Are Mast Cells MASTers in Cancer?

Abstract:

:Prolonged low-grade inflammation or smoldering inflammation is a hallmark of cancer. Mast cells form a heterogeneous population of immune cells with differences in their ultra-structure, morphology, mediator content, and surface receptors. Mast cells are widely distributed throughout all tissues and are stromal components of the inflammatory microenvironment that modulates tumor initiation and development. Although canonically associated with allergic disorders, mast cells are a major source of pro-tumorigenic (e.g., angiogenic and lymphangiogenic factors) and antitumorigenic molecules (e.g., TNF-α and IL-9), depending on the milieu. In certain neoplasias (e.g., gastric, thyroid and Hodgkin's lymphoma) mast cells play a pro-tumorigenic role, in others (e.g., breast cancer) a protective role, whereas in yet others they are apparently innocent bystanders. These seemingly conflicting results suggest that the role of mast cells and their mediators could be cancer specific. The microlocalization (e.g., peritumoral vs intratumoral) of mast cells is another important aspect in the initiation/progression of solid and hematologic tumors. Increasing evidence in certain experimental models indicates that targeting mast cells and/or their mediators represent a potential therapeutic target in cancer. Thus, mast cells deserve focused consideration also as therapeutic targets in different types of tumors. There are many unanswered questions that should be addressed before we understand whether mast cells are an ally, adversary, or innocent bystanders in human cancers.

journal_name

Front Immunol

journal_title

Frontiers in immunology

authors

Varricchi G,Galdiero MR,Loffredo S,Marone G,Iannone R,Marone G,Granata F

doi

10.3389/fimmu.2017.00424

subject

Has Abstract

pub_date

2017-04-12 00:00:00

pages

424

issn

1664-3224

journal_volume

8

pub_type

杂志文章,评审
  • Novel Association of High C-Reactive Protein Levels and A69S at Risk Alleles in Wet Age-Related Macular Degeneration Women.

    abstract:Purpose:To explore the relationship between plasma C-reactive protein (CRP) levels, the main ARMS2 gene single nucleotide polymorphism (SNP), and gender in patients with neovascular age-related macular degeneration (wet AMD). Methods:Our study included 131 patients with wetAMD [age-related eye disease study (AREDS) ca...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.01862

    authors: Fernandez-Robredo P,Recalde S,Hernandez M,Zarranz-Ventura J,Molins B,Casaroli-Marano RP,Adan A,Saenz-de-Viteri M,García-Layana A

    更新日期:2018-08-14 00:00:00

  • Recognition of Double-Stranded RNA and Regulation of Interferon Pathway by Toll-Like Receptor 10.

    abstract::Toll-like receptor (TLR)-10 remains an orphan receptor without well-characterized ligands or functions. Here, we reveal that TLR10 is predominantly localized to endosomes and binds dsRNA in vitro at endosomal pH, suggesting that dsRNA is a ligand of TLR10. Recognition of dsRNA by TLR10 activates recruitment of myeloid...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.00516

    authors: Lee SM,Yip TF,Yan S,Jin DY,Wei HL,Guo RT,Peiris JSM

    更新日期:2018-03-16 00:00:00

  • Staphylococcus aureus Avoids Autophagy Clearance of Bovine Mammary Epithelial Cells by Impairing Lysosomal Function.

    abstract::In dairy herds, mastitis caused by Staphylococcus aureus is difficult to completely cure on the account that S. aureus can invade bovine mammary epithelial cells (BMECs) and result in persistent infection in the mammary gland. Recent studies have demonstrated that autophagy can participate in cell homeostasis by elimi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2020.00746

    authors: Geng N,Wang X,Yu X,Wang R,Zhu Y,Zhang M,Liu J,Liu Y

    更新日期:2020-05-05 00:00:00

  • Mimicking Protein-Protein Interactions through Peptide-Peptide Interactions: HIV-1 gp120 and CXCR4.

    abstract::We have recently designed a soluble synthetic peptide that functionally mimics the HIV-1 coreceptor CXCR4, which is a chemokine receptor that belongs to the family of seven-transmembrane GPCRs. This CXCR4 mimetic peptide, termed CX4-M1, presents the three extracellular loops (ECLs) of the receptor. In binding assays i...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2013.00257

    authors: Groß A,Möbius K,Haußner C,Donhauser N,Schmidt B,Eichler J

    更新日期:2013-09-03 00:00:00

  • Sulforaphane Promotes Dendritic Cell Stimulatory Capacity Through Modulation of Regulatory Molecules, JAK/STAT3- and MicroRNA-Signaling.

    abstract:Introduction:The broccoli isothiocyanate sulforaphane was shown to inhibit inflammation and tumor progression, also in pancreatic cancer, while its effect on tumor immunity is poorly understood. We investigated the immunoregulatory effect of sulforaphane on human dendritic cells alone and in presence of pancreatic tumo...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2020.589818

    authors: Wang Y,Petrikova E,Gross W,Sticht C,Gretz N,Herr I,Karakhanova S

    更新日期:2020-10-30 00:00:00

  • Role of Dendritic Cells in Natural Immune Control of HIV-1 Infection.

    abstract::Dendritic cells (DCs) are professional antigen-presenting cells that link innate and adaptive immunity and are critical for the induction of protective immune responses against pathogens. Proportions of these cells are markedly decreased in the blood of untreated HIV-1-infected individuals, suggesting they might be in...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2019.01306

    authors: Martin-Gayo E,Yu XG

    更新日期:2019-06-06 00:00:00

  • Mutual Interference between Cytomegalovirus and Reconstitution of Protective Immunity after Hematopoietic Cell Transplantation.

    abstract::Hematopoietic cell transplantation (HCT) is a therapy option for aggressive forms of hematopoietic malignancies that are resistant to standard antitumoral therapies. Hematoablative treatment preceding HCT, however, opens a "window of opportunity" for latent Cytomegalovirus (CMV) by releasing it from immune control wit...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2016.00294

    authors: Reddehase MJ

    更新日期:2016-08-04 00:00:00

  • Differential Apoptotic Responses of Hemocyte Subpopulations to White Spot Syndrome Virus Infection in Fenneropenaeus chinensis.

    abstract::The apoptosis of hemocytes plays an essential function in shrimp immune defense against pathogen invasions. In order to further elucidate the differential apoptotic responses of the granulocytes and the hyalinocytes in Fenneropenaeus chinensis post WSSV infection, the characteristics of apoptotic dynamics and viral pr...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2020.594390

    authors: Cui C,Liang Q,Tang X,Xing J,Sheng X,Zhan W

    更新日期:2020-12-07 00:00:00

  • SARS-CoV-2 Viral RNA Shedding for More Than 87 Days in an Individual With an Impaired CD8+ T Cell Response.

    abstract::Prolonged shedding of viral RNA occurs in some individuals following SARS-CoV-2 infection. We perform comprehensive immunologic evaluation of one individual with prolonged shedding. The case subject recovered from severe COVID-19 and tested positive for SARS-CoV-2 viral RNA repeatedly as many as 87 days after the firs...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2020.618402

    authors: Turner JS,Day A,Alsoussi WB,Liu Z,O'Halloran JA,Presti RM,Patterson BK,Whelan SPJ,Ellebedy AH,Mudd PA

    更新日期:2021-01-08 00:00:00

  • OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis.

    abstract::IL-1β and IL-18 are pro-inflammatory cytokines that are linked to inflammation. Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome is involved in the maturation and secretion of IL-1β and IL-18 and, thus, plays a key role in the pathogenesis of many inflammatory conditions, including multiple sclerosis...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2019.02578

    authors: Sánchez-Fernández A,Skouras DB,Dinarello CA,López-Vales R

    更新日期:2019-11-01 00:00:00

  • Cell Versus Cytokine - Directed Therapies for Hemophagocytic Lymphohistiocytosis (HLH) in Inborn Errors of Immunity.

    abstract::Hemophagocytic lymphohistiocytosis (HLH) is a heterogeneous hyperinflammatory syndrome with different pathways of pathogenesis resulting in similar clinical presentations. It is best defined and understood if presenting in the context of genetic immunodeficiencies associated with defects of lymphocyte cytotoxicity. In...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2020.00808

    authors: Wegehaupt O,Wustrau K,Lehmberg K,Ehl S

    更新日期:2020-05-08 00:00:00

  • Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells.

    abstract::Immune checkpoint inhibition has been shown to successfully reactivate endogenous T cell responses directed against tumor-associated antigens, resulting in significantly prolonged overall survival in patients with various tumor entities. For malignancies with low endogenous immune responses, this approach has not show...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.00385

    authors: Lichtenegger FS,Rothe M,Schnorfeil FM,Deiser K,Krupka C,Augsberger C,Schlüter M,Neitz J,Subklewe M

    更新日期:2018-02-27 00:00:00

  • The Mononuclear Phagocytic System. Generation of Diversity.

    abstract::We are living through an unprecedented accumulation of data on gene expression by macrophages, reflecting their origin, distribution, and localization within all organs of the body. While the extensive heterogeneity of the cells of the mononuclear phagocyte system is evident, the functional significance of their diver...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2019.01893

    authors: Gordon S,Plüddemann A

    更新日期:2019-08-09 00:00:00

  • Distinct Roles of α7 nAChRs in Antigen-Presenting Cells and CD4+ T Cells in the Regulation of T Cell Differentiation.

    abstract::It is now apparent that immune cells express a functional cholinergic system and that α7 nicotinic acetylcholine receptors (α7 nAChRs) are involved in regulating T cell differentiation and the synthesis of antigen-specific antibodies and proinflammatory cytokines. Here, we investigated the specific function α7 nAChRs ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2019.01102

    authors: Mashimo M,Komori M,Matsui YY,Murase MX,Fujii T,Takeshima S,Okuyama H,Ono S,Moriwaki Y,Misawa H,Kawashima K

    更新日期:2019-05-31 00:00:00

  • Umbilical Cord Blood Natural Killer Cells, Their Characteristics, and Potential Clinical Applications.

    abstract::Natural killer (NK) cells are lymphocytes of the innate immune system able to kill different targets such as cancer cells and virally infected cells without prior activation making then attractive candidates for cancer immunotherapy. Umbilical cord blood (UCB) has become a source of hematopoietic stem cells for transp...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2017.00329

    authors: Sarvaria A,Jawdat D,Madrigal JA,Saudemont A

    更新日期:2017-03-23 00:00:00

  • PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells.

    abstract::Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibition by Idelalisib (CAL-101) in hematological malignancies directly induces apoptosis in cancer cells and disrupts immunological tolerance by depleting regulatory T cells. Yet, little is known about the direct impact of PI3Kδ blockade on effector T cells from CAL-101 t...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2017.01221

    authors: Bowers JS,Majchrzak K,Nelson MH,Aksoy BA,Wyatt MM,Smith AS,Bailey SR,Neal LR,Hammerbacher JE,Paulos CM

    更新日期:2017-09-29 00:00:00

  • Volcanic Ash Activates the NLRP3 Inflammasome in Murine and Human Macrophages.

    abstract::Volcanic ash is a heterogeneous mineral dust that is typically composed of a mixture of amorphous (glass) and crystalline (mineral) fragments. It commonly contains an abundance of the crystalline silica (SiO2) polymorph cristobalite. Inhalation of crystalline silica can induce inflammation by stimulating the NLRP3 inf...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2017.02000

    authors: Damby DE,Horwell CJ,Baxter PJ,Kueppers U,Schnurr M,Dingwell DB,Duewell P

    更新日期:2018-01-22 00:00:00

  • Fifth Percentile Cutoff Values for Antipneumococcal Polysaccharide and Anti-Salmonella typhi Vi IgG Describe a Normal Polysaccharide Response.

    abstract:BACKGROUND:Serotype-specific antibody responses to unconjugated pneumococcal polysaccharide vaccine (PPV) evaluated by a World Health Organization (WHO)-standardized enzyme-linked immunosorbent assay (ELISA) are the gold standard for diagnosis of specific polysaccharide antibody deficiency (SAD). The American Academy o...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2017.00546

    authors: Schaballie H,Bosch B,Schrijvers R,Proesmans M,De Boeck K,Boon MN,Vermeulen F,Lorent N,Dillaerts D,Frans G,Moens L,Derdelinckx I,Peetermans W,Kantsø B,Jørgensen CS,Emonds MP,Bossuyt X,Meyts I

    更新日期:2017-05-12 00:00:00

  • A Novel Model on DST-Induced Transplantation Tolerance by the Transfer of Self-Specific Donor tTregs to a Haplotype-Matched Organ Recipient.

    abstract::Donor-specific blood transfusion (DST) can lead to significant prolongation of allograft survival in experimental animal models and sometimes human recipients of solid organs. The mechanisms responsible for the beneficial effect on graft survival have been a topic of research and debate for decades and are not yet ful...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2017.00009

    authors: Mohr Gregoriussen AM,Bohr HG

    更新日期:2017-02-21 00:00:00

  • Expression of Tumor Necrosis Factor Receptor 2 Characterizes TLR9-Driven Formation of Interleukin-10-Producing B Cells.

    abstract::B cell-derived interleukin-10 (IL-10) production has been described as a hallmark for regulatory function in B lymphocytes. However, there is an ongoing debate on the origin of IL-10-secreting B cells and lack of specific surface markers has turned into an important obstacle for studying human B regulatory cells. In t...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2017.01951

    authors: Ticha O,Moos L,Wajant H,Bekeredjian-Ding I

    更新日期:2018-01-19 00:00:00

  • Impaired CpG Demethylation in Common Variable Immunodeficiency Associates With B Cell Phenotype and Proliferation Rate.

    abstract::Common Variable Immunodeficiency (CVID) is characterized by impaired antibody production and poor terminal differentiation of the B cell compartment, yet its pathogenesis is still poorly understood. We first reported the occurrence of epigenetic alterations in CVID by high-throughput methylation analysis in CVID-disco...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2019.00878

    authors: Del Pino-Molina L,Rodríguez-Ubreva J,Torres Canizales J,Coronel-Díaz M,Kulis M,Martín-Subero JI,van der Burg M,Ballestar E,López-Granados E

    更新日期:2019-04-24 00:00:00

  • Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection.

    abstract::Of all the microbial infections relevant to mammals the relationship between parasitic worms and what constitutes and regulates a host protective immune response is perhaps the most complex and evolved. Nippostrongylus brasiliensis is a tissue migrating parasitic roundworm of rodents that exemplifies many of the salie...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2013.00074

    authors: Harvie M,Camberis M,Le Gros G

    更新日期:2013-03-20 00:00:00

  • Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans.

    abstract::Macrophages have been found to both promote liver fibrosis and contribute to its resolution by acquiring different phenotypes based on signals from the micro-environment. The best-characterized phenotypes in the macrophage spectrum are labeled M1 (classically activated) and M2 (alternatively activated). Until now the ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2014.00430

    authors: Beljaars L,Schippers M,Reker-Smit C,Martinez FO,Helming L,Poelstra K,Melgert BN

    更新日期:2014-09-08 00:00:00

  • Expression and Roles of Antimicrobial Peptides in Innate Defense of Airway Mucosa: Potential Implication in Cystic Fibrosis.

    abstract::The treatment of respiratory infections is associated with the dissemination of antibiotic resistance in the community and clinical settings. Development of new antibiotics is notoriously costly and slow; therefore, alternative strategies are needed. Antimicrobial peptides (AMPs), the central effector molecules of the...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2020.01198

    authors: Geitani R,Moubareck CA,Xu Z,Karam Sarkis D,Touqui L

    更新日期:2020-06-30 00:00:00

  • Ruggero Ceppellini: A Perspective on His Contributions to Genetics and Immunology.

    abstract::Ruggero Ceppellini, who died at the age of 71 in 1988, was one of the most stimulating and original human geneticists of his generation (1). Ceppellini's outstanding contributions to the genetics of the human blood groups, immunoglobulin allotypes and the HLA system epitomize the study of immunogenetics. By using his ...

    journal_title:Frontiers in immunology

    pub_type: 传,历史文章,杂志文章

    doi:10.3389/fimmu.2019.01280

    authors: Bodmer W

    更新日期:2019-06-05 00:00:00

  • The Equivocal Role of Th17 Cells and Neutrophils on Immunopathogenesis of Leishmaniasis.

    abstract::Advances in the understanding of leishmaniasis progression indicate that cellular interactions more complex than the Th1/Th2 paradigm define the course of infection. Th17 cells are a crucial modulator of adaptive immunity against Leishmania parasites acting mainly on neutrophil recruitment and playing a dual role at t...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2017.01437

    authors: Gonçalves-de-Albuquerque SDC,Pessoa-E-Silva R,Trajano-Silva LAM,de Goes TC,de Morais RCS,da C Oliveira CN,de Lorena VMB,de Paiva-Cavalcanti M

    更新日期:2017-10-30 00:00:00

  • A Functional Genetic Variant at the C-Reactive Protein Promoter (rs3091244) Is Not Associated With Cancer Risk in a Chinese Population.

    abstract::Background: The association of genetically elevated levels of circulating C-reactive protein (CRP) with cancer risk has been extensively investigated in European populations; however, there are conflicting conclusions. The tri-allelic rs3091244 is a functionally validated genetic variant, and its allelic frequencies d...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2020.00926

    authors: Wang MY,Zhou HH,Zhang CM,Su HX,Li SL,Ji SR,Liu E,Wu Y

    更新日期:2020-05-14 00:00:00

  • Cross-Protective Potential and Protection-Relevant Immune Mechanisms of Whole Inactivated Influenza Virus Vaccines Are Determined by Adjuvants and Route of Immunization.

    abstract::Adjuvanted whole inactivated virus (WIV) influenza vaccines show promise as broadly protective influenza vaccine candidates. Using WIV as basis we assessed the relative efficacy of different adjuvants by carrying out a head-to-head comparison of the liposome-based adjuvants CAF01 and CAF09 and the protein-based adjuva...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2019.00646

    authors: Bhide Y,Dong W,Gribonika I,Voshart D,Meijerhof T,de Vries-Idema J,Norley S,Guilfoyle K,Skeldon S,Engelhardt OG,Boon L,Christensen D,Lycke N,Huckriede A

    更新日期:2019-03-29 00:00:00

  • Corticosterone Preexposure Increases NF-κB Translocation and Sensitizes IL-1β Responses in BV2 Microglia-Like Cells.

    abstract::Corticosterone (CORT), a critical mediator of the hypothalamus pituitary adrenal axis in rodents, is a stress hormone that is classically viewed as possessing immune-suppressive properties. CORT is now appreciated to also mediate the neuroimmune-priming effect of stress to innate-immune stimulation, and hence serves a...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.00003

    authors: Liu J,Mustafa S,Barratt DT,Hutchinson MR

    更新日期:2018-01-22 00:00:00

  • Key Aspects of the Immunobiology of Haploidentical Hematopoietic Cell Transplantation.

    abstract::Hematopoietic stem cell transplantation from a haploidentical donor is increasingly used and has become a standard donor option for patients lacking an appropriately matched sibling or unrelated donor. Historically, prohibitive immunological barriers resulting from the high degree of HLA-mismatch included graft-vs.-ho...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2020.00191

    authors: Baumeister SHC,Rambaldi B,Shapiro RM,Romee R

    更新日期:2020-02-14 00:00:00