmacologic regulator of many functions. Adenosine was first reported to inhibit the inflammatory actions of neutrophils nearly 30 years ago and since then the role of adenosine and its re...

journal_title：Frontiers in immunology

authors： Haskó G,Cronstein B

更新日期：2013-04-08 00:00:00

abstract：:Inflammation is a common characteristic of chronic liver disease (CLD). Inflammasomes are multiprotein complexes that can sense and recognize various exogenous and endogenous danger signals, eventually activating interleukin (IL)-1β and IL-18. The sensor component of the inflammasome system is a nucleotide-binding oli...

journal_title：Frontiers in immunology

authors： Wu X,Dong L,Lin X,Li J

更新日期：2017-12-12 00:00:00